Strain Name:
C57BL/6J-MtgxR1477Btlr/Mmmh
Stock Number:
039530-MU
Citation ID:
RRID:MMRRC_039530-MU
Other Names:
R1477 (G1), C57BL/6J-MtgxR1477Btlr
Major Collection:

Gene Information

Casq2
Name: calsequestrin 2
Synonyms: ESTM52, Csq2, cCSQ, cardiac calsequestrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12373
HGNC: HGNC:1513
Homologene: 20330
Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms: Acra-4, Acra4, a4 nicotinic receptor, alpha4 nAChR, alpha4-nAChR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11438
HGNC: HGNC:1958
Homologene: 592
Meis1
Name: Meis homeobox 1
Synonyms: C530044H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17268
HGNC: HGNC:7000
Homologene: 86803
Ctbp2
Name: C-terminal binding protein 2
Synonyms: Gtrgeo6, Ribeye, D7Ertd45e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13017
HGNC: HGNC:2495
Homologene: 75187
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Pdzd2
Name: PDZ domain containing 2
Synonyms: A930022H17Rik, Pdzk3, Gm21706, 4930537L06Rik, LOC223364
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 68070
Homologene: 23393
Serpina9
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
Synonyms: 2310014L03Rik, Centerin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 71907
Homologene: 23633
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Mhdadsk9, Dsk9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Trappc12
Name: trafficking protein particle complex 12
Synonyms: CGI-87, D930014A20Rik, Ttc15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217449
VEGA: 12
Homologene: 34805
Vps35
Name: VPS35 retromer complex component
Synonyms: Mem3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 65114
Homologene: 6221
Sall1
Name: spalt like transcription factor 1
Synonyms: Msal-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 58198
Homologene: 2230
Arfgef1
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms: D130059B05Rik, BIG1, ARFGEP1, P200, D730028O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 211673
Homologene: 4687
Rraga
Name: Ras-related GTP binding A
Synonyms: FIP-1, 1300010C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68441
Homologene: 68522
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: TAF2B, 4732460C16Rik, CIF150, TAFII150, 150kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 319944
VEGA: 15
Homologene: 31137
Ezh1
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14055
HGNC: HGNC:3526
Homologene: 20458
Stt3b
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
Synonyms: Simp, 1300006C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68292
VEGA: 9
Homologene: 7387
Grid2ip
Name: glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
Synonyms: delphilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 170935
Homologene: 15781
Peg3
Name: paternally expressed 3
Synonyms: Pw1, Zfp102, End4, Gcap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18616
HGNC: HGNC:8826
Homologene: 31363
Ipmk
Name: inositol polyphosphate multikinase
Synonyms: 2410017C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 69718
Homologene: 76214
Acsl5
Name: acyl-CoA synthetase long-chain family member 5
Synonyms: 1700030F05Rik, Facl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 433256
VEGA: 19
Homologene: 69208
Prdm4
Name: PR domain containing 4
Synonyms: 2810470D21Rik, SC-1, 1700031E19Rik, SC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 72843
VEGA: 10
HGNC: HGNC:9348
Homologene: 8235
Tlr3
Name: toll-like receptor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 142980
Homologene: 20696
Cmtr1
Name: cap methyltransferase 1
Synonyms: Ftsjd2, 1300018I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74157
Homologene: 9003
Ppp2r5b
Name: protein phosphatase 2, regulatory subunit B', beta
Synonyms: B'beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 225849
HGNC: HGNC:9310
Homologene: 38157
Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms: STK, Fv2, Ron, Fv-2, CDw136, friend virus susceptibility 2, PTK8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19882
HGNC: HGNC:7381
Homologene: 1835
Dock8
Name: dedicator of cytokinesis 8
Synonyms: A130095G14Rik, 1200017A24Rik, 5830472H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 76088
VEGA: 19
Homologene: 52414
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola-2, Cola2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Itga11
Name: integrin alpha 11
Synonyms: 4732459H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319480
HGNC: HGNC:6136
Homologene: 8151
Klhl6
Name: kelch-like 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239743
Homologene: 15603
Ush2a
Name: usherin
Synonyms: Ush2a, Ushrn, MUSH2A, A930037M10Rik, A930011D15Rik, LOC269160, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22283
Homologene: 66151
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 229003
Homologene: 14118
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Zfp790
Name: zinc finger protein 790
Synonyms: 6330581L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233056
Homologene: 51695
9530053A07Rik
Name: RIKEN cDNA 9530053A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 319482
Homologene: 130055
Pnp2
Name: purine-nucleoside phosphorylase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 667034
HGNC: HGNC:7892
Homologene: 227
Sema3d
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Synonyms: 4631426B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 108151
Homologene: 23664
Clec2e
Name: C-type lectin domain family 2, member e
Synonyms: Clra
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232409
Homologene: 131164
Adam2
Name: a disintegrin and metallopeptidase domain 2
Synonyms: fertilin beta, Ftnb, Ph30-beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 11495
VEGA: 14
HGNC: HGNC:198
Homologene: 1127
Trim34a
Name: tripartite motif-containing 34A
Synonyms: Trim34, Trim34-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 94094
Homologene: 128238
Mus81
Name: MUS81 structure-specific endonuclease subunit
Synonyms: 1200008A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 71711
Homologene: 5725
Olfr744
Name: olfactory receptor 744
Synonyms: MOR106-13P, GA_x6K02T2PMLR-6326342-6327313
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 257884
Homologene: 128063
Olfr291
Name: olfactory receptor 291
Synonyms: MOR254-2, GA_x6K02T2NHDJ-11231385-11230438
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258410
Homologene: 83130
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18080
Homologene: 40632
Cgrrf1
Name: cell growth regulator with ring finger domain 1
Synonyms: 1110038G02Rik, 1810009H17Rik, CGR19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 68755
Homologene: 4789
Ttbk1
Name: tau tubulin kinase 1
Synonyms: C330008L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106763
VEGA: 17
Homologene: 50342
P2rx1
Name: purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms: RP-2, P2X1 receptor, P2x, Pdcd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18436
HGNC: HGNC:8533
Homologene: 1921
Fbxl6
Name: F-box and leucine-rich repeat protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 30840
VEGA: 15
Homologene: 8130
Pnpt1
Name: polyribonucleotide nucleotidyltransferase 1
Synonyms: polynucleotide phosphorylase, 1200003F12Rik, PNPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71701
Homologene: 12404
Nox4
Name: NADPH oxidase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 50490
HGNC: HGNC:7891
Homologene: 41065
Ttll12
Name: tubulin tyrosine ligase-like family, member 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223723
Homologene: 9036
Ajm1
Name: apical junction component 1
Synonyms: LOC381353, Gm996
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 381353
Homologene: 19943
Ppp1r26
Name: protein phosphatase 1, regulatory subunit 26
Synonyms: LOC241289
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241289
Homologene: 49400
Krt222
Name: keratin 222
Synonyms: 6330509G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268481
Homologene: 17556
Pih1d3
Name: PIH1 domain containing 3
Synonyms: 4930521A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74708
Homologene: 16553
Olfr212
Name: olfactory receptor 212
Synonyms: GA_x54KRFPKN04-58149882-58150865, 4931403F16Rik, MOR119-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 258019
Homologene: 74186
Olfr61
Name: olfactory receptor 61
Synonyms: GA_x6K02T2PBJ9-42783826-42784758, MOR253-1, IH7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18362
Homologene: 79374
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 10,189,284 bp
  • G to A, chromosome 1 at 31,223,023 bp
  • G to A, chromosome 1 at 188,849,076 bp
  • G to C, chromosome 2 at 25,579,753 bp
  • C to T, chromosome 2 at 28,452,788 bp
  • G to A, chromosome 2 at 52,264,122 bp
  • G to T, chromosome 2 at 181,038,983 bp
  • T to C, chromosome 2 at 181,232,804 bp
  • T to C, chromosome 3 at 102,144,139 bp
  • A to G, chromosome 4 at 86,576,759 bp
  • A to T, chromosome 5 at 12,505,900 bp
  • G to A, chromosome 5 at 143,375,585 bp
  • T to C, chromosome 6 at 4,539,673 bp
  • A to T, chromosome 6 at 116,516,665 bp
  • A to T, chromosome 6 at 129,095,200 bp
  • T to A, chromosome 7 at 6,716,142 bp
  • C to A, chromosome 7 at 28,157,093 bp
  • C to T, chromosome 7 at 29,823,100 bp
  • T to A, chromosome 7 at 84,857,017 bp
  • T to C, chromosome 7 at 87,295,866 bp
  • T to A, chromosome 7 at 104,248,080 bp
  • T to C, chromosome 7 at 132,998,941 bp
  • T to A, chromosome 7 at 140,638,442 bp
  • A to G, chromosome 8 at 45,398,165 bp
  • T to A, chromosome 8 at 85,287,800 bp
  • T to C, chromosome 8 at 89,032,882 bp
  • A to G, chromosome 9 at 53,464,273 bp
  • G to A, chromosome 9 at 62,755,211 bp
  • T to C, chromosome 9 at 107,908,324 bp
  • A to G, chromosome 9 at 115,266,192 bp
  • A to G, chromosome 10 at 71,381,777 bp
  • C to T, chromosome 10 at 85,904,265 bp
  • G to A, chromosome 11 at 18,881,665 bp
  • T to A, chromosome 11 at 29,137,102 bp
  • T to C, chromosome 11 at 73,009,012 bp
  • C to T, chromosome 11 at 79,395,859 bp
  • A to G, chromosome 11 at 99,238,765 bp
  • A to T, chromosome 11 at 101,192,984 bp
  • A to T, chromosome 12 at 28,737,752 bp
  • T to C, chromosome 12 at 70,044,184 bp
  • T to C, chromosome 12 at 103,997,103 bp
  • A to G, chromosome 14 at 46,853,438 bp
  • A to T, chromosome 14 at 50,618,713 bp
  • A to G, chromosome 14 at 50,959,535 bp
  • A to C, chromosome 14 at 66,077,700 bp
  • A to T, chromosome 15 at 12,411,002 bp
  • A to T, chromosome 15 at 55,062,172 bp
  • A to G, chromosome 15 at 76,537,734 bp
  • A to G, chromosome 15 at 83,580,102 bp
  • T to C, chromosome 16 at 19,965,977 bp
  • T to C, chromosome 17 at 29,697,157 bp
  • A to C, chromosome 17 at 46,476,799 bp
  • G to T, chromosome 19 at 5,486,334 bp
  • A to G, chromosome 19 at 6,230,227 bp
  • A to T, chromosome 19 at 25,095,550 bp
  • A to C, chromosome 19 at 55,291,472 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1477 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039530-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.