Strain Name:
C57BL/6J-MtgxR1679Btlr/Mmmh
Stock Number:
039715-MU
Citation ID:
RRID:MMRRC_039715-MU
Other Names:
R1679 (G1), C57BL/6J-MtgxR1679Btlr
Major Collection:

Gene Information

Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 78757
VEGA: 15
Homologene: 34317
Kansl1
Name: KAT8 regulatory NSL complex subunit 1
Synonyms: 1700081L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 76719
Homologene: 9140
Kdsr
Name: 3-ketodihydrosphingosine reductase
Synonyms: Fvt1, 6330410P18Rik, 9430079B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 70750
HGNC: HGNC:4021
Homologene: 1539
Rif1
Name: replication timing regulatory factor 1
Synonyms: D2Ertd145e, 6530403D07Rik, 5730435J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 51869
Homologene: 41231
Mtmr2
Name: myotubularin related protein 2
Synonyms: 6030445P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 77116
HGNC: HGNC:7450
Homologene: 22951
Lmbr1
Name: limb region 1
Synonyms: 1110048D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 56873
Homologene: 49706
Wdfy1
Name: WD repeat and FYVE domain containing 1
Synonyms: 1700120F24Rik, 1700013B03Rik, Jr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 69368
Homologene: 10825
Fbf1
Name: Fas (TNFRSF6) binding factor 1
Synonyms: 1110033G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217335
Homologene: 16531
Crim1
Name: cysteine rich transmembrane BMP regulator 1 (chordin like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 50766
VEGA: 17
HGNC: HGNC:2359
Homologene: 9510
Cd164l2
Name: CD164 sialomucin-like 2
Synonyms: 2310047N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 69655
Homologene: 19231
Leprotl1
Name: leptin receptor overlapping transcript-like 1
Synonyms: 1520402O14Rik, 1110067H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 68192
HGNC: HGNC:6555
Homologene: 41031
Cdc25c
Name: cell division cycle 25C
Synonyms: Cdc25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 12532
VEGA: 18
HGNC: HGNC:1727
Homologene: 1356
Slc20a2
Name: solute carrier family 20, member 2
Synonyms: Ram1, Ram-1, PiT-2, MolPit2, Pit-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20516
Homologene: 68531
Incenp
Name: inner centromere protein
Synonyms: 2700067E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 16319
VEGA: 19
HGNC: HGNC:6058
Homologene: 9624
Adgre5
Name: adhesion G protein-coupled receptor E5
Synonyms: Cd97, EGF-TM7 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 26364
HGNC: HGNC:1711
Homologene: 8050
Nxf1
Name: nuclear RNA export factor 1
Synonyms: Mex67, Mvb1, TAP, Tip associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 53319
HGNC: HGNC:8071
Homologene: 38176
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 71175
VEGA: 15
Homologene: 15850
Eps8l2
Name: EPS8-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 98845
Homologene: 69358
Ruvbl2
Name: RuvB-like protein 2
Synonyms: mp47, p47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20174
Homologene: 4856
Exosc9
Name: exosome component 9
Synonyms: p6, RRP45, Pmscl1, PM/Scl-75, p5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 50911
HGNC: HGNC:9137
Homologene: 3693
Nutm2
Name: NUT family member 2
Synonyms: Gm806, LOC328250
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 328250
Homologene: 128615
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alphaMHC, alpha myosin, Myhca, alpha cardiac MHC, A830009F23Rik, Myhc-a, cardiomyopathy, hypertrophic 1, alpha-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, 1500031A17Rik, C530008O15Rik, C630040K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 665113
Homologene: 77943
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78309
Homologene: 56696
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mgr1, Mass1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110789
Homologene: 19815
Ddb2
Name: damage specific DNA binding protein 2
Synonyms: 2610043A19Rik, p48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 107986
HGNC: HGNC:2718
Homologene: 83
BC034090
Name: cDNA sequence BC034090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 207792
Homologene: 19490
Phactr1
Name: phosphatase and actin regulator 1
Synonyms: 9630030F18Rik, Rpel1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218194
Homologene: 33597
Capn8
Name: calpain 8
Synonyms: nCL-2, nCL-2'
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 170725
HGNC: HGNC:1485
Homologene: 15643
Eml3
Name: echinoderm microtubule associated protein like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 225898
VEGA: 19
Homologene: 27044
Il1rl2
Name: interleukin 1 receptor-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 107527
HGNC: HGNC:5999
Homologene: 2860
Mto1
Name: mitochondrial tRNA translation optimization 1
Synonyms: 5730419A02Rik, 2310039H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68291
Homologene: 5876
Adam6a
Name: a disintegrin and metallopeptidase domain 6A
Synonyms: Adam6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238406
HGNC: HGNC:213
Homologene: 128362
Gm20425
Name: predicted gene 20425
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Ano9
Name: anoctamin 9
Synonyms: Tmem16j, 5430425C04Rik, Tp53i5, Trp53i5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71345
Homologene: 67083
Cyp2c50
Name: cytochrome P450, family 2, subfamily c, polypeptide 50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107141
Homologene: 137231
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: gp115, EMILIN-1, 5830419M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100952
Homologene: 5117
Slc41a1
Name: solute carrier family 41, member 1
Synonyms: B230315F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98396
Homologene: 14871
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4930428C11Rik, Wdr96, D19Ertd652e, 4930463G05Rik, 4632415N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 100048534
Homologene: 36425
H2-Q10
Name: histocompatibility 2, Q region locus 10
Synonyms: H-2Q10, Q10, Qa10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 15007
HGNC: HGNC:4931
Homologene: 128352
Zfp683
Name: zinc finger protein 683
Synonyms: Hobit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100503878
Isg20l2
Name: interferon stimulated exonuclease gene 20-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229504
Homologene: 12814
Ccdc85a
Name: coiled-coil domain containing 85A
Synonyms: E030025D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216613
Homologene: 65605
4921517D22Rik
Name: RIKEN cDNA 4921517D22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 70900
VEGA: 13
Homologene: 87278
Olfr481
Name: olfactory receptor 481
Synonyms: GA_x6K02T2PBJ9-10409785-10410723, MOR204-2, MOR204-39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258927
Homologene: 105166
Vmn1r29
Name: vomeronasal 1 receptor 29
Synonyms: V1rc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 113859
Homologene: 123821
Pih1d1
Name: PIH1 domain containing 1
Synonyms: 4933413A04Rik, 1110061L23Rik, Nop17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 68845
Homologene: 9914
Hebp2
Name: heme binding protein 2
Synonyms: SOUL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 56016
VEGA: 10
Homologene: 8634
Lonrf2
Name: LON peptidase N-terminal domain and ring finger 2
Synonyms: 2900060P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381338
Homologene: 18871
Stx11
Name: syntaxin 11
Synonyms: 5830405C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 74732
VEGA: 10
Homologene: 2792
Bmp5
Name: bone morphogenetic protein 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12160
HGNC: HGNC:1072
Homologene: 22412
Cyp2a22
Name: cytochrome P450, family 2, subfamily a, polypeptide 22
Synonyms: EG233005
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233005
Homologene: 69128
AC131065.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 38,813,276 bp
  • A to G, chromosome 1 at 40,343,160 bp
  • A to T, chromosome 1 at 79,707,475 bp
  • T to A, chromosome 1 at 106,753,226 bp
  • T to C, chromosome 1 at 131,841,972 bp
  • A to T, chromosome 1 at 155,224,897 bp
  • T to C, chromosome 1 at 182,613,467 bp
  • GCCACCA to GCCA, chromosome 2 at 52,110,324 bp
  • C to T, chromosome 2 at 91,234,250 bp
  • T to A, chromosome 3 at 28,666,076 bp
  • C to T, chromosome 3 at 36,552,755 bp
  • T to A, chromosome 3 at 87,932,085 bp
  • A to G, chromosome 4 at 133,221,499 bp
  • T to C, chromosome 4 at 134,058,645 bp
  • C to T, chromosome 5 at 29,254,634 bp
  • T to C, chromosome 5 at 30,920,199 bp
  • A to T, chromosome 6 at 58,308,018 bp
  • T to A, chromosome 7 at 26,936,311 bp
  • T to C, chromosome 7 at 45,159,826 bp
  • T to C, chromosome 7 at 45,424,967 bp
  • A to T, chromosome 7 at 108,081,652 bp
  • T to A, chromosome 7 at 141,108,297 bp
  • G to A, chromosome 7 at 141,361,057 bp
  • T to G, chromosome 8 at 22,538,830 bp
  • T to G, chromosome 8 at 34,140,832 bp
  • C to A, chromosome 8 at 83,729,405 bp
  • T to A, chromosome 9 at 13,789,077 bp
  • T to C, chromosome 9 at 75,839,595 bp
  • A to G, chromosome 9 at 78,464,963 bp
  • A to G, chromosome 9 at 103,192,207 bp
  • A to T, chromosome 10 at 12,941,836 bp
  • G to T, chromosome 10 at 18,544,415 bp
  • A to G, chromosome 11 at 28,583,316 bp
  • A to T, chromosome 11 at 104,423,996 bp
  • A to G, chromosome 11 at 116,151,017 bp
  • A to G, chromosome 12 at 113,544,756 bp
  • G to A, chromosome 13 at 43,057,280 bp
  • A to T, chromosome 13 at 43,094,781 bp
  • A to G, chromosome 13 at 50,469,386 bp
  • GCC to GC, chromosome 13 at 59,691,598 bp
  • A to T, chromosome 13 at 81,559,552 bp
  • C to T, chromosome 14 at 54,965,247 bp
  • T to C, chromosome 15 at 6,768,090 bp
  • G to A, chromosome 15 at 8,302,912 bp
  • A to G, chromosome 17 at 35,473,595 bp
  • A to T, chromosome 17 at 46,521,156 bp
  • G to A, chromosome 17 at 78,200,799 bp
  • T to C, chromosome 18 at 34,747,295 bp
  • T to C, chromosome 18 at 80,089,739 bp
  • T to C, chromosome 19 at 8,769,074 bp
  • T to C, chromosome 19 at 8,936,637 bp
  • T to C, chromosome 19 at 9,895,414 bp
  • C to A, chromosome 19 at 40,111,415 bp
  • T to C, chromosome 19 at 47,773,114 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1679 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039715-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.