Strain Name:
C57BL/6J-MtgxR1576Btlr/Mmmh
Stock Number:
039614-MU
Citation ID:
RRID:MMRRC_039614-MU
Other Names:
R1576 (G1), C57BL/6J-MtgxR1576Btlr
Major Collection:

Gene Information

Ppp2r2a
Name: protein phosphatase 2, regulatory subunit B, alpha
Synonyms: 2410004D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 71978
VEGA: 14
HGNC: HGNC:9304
Homologene: 2035
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP, SHIP1, SHIP-1, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Nap1l1
Name: nucleosome assembly protein 1-like 1
Synonyms: D10Ertd68e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 53605
VEGA: 10
HGNC: HGNC:7637
Homologene: 129218
Jade1
Name: jade family PHD finger 1
Synonyms: D530048A03Rik, Phf17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 269424
Homologene: 18162
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Stk17b
Name: serine/threonine kinase 17b (apoptosis-inducing)
Synonyms: 3110009A03Rik, Drak2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98267
Homologene: 31231
Itga5
Name: integrin alpha 5 (fibronectin receptor alpha)
Synonyms: Cd49e, Fnra
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16402
VEGA: 15
HGNC: HGNC:6141
Homologene: 20508
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: eIF4GII, G1-419-52, repro8, 4930523M17Rik, 1500002J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Epc1
Name: enhancer of polycomb homolog 1
Synonyms: 5730566F07Rik, A930032N02Rik, 2400007E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13831
Homologene: 32627
Polr2j
Name: polymerase (RNA) II (DNA directed) polypeptide J
Synonyms: Rpb11a, Rpo2-4, 14.5kDa, RNA polymerase II subunit RPB14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20022
HGNC: HGNC:9197
Homologene: 4542
Nap1l4
Name: nucleosome assembly protein 1-like 4
Synonyms: 2810410H14Rik, Nap2, D7Wsu30e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17955
HGNC: HGNC:7640
Homologene: 133933
Lamb2
Name: laminin, beta 2
Synonyms: Lamb-2, npht, Lams
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Fh1
Name: fumarate hydratase 1
Synonyms: fumarase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14194
HGNC: HGNC:3700
Homologene: 115
Hook1
Name: hook microtubule tethering protein 1
Synonyms: abnormal spermatozoon head shape, A930033L17Rik, azh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 77963
Homologene: 9289
Dhx8
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 8
Synonyms: mDEAH6, Ddx8, RNA helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217207
HGNC: HGNC:2749
Homologene: 3628
Nufip1
Name: nuclear fragile X mental retardation protein interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 27275
VEGA: 14
HGNC: HGNC:8057
Homologene: 8216
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 209018
Homologene: 44592
Arfgap3
Name: ADP-ribosylation factor GTPase activating protein 3
Synonyms: 9130416J18Rik, 1810035F16Rik, 1810004P07Rik, 0610009H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66251
VEGA: 15
HGNC: HGNC:661
Homologene: 134103
Slc39a11
Name: solute carrier family 39 (metal ion transporter), member 11
Synonyms: 1810074D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69806
Homologene: 12331
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: 1700034M03Rik, Ccdc132, 8430415E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 73288
Homologene: 11498
Pum2
Name: pumilio RNA-binding family member 2
Synonyms: Pumm2, 5730503J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 80913
Homologene: 69183
Dpy19l2
Name: dpy-19-like 2 (C. elegans)
Synonyms: 4932443J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320752
VEGA: 9
Homologene: 77569
Maea
Name: macrophage erythroblast attacher
Synonyms: 1110030D19Rik, Gid9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 59003
Homologene: 4298
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: 2210407G14Rik, Hapip, E530005C20Rik, LOC224126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Cfi
Name: complement component factor i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12630
HGNC: HGNC:5394
Homologene: 171
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 545370
Homologene: 23741
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: FOAP-10, basilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 246707
VEGA: 17
Homologene: 36483
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip2, Birc1b, Naip-rs6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Kif1a
Name: kinesin family member 1A
Synonyms: C630002N23Rik, ATSV, Kns1, LOC381283, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Serpinb6d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms: Gm11390, SPI3D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 238568
HGNC: HGNC:8950
Insr
Name: insulin receptor
Synonyms: IR, IR-B, D630014A15Rik, 4932439J01Rik, CD220, IR-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Gata3
Name: GATA binding protein 3
Synonyms: jal, Gata-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14462
HGNC: HGNC:4172
Homologene: 1550
Myom2
Name: myomesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Lrrc19
Name: leucine rich repeat containing 19
Synonyms: 9130022A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100061
Homologene: 36410
Pcdhb8
Name: protocadherin beta 8
Synonyms: PcdhbH, Pcdhb5C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93879
Homologene: 89038
Spag17
Name: sperm associated antigen 17
Synonyms: 4931427F14Rik, PF6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74362
Homologene: 52601
Naalad2
Name: N-acetylated alpha-linked acidic dipeptidase 2
Synonyms: GCP3, Folh1b, D9Ertd285e, NAALADASE2, NAADALASE2, GCPIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 72560
Homologene: 3294
Zfp879
Name: zinc finger protein 879
Synonyms: 9630041N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 214779
Homologene: 45452
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 58234
Homologene: 75163
Sstr5
Name: somatostatin receptor 5
Synonyms: sst5, Smstr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20609
VEGA: 17
Homologene: 20287
Zfp316
Name: zinc finger protein 316
Synonyms: Emzf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 54201
Homologene: 69231
Tagln2
Name: transgelin 2
Synonyms: 2700094C18Rik, Sm22B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21346
Homologene: 20789
Arhgef16
Name: Rho guanine nucleotide exchange factor (GEF) 16
Synonyms: Neuroblastoma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230972
Homologene: 82484
Pla2g4d
Name: phospholipase A2, group IVD
Synonyms: 2610311B01Rik, Pla2delta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 78390
Homologene: 52252
Nudt21
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 21
Synonyms: 3110048P04Rik, Cpsf5, 5730530J16Rik, 25kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 68219
Homologene: 5090
Apol11a
Name: apolipoprotein L 11a
Synonyms: EG626615
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 626615
VEGA: 15
Homologene: 129975
1700041G16Rik
Name: RIKEN cDNA 1700041G16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
Rfxank
Name: regulatory factor X-associated ankyrin-containing protein
Synonyms: Tvl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 19727
HGNC: HGNC:9987
Homologene: 2760
Slc22a17
Name: solute carrier family 22 (organic cation transporter), member 17
Synonyms: 1700094C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 59049
VEGA: 14
Homologene: 10684
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 53,757,590 bp
  • A to T, chromosome 1 at 87,669,685 bp
  • A to T, chromosome 1 at 87,681,558 bp
  • A to G, chromosome 1 at 93,082,304 bp
  • A to T, chromosome 1 at 150,657,241 bp
  • A to G, chromosome 1 at 172,505,221 bp
  • G to A, chromosome 1 at 175,607,819 bp
  • A to T, chromosome 2 at 9,863,196 bp
  • C to T, chromosome 2 at 76,794,850 bp
  • A to G, chromosome 2 at 120,284,167 bp
  • T to A, chromosome 3 at 41,591,807 bp
  • T to C, chromosome 3 at 99,939,363 bp
  • T to C, chromosome 3 at 129,873,050 bp
  • G to A, chromosome 4 at 94,639,353 bp
  • A to G, chromosome 4 at 96,001,351 bp
  • T to A, chromosome 4 at 138,096,870 bp
  • A to C, chromosome 4 at 154,291,312 bp
  • A to G, chromosome 5 at 33,362,696 bp
  • C to A, chromosome 5 at 136,120,028 bp
  • T to C, chromosome 5 at 143,264,094 bp
  • A to G, chromosome 6 at 3,545,568 bp
  • G to T, chromosome 6 at 113,578,405 bp
  • T to A, chromosome 7 at 141,634,524 bp
  • C to T, chromosome 7 at 143,538,216 bp
  • G to A, chromosome 8 at 3,258,370 bp
  • A to G, chromosome 8 at 15,084,556 bp
  • G to A, chromosome 8 at 22,808,467 bp
  • C to A, chromosome 8 at 70,134,303 bp
  • A to C, chromosome 8 at 94,028,833 bp
  • T to G, chromosome 9 at 18,326,166 bp
  • T to A, chromosome 9 at 24,584,502 bp
  • T to C, chromosome 9 at 108,480,307 bp
  • A to G, chromosome 10 at 28,551,651 bp
  • A to G, chromosome 10 at 111,494,820 bp
  • T to A, chromosome 11 at 50,833,549 bp
  • T to C, chromosome 11 at 101,752,319 bp
  • G to T, chromosome 11 at 113,559,535 bp
  • A to G, chromosome 12 at 8,713,524 bp
  • G to A, chromosome 13 at 33,667,565 bp
  • A to T, chromosome 13 at 100,155,021 bp
  • G to A, chromosome 13 at 100,155,029 bp
  • A to G, chromosome 14 at 54,907,990 bp
  • A to G, chromosome 14 at 67,038,869 bp
  • A to G, chromosome 14 at 76,134,870 bp
  • T to A, chromosome 15 at 77,516,931 bp
  • A to G, chromosome 15 at 83,313,563 bp
  • C to A, chromosome 15 at 89,503,663 bp
  • T to C, chromosome 15 at 103,351,617 bp
  • A to G, chromosome 16 at 21,540,122 bp
  • A to G, chromosome 16 at 34,212,149 bp
  • C to T, chromosome 17 at 25,491,298 bp
  • A to G, chromosome 17 at 71,255,117 bp
  • T to C, chromosome 18 at 6,452,366 bp
  • A to G, chromosome 18 at 37,356,703 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1576 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039614-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.