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Strain Name:
C57BL/6J-MtgxR1554Btlr/Mmmh
Stock Number:
039593-MU
Citation ID:
RRID:MMRRC_039593-MU
Other Names:
R1554 (G1), C57BL/6J-MtgxR1554Btlr
Major Collection:

Strain Information

Kif3a
Name: kinesin family member 3A
Synonyms: kinesin-II subunit, Kns3, Kif3, Kifl, N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16568
HGNC: HGNC:6319
Homologene: 38266
Kitl
Name: kit ligand
Synonyms: SF, stem cell factor, Steel factor, SLF, Mgf, Sl, Gb, grizzle-belly, Steel, SCF, Kitlg, blz
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17311
HGNC: HGNC:6343
Homologene: 692
Npr3
Name: natriuretic peptide receptor 3
Synonyms: Nppc receptor, lgj, longjohn, NPR-C, B430320C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Etv1
Name: ets variant 1
Synonyms: ER81, Etsrp81
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Ptprf
Name: protein tyrosine phosphatase receptor type F
Synonyms: LAR, RPTP-LAR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Utp20
Name: UTP20 small subunit processome component
Synonyms: mDRIM, DRIM, 3830408P06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Psmd3
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Synonyms: AntP91a, Psd3, Tstap91a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22123
HGNC: HGNC:9560
Homologene: 2102
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,819,920 bp
  • T to C, chromosome 1 at 60,278,811 bp
  • C to A, chromosome 1 at 62,637,894 bp
  • A to G, chromosome 1 at 130,706,472 bp
  • T to C, chromosome 2 at 14,141,828 bp
  • T to C, chromosome 2 at 94,425,643 bp
  • T to C, chromosome 2 at 163,879,122 bp
  • C to T, chromosome 3 at 50,381,896 bp
  • T to C, chromosome 3 at 109,136,270 bp
  • A to T, chromosome 3 at 119,065,046 bp
  • C to T, chromosome 4 at 65,237,946 bp
  • G to T, chromosome 4 at 118,217,081 bp
  • A to T, chromosome 5 at 62,641,408 bp
  • A to G, chromosome 5 at 67,326,921 bp
  • G to A, chromosome 5 at 76,634,213 bp
  • T to A, chromosome 5 at 86,289,260 bp
  • G to A, chromosome 5 at 86,661,631 bp
  • T to A, chromosome 5 at 107,507,787 bp
  • T to A, chromosome 5 at 112,969,269 bp
  • T to C, chromosome 5 at 120,683,321 bp
  • A to T, chromosome 6 at 28,125,853 bp
  • T to C, chromosome 6 at 29,711,082 bp
  • A to G, chromosome 6 at 34,048,952 bp
  • T to A, chromosome 6 at 123,125,097 bp
  • G to T, chromosome 8 at 22,327,820 bp
  • G to A, chromosome 8 at 70,813,372 bp
  • T to C, chromosome 9 at 14,803,759 bp
  • A to G, chromosome 9 at 21,107,922 bp
  • T to C, chromosome 9 at 38,115,934 bp
  • T to C, chromosome 9 at 67,023,429 bp
  • A to T, chromosome 9 at 78,435,556 bp
  • A to T, chromosome 9 at 90,173,650 bp
  • T to A, chromosome 9 at 114,746,482 bp
  • G to T, chromosome 10 at 19,850,737 bp
  • T to C, chromosome 10 at 40,076,800 bp
  • T to C, chromosome 10 at 80,321,951 bp
  • A to C, chromosome 10 at 81,595,385 bp
  • A to T, chromosome 10 at 88,764,737 bp
  • T to A, chromosome 10 at 100,087,438 bp
  • A to C, chromosome 10 at 125,230,922 bp
  • C to T, chromosome 10 at 128,145,664 bp
  • C to A, chromosome 11 at 46,752,507 bp
  • A to G, chromosome 11 at 53,598,327 bp
  • T to C, chromosome 11 at 55,253,664 bp
  • A to G, chromosome 11 at 59,003,648 bp
  • T to C, chromosome 11 at 69,103,627 bp
  • T to G, chromosome 11 at 98,685,923 bp
  • A to G, chromosome 11 at 101,194,562 bp
  • T to C, chromosome 11 at 119,441,839 bp
  • A to T, chromosome 11 at 120,647,727 bp
  • T to C, chromosome 12 at 38,781,784 bp
  • C to T, chromosome 12 at 70,952,940 bp
  • A to T, chromosome 12 at 101,055,822 bp
  • C to T, chromosome 12 at 118,082,499 bp
  • A to G, chromosome 13 at 3,576,374 bp
  • A to T, chromosome 13 at 23,114,294 bp
  • A to C, chromosome 13 at 49,621,044 bp
  • T to G, chromosome 14 at 47,695,507 bp
  • C to A, chromosome 15 at 11,848,563 bp
  • A to G, chromosome 15 at 81,235,820 bp
  • A to G, chromosome 16 at 13,147,622 bp
  • T to C, chromosome 16 at 16,341,426 bp
  • T to C, chromosome 17 at 24,903,059 bp
  • T to A, chromosome 17 at 28,979,232 bp
  • T to C, chromosome 17 at 46,972,951 bp
  • T to C, chromosome 18 at 31,666,472 bp
  • T to A, chromosome 18 at 32,848,372 bp
  • T to C, chromosome 18 at 54,898,054 bp
  • T to C, chromosome 18 at 74,948,047 bp
  • A to G, chromosome 19 at 23,254,761 bp
  • T to A, chromosome 19 at 31,908,902 bp
  • A to G, chromosome 19 at 36,996,598 bp
  • T to G, chromosome 19 at 38,738,052 bp
  • T to C, chromosome 19 at 40,223,072 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1554 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039593-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.