Strain Name:
C57BL/6J-MtgxR1611Btlr/Mmmh
Stock Number:
039648-MU
Citation ID:
RRID:MMRRC_039648-MU
Other Names:
R1611 (G1), C57BL/6J-MtgxR1611Btlr
Major Collection:

Gene Information

Gene Symbol: Alg10b [MGI:2146159] (Mus musculus (mouse))
Name: asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase)
Synonyms: Deaf1, nse5, LOC380959
Chromosome: 15
Alteration at locus: Chemically Induced
Gene Symbol: Kmt2c [MGI:2444959] (Mus musculus (mouse))
Name: lysine (K)-specific methyltransferase 2C
Synonyms: HALR, E330008K23Rik, Mll3
Chromosome: 5
Alteration at locus: Chemically Induced
Gene Symbol: Pias3 [MGI:1913126] (Mus musculus (mouse))
Name: protein inhibitor of activated STAT 3
Synonyms: Pias3L
Chromosome: 3
Alteration at locus: Chemically Induced
Gene Symbol: Cacna1h [MGI:1928842] (Mus musculus (mouse))
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: Cav3.2, alpha13.2, T-type Cav3.2
Chromosome: 17
Alteration at locus: Chemically Induced
Gene Symbol: Erbb4 [MGI:104771] (Mus musculus (mouse))
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: Her4, ErbB4
Chromosome: 1
Alteration at locus: Chemically Induced
Gene Symbol: Lyst [MGI:107448] (Mus musculus (mouse))
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Chromosome: 13
Alteration at locus: Chemically Induced
Gene Symbol: Ptprf [MGI:102695] (Mus musculus (mouse))
Name: protein tyrosine phosphatase, receptor type, F
Synonyms: RPTP-LAR, LAR
Chromosome: 4
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 44,126,747 bp
  • C to A, chromosome 1 at 68,040,388 bp
  • T to A, chromosome 1 at 132,122,375 bp
  • G to A, chromosome 1 at 136,216,117 bp
  • C to T, chromosome 2 at 32,420,379 bp
  • T to A, chromosome 2 at 87,782,624 bp
  • T to C, chromosome 2 at 112,479,187 bp
  • C to T, chromosome 2 at 112,653,505 bp
  • C to A, chromosome 2 at 154,645,703 bp
  • T to C, chromosome 2 at 168,673,569 bp
  • T to A, chromosome 3 at 64,104,537 bp
  • T to A, chromosome 3 at 96,699,697 bp
  • T to C, chromosome 3 at 146,095,358 bp
  • T to A, chromosome 4 at 19,631,843 bp
  • T to C, chromosome 4 at 40,223,862 bp
  • A to T, chromosome 4 at 41,423,552 bp
  • A to G, chromosome 4 at 46,193,035 bp
  • A to G, chromosome 4 at 47,396,526 bp
  • A to G, chromosome 4 at 118,236,233 bp
  • A to G, chromosome 4 at 120,533,377 bp
  • A to T, chromosome 4 at 144,392,812 bp
  • A to G, chromosome 4 at 155,159,938 bp
  • G to A, chromosome 4 at 155,641,575 bp
  • C to A, chromosome 5 at 25,359,311 bp
  • C to A, chromosome 5 at 32,990,953 bp
  • T to A, chromosome 5 at 38,138,716 bp
  • A to G, chromosome 5 at 65,164,649 bp
  • T to C, chromosome 5 at 104,009,899 bp
  • T to C, chromosome 5 at 125,110,020 bp
  • A to T, chromosome 6 at 3,373,771 bp
  • T to C, chromosome 7 at 44,960,112 bp
  • T to A, chromosome 7 at 112,381,464 bp
  • T to C, chromosome 7 at 142,082,957 bp
  • T to C, chromosome 8 at 109,249,303 bp
  • G to A, chromosome 8 at 124,611,512 bp
  • T to C, chromosome 9 at 44,956,737 bp
  • C to T, chromosome 9 at 105,442,852 bp
  • T to C, chromosome 10 at 20,323,252 bp
  • T to C, chromosome 10 at 20,434,490 bp
  • T to A, chromosome 10 at 30,834,440 bp
  • T to C, chromosome 10 at 53,348,681 bp
  • T to A, chromosome 10 at 75,125,202 bp
  • T to A, chromosome 10 at 89,732,202 bp
  • T to A, chromosome 10 at 117,361,828 bp
  • T to C, chromosome 11 at 44,551,798 bp
  • A to T, chromosome 11 at 54,325,564 bp
  • T to A, chromosome 11 at 86,704,016 bp
  • C to T, chromosome 11 at 88,845,278 bp
  • A to T, chromosome 11 at 116,295,265 bp
  • A to T, chromosome 12 at 16,577,218 bp
  • C to G, chromosome 12 at 100,570,852 bp
  • A to G, chromosome 13 at 13,634,897 bp
  • T to C, chromosome 13 at 33,492,874 bp
  • T to A, chromosome 13 at 41,316,930 bp
  • G to T, chromosome 13 at 48,885,743 bp
  • G to A, chromosome 13 at 52,835,496 bp
  • G to T, chromosome 13 at 59,628,933 bp
  • A to T, chromosome 13 at 81,559,117 bp
  • A to G, chromosome 14 at 32,238,570 bp
  • T to A, chromosome 15 at 8,130,160 bp
  • T to A, chromosome 15 at 90,225,781 bp
  • T to A, chromosome 15 at 102,430,935 bp
  • C to T, chromosome 16 at 32,750,986 bp
  • A to G, chromosome 17 at 25,381,471 bp
  • C to T, chromosome 17 at 35,987,549 bp
  • A to T, chromosome 18 at 14,844,469 bp
  • A to T, chromosome 18 at 35,269,088 bp
  • A to C, chromosome 18 at 37,900,702 bp
  • T to C, chromosome 18 at 74,948,059 bp
  • T to A, chromosome 19 at 5,551,070 bp
  • T to A, chromosome 19 at 10,612,888 bp
  • T to A, chromosome 19 at 10,626,764 bp
  • G to A, chromosome 19 at 42,789,065 bp
  • C to A, chromosome 19 at 55,894,741 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1611 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039648-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.