Strain Name:
C57BL/6J-MtgxR1593Btlr/Mmmh
Stock Number:
039630-MU
Citation ID:
RRID:MMRRC_039630-MU
Other Names:
R1593 (G1), C57BL/6J-MtgxR1593Btlr
Major Collection:

Gene Information

Lamb3
Name: laminin, beta 3
Synonyms: nicein, 125kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16780
HGNC: HGNC:6490
Homologene: 191
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: CalDAG-GEFI, Caldaggef1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Gldc
Name: glycine decarboxylase
Synonyms: D030049L12Rik, b2b2679Clo, D19Wsu57e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Rarg
Name: retinoic acid receptor, gamma
Synonyms: RARgamma2, RAR gamma 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 19411
HGNC: HGNC:9866
Homologene: 20263
Esrrg
Name: estrogen-related receptor gamma
Synonyms: NR3B3, Errg, ERR3, estrogen-related receptor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 26381
HGNC: HGNC:3474
Homologene: 55581
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Rrp12
Name: ribosomal RNA processing 12 homolog (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107094
VEGA: 19
Homologene: 22370
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: Pdzgef2, PDZ-GEF2, C030018K18Rik, RA-GEF-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192786
Homologene: 22968
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218503
VEGA: 13
Homologene: 9030
Ap3b1
Name: adaptor-related protein complex 3, beta 1 subunit
Synonyms: AP-3, beta3A, rim2, Hps2, recombination induced mutation 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 11774
VEGA: 13
HGNC: HGNC:566
Homologene: 68125
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22019
Homologene: 2471
Exoc2
Name: exocyst complex component 2
Synonyms: Sec5l1, 2410030I24Rik, Sec5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 66482
Homologene: 10122
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71643
Homologene: 34708
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, 2310003F20Rik, Garnl1, Tulip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 56784
VEGA: 12
Homologene: 84805
Fgd6
Name: FYVE, RhoGEF and PH domain containing 6
Synonyms: ZFYVE24, Etohd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 13998
Homologene: 14209
Ctr9
Name: CTR9 homolog, Paf1/RNA polymerase II complex component
Synonyms: Tsbp, Tsp, Sh2bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22083
Homologene: 40668
Zbtb20
Name: zinc finger and BTB domain containing 20
Synonyms: A930017C21Rik, D16Wsu73e, 1300017A20Rik, HOF, 7330412A13Rik, Zfp288
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 56490
Homologene: 9226
Spag9
Name: sperm associated antigen 9
Synonyms: 3110018C07Rik, JIP4, 4831406C20Rik, Mapk8ip4, JLP, syd1, 4733401I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70834
Homologene: 2954
Vsir
Name: V-set immunoregulatory receptor
Synonyms: Dies1, VISTA, 4632428N05Rik, PD-1H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 74048
Homologene: 81923
Epha6
Name: Eph receptor A6
Synonyms: Hek12, m-ehk2, Ehk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13840
Homologene: 56396
Pon2
Name: paraoxonase 2
Synonyms: 6330405I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330260
HGNC: HGNC:9205
Homologene: 385
Cdc23
Name: CDC23 cell division cycle 23
Synonyms: D18Ertd243e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 52563
HGNC: HGNC:1724
Homologene: 3426
Tmod3
Name: tropomodulin 3
Synonyms: UTMOD, U-Tmod, ubiquitous tropomodulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 50875
VEGA: 9
Homologene: 8727
Exosc7
Name: exosome component 7
Synonyms: 2610002K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66446
Homologene: 8994
Slc39a9
Name: solute carrier family 39 (zinc transporter), member 9
Synonyms: 2610511I23Rik, 2010002A02Rik, 4833420E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 328133
VEGA: 12
Homologene: 6935
Hectd3
Name: HECT domain E3 ubiquitin protein ligase 3
Synonyms: 1700064K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 76608
Homologene: 18426
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: 9830168K16Rik, Trrp7, TRPC7, LTRPC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 28240
Homologene: 20709
Grm2
Name: glutamate receptor, metabotropic 2
Synonyms: 4930441L02Rik, mGluR2, Gprc1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 108068
HGNC: HGNC:4594
Homologene: 20229
Arrdc2
Name: arrestin domain containing 2
Synonyms: 4632416I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 70807
Homologene: 79540
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Nckap1l
Name: NCK associated protein 1 like
Synonyms: Hem1, 4930568P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Pabpc6
Name: poly(A) binding protein, cytoplasmic 6
Synonyms: 4932702K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 67543
VEGA: 17
Homologene: 129776
Olfr800
Name: olfactory receptor 800
Synonyms: MOR114-7, GA_x6K02T2PULF-11338429-11339364
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258541
Homologene: 27203
Ctsq
Name: cathepsin Q
Synonyms: 1600010J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 104002
Homologene: 122226
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: insulin level locus 1, tomosyn-2, t2md1, LLGL4, A830015P08Rik, T2dm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 207227
Homologene: 18173
Frmd4a
Name: FERM domain containing 4A
Synonyms: 2700017I06Rik, C230040M21Rik, Gm13190
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 209630
Homologene: 9971
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Nlrp4d
Name: NLR family, pyrin domain containing 4D
Synonyms: Nalp-beta, Nalp4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 384752
AC168120.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
Gm13084
Name: predicted gene 13084
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381569
Homologene: 77858
Ppig
Name: peptidyl-prolyl isomerase G (cyclophilin G)
Synonyms: SRCyp, B230312B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228005
Homologene: 3520
Atg10
Name: autophagy related 10
Synonyms: 5330424L23Rik, 5430428K15Rik, Apg10l, APG10, Apg10p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 66795
VEGA: 13
Homologene: 12036
Meis2
Name: Meis homeobox 2
Synonyms: A430109D20Rik, Meis2, Mrg1, Stra10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17536
HGNC: HGNC:7001
Homologene: 7846
Ccdc136
Name: coiled-coil domain containing 136
Synonyms: 4921511K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232664
Homologene: 23378
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: A330035H04Rik, Lacsl, Facl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216739
Homologene: 100939
Tmem8
Name: transmembrane protein 8
Synonyms: M83, Tmem8, Rxylt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 60455
Homologene: 10944
A230052G05Rik
Name: RIKEN cDNA A230052G05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 442796
Slc16a13
Name: solute carrier family 16 (monocarboxylic acid transporters), member 13
Synonyms: 1700007D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69309
Homologene: 71749
Tulp1
Name: tubby like protein 1
Synonyms: Tulp1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22157
Homologene: 2491
Ehd1
Name: EH-domain containing 1
Synonyms: RME-1, Past1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 13660
HGNC: HGNC:3242
Homologene: 81678
Tex19.1
Name: testis expressed gene 19.1
Synonyms: 2410081M02Rik, Tex19, Tex19.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 73679
Homologene: 75271
Adam1a
Name: a disintegrin and metallopeptidase domain 1a
Synonyms: Ftna, PH-30 alpha, fertilin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 280668
HGNC: HGNC:187
Homologene: 73803
Zfp583
Name: zinc finger protein 583
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 213011
Homologene: 65048
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 43,975,433 bp
  • A to T, chromosome 1 at 188,066,385 bp
  • A to G, chromosome 1 at 193,330,796 bp
  • A to G, chromosome 2 at 4,473,188 bp
  • T to A, chromosome 2 at 69,749,081 bp
  • T to A, chromosome 2 at 116,000,264 bp
  • T to C, chromosome 3 at 75,396,941 bp
  • T to A, chromosome 3 at 127,561,026 bp
  • C to A, chromosome 4 at 116,997,020 bp
  • T to C, chromosome 4 at 143,811,487 bp
  • C to T, chromosome 4 at 148,014,594 bp
  • A to C, chromosome 5 at 121,519,643 bp
  • T to C, chromosome 6 at 5,273,003 bp
  • T to C, chromosome 6 at 29,415,584 bp
  • T to G, chromosome 6 at 104,832,580 bp
  • C to T, chromosome 7 at 6,317,009 bp
  • C to T, chromosome 7 at 10,375,022 bp
  • T to C, chromosome 7 at 111,042,853 bp
  • T to C, chromosome 8 at 70,837,120 bp
  • C to T, chromosome 8 at 70,864,108 bp
  • C to A, chromosome 8 at 125,759,273 bp
  • T to C, chromosome 9 at 75,511,163 bp
  • A to T, chromosome 9 at 106,650,914 bp
  • G to C, chromosome 9 at 123,131,993 bp
  • A to G, chromosome 10 at 60,357,958 bp
  • A to G, chromosome 10 at 77,059,097 bp
  • A to G, chromosome 10 at 77,943,076 bp
  • T to C, chromosome 10 at 94,045,032 bp
  • A to T, chromosome 10 at 129,660,225 bp
  • A to G, chromosome 11 at 54,323,308 bp
  • TG to TGG, chromosome 11 at 54,546,397 bp
  • C to A, chromosome 11 at 70,219,082 bp
  • A to G, chromosome 11 at 94,097,233 bp
  • A to T, chromosome 11 at 100,481,755 bp
  • T to C, chromosome 11 at 115,980,991 bp
  • T to A, chromosome 11 at 121,147,253 bp
  • T to A, chromosome 12 at 55,770,703 bp
  • T to C, chromosome 12 at 80,677,272 bp
  • C to A, chromosome 13 at 30,856,761 bp
  • T to A, chromosome 13 at 61,036,172 bp
  • T to C, chromosome 13 at 91,154,261 bp
  • T to C, chromosome 13 at 94,501,927 bp
  • T to C, chromosome 13 at 98,784,807 bp
  • A to G, chromosome 15 at 102,239,941 bp
  • A to G, chromosome 15 at 103,478,854 bp
  • A to G, chromosome 16 at 32,754,686 bp
  • A to G, chromosome 16 at 37,116,052 bp
  • A to G, chromosome 16 at 43,609,423 bp
  • A to T, chromosome 16 at 60,424,904 bp
  • A to T, chromosome 17 at 9,667,813 bp
  • T to A, chromosome 17 at 26,118,407 bp
  • T to C, chromosome 17 at 28,362,701 bp
  • C to A, chromosome 18 at 34,636,326 bp
  • A to G, chromosome 19 at 6,298,300 bp
  • T to C, chromosome 19 at 6,403,460 bp
  • A to T, chromosome 19 at 30,113,750 bp
  • T to A, chromosome 19 at 41,863,241 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1593 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039630-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.