Strain Name:
C57BL/6J-MtgxR1444Btlr/Mmmh
Stock Number:
039499-MU
Citation ID:
RRID:MMRRC_039499-MU
Other Names:
R1444 (G1), C57BL/6J-MtgxR1444Btlr
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: N-CoR, 5730405M06Rik, Rxrip13, A230020K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Slc6a2
Name: solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Synonyms: NET, Slc6a5, norepinephrine transporter, NE transporter
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20538
Homologene: 816
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: Her4, ErbB4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Cr1l
Name: complement C3b/C4b receptor 1 like
Synonyms: Crry, mCRY
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12946
Homologene: 128275
Adgrl3
Name: adhesion G protein-coupled receptor L3
Synonyms: D130075K09Rik, Lphn3, lectomedin 3, 5430402I23Rik, LEC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319387
Homologene: 22878
Ephx2
Name: epoxide hydrolase 2, cytoplasmic
Synonyms: sEP, Eph2, sEH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13850
VEGA: 14
HGNC: HGNC:3402
Homologene: 37558
Vsnl1
Name: visinin-like 1
Synonyms: VILIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 26950
VEGA: 12
Homologene: 2542
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: A330064G03Rik, HELIC2, U5-200KD, Ascc3l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320632
Homologene: 5859
Epb41
Name: erythrocyte membrane protein band 4.1
Synonyms: D4Ertd442e, 4.1R, Epb4.1, Elp-1, Elp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269587
HGNC: HGNC:3377
Homologene: 44324
Xrn2
Name: 5'-3' exoribonuclease 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 24128
Homologene: 6927
Rttn
Name: rotatin
Synonyms: C530033I08Rik, 4921538A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
Zfp871
Name: zinc finger protein 871
Synonyms: 9030612M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 208292
Homologene: 138401
Lpl
Name: lipoprotein lipase
Synonyms: O 1-4-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16956
HGNC: HGNC:6677
Homologene: 200
Tgfbr1
Name: transforming growth factor, beta receptor I
Synonyms: ALK5, TbetaRI, Alk-5, TbetaR-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21812
Homologene: 3177
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Tmem183a
Name: transmembrane protein 183A
Synonyms: 1300007B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57439
Homologene: 10757
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: 4432404A22Rik, Snf2p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Hectd3
Name: HECT domain E3 ubiquitin protein ligase 3
Synonyms: 1700064K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76608
Homologene: 18426
Spindoc
Name: spindlin interactor and repressor of chromatin binding
Synonyms: AI846148
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68229
VEGA: 19
Homologene: 19195
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: A230048G03Rik, 2010013B10Rik, D330050P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171395
Homologene: 51376
Cdh6
Name: cadherin 6
Synonyms: K-cadherin, cad6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12563
VEGA: 15
HGNC: HGNC:1765
Homologene: 21027
Zfp750
Name: zinc finger protein 750
Synonyms: A030007D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319530
Homologene: 36423
Wdr87-ps
Name: WD repeat domain 87, pseudogene
Synonyms: 4932431P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114675
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 1110021D17Rik, D430029O09Rik, Polydom, 4833413O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Cadm4
Name: cell adhesion molecule 4
Synonyms: Igsf4c, SynCAM 4, Necl-4, Tsll2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 260299
Homologene: 17063
Trim67
Name: tripartite motif-containing 67
Synonyms: D130049O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330863
Homologene: 45699
Cds1
Name: CDP-diacylglycerol synthase 1
Synonyms: phosphatidate cytidylyltransferase, 4833409J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74596
HGNC: HGNC:1800
Homologene: 68173
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229574
Homologene: 134146
Acad9
Name: acyl-Coenzyme A dehydrogenase family, member 9
Synonyms: 2600017P15Rik, NPD002, C630012L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229211
Homologene: 8539
Kcnc2
Name: potassium voltage gated channel, Shaw-related subfamily, member 2
Synonyms: Kv3.2, KShIIIA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268345
VEGA: 10
HGNC: HGNC:6234
Homologene: 71199
Or2ad1
Name: olfactory receptor family 2 subfamily AD member 1
Synonyms: Olfr1368, GA_x6K02T2QHY8-12104556-12105500, MOR256-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 258527
Homologene: 105156
Phldb2
Name: pleckstrin homology like domain, family B, member 2
Synonyms: LL5beta, LL5b, C820004H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208177
Homologene: 17100
Daam2
Name: dishevelled associated activator of morphogenesis 2
Synonyms: 2310016D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76441
VEGA: 17
Homologene: 69186
Lrit1
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
Synonyms: Lrrc21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239037
Homologene: 9215
Cactin
Name: cactin, spliceosome C complex subunit
Synonyms: 2510012J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70312
VEGA: 10
Homologene: 69553
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74376
Homologene: 53435
Mmp8
Name: matrix metallopeptidase 8
Synonyms: Collagenase-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17394
VEGA: 9
HGNC: HGNC:7175
Homologene: 22482
Il10rb
Name: interleukin 10 receptor, beta
Synonyms: 6620401D04Rik, CRF2-4, D16H21S58, Il10r2, Crfb4, D21S58h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16155
HGNC: HGNC:5965
Homologene: 523
1700030K09Rik
Name: RIKEN cDNA 1700030K09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72254
Homologene: 12975
Calr4
Name: calreticulin 4
Synonyms: 4933403L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 108802
Homologene: 86813
Card10
Name: caspase recruitment domain family, member 10
Synonyms: Bimp1, CARMA3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105844
Homologene: 8728
Toporsl
Name: topoisomerase I binding, arginine/serine-rich like
Synonyms: 4930547C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68274
Homologene: 130753
Potefam1
Name: POTE ankyrin domain family member 1
Synonyms: A26c3, Potea, 4930430A15Rik, Pote1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67575
Homologene: 69410
Or4d2b
Name: olfactory receptor family 4 subfamily D member 2B
Synonyms: GA_x6K02T2PAEV-9536824-9535889, Olfr462, MOR240-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258406
HGNC: HGNC:8294
Homologene: 64870
A630010A05Rik
Name: RIKEN cDNA A630010A05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545280
Gje1
Name: gap junction protein, epsilon 1
Synonyms: connexin 23, Cx23, Gsfaey12, AEY12, D230044M03Rik, Gjf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76743
Homologene: 87405
Tmem212
Name: transmembrane protein 212
Synonyms: E030011K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 208613
Homologene: 28471
Hsd3b6
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
Synonyms: 3beta-HSD VI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15497
Homologene: 133013
Obox2
Name: oocyte specific homeobox 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246792
Homologene: 44937
Zfp131
Name: zinc finger protein 131
Synonyms: Znf131, 2610109I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72465
VEGA: 13
Homologene: 12464
Ddn
Name: dendrin
Synonyms: LOC328602
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13199
VEGA: 15
Homologene: 12816
Prss30
Name: serine protease 30
Synonyms: Disp1, Tmprss8, 2010015P21Rik, Disp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 30943
Homologene: 88826
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 68,254,600 bp
  • T to C, chromosome 1 at 134,361,546 bp
  • A to T, chromosome 1 at 195,131,202 bp
  • AATATATATATATATATATATATATATATA to AATATATATATATATATATATATATATATATA, chromosome 2 at 111,198,021 bp
  • T to C, chromosome 2 at 127,228,238 bp
  • C to T, chromosome 2 at 147,061,488 bp
  • C to T, chromosome 3 at 27,885,095 bp
  • T to A, chromosome 3 at 36,078,508 bp
  • T to A, chromosome 3 at 93,202,313 bp
  • C to T, chromosome 3 at 97,582,731 bp
  • T to C, chromosome 3 at 98,807,921 bp
  • A to G, chromosome 4 at 47,393,259 bp
  • T to A, chromosome 4 at 52,610,254 bp
  • T to C, chromosome 4 at 58,115,754 bp
  • A to G, chromosome 4 at 109,246,241 bp
  • G to T, chromosome 4 at 116,996,396 bp
  • G to A, chromosome 4 at 132,006,071 bp
  • G to T, chromosome 4 at 143,896,891 bp
  • A to T, chromosome 5 at 81,512,353 bp
  • A to G, chromosome 5 at 101,798,379 bp
  • A to G, chromosome 5 at 112,775,251 bp
  • T to A, chromosome 5 at 150,542,450 bp
  • A to C, chromosome 7 at 15,397,032 bp
  • A to G, chromosome 7 at 24,503,621 bp
  • T to C, chromosome 7 at 29,529,955 bp
  • T to A, chromosome 8 at 68,892,747 bp
  • A to T, chromosome 8 at 72,451,386 bp
  • A to G, chromosome 8 at 92,971,254 bp
  • A to G, chromosome 8 at 124,823,193 bp
  • T to C, chromosome 9 at 7,567,263 bp
  • A to G, chromosome 10 at 14,716,636 bp
  • A to T, chromosome 10 at 81,322,436 bp
  • T to C, chromosome 10 at 112,455,601 bp
  • A to G, chromosome 11 at 8,854,386 bp
  • T to A, chromosome 11 at 62,403,806 bp
  • T to A, chromosome 11 at 87,889,759 bp
  • T to C, chromosome 11 at 119,442,400 bp
  • C to T, chromosome 11 at 121,512,047 bp
  • T to C, chromosome 12 at 11,332,218 bp
  • C to T, chromosome 13 at 21,142,167 bp
  • A to T, chromosome 13 at 119,790,248 bp
  • T to C, chromosome 14 at 37,061,971 bp
  • T to C, chromosome 14 at 66,107,320 bp
  • C to A, chromosome 15 at 13,091,838 bp
  • A to T, chromosome 15 at 78,787,841 bp
  • G to A, chromosome 15 at 98,806,604 bp
  • T to A, chromosome 16 at 14,609,694 bp
  • T to A, chromosome 16 at 45,757,253 bp
  • T to G, chromosome 16 at 91,421,787 bp
  • T to C, chromosome 17 at 23,973,738 bp
  • G to T, chromosome 17 at 32,774,926 bp
  • T to C, chromosome 17 at 49,480,751 bp
  • G to A, chromosome 17 at 78,753,193 bp
  • A to T, chromosome 17 at 78,755,427 bp
  • A to G, chromosome 18 at 89,042,867 bp
  • G to T, chromosome 19 at 7,382,721 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1444 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039499-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.