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Strain Name:
C57BL/6J-MtgxR1473Btlr/Mmmh
Stock Number:
039526-MU
Citation ID:
RRID:MMRRC_039526-MU
Other Names:
R1473 (G1), C57BL/6J-MtgxR1473Btlr
Major Collection:

Strain Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: Del1, Col2a-1, Col2a, Col2, M100856, Rgsc856, Lpk, M100413, Rgsc413
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: separase, SSE, ESP1, PRCE, PRCE, Cerp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Rnf38
Name: ring finger protein 38
Synonyms: Oip1, 1700065B19Rik, 2610202O07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73469
Homologene: 32550
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: MAST205, Mtssk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17776
Homologene: 7428
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 20,522,983 bp
  • G to A, chromosome 1 at 30,805,940 bp
  • A to C, chromosome 1 at 53,496,014 bp
  • C to T, chromosome 1 at 54,417,778 bp
  • C to T, chromosome 1 at 66,521,581 bp
  • A to T, chromosome 1 at 88,701,609 bp
  • T to C, chromosome 1 at 92,029,968 bp
  • G to A, chromosome 1 at 93,281,654 bp
  • G to A, chromosome 1 at 150,772,552 bp
  • A to G, chromosome 1 at 173,695,654 bp
  • G to T, chromosome 1 at 174,099,749 bp
  • T to A, chromosome 1 at 174,430,643 bp
  • G to A, chromosome 1 at 179,776,108 bp
  • A to G, chromosome 1 at 179,799,279 bp
  • G to A, chromosome 2 at 6,421,026 bp
  • C to A, chromosome 2 at 26,981,753 bp
  • A to G, chromosome 2 at 39,000,979 bp
  • A to G, chromosome 2 at 52,858,207 bp
  • A to T, chromosome 2 at 76,727,032 bp
  • A to T, chromosome 2 at 89,296,906 bp
  • A to G, chromosome 2 at 122,287,121 bp
  • A to T, chromosome 2 at 128,617,697 bp
  • A to G, chromosome 2 at 153,261,246 bp
  • A to T, chromosome 2 at 157,020,448 bp
  • A to T, chromosome 3 at 59,318,767 bp
  • G to T, chromosome 3 at 64,538,158 bp
  • A to G, chromosome 3 at 88,565,845 bp
  • G to T, chromosome 3 at 96,270,072 bp
  • T to C, chromosome 4 at 44,131,584 bp
  • A to G, chromosome 4 at 63,580,338 bp
  • A to G, chromosome 4 at 116,311,955 bp
  • G to T, chromosome 4 at 117,869,904 bp
  • G to A, chromosome 4 at 136,694,058 bp
  • A to C, chromosome 4 at 141,616,278 bp
  • A to C, chromosome 4 at 148,024,156 bp
  • A to G, chromosome 5 at 87,564,739 bp
  • T to C, chromosome 5 at 112,354,549 bp
  • T to A, chromosome 5 at 113,263,257 bp
  • T to C, chromosome 5 at 140,328,688 bp
  • C to T, chromosome 6 at 12,338,622 bp
  • T to C, chromosome 6 at 48,539,264 bp
  • T to A, chromosome 6 at 94,607,313 bp
  • A to G, chromosome 7 at 17,905,091 bp
  • A to C, chromosome 7 at 26,314,763 bp
  • C to A, chromosome 7 at 63,754,629 bp
  • T to C, chromosome 7 at 66,712,046 bp
  • T to C, chromosome 7 at 80,734,011 bp
  • A to T, chromosome 7 at 85,961,410 bp
  • T to G, chromosome 7 at 110,804,935 bp
  • A to G, chromosome 7 at 126,292,252 bp
  • C to T, chromosome 7 at 139,125,179 bp
  • A to G, chromosome 7 at 143,841,368 bp
  • T to C, chromosome 7 at 143,847,068 bp
  • A to G, chromosome 8 at 33,629,385 bp
  • C to A, chromosome 8 at 48,310,625 bp
  • T to C, chromosome 8 at 52,196,614 bp
  • T to C, chromosome 8 at 109,996,918 bp
  • T to A, chromosome 9 at 21,027,876 bp
  • T to C, chromosome 9 at 22,058,220 bp
  • T to C, chromosome 9 at 26,979,041 bp
  • A to G, chromosome 10 at 63,397,244 bp
  • T to C, chromosome 11 at 3,717,175 bp
  • C to T, chromosome 11 at 11,934,249 bp
  • C to T, chromosome 11 at 76,263,187 bp
  • T to C, chromosome 11 at 100,379,601 bp
  • A to T, chromosome 11 at 115,984,047 bp
  • T to A, chromosome 12 at 40,077,502 bp
  • G to A, chromosome 12 at 82,341,111 bp
  • T to A, chromosome 12 at 113,143,500 bp
  • T to C, chromosome 13 at 55,721,574 bp
  • T to C, chromosome 13 at 102,772,519 bp
  • A to G, chromosome 13 at 112,859,664 bp
  • A to G, chromosome 14 at 43,748,846 bp
  • A to G, chromosome 14 at 54,508,915 bp
  • T to C, chromosome 14 at 56,019,533 bp
  • G to A, chromosome 15 at 12,912,520 bp
  • T to C, chromosome 15 at 39,030,963 bp
  • A to G, chromosome 15 at 97,982,908 bp
  • T to A, chromosome 15 at 98,592,743 bp
  • C to T, chromosome 15 at 102,320,443 bp
  • A to G, chromosome 16 at 8,473,961 bp
  • T to G, chromosome 16 at 14,185,864 bp
  • G to A, chromosome 16 at 17,277,962 bp
  • T to A, chromosome 16 at 46,154,819 bp
  • T to A, chromosome 16 at 48,818,665 bp
  • A to T, chromosome 16 at 58,999,912 bp
  • A to T, chromosome 16 at 91,170,735 bp
  • A to T, chromosome 17 at 19,694,581 bp
  • A to T, chromosome 17 at 25,991,322 bp
  • A to T, chromosome 17 at 71,361,837 bp
  • T to A, chromosome 19 at 34,974,496 bp
  • T to C, chromosome 19 at 57,068,236 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1473 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039526-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.