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Strain Name:
C57BL/6J-MtgxR1489Btlr/Mmmh
Stock Number:
039541-MU
Citation ID:
RRID:MMRRC_039541-MU
Other Names:
R1489 (G1), C57BL/6J-MtgxR1489Btlr
Major Collection:

Strain Information

Slc7a7
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
Synonyms: my+lat1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20540
Homologene: 88701
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66185
Homologene: 41043
Exoc6
Name: exocyst complex component 6
Synonyms: msec15, 4833405E05Rik, Sec15, Sec15l1, hbd
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107371
VEGA: 19
Homologene: 41305
Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms: Ddef1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13196
HGNC: HGNC:2720
Homologene: 7684
2700097O09Rik
Name: RIKEN cDNA 2700097O09 gene
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72658
Homologene: 36458
Atxn2l
Name: ataxin 2-like
Synonyms: A2RP, A2LG, A2D, A2lp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233871
Homologene: 16513
Tnip1
Name: TNFAIP3 interacting protein 1
Synonyms: A20-binding inhibitor of NF-kappa B activation, ABIN1, VAN, Nef
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57783
Homologene: 31355
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 44,057,790 bp
  • T to C, chromosome 1 at 44,061,507 bp
  • T to A, chromosome 1 at 75,186,090 bp
  • T to C, chromosome 1 at 138,120,086 bp
  • A to G, chromosome 1 at 174,231,325 bp
  • A to G, chromosome 1 at 183,338,674 bp
  • G to T, chromosome 1 at 184,731,987 bp
  • G to T, chromosome 2 at 13,010,642 bp
  • A to T, chromosome 2 at 19,310,047 bp
  • GCCCCC to GCCCCCCCC, chromosome 2 at 34,812,817 bp
  • A to G, chromosome 2 at 82,979,811 bp
  • T to A, chromosome 2 at 113,365,212 bp
  • T to C, chromosome 2 at 121,300,437 bp
  • T to A, chromosome 2 at 122,293,396 bp
  • T to G, chromosome 2 at 126,331,013 bp
  • T to C, chromosome 2 at 164,819,981 bp
  • T to A, chromosome 3 at 124,414,299 bp
  • T to C, chromosome 4 at 11,521,164 bp
  • A to T, chromosome 4 at 65,180,948 bp
  • T to C, chromosome 4 at 109,505,457 bp
  • T to A, chromosome 5 at 8,686,300 bp
  • T to C, chromosome 5 at 31,293,451 bp
  • A to G, chromosome 5 at 74,660,560 bp
  • A to T, chromosome 7 at 4,507,525 bp
  • T to C, chromosome 7 at 4,530,759 bp
  • C to T, chromosome 7 at 23,754,556 bp
  • A to T, chromosome 7 at 35,725,410 bp
  • C to A, chromosome 7 at 81,463,690 bp
  • A to G, chromosome 7 at 87,304,889 bp
  • T to C, chromosome 7 at 105,556,554 bp
  • A to T, chromosome 7 at 126,496,467 bp
  • T to C, chromosome 8 at 22,349,389 bp
  • A to G, chromosome 8 at 36,222,954 bp
  • A to G, chromosome 8 at 40,824,994 bp
  • A to G, chromosome 8 at 72,579,635 bp
  • A to T, chromosome 9 at 104,231,035 bp
  • T to C, chromosome 9 at 120,432,529 bp
  • T to C, chromosome 10 at 79,544,690 bp
  • C to G, chromosome 10 at 80,393,906 bp
  • T to C, chromosome 11 at 54,940,698 bp
  • C to T, chromosome 11 at 100,768,257 bp
  • A to T, chromosome 12 at 23,780,031 bp
  • A to G, chromosome 12 at 55,059,510 bp
  • T to C, chromosome 12 at 81,474,615 bp
  • A to G, chromosome 12 at 83,795,443 bp
  • T to A, chromosome 12 at 113,491,451 bp
  • T to G, chromosome 12 at 113,796,453 bp
  • A to T, chromosome 13 at 27,057,636 bp
  • C to T, chromosome 13 at 31,808,612 bp
  • A to T, chromosome 13 at 46,609,635 bp
  • C to T, chromosome 14 at 54,408,646 bp
  • T to C, chromosome 14 at 56,027,519 bp
  • A to G, chromosome 15 at 64,172,730 bp
  • T to A, chromosome 15 at 76,699,160 bp
  • T to C, chromosome 15 at 92,677,712 bp
  • G to A, chromosome 17 at 79,852,706 bp
  • T to A, chromosome 19 at 10,980,557 bp
  • T to A, chromosome 19 at 37,597,120 bp
  • C to T, chromosome X at 20,637,664 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1489 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039541-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.