Strain Name:
C57BL/6J-MtgxR1428Btlr/Mmmh
Stock Number:
039484-MU
Citation ID:
RRID:MMRRC_039484-MU
Other Names:
R1428 (G1), C57BL/6J-MtgxR1428Btlr
Major Collection:

Gene Information

Pknox1
Name: Pbx/knotted 1 homeobox
Synonyms: D17Wsu76e, PREP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18771
HGNC: HGNC:9022
Homologene: 3363
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: Cerp, PRCE, ESP1, separase, PRCE, SSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105988
VEGA: 15
Homologene: 32151
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Mtss1
Name: MTSS I-BAR domain containing 1
Synonyms: MIM, 2310003N14Rik, D130001D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 211401
VEGA: 15
Homologene: 8841
Rps6kc1
Name: ribosomal protein S6 kinase polypeptide 1
Synonyms: B130003F20Rik, RPK118
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 320119
Homologene: 8244
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98732
Homologene: 40842
Helz
Name: helicase with zinc finger domain
Synonyms: 3110078M01Rik, 9430093I07Rik, 9630002H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78455
Homologene: 8918
Gsk3b
Name: glycogen synthase kinase 3 beta
Synonyms: 7330414F15Rik, 8430431H08Rik, GSK-3, GSK3, GSK-3beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 56637
HGNC: HGNC:4617
Homologene: 55629
Kpna3
Name: karyopherin (importin) alpha 3
Synonyms: IPOA4, importin alpha 4, importin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16648
VEGA: 14
HGNC: HGNC:6396
Homologene: 20520
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: c-Abl, E430008G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Gins4
Name: GINS complex subunit 4 (Sld5 homolog)
Synonyms: 4933405K01Rik, 2810037C03Rik, SLD5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 109145
Homologene: 5759
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 100502841
VEGA: 18
Homologene: 14575
Atad3a
Name: ATPase family, AAA domain containing 3A
Synonyms: 2400004H09Rik, Tob3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 108888
Homologene: 10059
Rnf103
Name: ring finger protein 103
Synonyms: Zfp103, kf-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22644
Homologene: 4146
Olfm4
Name: olfactomedin 4
Synonyms: pPD4, LOC239192, OlfD, GC1, LOC380924, GW112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 380924
VEGA: 14
Homologene: 4684
Canx
Name: calnexin
Synonyms: 1110069N15Rik, CNX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12330
HGNC: HGNC:1473
Homologene: 1324
Kif13a
Name: kinesin family member 13A
Synonyms: 4930505I07Rik, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 16553
VEGA: 13
Homologene: 22589
Cyc1
Name: cytochrome c-1
Synonyms: Cyct1, 2610002H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66445
VEGA: 15
HGNC: HGNC:2579
Homologene: 55617
Acbd5
Name: acyl-Coenzyme A binding domain containing 5
Synonyms: 1300014E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 74159
Homologene: 12541
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Phlpp, Plekhe1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98432
Homologene: 11015
Ccdc127
Name: coiled-coil domain containing 127
Synonyms: 0610011N22Rik, 5430420E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 67433
Homologene: 11482
Fat2
Name: FAT atypical cadherin 2
Synonyms: Fath2, mKIAA0811, LOC245827, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Mrc1
Name: mannose receptor, C type 1
Synonyms: CD206, MR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Plb1
Name: phospholipase B1
Synonyms: 4632413E21Rik, 4930433E17Rik, 4930539A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 665270
Homologene: 82108
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Hug, Jbts17, b2b012Clo, 2410089E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 73692
Homologene: 11315
Cyp2j11
Name: cytochrome P450, family 2, subfamily j, polypeptide 11
Synonyms: Cyp2j11-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100066
Homologene: 133819
Fam214a
Name: family with sequence similarity 214, member A
Synonyms: C130047D21Rik, BC031353, 6330415I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235493
VEGA: 9
Homologene: 35065
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Olfr517
Name: olfactory receptor 517
Synonyms: GA_x6K02T2PBJ9-11199311-11198367, MOR268-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258136
Homologene: 79413
Ddx60
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234311
Homologene: 23031
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 320277
Homologene: 23371
Mmp15
Name: matrix metallopeptidase 15
Synonyms: MT2-MMP, Membrane type 2-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 17388
HGNC: HGNC:7161
Homologene: 20549
Fam71e2
Name: family with sequence similarity 71, member E2
Synonyms: 4930401F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243822
Homologene: 89225
Armc12
Name: armadillo repeat containing 12
Synonyms: 4930511I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 67645
Homologene: 12168
1700034J05Rik
Name: RIKEN cDNA 1700034J05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 73344
Homologene: 53485
Cdh15
Name: cadherin 15
Synonyms: Mcad, Cdh14, M cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Krc, E030045D18Rik, Schnurri-3, 2900056N03Rik, Shn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16656
Homologene: 7803
Sstr4
Name: somatostatin receptor 4
Synonyms: sst4, Smstr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20608
Homologene: 20286
C2cd4c
Name: C2 calcium-dependent domain containing 4C
Synonyms: 4932409I22Rik, LOC237397, Fam148c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237397
VEGA: 10
Homologene: 19012
Pacsin1
Name: protein kinase C and casein kinase substrate in neurons 1
Synonyms: Syndapin I, A830061D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 23969
HGNC: HGNC:8570
Homologene: 22674
Olfr1255
Name: olfactory receptor 1255
Synonyms: MOR232-4, GA_x6K02T2Q125-51257221-51258135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258979
Homologene: 82298
Gykl1
Name: glycerol kinase-like 1
Synonyms: Gk-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14625
VEGA: 18
HGNC: HGNC:4289
Homologene: 21848
Ifi27l2a
Name: interferon, alpha-inducible protein 27 like 2A
Synonyms: 2310061N23Rik, Ifi27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 76933
Homologene: 137395
Cnbd2
Name: cyclic nucleotide binding domain containing 2
Synonyms: 4921517L17Rik, 5430421B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 70873
Homologene: 15440
Uck1
Name: uridine-cytidine kinase 1
Synonyms: URK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22245
Homologene: 7990
P2rx3
Name: purinergic receptor P2X, ligand-gated ion channel, 3
Synonyms: P2X3, 4930513E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228139
HGNC: HGNC:8534
Homologene: 1922
Yipf4
Name: Yip1 domain family, member 4
Synonyms: 2310034L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 67864
VEGA: 17
Homologene: 32658
Cdc42ep3
Name: CDC42 effector protein (Rho GTPase binding) 3
Synonyms: UB1, Borg2, 3200001F04Rik, Cep3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 260409
VEGA: 17
Homologene: 4708
Timm8a1
Name: translocase of inner mitochondrial membrane 8A1
Synonyms: DXHXS1274E, Tim8a, Ddp1, Fci-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 30058
Homologene: 37878
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 14,304,414 bp
  • A to G, chromosome 1 at 106,380,425 bp
  • G to A, chromosome 1 at 185,247,904 bp
  • G to A, chromosome 1 at 190,798,726 bp
  • A to T, chromosome 2 at 14,315,263 bp
  • T to C, chromosome 2 at 23,099,721 bp
  • G to T, chromosome 2 at 31,801,810 bp
  • A to C, chromosome 2 at 32,258,355 bp
  • G to C, chromosome 2 at 85,024,950 bp
  • G to C, chromosome 2 at 89,816,381 bp
  • A to G, chromosome 2 at 148,396,359 bp
  • T to C, chromosome 2 at 156,339,284 bp
  • T to C, chromosome 4 at 96,294,880 bp
  • C to T, chromosome 4 at 120,096,575 bp
  • T to A, chromosome 4 at 155,755,682 bp
  • A to G, chromosome 5 at 32,264,912 bp
  • T to A, chromosome 6 at 71,508,999 bp
  • T to C, chromosome 6 at 146,952,411 bp
  • T to A, chromosome 7 at 4,757,688 bp
  • T to A, chromosome 7 at 108,868,960 bp
  • T to C, chromosome 8 at 23,227,128 bp
  • T to C, chromosome 8 at 61,958,159 bp
  • C to G, chromosome 8 at 95,369,562 bp
  • G to C, chromosome 8 at 122,857,495 bp
  • A to T, chromosome 9 at 75,006,321 bp
  • T to C, chromosome 10 at 43,975,078 bp
  • A to T, chromosome 10 at 79,612,230 bp
  • A to G, chromosome 11 at 50,308,394 bp
  • T to A, chromosome 11 at 55,296,087 bp
  • T to A, chromosome 11 at 107,073,047 bp
  • T to A, chromosome 11 at 107,592,840 bp
  • G to T, chromosome 12 at 103,442,834 bp
  • A to G, chromosome 13 at 46,791,511 bp
  • C to T, chromosome 13 at 74,356,915 bp
  • C to T, chromosome 14 at 61,383,220 bp
  • T to A, chromosome 14 at 80,021,403 bp
  • T to A, chromosome 15 at 8,219,369 bp
  • T to C, chromosome 15 at 9,596,707 bp
  • T to C, chromosome 15 at 58,947,390 bp
  • T to C, chromosome 15 at 76,344,348 bp
  • A to T, chromosome 15 at 102,305,685 bp
  • T to C, chromosome 16 at 38,090,575 bp
  • C to T, chromosome 17 at 27,705,963 bp
  • A to G, chromosome 17 at 28,537,936 bp
  • T to C, chromosome 17 at 31,592,092 bp
  • A to G, chromosome 17 at 74,498,305 bp
  • T to C, chromosome 17 at 79,335,036 bp
  • A to T, chromosome 18 at 52,694,761 bp
  • T to C, chromosome 18 at 77,962,427 bp
  • C to T, chromosome X at 134,538,123 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1428 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039484-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.