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Strain Name:
C57BL/6J-MtgxR1439Btlr/Mmmh
Stock Number:
039494-MU
Citation ID:
RRID:MMRRC_039494-MU
Other Names:
R1439 (G1), C57BL/6J-MtgxR1439Btlr
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Itga6
Name: integrin alpha 6
Synonyms: Cd49f, 5033401O05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16403
HGNC: HGNC:6142
Homologene: 20091
Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: TrkA, Tkr
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Ep400
Name: E1A binding protein p400
Synonyms: p400, mDomino, 1700020J09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2210413N07Rik, SBP2, 2810012K13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75420
Homologene: 11415
Fubp3
Name: far upstream element (FUSE) binding protein 3
Synonyms: FBP3, A330051M14Rik, Marta2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320267
HGNC: HGNC:4005
Homologene: 45954
Agap1
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Synonyms: Ggap1, Centg2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 347722
Homologene: 56689
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,447,943 bp
  • C to A, chromosome 1 at 75,486,784 bp
  • G to C, chromosome 1 at 88,257,802 bp
  • A to G, chromosome 1 at 89,843,186 bp
  • A to T, chromosome 1 at 120,227,820 bp
  • A to G, chromosome 1 at 156,277,487 bp
  • G to T, chromosome 1 at 184,731,987 bp
  • T to C, chromosome 2 at 13,287,568 bp
  • C to A, chromosome 2 at 31,598,551 bp
  • A to C, chromosome 2 at 38,043,400 bp
  • T to G, chromosome 2 at 71,834,034 bp
  • T to C, chromosome 2 at 88,746,834 bp
  • A to G, chromosome 2 at 143,955,112 bp
  • A to G, chromosome 2 at 173,228,081 bp
  • A to G, chromosome 3 at 87,789,611 bp
  • A to G, chromosome 4 at 11,606,152 bp
  • A to G, chromosome 4 at 40,929,121 bp
  • A to G, chromosome 4 at 76,066,200 bp
  • C to T, chromosome 4 at 84,276,068 bp
  • T to C, chromosome 4 at 109,101,156 bp
  • G to T, chromosome 4 at 130,926,209 bp
  • A to G, chromosome 4 at 133,301,807 bp
  • T to C, chromosome 5 at 76,840,910 bp
  • G to T, chromosome 5 at 109,294,087 bp
  • A to T, chromosome 5 at 110,685,478 bp
  • A to G, chromosome 5 at 124,384,460 bp
  • T to A, chromosome 6 at 124,630,167 bp
  • T to C, chromosome 7 at 88,530,547 bp
  • T to C, chromosome 7 at 98,600,841 bp
  • A to T, chromosome 7 at 128,183,006 bp
  • A to T, chromosome 7 at 139,029,646 bp
  • T to A, chromosome 8 at 93,963,437 bp
  • T to C, chromosome 8 at 111,278,288 bp
  • T to A, chromosome 8 at 119,443,113 bp
  • T to A, chromosome 9 at 20,594,097 bp
  • T to A, chromosome 9 at 27,087,566 bp
  • A to G, chromosome 9 at 43,792,099 bp
  • T to A, chromosome 9 at 53,240,487 bp
  • A to C, chromosome 9 at 97,093,073 bp
  • A to T, chromosome 9 at 104,989,632 bp
  • G to C, chromosome 9 at 121,266,258 bp
  • A to T, chromosome 10 at 12,744,049 bp
  • T to C, chromosome 10 at 75,439,942 bp
  • A to G, chromosome 10 at 75,656,806 bp
  • A to G, chromosome 10 at 107,779,252 bp
  • A to G, chromosome 11 at 32,617,919 bp
  • T to C, chromosome 11 at 65,874,132 bp
  • C to A, chromosome 11 at 74,869,138 bp
  • G to T, chromosome 11 at 77,506,418 bp
  • T to C, chromosome 11 at 83,427,472 bp
  • C to A, chromosome 11 at 88,844,751 bp
  • A to G, chromosome 12 at 28,747,161 bp
  • G to A, chromosome 12 at 70,251,093 bp
  • G to T, chromosome 12 at 79,252,163 bp
  • A to G, chromosome 12 at 87,429,145 bp
  • C to T, chromosome 13 at 11,714,503 bp
  • T to C, chromosome 13 at 51,679,723 bp
  • T to C, chromosome 15 at 5,164,744 bp
  • A to G, chromosome 15 at 27,897,914 bp
  • G to T, chromosome 15 at 36,025,793 bp
  • A to G, chromosome 15 at 43,278,428 bp
  • A to G, chromosome 15 at 71,952,377 bp
  • G to A, chromosome 15 at 95,094,597 bp
  • A to G, chromosome 16 at 7,330,433 bp
  • A to T, chromosome 16 at 46,448,394 bp
  • A to G, chromosome 17 at 20,113,607 bp
  • C to A, chromosome 17 at 22,571,116 bp
  • C to A, chromosome 17 at 47,466,662 bp
  • A to T, chromosome 17 at 56,787,720 bp
  • G to C, chromosome 19 at 5,485,117 bp
  • A to T, chromosome 19 at 29,706,852 bp
  • T to A, chromosome 19 at 46,063,736 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1439 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039494-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.