Strain Name:
C57BL/6J-MtgxR1489Btlr/Mmmh
Stock Number:
039541-MU
Citation ID:
RRID:MMRRC_039541-MU
Other Names:
R1489 (G1), C57BL/6J-MtgxR1489Btlr
Major Collection:

Gene Information

Slc7a7
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
Synonyms: my+lat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 20540
Homologene: 88701
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66185
Homologene: 41043
Exoc6
Name: exocyst complex component 6
Synonyms: Sec15l1, Sec15, msec15, 4833405E05Rik, hbd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107371
VEGA: 19
Homologene: 41305
Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms: Ddef1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 13196
HGNC: HGNC:2720
Homologene: 7684
2700097O09Rik
Name: RIKEN cDNA 2700097O09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 72658
Homologene: 36458
Atxn2l
Name: ataxin 2-like
Synonyms: A2LG, A2lp, A2D, A2RP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233871
Homologene: 16513
Tnip1
Name: TNFAIP3 interacting protein 1
Synonyms: ABIN1, A20-binding inhibitor of NF-kappa B activation, Nef, VAN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 57783
Homologene: 31355
Mier2
Name: MIER family member 2
Synonyms: 2700087H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 70427
Homologene: 18941
Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Synonyms: Lyt-4, CD45, Ly-5, T200, B220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Numb
Name: NUMB endocytic adaptor protein
Synonyms: m-numb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18222
HGNC: HGNC:8060
Homologene: 2775
Rbm10
Name: RNA binding motif protein 10
Synonyms: E430039K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 236732
HGNC: HGNC:9896
Homologene: 31330
Lnx1
Name: ligand of numb-protein X 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 16924
HGNC: HGNC:6657
Homologene: 7819
Atl2
Name: atlastin GTPase 2
Synonyms: Aip-2, Arl6ip2, 2010110I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 56298
VEGA: 17
Homologene: 56949
Lonrf1
Name: LON peptidase N-terminal domain and ring finger 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244421
Homologene: 34980
Tnnt1
Name: troponin T1, skeletal, slow
Synonyms: sTnT, Tnt, skeletal muscle slow-twitch TnT, ssTnT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 21955
Homologene: 20704
Cox16
Name: cytochrome c oxidase assembly protein 16
Synonyms: 1810020G14Rik, 1810055I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 66272
Homologene: 9520
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: D030002L11Rik, LOC382100, Rme8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235567
Homologene: 13574
C1ql3
Name: C1q-like 3
Synonyms: K100, 1110065A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227580
Homologene: 17701
Prl
Name: prolactin
Synonyms: Prl1a1, Prl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 19109
HGNC: HGNC:9445
Homologene: 732
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: erythroid, Spna1, Spna-1, ihj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20739
Homologene: 74460
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 70882
Homologene: 31589
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241516
Homologene: 110349
Gm8251
Name: predicted gene 8251
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 102636082
VEGA: 1
Homologene: 141149
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: beta3B, Naptb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Duox2
Name: dual oxidase 2
Synonyms: A430065P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 214593
Homologene: 9689
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 245860
Homologene: 34495
Cap2
Name: CAP, adenylate cyclase-associated protein, 2 (yeast)
Synonyms: 2810452G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 67252
Homologene: 101397
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: IGFBP-4ase, PAPP-A, PAG1, 8430414N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: 1700056P18Rik, testase 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
1700006A11Rik
Name: RIKEN cDNA 1700006A11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71824
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap1, 6330416M19Rik, Mtap-1, Mtap1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Ms4a15
Name: membrane-spanning 4-domains, subfamily A, member 15
Synonyms: Gm1286, LOC383468, E530011F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 545279
Homologene: 27391
Dpy19l3
Name: dpy-19-like 3 (C. elegans)
Synonyms: 9330164H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233115
Homologene: 18692
Tpte
Name: transmembrane phosphatase with tensin homology
Synonyms: Pten2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234129
Homologene: 50411
Mcpt9
Name: mast cell protease 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 17232
VEGA: 14
Homologene: 115745
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238405
Homologene: 128362
Pdzrn4
Name: PDZ domain containing RING finger 4
Synonyms: SAMCAP3L, LNX4, 1110017D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239618
VEGA: 15
Homologene: 85433
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241633
Homologene: 133162
Zswim3
Name: zinc finger SWIM-type containing 3
Synonyms: 4921517A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67538
Homologene: 15436
Fmn1
Name: formin 1
Synonyms: Fmn, formin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14260
HGNC: HGNC:3768
Homologene: 121778
Nox4
Name: NADPH oxidase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 50490
HGNC: HGNC:7891
Homologene: 41065
4930522H14Rik
Name: RIKEN cDNA 4930522H14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67646
Homologene: 49856
Foxc1
Name: forkhead box C1
Synonyms: frkhda, FREAC3, fkh-1, Mf4, Fkh1, fkh1, Mf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17300
HGNC: HGNC:3800
Homologene: 20373
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: Mdr1a, P-glycoprotein, Evi32, mdr-3, multiple drug resistant 1a, MDR3, Pgp, Pgy-3, Pgy3, P-gp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Myrip
Name: myosin VIIA and Rab interacting protein
Synonyms: A230081N12Rik, Slac2-c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245049
Homologene: 9150
Hlx
Name: H2.0-like homeobox
Synonyms: Hlx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 15284
HGNC: HGNC:4978
Homologene: 7363
Vmn1r174
Name: vomeronasal 1 receptor 174
Synonyms: V1rd22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 404291
Homologene: 79577
Fbxw2
Name: F-box and WD-40 domain protein 2
Synonyms: FBW2, MD6, Fwd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 30050
Homologene: 8131
Tmem38a
Name: transmembrane protein 38A
Synonyms: TRIC-A, 1110001E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74166
Homologene: 11449
Smpd1
Name: sphingomyelin phosphodiesterase 1, acid lysosomal
Synonyms: acid sphingomyelinase, Zn-SMase, aSMase, A-SMase, ASM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20597
Homologene: 457
CAAA01083517.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Fndc4
Name: fibronectin type III domain containing 4
Synonyms: 6330410H20Rik, FRCP1, 2810430J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 64339
Homologene: 49716
Dnaaf3
Name: dynein, axonemal assembly factor 3
Synonyms: b2b1739Clo, 6030429G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 436022
Homologene: 16205
Mbd3
Name: methyl-CpG binding domain protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 17192
HGNC: HGNC:6918
Homologene: 2917
Ghdc
Name: GH3 domain containing
Synonyms: D11Lgp1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 80860
Homologene: 32760
Gm10330
Name: predicted gene 10330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
Ighv2-6-8
Name: immunoglobulin heavy variable 2-6-8
Synonyms: Gm16887
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 791090
Gpt
Name: glutamic pyruvic transaminase, soluble
Synonyms: 2310022B03Rik, Gpt1, 1300007J06Rik, ALT, Gpt-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 76282
VEGA: 15
HGNC: HGNC:4552
Homologene: 134231
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 44,057,790 bp
  • T to C, chromosome 1 at 44,061,507 bp
  • T to A, chromosome 1 at 75,186,090 bp
  • T to C, chromosome 1 at 138,120,086 bp
  • A to G, chromosome 1 at 174,231,325 bp
  • A to G, chromosome 1 at 183,338,674 bp
  • G to T, chromosome 1 at 184,731,987 bp
  • G to T, chromosome 2 at 13,010,642 bp
  • A to T, chromosome 2 at 19,310,047 bp
  • GCCCCC to GCCCCCCCC, chromosome 2 at 34,812,817 bp
  • A to G, chromosome 2 at 82,979,811 bp
  • T to A, chromosome 2 at 113,365,212 bp
  • T to C, chromosome 2 at 121,300,437 bp
  • T to A, chromosome 2 at 122,293,396 bp
  • T to G, chromosome 2 at 126,331,013 bp
  • T to C, chromosome 2 at 164,819,981 bp
  • T to A, chromosome 3 at 124,414,299 bp
  • T to C, chromosome 4 at 11,521,164 bp
  • A to T, chromosome 4 at 65,180,948 bp
  • T to C, chromosome 4 at 109,505,457 bp
  • T to A, chromosome 5 at 8,686,300 bp
  • T to C, chromosome 5 at 31,293,451 bp
  • A to G, chromosome 5 at 74,660,560 bp
  • A to T, chromosome 7 at 4,507,525 bp
  • T to C, chromosome 7 at 4,530,759 bp
  • C to T, chromosome 7 at 23,754,556 bp
  • A to T, chromosome 7 at 35,725,410 bp
  • C to A, chromosome 7 at 81,463,690 bp
  • A to G, chromosome 7 at 87,304,889 bp
  • T to C, chromosome 7 at 105,556,554 bp
  • A to T, chromosome 7 at 126,496,467 bp
  • T to C, chromosome 8 at 22,349,389 bp
  • A to G, chromosome 8 at 36,222,954 bp
  • A to G, chromosome 8 at 40,824,994 bp
  • A to G, chromosome 8 at 72,579,635 bp
  • A to T, chromosome 9 at 104,231,035 bp
  • T to C, chromosome 9 at 120,432,529 bp
  • T to C, chromosome 10 at 79,544,690 bp
  • C to G, chromosome 10 at 80,393,906 bp
  • T to C, chromosome 11 at 54,940,698 bp
  • C to T, chromosome 11 at 100,768,257 bp
  • A to T, chromosome 12 at 23,780,031 bp
  • A to G, chromosome 12 at 55,059,510 bp
  • T to C, chromosome 12 at 81,474,615 bp
  • A to G, chromosome 12 at 83,795,443 bp
  • T to A, chromosome 12 at 113,491,451 bp
  • T to G, chromosome 12 at 113,796,453 bp
  • A to T, chromosome 13 at 27,057,636 bp
  • C to T, chromosome 13 at 31,808,612 bp
  • A to T, chromosome 13 at 46,609,635 bp
  • C to T, chromosome 14 at 54,408,646 bp
  • T to C, chromosome 14 at 56,027,519 bp
  • A to G, chromosome 15 at 64,172,730 bp
  • T to A, chromosome 15 at 76,699,160 bp
  • T to C, chromosome 15 at 92,677,712 bp
  • G to A, chromosome 17 at 79,852,706 bp
  • T to A, chromosome 19 at 10,980,557 bp
  • T to A, chromosome 19 at 37,597,120 bp
  • C to T, chromosome X at 20,637,664 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1489 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039541-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.