Strain Name:
C57BL/6J-MtgxR1475Btlr/Mmmh
Stock Number:
039528-MU
Citation ID:
RRID:MMRRC_039528-MU
Other Names:
R1475 (G1), C57BL/6J-MtgxR1475Btlr
Major Collection:

Gene Information

Bmp6
Name: bone morphogenetic protein 6
Synonyms: Vgr1, D13Wsu115e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12161
VEGA: 13
HGNC: HGNC:1073
Homologene: 1300
Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms: alpha4 nAChR, Acra-4, Acra4, a4 nicotinic receptor, alpha4-nAChR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11438
HGNC: HGNC:1958
Homologene: 592
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Gaa
Name: glucosidase, alpha, acid
Synonyms: E430018M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14387
HGNC: HGNC:4065
Homologene: 37268
Cdk11b
Name: cyclin-dependent kinase 11B
Synonyms: CDK11-p110, PITSLRE proteins, CDK11-p46, CDK11-p58, Cdc2l2, Cdc2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12537
Homologene: 22416
Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: LOC328902, G430090F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 64291
Homologene: 84746
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15184
Homologene: 3995
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: Nezha, 2310057J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69697
Homologene: 18966
Lrsam1
Name: leucine rich repeat and sterile alpha motif containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227738
Homologene: 44526
Rbm25
Name: RNA binding motif protein 25
Synonyms: 2610015J01Rik, A130095G20Rik, 2600011C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67039
Stam
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Synonyms: STAM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20844
Homologene: 37788
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17847
Homologene: 40978
Pgd
Name: phosphogluconate dehydrogenase
Synonyms: 0610042A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 110208
HGNC: HGNC:8891
Homologene: 68268
Dffa
Name: DNA fragmentation factor, alpha subunit
Synonyms: ICAD-S, ICAD-L, Dff45, DFF35, A330085O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13347
HGNC: HGNC:2772
Homologene: 3240
Srf
Name: serum response factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20807
VEGA: 17
Homologene: 31135
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lec2, lectomedin-2, 2900070I05Rik, Lphn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330814
Homologene: 8951
Rasal1
Name: RAS protein activator like 1 (GAP1 like)
Synonyms: MRASAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19415
HGNC: HGNC:9873
Homologene: 3423
Adcy1
Name: adenylate cyclase 1
Synonyms: AC1, I-AC, D11Bwg1392e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432530
HGNC: HGNC:232
Homologene: 41419
C2cd5
Name: C2 calcium-dependent domain containing 5
Synonyms: C030008B15Rik, CDP138, 5730419I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74741
Homologene: 8873
Nmnat2
Name: nicotinamide nucleotide adenylyltransferase 2
Synonyms: PNAT1, D030041I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226518
Homologene: 75037
Cpsf2
Name: cleavage and polyadenylation specific factor 2
Synonyms: Cpsf, 2610024B04Rik, 100kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 51786
VEGA: 12
HGNC: HGNC:2325
Homologene: 6460
Creld2
Name: cysteine-rich with EGF-like domains 2
Synonyms: 5730592L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76737
VEGA: 15
Homologene: 11526
Bsdc1
Name: BSD domain containing 1
Synonyms: 1110063F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100383
Homologene: 32386
Plekhm2
Name: pleckstrin homology domain containing, family M (with RUN domain) member 2
Synonyms: 2310034J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69582
Homologene: 19575
Klhl20
Name: kelch-like 20
Synonyms: D930050H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226541
Homologene: 8699
Fermt3
Name: fermitin family member 3
Synonyms: C79673, Kindlin-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 108101
VEGA: 19
Homologene: 12877
Pigg
Name: phosphatidylinositol glycan anchor biosynthesis, class G
Synonyms: Gpi7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 433931
Homologene: 39421
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Glce
Name: glucuronyl C5-epimerase
Synonyms: heparan sulfate-glucuronic acid C5-epimerase, Hsepi, C130034A12Rik, 1110017N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 93683
Homologene: 14111
Olfr901
Name: olfactory receptor 901
Synonyms: GA_x6K02T2PVTD-32123032-32123967, MOR162-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258028
VEGA: 9
Homologene: 79399
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545030
Homologene: 83473
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Espn
Name: espin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56226
Homologene: 23164
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, D16Ertd642e, Wdr52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212517
Homologene: 75085
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209590
Homologene: 16930
Usp50
Name: ubiquitin specific peptidase 50
Synonyms: 1700086G18Rik, 4930511O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75083
Homologene: 75281
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 192187
Homologene: 9035
Emcn
Name: endomucin
Synonyms: 0610012K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 59308
Homologene: 9438
Aatk
Name: apoptosis-associated tyrosine kinase
Synonyms: AATYK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11302
HGNC: HGNC:21
Homologene: 74861
Pitpnm3
Name: PITPNM family member 3
Synonyms: A330068P14Rik, Ackr6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327958
Homologene: 66271
Bphl
Name: biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)
Synonyms: 2010012D11Rik, 5730533B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68021
VEGA: 13
HGNC: HGNC:1094
Homologene: 55812
Myf5
Name: myogenic factor 5
Synonyms: B130010J22Rik, Myf-5, bHLHc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17877
VEGA: 10
HGNC: HGNC:7565
Homologene: 4085
Acap3
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Synonyms: Kiaa1716-hp, Centb5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 140500
Homologene: 23708
Pramel14
Name: PRAME like 14
Synonyms: Gm13107, Pramef17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 626943
Homologene: 129642
Zfp874b
Name: zinc finger protein 874b
Synonyms: 9630025I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 408067
Homologene: 135597
9230112D13Rik
Name: RIKEN cDNA 9230112D13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 78243
VEGA: 14
Fbxo6
Name: F-box protein 6
Synonyms: Fbx6b, FBG2, Fbs2, Fbxo6b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50762
Homologene: 9274
Syf2
Name: SYF2 homolog, RNA splicing factor (S. cerevisiae)
Synonyms: p29, mp29, 1110018L13Rik, D4Bwg1551e, Gcipip, Cbpin, Ntc31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68592
Homologene: 5993
Fcamr
Name: Fc receptor, IgA, IgM, high affinity
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 64435
Homologene: 12929
Olfr1051
Name: olfactory receptor 1051
Synonyms: GA_x6K02T2Q125-47756192-47755266, MOR187-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404324
Homologene: 77387
Kcnj4
Name: potassium inwardly-rectifying channel, subfamily J, member 4
Synonyms: IRK3, Kir 2.3, MB-IRK3, Kcnf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16520
VEGA: 15
HGNC: HGNC:6265
Homologene: 3653
Fam78b
Name: family with sequence similarity 78, member B
Synonyms: C030020L09Rik, C030014K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226610
Homologene: 18451
1700018B08Rik
Name: RIKEN cDNA 1700018B08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76405
Homologene: 81929
Fam89b
Name: family with sequence similarity 89, member B
Synonyms: 1110021A21Rik, Fam89b, Mtvr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17826
Homologene: 18749
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 130,814,484 bp
  • G to A, chromosome 1 at 153,074,695 bp
  • A to T, chromosome 1 at 161,109,804 bp
  • T to A, chromosome 1 at 167,001,777 bp
  • G to A, chromosome 2 at 14,102,497 bp
  • G to T, chromosome 2 at 32,954,265 bp
  • A to T, chromosome 2 at 82,987,195 bp
  • A to T, chromosome 2 at 86,275,561 bp
  • T to C, chromosome 2 at 126,769,867 bp
  • T to C, chromosome 2 at 181,029,379 bp
  • G to A, chromosome 3 at 38,888,323 bp
  • C to T, chromosome 3 at 137,379,907 bp
  • T to C, chromosome 4 at 129,468,982 bp
  • T to A, chromosome 4 at 134,935,434 bp
  • T to C, chromosome 4 at 141,627,854 bp
  • T to C, chromosome 4 at 143,994,312 bp
  • A to G, chromosome 4 at 148,146,110 bp
  • T to A, chromosome 4 at 149,117,478 bp
  • T to C, chromosome 4 at 149,156,775 bp
  • G to A, chromosome 4 at 152,134,271 bp
  • G to A, chromosome 4 at 155,634,217 bp
  • T to C, chromosome 4 at 155,902,821 bp
  • T to C, chromosome 5 at 108,313,950 bp
  • T to C, chromosome 5 at 114,195,252 bp
  • T to A, chromosome 5 at 120,662,982 bp
  • C to A, chromosome 6 at 67,452,296 bp
  • T to C, chromosome 6 at 143,072,572 bp
  • C to T, chromosome 8 at 3,604,708 bp
  • A to G, chromosome 8 at 83,938,350 bp
  • A to T, chromosome 8 at 121,540,588 bp
  • T to A, chromosome 9 at 38,430,864 bp
  • T to C, chromosome 9 at 62,060,928 bp
  • A to G, chromosome 10 at 107,484,654 bp
  • T to C, chromosome 11 at 7,161,962 bp
  • C to A, chromosome 11 at 23,473,253 bp
  • T to C, chromosome 11 at 72,074,627 bp
  • T to C, chromosome 11 at 102,202,186 bp
  • G to A, chromosome 11 at 119,274,316 bp
  • G to A, chromosome 11 at 120,010,888 bp
  • G to T, chromosome 12 at 83,674,677 bp
  • T to C, chromosome 12 at 101,985,236 bp
  • T to A, chromosome 13 at 13,708,212 bp
  • A to C, chromosome 13 at 34,060,524 bp
  • A to T, chromosome 13 at 38,484,881 bp
  • A to T, chromosome 13 at 67,474,092 bp
  • T to C, chromosome 14 at 31,163,828 bp
  • A to T, chromosome 14 at 33,108,688 bp
  • T to A, chromosome 14 at 34,512,055 bp
  • T to A, chromosome 15 at 79,484,630 bp
  • G to A, chromosome 15 at 88,820,631 bp
  • T to C, chromosome 16 at 44,433,812 bp
  • T to C, chromosome 17 at 46,549,426 bp
  • T to A, chromosome 18 at 12,757,680 bp
  • A to G, chromosome 19 at 5,729,419 bp
  • T to C, chromosome 19 at 7,018,874 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1475 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039528-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.