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Strain Name:
C57BL/6J-MtgxR1700Btlr/Mmmh
Stock Number:
039733-MU
Citation ID:
RRID:MMRRC_039733-MU
Other Names:
R1700 (G1), C57BL/6J-MtgxR1700Btlr
Major Collection:

Strain Information

Strap
Name: serine/threonine kinase receptor associated protein
Synonyms: C78091, Unrip
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20901
Homologene: 43881
Gpr37
Name: G protein-coupled receptor 37
Synonyms: Pael-R, parkin-associated endothelin B-like receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Slc12a5
Name: solute carrier family 12, member 5
Synonyms: KCC2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57138
Homologene: 10665
Strn
Name: striatin, calmodulin binding protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268980
Homologene: 2380
Uri1
Name: URI1, prefoldin-like chaperone
Synonyms: NNX3, Rmp, C80913
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19777
Homologene: 2813
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Tex21
Name: testis expressed gene 21
Synonyms: tsec-2, 4931412D23Rik, 4931406F04Rik, 4931421K24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 80384
VEGA: 12
Homologene: 10510
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 63,302,741 bp
  • G to A, chromosome 1 at 83,277,515 bp
  • A to G, chromosome 1 at 128,252,286 bp
  • C to A, chromosome 1 at 171,283,722 bp
  • A to G, chromosome 1 at 188,043,653 bp
  • A to G, chromosome 2 at 31,670,806 bp
  • T to C, chromosome 2 at 82,991,737 bp
  • T to G, chromosome 2 at 87,149,779 bp
  • T to C, chromosome 2 at 87,810,768 bp
  • C to T, chromosome 2 at 128,877,533 bp
  • A to G, chromosome 2 at 129,123,121 bp
  • G to A, chromosome 2 at 130,709,938 bp
  • C to A, chromosome 2 at 164,992,376 bp
  • T to C, chromosome 2 at 165,170,796 bp
  • A to G, chromosome 3 at 9,470,886 bp
  • A to G, chromosome 3 at 88,536,375 bp
  • T to C, chromosome 3 at 97,703,323 bp
  • T to A, chromosome 4 at 33,330,864 bp
  • G to A, chromosome 4 at 65,746,354 bp
  • C to T, chromosome 4 at 118,412,734 bp
  • C to A, chromosome 4 at 131,900,560 bp
  • C to T, chromosome 4 at 138,262,698 bp
  • T to A, chromosome 4 at 143,398,429 bp
  • T to G, chromosome 4 at 155,861,570 bp
  • T to C, chromosome 5 at 8,849,537 bp
  • A to T, chromosome 5 at 24,871,541 bp
  • T to G, chromosome 5 at 27,722,658 bp
  • A to T, chromosome 5 at 92,347,855 bp
  • A to G, chromosome 5 at 123,630,370 bp
  • A to G, chromosome 6 at 25,669,624 bp
  • A to T, chromosome 6 at 89,357,008 bp
  • A to G, chromosome 6 at 113,415,533 bp
  • A to G, chromosome 6 at 132,893,792 bp
  • A to T, chromosome 6 at 133,036,811 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to G, chromosome 6 at 137,739,350 bp
  • T to A, chromosome 7 at 22,842,965 bp
  • T to C, chromosome 7 at 37,963,524 bp
  • T to C, chromosome 7 at 67,759,628 bp
  • T to A, chromosome 7 at 104,004,122 bp
  • C to T, chromosome 7 at 118,735,313 bp
  • T to A, chromosome 7 at 126,462,909 bp
  • T to A, chromosome 8 at 45,800,984 bp
  • T to C, chromosome 8 at 109,853,612 bp
  • C to T, chromosome 8 at 122,487,502 bp
  • C to T, chromosome 9 at 15,340,883 bp
  • G to A, chromosome 9 at 44,316,612 bp
  • A to G, chromosome 9 at 65,371,743 bp
  • T to A, chromosome 9 at 66,450,678 bp
  • T to A, chromosome 9 at 73,175,427 bp
  • A to G, chromosome 9 at 77,776,289 bp
  • C to T, chromosome 9 at 106,239,646 bp
  • T to C, chromosome 10 at 63,852,772 bp
  • A to T, chromosome 10 at 79,899,335 bp
  • A to G, chromosome 10 at 80,312,769 bp
  • T to A, chromosome 10 at 94,199,993 bp
  • T to C, chromosome 10 at 107,493,359 bp
  • T to C, chromosome 11 at 30,856,129 bp
  • A to T, chromosome 11 at 69,232,058 bp
  • C to T, chromosome 11 at 78,049,547 bp
  • A to G, chromosome 11 at 113,702,075 bp
  • A to G, chromosome 12 at 33,395,171 bp
  • A to T, chromosome 12 at 40,180,678 bp
  • T to C, chromosome 12 at 76,221,672 bp
  • A to G, chromosome 13 at 21,434,481 bp
  • G to A, chromosome 13 at 70,779,518 bp
  • G to T, chromosome 13 at 106,795,662 bp
  • T to C, chromosome 14 at 54,469,752 bp
  • T to A, chromosome 15 at 5,002,792 bp
  • T to A, chromosome 15 at 11,152,057 bp
  • T to A, chromosome 15 at 37,397,343 bp
  • T to G, chromosome 15 at 94,563,007 bp
  • G to A, chromosome 16 at 4,684,165 bp
  • T to C, chromosome 17 at 25,249,328 bp
  • A to G, chromosome 17 at 31,215,044 bp
  • A to G, chromosome 17 at 32,057,204 bp
  • G to A, chromosome 17 at 55,974,307 bp
  • T to C, chromosome 17 at 78,692,402 bp
  • A to C, chromosome 17 at 80,034,105 bp
  • T to C, chromosome 18 at 20,832,998 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1700 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039733-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.