Strain Name:
C57BL/6J-MtgxR1421Btlr/Mmmh
Stock Number:
039477-MU
Citation ID:
RRID:MMRRC_039477-MU
Other Names:
R1421 (G1), C57BL/6J-MtgxR1421Btlr
Major Collection:

Gene Information

Slc6a12
Name: solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Synonyms: Gabt2, BGT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14411
Homologene: 128225
Adcy10
Name: adenylate cyclase 10
Synonyms: Sacy, 4930431D04Rik, sAC, soluble adenylyl cyclase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 271639
Homologene: 10188
Pomt1
Name: protein-O-mannosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99011
HGNC: HGNC:9202
Homologene: 68548
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: Bat2l, 5830434P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227723
Homologene: 106649
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Emb
Name: embigin
Synonyms: Gp70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13723
Homologene: 7743
Grhl2
Name: grainyhead like transcription factor 2
Synonyms: 0610015A08Rik, clft3, Tcfcp2l3, grainyheadlike, BOM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 252973
HGNC: HGNC:2799
Homologene: 32616
Ano6
Name: anoctamin 6
Synonyms: Tmem16f, 2900059G15Rik, F730003B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: Adprt1, parp-1, sPARP-1, PARP, 5830444G22Rik, Adprp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11545
HGNC: HGNC:270
Homologene: 1222
Xrcc5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Synonyms: Ku86, Ku80
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22596
VEGA: 1
Homologene: 40681
L2hgdh
Name: L-2-hydroxyglutarate dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217666
VEGA: 12
Homologene: 11767
Zfp407
Name: zinc finger protein 407
Synonyms: LOC240469, 6430585N13Rik, LOC381139
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240476
Homologene: 86402
Atg16l1
Name: autophagy related 16-like 1 (S. cerevisiae)
Synonyms: 1500009K01Rik, WDR30, APG16L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77040
Homologene: 41786
Ifitm2
Name: interferon induced transmembrane protein 2
Synonyms: fragilis3, mil-3, Ifitm3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80876
HGNC: HGNC:5413
Homologene: 74574
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: Pip5k3, 5230400C17Rik, PipkIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18711
Homologene: 32115
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Abcf1
Name: ATP-binding cassette, sub-family F (GCN20), member 1
Synonyms: GCN20, Abc50, D17Wsu166e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224742
HGNC: HGNC:70
Homologene: 849
Crebbp
Name: CREB binding protein
Synonyms: CBP, KAT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Snx9
Name: sorting nexin 9
Synonyms: SH3PX1, SDP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66616
VEGA: 17
Homologene: 49454
Nav1
Name: neuron navigator 1
Synonyms: POMFIL3, 9930003A20Rik, unc53H1, C230080M11Rik, steerin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Dpy19l4
Name: dpy-19-like 4 (C. elegans)
Synonyms: LOC381510, Narg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381510
Homologene: 18773
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: 5730402G09Rik, 1700020N17Rik, 4930445M19Rik, atms, 2310001G17Rik, Nna1, 2900054O13Rik, Ccp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67269
Homologene: 9067
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: 2810027M23Rik, auxilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72685
Homologene: 8865
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Gls2
Name: glutaminase 2 (liver, mitochondrial)
Synonyms: A330074B06Rik, Lga
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216456
Homologene: 40861
Cdhr3
Name: cadherin-related family member 3
Synonyms: 1110049B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68764
VEGA: 12
Homologene: 45146
Wdr64
Name: WD repeat domain 64
Synonyms: 4930511H01Rik, 4930415O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75820
Homologene: 51634
Arhgap5
Name: Rho GTPase activating protein 5
Synonyms: p190-B, p190B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11855
VEGA: 12
HGNC: HGNC:675
Homologene: 907
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 1300010F03Rik, 4932416F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 2310047C17Rik, DY6, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232400
Homologene: 45969
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: AN2, 4732461B14Rik, NG2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76390
Homologene: 88945
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224552
Homologene: 115024
Lgals12
Name: lectin, galactose binding, soluble 12
Synonyms: GRIP1, galectin-related inhibitor of proliferation, galectin-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56072
Homologene: 10462
Pla2g4b
Name: phospholipase A2, group IVB (cytosolic)
Synonyms: A030011C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 211429
HGNC: HGNC:9036
Homologene: 3730
Zfp820
Name: zinc finger protein 820
Synonyms: 2610036F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75424
VEGA: 17
Lrrc4b
Name: leucine rich repeat containing 4B
Synonyms: Lrig4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 272381
Homologene: 45681
Gramd1a
Name: GRAM domain containing 1A
Synonyms: D7Bwg0611e, 1300003M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52857
Homologene: 10843
4933416C03Rik
Name: RIKEN cDNA 4933416C03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Kptn
Name: kaptin
Synonyms: 2310042D10Rik, C030013F01Rik, 2E4, actin-binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70394
HGNC: HGNC:6404
Homologene: 5127
Gbp10
Name: guanylate-binding protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 626578
Homologene: 128731
Selenbp1
Name: selenium binding protein 1
Synonyms: Lpsb, Lp56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20341
Homologene: 2930
Tnnt3
Insyn2a
Name: inhibitory synaptic factor 2A
Synonyms: Fam196a, B830028B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 627214
Homologene: 85469
Ston1
Name: stonin 1
Synonyms: 4921524J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77057
Homologene: 122152
Gcm1
Name: glial cells missing homolog 1
Synonyms: GCMa, glial cell deficient, Gcm a, glide, Gcm 1, Gcm1-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14531
VEGA: 9
HGNC: HGNC:4197
Homologene: 2702
Misp
Name: mitotic spindle positioning
Synonyms: 9130017N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 78906
VEGA: 10
Homologene: 49933
Coq8a
Name: coenzyme Q8A
Synonyms: Adck3, Cabc1, 4632432J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67426
Homologene: 11345
Ifi203-ps
Name: interferon activated gene 203, pseudogene
Synonyms: Gm16340
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100504287
HGNC: HGNC:5395
Homologene: 115929
Tex36
Name: testis expressed 36
Synonyms: 4930404H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73808
Homologene: 67014
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 53,540,873 bp
  • G to A, chromosome 1 at 65,271,311 bp
  • A to G, chromosome 1 at 72,310,477 bp
  • T to C, chromosome 1 at 87,786,358 bp
  • T to C, chromosome 1 at 135,585,010 bp
  • T to C, chromosome 1 at 165,563,947 bp
  • T to C, chromosome 1 at 173,797,997 bp
  • T to C, chromosome 1 at 175,767,150 bp
  • A to G, chromosome 1 at 180,170,441 bp
  • T to C, chromosome 1 at 180,600,088 bp
  • C to T, chromosome 2 at 32,200,978 bp
  • A to G, chromosome 2 at 32,236,753 bp
  • T to A, chromosome 2 at 120,036,463 bp
  • T to C, chromosome 3 at 94,943,872 bp
  • A to T, chromosome 4 at 11,304,011 bp
  • A to T, chromosome 4 at 101,611,316 bp
  • T to C, chromosome 5 at 105,217,349 bp
  • T to A, chromosome 6 at 121,359,126 bp
  • T to C, chromosome 6 at 128,543,960 bp
  • T to G, chromosome 7 at 16,123,024 bp
  • T to A, chromosome 7 at 31,142,866 bp
  • A to G, chromosome 7 at 44,461,051 bp
  • A to T, chromosome 7 at 133,595,349 bp
  • A to T, chromosome 7 at 134,899,231 bp
  • T to C, chromosome 7 at 140,955,059 bp
  • A to G, chromosome 7 at 142,511,366 bp
  • T to A, chromosome 8 at 40,796,747 bp
  • T to A, chromosome 9 at 56,896,626 bp
  • A to T, chromosome 9 at 78,059,700 bp
  • A to G, chromosome 10 at 79,826,847 bp
  • A to G, chromosome 10 at 116,113,438 bp
  • A to T, chromosome 10 at 128,201,348 bp
  • C to A, chromosome 11 at 73,710,697 bp
  • A to T, chromosome 12 at 33,060,292 bp
  • T to C, chromosome 12 at 52,516,848 bp
  • C to T, chromosome 12 at 69,701,318 bp
  • A to G, chromosome 13 at 59,495,575 bp
  • T to C, chromosome 13 at 117,272,088 bp
  • C to T, chromosome 14 at 78,908,230 bp
  • A to T, chromosome 15 at 8,157,760 bp
  • A to G, chromosome 15 at 37,309,716 bp
  • A to G, chromosome 15 at 95,913,385 bp
  • A to G, chromosome 16 at 4,124,647 bp
  • G to A, chromosome 17 at 5,902,484 bp
  • T to A, chromosome 17 at 19,065,178 bp
  • A to T, chromosome 17 at 21,819,880 bp
  • G to A, chromosome 17 at 35,960,909 bp
  • T to C, chromosome 17 at 88,635,793 bp
  • C to T, chromosome 18 at 84,559,773 bp
  • T to C, chromosome 19 at 7,606,714 bp
  • T to A, chromosome 19 at 9,015,631 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1421 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039477-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.