Strain Name:
C57BL/6J-MtgxR1451Btlr/Mmmh
Stock Number:
039506-MU
Citation ID:
RRID:MMRRC_039506-MU
Other Names:
R1451 (G1), C57BL/6J-MtgxR1451Btlr
Major Collection:

Strain Information

Neurog2
Name: neurogenin 2
Synonyms: Math4A, ngn2, Atoh4, bHLHa8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11924
Homologene: 7633
Slc6a1
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Synonyms: XT-1, Gabt, Xtrp1, Gat1, Gabt1, GAT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232333
Homologene: 2290
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9130004I02Rik, 9430095K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Arhgef12
Name: Rho guanine nucleotide exchange factor (GEF) 12
Synonyms: LARG, 2310014B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109294
Homologene: 23523
Gars
Name: glycyl-tRNA synthetase
Synonyms: Sgrp23, GENA202, Gena201
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353172
HGNC: HGNC:4162
Homologene: 1547
Lta4h
Name: leukotriene A4 hydrolase
Synonyms: LTA4 hydrodase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16993
VEGA: 10
HGNC: HGNC:6710
Homologene: 6820
Cog6
Name: component of oligomeric golgi complex 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67542
Homologene: 10802
Zfp180
Name: zinc finger protein 180
Synonyms: D130011P11, HHZ168, 2310040I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210135
Homologene: 8306
Kif23
Name: kinesin family member 23
Synonyms: 3110001D19Rik, CHO1, MKLP-1, MKLP1, Knsl5, C87313
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71819
VEGA: 9
HGNC: HGNC:6392
Homologene: 11491
Robo3
Name: roundabout guidance receptor 3
Synonyms: Rig-1, Rbig1, Robo3b, Robo3a, Rig1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19649
Homologene: 32119
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: 8430415E05Rik, 1700034M03Rik, Ccdc132
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 73288
Homologene: 11498
Mphosph8
Name: M-phase phosphoprotein 8
Synonyms: 1500035L22Rik, 4930548G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75339
Homologene: 11380
Sppl3
Name: signal peptide peptidase 3
Synonyms: 4833416I09Rik, Usmg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74585
Homologene: 15563
Tia1
Name: cytotoxic granule-associated RNA binding protein 1
Synonyms: mTIA-1, 2310050N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21841
Homologene: 20692
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930516E05Rik, D330038K10Rik, 4930543C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Tns2
Name: tensin 2
Synonyms: nep, nph, Tenc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 209039
VEGA: 15
Homologene: 37077
Or8b50
Name: olfactory receptor family 8 subfamily B member 50
Synonyms: GA_x6K02T2PVTD-32308823-32309773, MOR165-7, Olfr914
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258782
VEGA: 9
Homologene: 115511
Snx13
Name: sorting nexin 13
Synonyms: RGS-PX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217463
VEGA: 12
Homologene: 41011
Ushbp1
Name: USH1 protein network component harmonin binding protein 1
Synonyms: MCC2, 2210404N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234395
Homologene: 12914
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70417
Homologene: 23771
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
9530053A07Rik
Name: RIKEN cDNA 9530053A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319482
Homologene: 130055
Abcc12
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Synonyms: MRP9, 4930467B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244562
Homologene: 57211
Vmn1r179
Name: vomeronasal 1 receptor 179
Synonyms: V1rd17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404286
Homologene: 134022
Ptchd4
Name: patched domain containing 4
Synonyms: 3110082D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627626
VEGA: 17
Homologene: 78322
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74978
Homologene: 46007
Abca9
Name: ATP-binding cassette, sub-family A (ABC1), member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Ccdc106
Name: coiled-coil domain containing 106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232821
Homologene: 81845
Or1j11
Name: olfactory receptor family 1 subfamily E member 1
Synonyms: GA_x6K02T2NLDC-33116096-33117025, MOR136-3, Olfr339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258951
Homologene: 133615
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 319734
Homologene: 26544
Usp43
Name: ubiquitin specific peptidase 43
Synonyms: C630032K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216835
Homologene: 129879
Lgmn
Name: legumain
Synonyms: preprolegumain, Prsc1, AEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19141
HGNC: HGNC:9472
Homologene: 38075
Trappc2l
Name: trafficking protein particle complex 2L
Synonyms: 1810017G16Rik, Tca17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 59005
Homologene: 9424
Fscn2
Name: fascin actin-bundling protein 2
Synonyms: C630046B20Rik, ahl8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 238021
HGNC: HGNC:3960
Homologene: 22722
Krt8
Name: keratin 8
Synonyms: K8, EndoA, cytokeratin-8, cytokeratin8, cytokeratin 8, Krt-2.8, Card2, Krt2-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16691
VEGA: 15
HGNC: HGNC:6446
Homologene: 55643
Adarb2
Name: adenosine deaminase, RNA-specific, B2
Synonyms: RED2, Adar3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 94191
HGNC: HGNC:227
Homologene: 10276
Vmn2r8
Name: vomeronasal 2, receptor 8
Synonyms: EG627479
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 627479
Homologene: 129606
C1ra
Name: complement component 1, r subcomponent A
Synonyms: mC1rA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 50909
HGNC: HGNC:1246
Homologene: 1313
Pcdhb17
Name: protocadherin beta 17
Synonyms: Pcdhb16, PcdhbQ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93888
Homologene: 81881
Epha1
Name: Eph receptor A1
Synonyms: Esk, 5730453L17Rik, Eph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Ccdc136
Name: coiled-coil domain containing 136
Synonyms: 4921511K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232664
Homologene: 23378
Or2z2
Name: olfactory receptor family 2 subfamily Z member 2
Synonyms: MTPCR07, MOR281-1, GA_x6K02T2NKPP-957001-957948, Olfr30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18329
Homologene: 131139
Or2w2
Name: olfactory receptor family 2 subfamily W member 2
Synonyms: GA_x6K02T2QHY8-11663090-11664010, MOR256-13, Olfr1364
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 258533
Homologene: 64885
Zgpat
Name: zinc finger, CCCH-type with G patch domain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229007
Homologene: 41874
Asah1
Name: N-acylsphingosine amidohydrolase 1
Synonyms: acid ceramidase, 2310081N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11886
HGNC: HGNC:735
Homologene: 10504
C1s2
Name: complement component 1, s subcomponent 2
Synonyms: Gm5077
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 317677
HGNC: HGNC:1247
Homologene: 1314
Cd200r3
Name: CD200 receptor 3
Synonyms: 4733401I18Rik, mCD200RLb, 4833409J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74603
Cnksr3
Name: Cnksr family member 3
Synonyms: Magi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215748
Homologene: 18192
Car8
Name: carbonic anhydrase 8
Synonyms: Carp, Cals1, CA-RP VIII, wdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12319
HGNC: HGNC:1382
Homologene: 20861
Pde2a
Name: phosphodiesterase 2A, cGMP-stimulated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207728
HGNC: HGNC:8777
Homologene: 1952
Or8g50
Name: olfactory receptor family 8 subfamily G member 50
Synonyms: M93, MOR171-18, GA_x6K02T2PVTD-33434302-33435240, Olfr150
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258602
VEGA: 9
Or6b3
Name: olfactory receptor family 6 subfamily B member 3
Synonyms: GA_x6K02T2R7CC-81245243-81246181, MOR103-2, Olfr1414
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 259041
Homologene: 88368
Ebna1bp2
Name: EBNA1 binding protein 2
Synonyms: p40, 1810014B19Rik, Nobp, Ebp2, B830003A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69072
Homologene: 4969
1700024G13Rik
Name: RIKEN cDNA 1700024G13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67085
VEGA: 14
Homologene: 28053
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 11,156,259 bp
  • T to A, chromosome 1 at 92,511,795 bp
  • G to T, chromosome 2 at 36,421,865 bp
  • A to G, chromosome 2 at 181,380,191 bp
  • T to C, chromosome 3 at 53,009,113 bp
  • A to G, chromosome 3 at 127,633,841 bp
  • A to T, chromosome 4 at 8,189,327 bp
  • C to A, chromosome 4 at 118,621,072 bp
  • T to A, chromosome 5 at 108,798,067 bp
  • T to C, chromosome 5 at 115,088,365 bp
  • A to G, chromosome 6 at 3,565,628 bp
  • T to A, chromosome 6 at 29,419,377 bp
  • C to A, chromosome 6 at 42,361,451 bp
  • T to C, chromosome 6 at 55,053,123 bp
  • A to T, chromosome 6 at 86,430,339 bp
  • C to A, chromosome 6 at 114,307,795 bp
  • C to T, chromosome 6 at 119,236,824 bp
  • A to T, chromosome 6 at 124,521,641 bp
  • A to T, chromosome 6 at 124,625,494 bp
  • A to G, chromosome 7 at 5,059,528 bp
  • T to A, chromosome 7 at 23,928,850 bp
  • T to C, chromosome 7 at 24,105,218 bp
  • T to C, chromosome 7 at 28,137,157 bp
  • G to T, chromosome 7 at 101,421,991 bp
  • A to G, chromosome 8 at 41,354,012 bp
  • G to T, chromosome 8 at 71,386,019 bp
  • T to A, chromosome 8 at 86,557,693 bp
  • T to C, chromosome 8 at 122,615,395 bp
  • C to T, chromosome 9 at 37,417,711 bp
  • A to T, chromosome 9 at 38,606,938 bp
  • T to A, chromosome 9 at 39,737,316 bp
  • C to T, chromosome 9 at 42,992,578 bp
  • C to T, chromosome 9 at 61,924,802 bp
  • T to A, chromosome 10 at 7,126,830 bp
  • A to G, chromosome 10 at 93,480,728 bp
  • A to G, chromosome 10 at 103,202,515 bp
  • T to C, chromosome 10 at 126,010,057 bp
  • C to T, chromosome 11 at 58,455,532 bp
  • T to A, chromosome 11 at 67,856,181 bp
  • A to G, chromosome 11 at 110,127,447 bp
  • G to T, chromosome 11 at 115,990,884 bp
  • A to T, chromosome 11 at 120,362,022 bp
  • G to A, chromosome 12 at 35,078,984 bp
  • A to G, chromosome 12 at 102,405,892 bp
  • A to G, chromosome 13 at 8,339,621 bp
  • A to T, chromosome 13 at 21,574,287 bp
  • T to C, chromosome 14 at 32,376,631 bp
  • C to T, chromosome 14 at 56,668,421 bp
  • T to C, chromosome 15 at 101,998,829 bp
  • C to T, chromosome 15 at 102,108,934 bp
  • A to G, chromosome 16 at 44,951,547 bp
  • A to G, chromosome 17 at 42,502,918 bp
  • A to T, chromosome 18 at 37,486,936 bp
  • A to T, chromosome 18 at 57,252,859 bp
  • T to C, chromosome 19 at 16,710,864 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1451 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039506-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.