Strain Name:
C57BL/6J-MtgxR1430Btlr/Mmmh
Stock Number:
039486-MU
Citation ID:
RRID:MMRRC_039486-MU
Other Names:
R1430 (G1), C57BL/6J-MtgxR1430Btlr
Major Collection:

Gene Information

Psenen
Name: presenilin enhancer gamma secretase subunit
Synonyms: 1700023M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66340
Homologene: 11952
Ggta1
Name: glycoprotein galactosyltransferase alpha 1, 3
Synonyms: Gal, glycoprotein alpha galactosyl transferase 1, alpha Gal, Ggta-1, GALT, Ggta, alpha3GalT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14594
HGNC: HGNC:4253
Homologene: 7730
Cdyl2
Name: chromodomain protein, Y chromosome-like 2
Synonyms: 1700029M19Rik, 4930453I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 75796
Homologene: 41779
Dhx9
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 9
Synonyms: NDHII, RNA helicase, RHA, nuclear DNA helicase II, NDH II, leukophysin, Ddx9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Ubxn4
Name: UBX domain protein 4
Synonyms: 1300013G12Rik, Ubxd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67812
Homologene: 40962
Zfp407
Name: zinc finger protein 407
Synonyms: LOC381139, 6430585N13Rik, LOC240469
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240476
Homologene: 86402
Tbc1d23
Name: TBC1 domain family, member 23
Synonyms: D030022P07Rik, 4930451A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67581
VEGA: 16
Homologene: 10126
Gab1
Name: growth factor receptor bound protein 2-associated protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14388
HGNC: HGNC:4066
Homologene: 1542
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17847
Homologene: 40978
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Msn
Name: moesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 17698
HGNC: HGNC:7373
Homologene: 1833
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Rbl1
Name: RB transcriptional corepressor like 1
Synonyms: p107, retinoblastoma-like 1 (p107)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19650
HGNC: HGNC:9893
Homologene: 2172
Dapk1
Name: death associated protein kinase 1
Synonyms: DAP-Kinase, 2310039H24Rik, D13Ucla1, 2810425C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: LOC380767, 9330197E15Rik, A630028O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 211978
VEGA: 12
Homologene: 9102
Tbk1
Name: TANK-binding kinase 1
Synonyms: 1200008B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 56480
VEGA: 10
Homologene: 22742
Tsc2
Name: TSC complex subunit 2
Synonyms: tuberin, tuberous sclerosis 2, Nafld
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22084
VEGA: 17
Homologene: 462
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b3491Clo, b2b1565Clo, Mdnah5, b2b1154Clo, b2b1537Clo, b2b1134Clo, Dnahc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Slc1a5
Name: solute carrier family 1 (neutral amino acid transporter), member 5
Synonyms: ASCT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20514
Homologene: 21155
Hsh2d
Name: hematopoietic SH2 domain containing
Synonyms: Hsh2, ALX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 209488
Homologene: 13142
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237979
Homologene: 10406
Slc35e1
Name: solute carrier family 35, member E1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 270066
Homologene: 49075
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Olfr170
Name: olfactory receptor 170
Synonyms: MOR273-2, GA_x54KRFPKG5P-16052703-16051765
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258959
Homologene: 128058
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241516
Homologene: 110349
Tmem132e
Name: transmembrane protein 132E
Synonyms: LOC270893
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 270893
Homologene: 41524
Cyp2j9
Name: cytochrome P450, family 2, subfamily j, polypeptide 9
Synonyms: 8430417E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74519
Homologene: 137388
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 629499
Homologene: 51864
Aoc2
Name: amine oxidase, copper containing 2 (retina-specific)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237940
HGNC: HGNC:549
Homologene: 56457
Prkce
Name: protein kinase C, epsilon
Synonyms: 5830406C15Rik, PKCepsilon, PKC[e], Pkce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18754
HGNC: HGNC:9401
Homologene: 48343
Megf8
Name: multiple EGF-like-domains 8
Synonyms: m687Ddg, Egfl4, b2b288Clo, b2b1702Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: Factor XIIIA, 1200014I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
Tmem241
Name: transmembrane protein 241
Synonyms: 6030446N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 338363
Homologene: 87267
Mak
Name: male germ cell-associated kinase
Synonyms: A930010O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17152
VEGA: 13
HGNC: HGNC:6816
Homologene: 31344
Ppm1h
Name: protein phosphatase 1H (PP2C domain containing)
Synonyms: ARHCL1, C030002B11Rik, A430075L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 319468
Homologene: 18537
Zfp879
Name: zinc finger protein 879
Synonyms: 9630041N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 214779
Homologene: 45452
Gramd1a
Name: GRAM domain containing 1A
Synonyms: 1300003M23Rik, D7Bwg0611e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 52857
Homologene: 10843
C030006K11Rik
Name: RIKEN cDNA C030006K11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223665
VEGA: 15
Homologene: 17079
Olfr1440
Name: olfactory receptor 1440
Synonyms: MOR215-1, GA_x6K02T2RE5P-2725206-2726153
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258679
Homologene: 128133
Doc2b
Name: double C2, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 13447
HGNC: HGNC:2986
Homologene: 20796
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: Snep, 6720455I24Rik, D430044C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 208777
Homologene: 14708
Cfh
Name: complement component factor h
Synonyms: Mud-1, Sas1, Sas-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Fmo1
Name: flavin containing monooxygenase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14261
HGNC: HGNC:3769
Homologene: 55520
Mettl24
Name: methyltransferase like 24
Synonyms: 9030224M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 327747
Homologene: 65335
Eppin
Name: epididymal peptidase inhibitor
Synonyms: 1700024E17Rik, Spinlw1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 75526
Homologene: 41775
Adam3
Name: a disintegrin and metallopeptidase domain 3 (cyritestin)
Synonyms: tMDC, Taz83, ADAM3, Taz83, Cyrn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Olfr10
Name: olfactory receptor 10
Synonyms: L45, GA_x6K02T2QP88-6117098-6116163, MOR256-55
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18307
Homologene: 81347
Ncoa4
Name: nuclear receptor coactivator 4
Synonyms: 1110034E15Rik, 4432406M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 27057
HGNC: HGNC:7671
Homologene: 38052
Utp14b
Name: UTP14B small subunit processome component
Synonyms: jsd, 4932411L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 195434
Homologene: 78703
Dock11
Name: dedicator of cytokinesis 11
Synonyms: Zizimin2, 5033414A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 75974
Homologene: 70950
Syce1
Name: synaptonemal complex central element protein 1
Synonyms: 4933406J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74075
Homologene: 77044
Dram1
Name: DNA-damage regulated autophagy modulator 1
Synonyms: 1200002N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 71712
Homologene: 41255
Olfr1087
Name: olfactory receptor 1087
Synonyms: MOR188-5, GA_x6K02T2Q125-48182406-48181465
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258843
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 54,417,778 bp
  • A to G, chromosome 1 at 78,666,394 bp
  • G to A, chromosome 1 at 93,281,654 bp
  • T to A, chromosome 1 at 128,274,880 bp
  • A to G, chromosome 1 at 140,102,698 bp
  • A to T, chromosome 1 at 153,483,747 bp
  • C to A, chromosome 1 at 162,839,724 bp
  • T to C, chromosome 2 at 35,408,017 bp
  • C to A, chromosome 2 at 82,998,063 bp
  • T to C, chromosome 2 at 86,690,522 bp
  • T to C, chromosome 2 at 157,169,906 bp
  • T to C, chromosome 2 at 157,269,525 bp
  • G to A, chromosome 2 at 164,589,403 bp
  • G to T, chromosome 4 at 96,583,964 bp
  • G to C, chromosome 6 at 40,756,371 bp
  • A to G, chromosome 7 at 16,782,403 bp
  • G to A, chromosome 7 at 25,364,343 bp
  • T to C, chromosome 7 at 30,562,390 bp
  • A to G, chromosome 7 at 31,132,786 bp
  • A to T, chromosome 7 at 140,779,438 bp
  • T to A, chromosome 8 at 24,714,271 bp
  • G to A, chromosome 8 at 72,200,460 bp
  • T to C, chromosome 8 at 72,492,571 bp
  • G to T, chromosome 8 at 80,788,612 bp
  • A to G, chromosome 8 at 116,579,317 bp
  • T to C, chromosome 10 at 40,737,795 bp
  • T to C, chromosome 10 at 88,324,779 bp
  • A to G, chromosome 10 at 121,559,934 bp
  • T to C, chromosome 10 at 122,857,099 bp
  • A to G, chromosome 11 at 23,459,151 bp
  • A to G, chromosome 11 at 49,318,101 bp
  • A to G, chromosome 11 at 50,833,957 bp
  • A to T, chromosome 11 at 75,780,155 bp
  • T to C, chromosome 11 at 82,438,296 bp
  • A to G, chromosome 11 at 101,326,495 bp
  • C to T, chromosome 11 at 113,838,646 bp
  • A to G, chromosome 12 at 79,282,817 bp
  • T to C, chromosome 13 at 36,898,131 bp
  • C to A, chromosome 13 at 41,070,284 bp
  • T to G, chromosome 13 at 60,754,143 bp
  • G to A, chromosome 14 at 32,176,722 bp
  • G to A, chromosome 15 at 28,345,857 bp
  • G to T, chromosome 15 at 76,723,792 bp
  • A to G, chromosome 16 at 19,606,002 bp
  • G to T, chromosome 16 at 57,214,210 bp
  • A to G, chromosome 17 at 24,599,023 bp
  • A to G, chromosome 17 at 67,782,155 bp
  • T to A, chromosome 17 at 86,559,137 bp
  • T to C, chromosome 18 at 11,993,594 bp
  • C to T, chromosome 18 at 84,209,455 bp
  • C to T, chromosome 19 at 12,394,437 bp
  • A to G, chromosome X at 36,069,912 bp
  • G to A, chromosome X at 96,152,719 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1430 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039486-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.