Strain Name:
C57BL/6J-MtgxR1602Btlr/Mmmh
Stock Number:
039639-MU
Citation ID:
RRID:MMRRC_039639-MU
Other Names:
R1602 (G1), C57BL/6J-MtgxR1602Btlr
Major Collection:

Gene Information

Ptpa
Name: protein phosphatase 2 protein activator
Synonyms: 2610042B21Rik, Ppp2r4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110854
HGNC: HGNC:9308
Homologene: 6149
Kcnc4
Name: potassium voltage gated channel, Shaw-related subfamily, member 4
Synonyms: Kv3.4, Kcr2-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99738
HGNC: HGNC:6236
Homologene: 68427
Diaph3
Name: diaphanous related formin 3
Synonyms: p134MDia2, mDia2, 4930417P13Rik, Drf3, Diap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: ANCO-2, GAC-1, 2900001A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106585
Homologene: 9059
Lig3
Name: ligase III, DNA, ATP-dependent
Synonyms: D11Wsu78e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16882
HGNC: HGNC:6600
Homologene: 32109
Pkn2
Name: protein kinase N2
Synonyms: PRK2, 6030436C20Rik, Stk7, Prkcl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109333
HGNC: HGNC:9406
Homologene: 2054
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Arfgef1
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms: D730028O18Rik, ARFGEP1, P200, BIG1, D130059B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211673
Homologene: 4687
Kank2
Name: KN motif and ankyrin repeat domains 2
Synonyms: Ankrd25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235041
VEGA: 9
Homologene: 9163
Cit
Name: citron
Synonyms: CRIK-SK, citron-N, citron kinase, Cit-k, C030025P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Gcfc2
Name: GC-rich sequence DNA binding factor 2
Synonyms: AW146020
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330361
HGNC: HGNC:1317
Homologene: 2411
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: 2810409N01Rik, 2610101O16Rik, Gtl4, cat eye syndrome chromosome region, candidate 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Shld2
Name: shieldin complex subunit 2
Synonyms: 3110001K24Rik, Fam35a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75698
VEGA: 14
Homologene: 56840
Cpne6
Name: copine VI
Synonyms: neuronal copine
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12891
HGNC: HGNC:2319
Homologene: 81815
Treml1
Name: triggering receptor expressed on myeloid cells-like 1
Synonyms: TLT-1, 5430401J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71326
VEGA: 17
Homologene: 52257
Ctsc
Name: cathepsin C
Synonyms: DPP1, dipeptidylpeptidase 1, DPPI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13032
HGNC: HGNC:2528
Homologene: 1373
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Pcnx3
Name: pecanex homolog 3
Synonyms: Pcnxl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 104401
Homologene: 17000
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Oat
Name: ornithine aminotransferase
Synonyms: rhg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18242
HGNC: HGNC:8091
Homologene: 231
Afm
Name: afamin
Synonyms: Alf, alpha albumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 280662
HGNC: HGNC:316
Homologene: 881
Ankrd34c
Name: ankyrin repeat domain 34C
Synonyms: LOC330998, B230218L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330998
Homologene: 19814
Fgd5
Name: FYVE, RhoGEF and PH domain containing 5
Synonyms: ZFYVE23, C330025N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232237
Homologene: 27798
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212392
Homologene: 17668
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Pex6
Name: peroxisomal biogenesis factor 6
Synonyms: D130055I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224824
HGNC: HGNC:8859
Homologene: 47914
Elmod3
Name: ELMO/CED-12 domain containing 3
Synonyms: ELMOD3, RBM29, C330008I15Rik, Rbed1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232089
Homologene: 12978
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: C130044A18Rik, Phlppl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244650
Homologene: 71015
Filip1
Name: filamin A interacting protein 1
Synonyms: 5730485H21Rik, FILIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70598
Homologene: 6700
Plch2
Name: phospholipase C, eta 2
Synonyms: PLCeta2, A930027K05Rik, Plcl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269615
Homologene: 85172
St6galnac1
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Synonyms: ST6GalNAc I, Siat7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20445
Homologene: 7937
Olfr1368
Name: olfactory receptor 1368
Synonyms: GA_x6K02T2QHY8-12104556-12105500, MOR256-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 258527
Homologene: 105156
Vmn2r55
Name: vomeronasal 2, receptor 55
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042499
Homologene: 104040
Eif4a3l1
Name: eukaryotic translation initiation factor 4A3 like 1
Synonyms: Gm8994, B020013A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 668137
Lamc2
Name: laminin, gamma 2
Synonyms: nicein, 100kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16782
HGNC: HGNC:6493
Homologene: 4062
Gm12169
Name: predicted gene 12169
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 210535
Homologene: 130033
Fmn1
Name: formin 1
Synonyms: Fmn, formin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14260
HGNC: HGNC:3768
Homologene: 121778
Pctp
Name: phosphatidylcholine transfer protein
Synonyms: PC-TP, StarD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18559
HGNC: HGNC:8752
Homologene: 32054
Slfn3
Name: schlafen 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20557
Homologene: 133236
Pskh1
Name: protein serine kinase H1
Synonyms: E130013P03Rik, b2b1230Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244631
HGNC: HGNC:9529
Homologene: 48461
Pla2g12b
Name: phospholipase A2, group XIIB
Synonyms: 2010002E04Rik, Pla2g13, hlb218
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69836
Homologene: 11356
Chfr
Name: checkpoint with forkhead and ring finger domains
Synonyms: RNF116, 5730484M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231600
Homologene: 10078
Olfr32
Name: olfactory receptor 32
Synonyms: MTPCR05, MOR227-7P, GA_x6K02T2Q125-51573576-51572650, MOR227-9_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18331
HGNC: HGNC:8290
Homologene: 110550
Olfr1356
Name: olfactory receptor 1356
Synonyms: GA_x6K02T2QGN0-2962025-2962987, MOR142-2_p, MOR142-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258305
HGNC: HGNC:8374
Homologene: 71958
Gsg1l2
Name: GSG1-like 2
Synonyms: Gm12302
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544792
Homologene: 132038
AC079644.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 10,204,890 bp
  • G to A, chromosome 1 at 153,127,028 bp
  • G to T, chromosome 2 at 30,437,590 bp
  • A to G, chromosome 2 at 90,139,055 bp
  • C to T, chromosome 2 at 113,525,623 bp
  • A to T, chromosome 3 at 107,448,204 bp
  • A to T, chromosome 3 at 142,853,538 bp
  • C to T, chromosome 4 at 154,984,450 bp
  • C to T, chromosome 5 at 90,519,089 bp
  • A to G, chromosome 5 at 110,151,665 bp
  • T to A, chromosome 5 at 115,997,730 bp
  • A to G, chromosome 6 at 72,569,259 bp
  • T to A, chromosome 6 at 73,067,469 bp
  • A to G, chromosome 6 at 81,944,420 bp
  • T to C, chromosome 6 at 92,066,184 bp
  • T to C, chromosome 6 at 120,755,587 bp
  • G to A, chromosome 6 at 136,328,780 bp
  • A to T, chromosome 7 at 12,652,644 bp
  • T to A, chromosome 7 at 88,278,304 bp
  • A to G, chromosome 7 at 128,190,939 bp
  • G to T, chromosome 7 at 132,570,007 bp
  • A to G, chromosome 8 at 45,938,918 bp
  • T to A, chromosome 8 at 105,912,821 bp
  • T to C, chromosome 8 at 109,934,023 bp
  • T to C, chromosome 9 at 21,769,837 bp
  • T to C, chromosome 9 at 79,820,591 bp
  • T to C, chromosome 9 at 89,729,005 bp
  • T to C, chromosome 9 at 95,951,557 bp
  • T to C, chromosome 10 at 59,421,553 bp
  • T to A, chromosome 10 at 78,846,968 bp
  • T to C, chromosome 11 at 46,535,588 bp
  • T to A, chromosome 11 at 67,782,564 bp
  • T to C, chromosome 11 at 82,792,194 bp
  • A to G, chromosome 11 at 83,212,715 bp
  • T to C, chromosome 11 at 89,988,735 bp
  • A to T, chromosome 11 at 116,769,287 bp
  • C to A, chromosome 12 at 88,018,364 bp
  • T to C, chromosome 13 at 21,142,650 bp
  • A to G, chromosome 14 at 34,267,650 bp
  • C to T, chromosome 14 at 55,513,625 bp
  • T to A, chromosome 14 at 87,091,158 bp
  • G to T, chromosome 17 at 46,712,137 bp
  • A to C, chromosome 17 at 46,941,061 bp
  • A to G, chromosome 17 at 48,364,889 bp
  • A to T, chromosome 17 at 65,983,688 bp
  • G to T, chromosome 19 at 5,672,515 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1602 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039639-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.