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Strain Name:
C57BL/6J-MtgxR1676Btlr/Mmmh
Stock Number:
039712-MU
Citation ID:
RRID:MMRRC_039712-MU
Other Names:
R1676 (G1), C57BL/6J-MtgxR1676Btlr
Major Collection:

Strain Information

Casp8
Name: caspase 8
Synonyms: Mch5, MACH, FLICE, Caspase-8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Acvr2a
Name: activin receptor IIA
Synonyms: ActRIIa, tActRII, Acvr2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11480
HGNC: HGNC:173
Homologene: 20391
Polr2f
Name: polymerase (RNA) II (DNA directed) polypeptide F
Synonyms: RNA Pol II, 1810060D16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69833
VEGA: 15
HGNC: HGNC:9193
Homologene: 7178
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Nudt1
Name: nudix hydrolase 1
Synonyms: 8-oxo-7,8-dihydro-2'-dGTPase, Mth1, nudix (nucleoside diphosphate linked moiety X)-type motif 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17766
HGNC: HGNC:8048
Homologene: 1839
Ppp1r1a
Name: protein phosphatase 1, regulatory inhibitor subunit 1A
Synonyms: I-1, protein phosphatase inhibitor-1, inhibitor-1, 0610038N18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58200
VEGA: 15
HGNC: HGNC:9286
Homologene: 4905
Slc29a1
Name: solute carrier family 29 (nucleoside transporters), member 1
Synonyms: ENT1, NBMPR-sensitive equilibrative nucleoside transporter, 1200014D21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63959
Homologene: 37985
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 51,301,171 bp
  • T to A, chromosome 1 at 53,062,065 bp
  • T to A, chromosome 1 at 58,844,416 bp
  • A to T, chromosome 1 at 92,054,889 bp
  • A to G, chromosome 1 at 134,777,452 bp
  • A to G, chromosome 1 at 170,200,012 bp
  • G to A, chromosome 1 at 174,179,839 bp
  • T to G, chromosome 1 at 177,447,347 bp
  • T to C, chromosome 1 at 188,728,585 bp
  • T to A, chromosome 2 at 15,047,213 bp
  • T to C, chromosome 2 at 35,186,723 bp
  • A to T, chromosome 2 at 37,219,641 bp
  • G to A, chromosome 2 at 48,873,083 bp
  • TCCC to TCCCC, chromosome 2 at 76,742,907 bp
  • T to G, chromosome 2 at 88,701,317 bp
  • T to C, chromosome 2 at 112,406,109 bp
  • T to C, chromosome 2 at 122,521,859 bp
  • T to C, chromosome 2 at 125,309,781 bp
  • A to G, chromosome 2 at 157,195,449 bp
  • G to A, chromosome 2 at 181,574,918 bp
  • C to T, chromosome 3 at 64,090,182 bp
  • A to G, chromosome 3 at 94,944,543 bp
  • G to A, chromosome 3 at 141,757,837 bp
  • A to G, chromosome 3 at 154,762,623 bp
  • A to G, chromosome 4 at 8,185,616 bp
  • T to A, chromosome 4 at 14,825,617 bp
  • A to T, chromosome 4 at 63,319,042 bp
  • T to A, chromosome 4 at 118,595,940 bp
  • T to C, chromosome 4 at 129,085,535 bp
  • C to T, chromosome 4 at 154,897,063 bp
  • A to G, chromosome 5 at 36,616,109 bp
  • GAA to GA, chromosome 5 at 124,459,885 bp
  • A to G, chromosome 5 at 140,334,623 bp
  • A to G, chromosome 6 at 91,492,947 bp
  • G to T, chromosome 6 at 114,247,666 bp
  • T to A, chromosome 6 at 126,642,682 bp
  • A to T, chromosome 6 at 136,920,010 bp
  • T to C, chromosome 7 at 27,208,281 bp
  • T to A, chromosome 7 at 83,964,038 bp
  • A to G, chromosome 7 at 87,002,631 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • A to G, chromosome 7 at 98,099,472 bp
  • T to A, chromosome 7 at 102,742,398 bp
  • T to C, chromosome 7 at 103,717,112 bp
  • T to C, chromosome 7 at 103,839,155 bp
  • C to T, chromosome 7 at 105,754,921 bp
  • T to A, chromosome 7 at 110,795,733 bp
  • T to C, chromosome 7 at 126,863,475 bp
  • A to T, chromosome 7 at 135,518,578 bp
  • C to T, chromosome 8 at 25,954,605 bp
  • C to A, chromosome 8 at 36,102,898 bp
  • T to C, chromosome 8 at 46,592,768 bp
  • T to A, chromosome 8 at 48,417,119 bp
  • T to A, chromosome 8 at 71,461,873 bp
  • G to A, chromosome 9 at 21,115,249 bp
  • G to A, chromosome 9 at 36,257,371 bp
  • G to A, chromosome 9 at 49,557,172 bp
  • T to C, chromosome 9 at 67,926,962 bp
  • T to A, chromosome 9 at 70,573,647 bp
  • G to A, chromosome 10 at 4,083,877 bp
  • T to C, chromosome 10 at 5,047,518 bp
  • T to A, chromosome 10 at 67,224,809 bp
  • T to G, chromosome 10 at 127,526,208 bp
  • T to C, chromosome 10 at 128,583,248 bp
  • G to T, chromosome 11 at 58,880,993 bp
  • A to T, chromosome 11 at 71,182,811 bp
  • A to G, chromosome 11 at 73,711,475 bp
  • A to T, chromosome 11 at 80,684,421 bp
  • G to A, chromosome 11 at 102,605,881 bp
  • T to C, chromosome 12 at 36,476,721 bp
  • G to T, chromosome 12 at 51,744,788 bp
  • C to A, chromosome 12 at 66,568,772 bp
  • C to A, chromosome 12 at 66,568,773 bp
  • G to A, chromosome 12 at 71,075,338 bp
  • A to G, chromosome 12 at 101,688,992 bp
  • A to T, chromosome 13 at 38,193,374 bp
  • T to G, chromosome 13 at 46,637,859 bp
  • A to G, chromosome 13 at 58,179,391 bp
  • A to T, chromosome 13 at 59,612,676 bp
  • A to T, chromosome 13 at 64,225,602 bp
  • A to G, chromosome 13 at 66,933,637 bp
  • A to T, chromosome 13 at 67,052,336 bp
  • T to A, chromosome 13 at 116,877,528 bp
  • A to G, chromosome 14 at 20,651,021 bp
  • T to C, chromosome 14 at 31,180,902 bp
  • A to G, chromosome 14 at 34,089,612 bp
  • T to A, chromosome 14 at 115,370,098 bp
  • T to C, chromosome 15 at 36,247,744 bp
  • T to A, chromosome 15 at 47,950,140 bp
  • C to A, chromosome 15 at 79,151,581 bp
  • C to T, chromosome 15 at 97,761,182 bp
  • T to C, chromosome 15 at 100,936,606 bp
  • T to G, chromosome 15 at 103,533,488 bp
  • T to C, chromosome 16 at 4,763,858 bp
  • T to A, chromosome 16 at 17,211,113 bp
  • C to T, chromosome 16 at 17,623,998 bp
  • T to A, chromosome 16 at 32,794,279 bp
  • T to A, chromosome 16 at 94,832,584 bp
  • A to T, chromosome 17 at 19,611,922 bp
  • A to G, chromosome 17 at 32,482,202 bp
  • T to C, chromosome 17 at 33,135,981 bp
  • T to C, chromosome 17 at 45,589,010 bp
  • T to C, chromosome 17 at 55,496,395 bp
  • T to C, chromosome 17 at 71,274,090 bp
  • T to C, chromosome 18 at 37,320,752 bp
  • T to C, chromosome 18 at 46,560,610 bp
  • G to T, chromosome 19 at 5,706,978 bp
  • T to A, chromosome 19 at 56,335,255 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1676 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039712-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.