Strain Name:
C57BL/6J-MtgxR1561Btlr/Mmmh
Stock Number:
039600-MU
Citation ID:
RRID:MMRRC_039600-MU
Other Names:
R1561 (G1), C57BL/6J-MtgxR1561Btlr
Major Collection:

Strain Information

Atg7
Name: autophagy related 7
Synonyms: 1810013K23Rik, Apg7l
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74244
Homologene: 4662
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Slc2a1
Name: solute carrier family 2 (facilitated glucose transporter), member 1
Synonyms: Glut-1, Glut1, M100200, Rgsc200
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20525
Homologene: 68520
Gpr151
Name: G protein-coupled receptor 151
Synonyms: C130082O03Rik, GalRL, PGR7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240239
VEGA: 18
Homologene: 18754
Polk
Name: polymerase (DNA directed), kappa
Synonyms: Dinb1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27015
VEGA: 13
HGNC: HGNC:9183
Homologene: 32140
Sf3b1
Name: splicing factor 3b, subunit 1
Synonyms: SAP155, Prp10, SF3b155, 2810001M05Rik, Targ4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 81898
Homologene: 6696
Trappc8
Name: trafficking protein particle complex 8
Synonyms: 5033403J15Rik, D030074E01Rik, Trs85
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75964
VEGA: 18
Homologene: 40993
Srrt
Name: serrate RNA effector molecule homolog (Arabidopsis)
Synonyms: Asr2, Ars2, 2810019G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83701
Homologene: 9298
Polr3b
Name: polymerase (RNA) III (DNA directed) polypeptide B
Synonyms: RPC2, 2700078H01Rik, A330032P03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70428
VEGA: 10
Homologene: 6981
Ruvbl1
Name: RuvB-like AAA ATPase 1
Synonyms: Pontin52, 2510009G06Rik, Tip49a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56505
Homologene: 37839
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Ckap2l
Name: cytoskeleton associated protein 2-like
Synonyms: 2010016H04Rik, 2610318C08Rik, Radmis
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70466
Homologene: 51866
Neo1
Name: neogenin
Synonyms: D930014N22Rik, 2610028H22Rik, Igdcc2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18007
VEGA: 9
HGNC: HGNC:7754
Homologene: 1870
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Naca
Name: nascent polypeptide-associated complex alpha polypeptide
Synonyms: skNAC, LOC380777
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17938
VEGA: 10
HGNC: HGNC:7629
Homologene: 136025
Srsf4
Name: serine and arginine-rich splicing factor 4
Synonyms: MNCb-2616, 5730499P16Rik, SRp75, Sfrs4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 57317
Homologene: 25624
Ptprm
Name: protein tyrosine phosphatase receptor type M
Synonyms: RPTPmu
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Khsrp
Name: KH-type splicing regulatory protein
Synonyms: 6330409F21Rik, KSRP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16549
VEGA: 17
HGNC: HGNC:6316
Homologene: 2734
Pold3
Name: polymerase (DNA-directed), delta 3, accessory subunit
Synonyms: P68, P66, 2410142G14Rik, C85233, GC12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67967
Homologene: 38202
Mrnip
Name: MRN complex interacting protein
Synonyms: 3010026O09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68067
Homologene: 75241
Cmip
Name: c-Maf inducing protein
Synonyms: 5830471E12Rik, 4933407C03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74440
Homologene: 18869
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Asxl3
Name: ASXL transcriptional regulator 3
Synonyms: LOC381127, D930044O18Rik, D430002O22Rik, C230079D11Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211961
Homologene: 19371
Sf3a1
Name: splicing factor 3a, subunit 1
Synonyms: 1200014H24Rik, 5930416L09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67465
Homologene: 4294
4930432E11Rik
Name: RIKEN cDNA 4930432E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243900
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Gh
Name: growth hormone
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14599
Homologene: 47932
Nprl2
Name: NPR2 like, GATOR1 complex subunit
Synonyms: G21, NPR2L, NPRL2, 2810446G01Rik, Tusc4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56032
Homologene: 4771
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Mrgprb1
Name: MAS-related GPR, member B1
Synonyms: MrgB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233231
Homologene: 24986
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Tdrd6
Name: tudor domain containing 6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210510
Homologene: 19364
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241263
Homologene: 19381
Bace1
Name: beta-site APP cleaving enzyme 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23821
HGNC: HGNC:933
Homologene: 8014
Or13p3
Name: olfactory receptor family 13 subfamily P member 3
Synonyms: GA_x6K02T2QD9B-18838170-18837232, MOR258-1, Olfr1341
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258852
Homologene: 27281
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21974
Homologene: 134711
Mtus2
Name: microtubule associated tumor suppressor candidate 2
Synonyms: 5730592G18Rik, A730013O20Rik, C130038G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77521
Homologene: 78141
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75729
Homologene: 123434
Kcna5
Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms: Kv1.5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16493
HGNC: HGNC:6224
Homologene: 1683
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209683
Homologene: 41023
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230872
Homologene: 16811
Acsbg3
Name: acyl-CoA synthetase bubblegum family member 3
Synonyms: 1700061G19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78625
Homologene: 28378
Zfp759
Name: zinc finger protein 759
Synonyms: Rslcan-8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268670
VEGA: 13
Pdzrn4
Name: PDZ domain containing RING finger 4
Synonyms: SAMCAP3L, LNX4, 1110017D07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239618
VEGA: 15
Homologene: 85433
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Ap1g2
Name: adaptor protein complex AP-1, gamma 2 subunit
Synonyms: gamma 2-adaptin, Adtg2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11766
HGNC: HGNC:556
Homologene: 49141
D6Ertd527e
Name: DNA segment, Chr 6, ERATO Doi 527, expressed
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52372
CT030661.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Ecm1
Name: extracellular matrix protein 1
Synonyms: p85
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13601
HGNC: HGNC:3153
Homologene: 3260
Slc26a3
Name: solute carrier family 26, member 3
Synonyms: Dra, 9030623B18Rik, 9130013M11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13487
HGNC: HGNC:3018
Homologene: 55435
Or9m1
Name: olfactory receptor family 9 subfamily M member 1
Synonyms: GA_x6K02T2Q125-49403456-49402524, MOR173-2, Olfr1154
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258641
Homologene: 74192
Prkag2
Name: protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Synonyms: 2410051C13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108099
HGNC: HGNC:9386
Homologene: 136125
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57257
Homologene: 38143
Cd200l1
Name: CD200 molecule like 1
Synonyms: LOC208166, LOC385647, Gm609, iSEC1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208166
Homologene: 86707
Chfr
Name: checkpoint with forkhead and ring finger domains
Synonyms: RNF116, 5730484M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231600
Homologene: 10078
Prss47
Name: serine protease 47
Synonyms: LOC218304, Gm274
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218304
Homologene: 28158
Vmn1r42
Name: vomeronasal 1 receptor 42
Synonyms: V1ra6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113848
Homologene: 130651
Slc35a5
Name: solute carrier family 35, member A5
Synonyms: D16Ertd450e, 1010001J06Rik, D730043G07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74102
Homologene: 9930
AC159899.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Ovca2
Name: candidate tumor suppressor in ovarian cancer 2
Synonyms: 9030414M07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246257
Homologene: 6086
Tmem65
Name: transmembrane protein 65
Synonyms: 2610029O13Rik, 4930438D12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74868
Homologene: 45494
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to G, chromosome 1 at 55,019,395 bp
  • C to A, chromosome 1 at 164,186,903 bp
  • A to T, chromosome 2 at 21,815,694 bp
  • C to T, chromosome 2 at 87,903,161 bp
  • T to G, chromosome 2 at 112,678,025 bp
  • G to A, chromosome 2 at 129,270,725 bp
  • G to A, chromosome 3 at 95,735,963 bp
  • T to C, chromosome 3 at 109,494,838 bp
  • T to A, chromosome 4 at 118,709,554 bp
  • A to G, chromosome 4 at 119,136,409 bp
  • T to A, chromosome 4 at 131,897,695 bp
  • C to T, chromosome 4 at 141,030,268 bp
  • C to A, chromosome 4 at 141,472,383 bp
  • T to C, chromosome 5 at 24,871,595 bp
  • A to T, chromosome 5 at 110,158,808 bp
  • G to A, chromosome 5 at 111,225,677 bp
  • A to T, chromosome 5 at 125,024,286 bp
  • T to A, chromosome 5 at 137,300,019 bp
  • A to T, chromosome 5 at 137,380,838 bp
  • A to C, chromosome 5 at 148,076,552 bp
  • T to A, chromosome 6 at 85,629,052 bp
  • C to G, chromosome 6 at 87,111,524 bp
  • T to C, chromosome 6 at 88,479,154 bp
  • C to T, chromosome 6 at 89,845,381 bp
  • T to C, chromosome 6 at 114,701,172 bp
  • T to C, chromosome 6 at 126,534,583 bp
  • T to C, chromosome 7 at 29,562,296 bp
  • C to G, chromosome 7 at 48,447,125 bp
  • A to T, chromosome 7 at 100,108,560 bp
  • A to G, chromosome 8 at 109,614,813 bp
  • A to G, chromosome 8 at 117,453,850 bp
  • G to T, chromosome 9 at 45,839,194 bp
  • G to A, chromosome 9 at 58,894,031 bp
  • A to T, chromosome 9 at 99,234,286 bp
  • G to A, chromosome 9 at 107,544,740 bp
  • C to T, chromosome 10 at 62,949,187 bp
  • T to A, chromosome 10 at 84,634,912 bp
  • G to T, chromosome 10 at 128,040,398 bp
  • T to C, chromosome 11 at 4,179,217 bp
  • C to T, chromosome 11 at 50,176,849 bp
  • T to G, chromosome 11 at 59,036,073 bp
  • A to G, chromosome 11 at 75,177,979 bp
  • A to T, chromosome 11 at 106,301,216 bp
  • A to G, chromosome 12 at 31,466,452 bp
  • G to A, chromosome 13 at 48,820,037 bp
  • A to T, chromosome 13 at 65,046,248 bp
  • G to T, chromosome 13 at 67,137,420 bp
  • A to G, chromosome 13 at 96,501,508 bp
  • A to G, chromosome 14 at 16,398,993 bp
  • T to C, chromosome 14 at 55,104,887 bp
  • T to A, chromosome 15 at 58,822,858 bp
  • T to A, chromosome 15 at 79,636,762 bp
  • T to C, chromosome 15 at 92,677,637 bp
  • A to C, chromosome 16 at 45,151,521 bp
  • A to G, chromosome 16 at 45,442,512 bp
  • A to C, chromosome 17 at 22,201,225 bp
  • G to A, chromosome 17 at 43,625,624 bp
  • A to G, chromosome 17 at 56,877,431 bp
  • A to G, chromosome 17 at 57,025,639 bp
  • T to C, chromosome 17 at 66,940,541 bp
  • G to A, chromosome 18 at 20,841,623 bp
  • T to C, chromosome 18 at 22,509,239 bp
  • A to T, chromosome 18 at 42,579,156 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1561 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039600-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.