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Strain Name:
C57BL/6J-MtgxR1589Btlr/Mmmh
Stock Number:
039626-MU
Citation ID:
RRID:MMRRC_039626-MU
Other Names:
R1589 (G1), C57BL/6J-MtgxR1589Btlr
Major Collection:

Strain Information

Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Acadl
Name: acyl-Coenzyme A dehydrogenase, long-chain
Synonyms: LCAD, C79855
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11363
HGNC: HGNC:88
Homologene: 37498
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, HGF/SF, NK2, C230052L06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
B4galt1
Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Synonyms: Ggtb, Ggtb2, B-1,4-GalT1, beta-1,4-GalT1, GalT, beta 1,4-Galactosyltransferase I, b1,4-Galactosyltransferase I
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14595
HGNC: HGNC:924
Homologene: 20378
Usp30
Name: ubiquitin specific peptidase 30
Synonyms: 6330590F17Rik, D5Ertd483e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100756
Homologene: 32789
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 66,853,223 bp
  • A to T, chromosome 1 at 93,579,860 bp
  • A to T, chromosome 1 at 106,734,541 bp
  • T to C, chromosome 1 at 116,060,200 bp
  • A to T, chromosome 1 at 125,408,563 bp
  • A to T, chromosome 1 at 134,354,706 bp
  • A to T, chromosome 1 at 153,905,538 bp
  • G to T, chromosome 1 at 173,582,209 bp
  • G to T, chromosome 1 at 181,922,293 bp
  • C to T, chromosome 2 at 28,469,488 bp
  • T to C, chromosome 2 at 51,958,977 bp
  • T to C, chromosome 2 at 62,257,462 bp
  • A to G, chromosome 2 at 120,041,406 bp
  • A to G, chromosome 2 at 121,106,993 bp
  • A to T, chromosome 2 at 130,247,960 bp
  • A to G, chromosome 2 at 144,394,100 bp
  • A to T, chromosome 2 at 157,027,637 bp
  • A to C, chromosome 3 at 5,241,729 bp
  • A to G, chromosome 3 at 6,620,441 bp
  • T to C, chromosome 3 at 41,033,474 bp
  • C to T, chromosome 3 at 60,010,576 bp
  • A to G, chromosome 3 at 96,168,113 bp
  • C to T, chromosome 3 at 96,651,738 bp
  • T to G, chromosome 3 at 133,100,819 bp
  • T to C, chromosome 4 at 40,823,575 bp
  • T to A, chromosome 4 at 63,166,500 bp
  • T to A, chromosome 4 at 81,421,176 bp
  • T to C, chromosome 4 at 94,640,950 bp
  • T to A, chromosome 4 at 116,703,524 bp
  • T to C, chromosome 4 at 126,575,168 bp
  • T to C, chromosome 4 at 141,488,024 bp
  • T to G, chromosome 5 at 16,613,785 bp
  • C to A, chromosome 5 at 38,529,972 bp
  • T to A, chromosome 5 at 110,181,783 bp
  • T to C, chromosome 5 at 114,112,961 bp
  • T to C, chromosome 5 at 115,651,266 bp
  • G to T, chromosome 6 at 3,565,507 bp
  • A to G, chromosome 6 at 34,857,517 bp
  • T to C, chromosome 6 at 123,806,520 bp
  • C to T, chromosome 6 at 141,845,447 bp
  • T to C, chromosome 7 at 4,520,526 bp
  • T to A, chromosome 7 at 13,131,776 bp
  • T to C, chromosome 7 at 18,245,647 bp
  • T to C, chromosome 7 at 45,465,247 bp
  • A to G, chromosome 7 at 46,283,908 bp
  • G to T, chromosome 7 at 98,145,359 bp
  • A to G, chromosome 7 at 105,024,560 bp
  • A to G, chromosome 7 at 106,845,196 bp
  • A to G, chromosome 7 at 138,361,767 bp
  • A to G, chromosome 7 at 139,119,015 bp
  • G to T, chromosome 8 at 47,501,680 bp
  • C to T, chromosome 8 at 54,703,907 bp
  • T to C, chromosome 8 at 86,673,072 bp
  • A to T, chromosome 8 at 88,709,990 bp
  • A to T, chromosome 8 at 121,117,176 bp
  • T to A, chromosome 8 at 128,705,458 bp
  • G to T, chromosome 8 at 128,705,459 bp
  • A to G, chromosome 9 at 14,894,128 bp
  • G to T, chromosome 9 at 26,769,038 bp
  • T to C, chromosome 9 at 118,607,117 bp
  • A to G, chromosome 9 at 119,769,807 bp
  • A to T, chromosome 10 at 10,719,967 bp
  • A to G, chromosome 10 at 33,905,529 bp
  • A to G, chromosome 10 at 58,463,986 bp
  • C to A, chromosome 10 at 79,293,024 bp
  • G to A, chromosome 10 at 86,776,390 bp
  • G to A, chromosome 10 at 91,153,411 bp
  • A to G, chromosome 10 at 105,779,632 bp
  • G to A, chromosome 10 at 117,690,529 bp
  • A to G, chromosome 10 at 119,213,566 bp
  • C to T, chromosome 10 at 127,605,606 bp
  • A to G, chromosome 10 at 129,911,681 bp
  • C to T, chromosome 11 at 32,733,612 bp
  • A to G, chromosome 11 at 34,706,461 bp
  • A to G, chromosome 11 at 51,997,872 bp
  • A to T, chromosome 11 at 59,036,075 bp
  • A to T, chromosome 11 at 102,268,995 bp
  • A to G, chromosome 11 at 102,606,328 bp
  • G to T, chromosome 11 at 106,800,104 bp
  • A to G, chromosome 12 at 105,591,859 bp
  • A to T, chromosome 13 at 21,002,948 bp
  • A to G, chromosome 13 at 21,423,292 bp
  • G to T, chromosome 13 at 73,614,673 bp
  • T to C, chromosome 14 at 32,325,865 bp
  • A to T, chromosome 14 at 33,955,792 bp
  • A to G, chromosome 14 at 56,165,911 bp
  • G to A, chromosome 14 at 62,674,381 bp
  • C to T, chromosome 14 at 78,908,230 bp
  • A to G, chromosome 15 at 11,388,175 bp
  • A to C, chromosome 15 at 28,453,255 bp
  • A to G, chromosome 16 at 62,928,020 bp
  • G to A, chromosome 17 at 24,505,478 bp
  • A to G, chromosome 18 at 20,863,551 bp
  • C to T, chromosome 19 at 5,069,932 bp
  • T to A, chromosome 19 at 8,831,332 bp
  • C to T, chromosome 19 at 13,502,757 bp
  • T to C, chromosome 19 at 42,171,745 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1589 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039626-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.