Strain Name:
C57BL/6J-MtgxR1555Btlr/Mmmh
Stock Number:
039594-MU
Citation ID:
RRID:MMRRC_039594-MU
Other Names:
R1555 (G1), C57BL/6J-MtgxR1555Btlr
Major Collection:

Gene Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Rxra
Name: retinoid X receptor alpha
Synonyms: RXRalpha1, RXR alpha 1, 9530071D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20181
Homologene: 2220
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Mier3
Name: MIER family member 3
Synonyms: D130064H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218613
Homologene: 18196
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67958
Homologene: 13964
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Zfp90
Name: zinc finger protein 90
Synonyms: Nk10 expressed protein, NK10, 6430515L01Rik, Zfp64, KRAB17, Zfp83
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22751
Homologene: 86800
Ate1
Name: arginyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11907
HGNC: HGNC:782
Homologene: 31420
Zfp180
Name: zinc finger protein 180
Synonyms: D130011P11, HHZ168, 2310040I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210135
Homologene: 8306
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: C530005A01Rik, 6030465E24Rik, spastic paraplegia 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214585
Homologene: 41614
Sbf1
Name: SET binding factor 1
Synonyms: Mtmr5, B230113C15Rik, 2610510A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77980
Homologene: 84710
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: D14Ertd171e, ELKS2alpha, CAST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 238988
Homologene: 69188
Dcakd
Name: dephospho-CoA kinase domain containing
Synonyms: 3010024O21Rik, 6720485C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68087
Homologene: 5652
Uts2
Name: urotensin 2
Synonyms: urotensin II precursor, prepro-UII, Ucn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 24111
Homologene: 4939
Wdr19
Name: WD repeat domain 19
Synonyms: C330027H04Rik, D330023L08Rik, Ift144, DYF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 213081
Homologene: 11842
Hps3
Name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Synonyms: Hermansky-Pudlak syndrome 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12807
Homologene: 13019
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, erythroid, ihj, Spna1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20739
Homologene: 74460
Dcdc5
Name: doublecortin domain containing 5
Synonyms: 4732421G10Rik, EG436559
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329482
Homologene: 79722
Olfr214
Name: olfactory receptor 214
Synonyms: GA_x54KRFPKN04-58190962-58191900, MOR119-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258754
Homologene: 133694
Cdkl4
Name: cyclin-dependent kinase-like 4
Synonyms: LOC381113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381113
VEGA: 17
Homologene: 28725
Myo5b
Name: myosin VB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: EG235580, 1110001D15Rik, Dvwa, Vwa6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68553
Homologene: 130754
Vwa5b1
Name: von Willebrand factor A domain containing 5B1
Synonyms: 4931403E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75718
Homologene: 19431
Adamts1
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
Synonyms: ADAM-TS1, METH1, METH-1, ADAMTS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Adamts18
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 208936
Homologene: 65241
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: GluRdelta2, tpr, B230104L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Xkr6
Name: X-linked Kx blood group related 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219149
Homologene: 18287
Clcnkb
Name: chloride channel, voltage-sensitive Kb
Synonyms: Clcnk1l, Clck2, ClC-K2, Clcnk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56365
Homologene: 107317
Rad21l
Name: RAD21-like (S. pombe)
Synonyms: Gm14160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668929
Homologene: 82650
Phyhd1
Name: phytanoyl-CoA dioxygenase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227696
Homologene: 14939
Sry
Name: sex determining region of Chr Y
Synonyms: Tdf, Tdy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 21674
Ttll6
Name: tubulin tyrosine ligase-like family, member 6
Synonyms: t8130b59, 4932418K24Rik, D11Moh43e, D11Moh44e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237930
Homologene: 18229
Ttll10
Name: tubulin tyrosine ligase-like family, member 10
Synonyms: 4930595O22Rik, 4833412E22Rik, Ttll5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 330010
Homologene: 51912
Tmem200a
Name: transmembrane protein 200A
Synonyms: C030003D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77220
VEGA: 10
Homologene: 14175
Sac3d1
Name: SAC3 domain containing 1
Synonyms: Shd1, 2410004C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66406
VEGA: 19
Homologene: 40867
Tpra1
Name: transmembrane protein, adipocyte asscociated 1
Synonyms: Tpra40, 40kDa, Gpr175
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 24100
Homologene: 40799
Tmprss11e
Name: transmembrane protease, serine 11e
Synonyms: DESC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243084
Homologene: 8543
Tedc1
Name: tubulin epsilon and delta complex 1
Synonyms: 4930427A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104732
Homologene: 77129
Hebp2
Name: heme binding protein 2
Synonyms: SOUL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56016
VEGA: 10
Homologene: 8634
Olfr675
Name: olfactory receptor 675
Synonyms: GA_x6K02T2PBJ9-7653782-7652841, MOR32-9P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258147
Homologene: 133595
Neurl3
Name: neuralized E3 ubiquitin protein ligase 3
Synonyms: 2010300P06Rik, Lincr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214854
Homologene: 35002
Ac174597.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Gm11651
Name: predicted gene 11651
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100379610
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 30,805,877 bp
  • A to G, chromosome 1 at 36,266,532 bp
  • A to G, chromosome 1 at 174,178,749 bp
  • C to T, chromosome 2 at 27,748,678 bp
  • T to A, chromosome 2 at 30,274,706 bp
  • T to G, chromosome 2 at 106,384,135 bp
  • T to C, chromosome 2 at 122,097,377 bp
  • T to A, chromosome 2 at 151,658,428 bp
  • T to C, chromosome 3 at 20,019,788 bp
  • C to A, chromosome 3 at 98,131,340 bp
  • T to C, chromosome 4 at 138,605,477 bp
  • T to C, chromosome 4 at 141,411,739 bp
  • C to T, chromosome 4 at 150,997,245 bp
  • T to C, chromosome 4 at 156,035,139 bp
  • A to G, chromosome 5 at 65,256,440 bp
  • T to A, chromosome 5 at 86,715,588 bp
  • A to T, chromosome 6 at 64,429,684 bp
  • C to T, chromosome 6 at 68,632,381 bp
  • A to G, chromosome 6 at 88,910,203 bp
  • A to T, chromosome 6 at 116,556,826 bp
  • T to C, chromosome 7 at 24,101,574 bp
  • T to C, chromosome 7 at 105,024,522 bp
  • A to T, chromosome 7 at 130,509,091 bp
  • A to G, chromosome 8 at 106,424,095 bp
  • A to G, chromosome 8 at 113,709,571 bp
  • A to G, chromosome 9 at 95,466,577 bp
  • C to T, chromosome 9 at 106,000,886 bp
  • G to T, chromosome 10 at 18,544,415 bp
  • A to T, chromosome 10 at 25,993,884 bp
  • A to G, chromosome 10 at 117,751,490 bp
  • G to T, chromosome 11 at 96,145,582 bp
  • C to T, chromosome 11 at 103,000,213 bp
  • A to G, chromosome 11 at 105,974,901 bp
  • G to T, chromosome 12 at 113,156,497 bp
  • T to A, chromosome 13 at 111,708,359 bp
  • T to A, chromosome 14 at 28,011,665 bp
  • A to G, chromosome 14 at 63,818,925 bp
  • A to G, chromosome 15 at 89,305,076 bp
  • T to A, chromosome 16 at 85,797,888 bp
  • T to A, chromosome 17 at 80,543,614 bp
  • A to T, chromosome 18 at 74,569,782 bp
  • T to C, chromosome 19 at 6,118,405 bp
  • C to G, chromosome Y at 2,662,975 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1555 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039594-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.