Strain Name:
C57BL/6J-MtgxR1705Btlr/Mmmh
Stock Number:
039738-MU
Citation ID:
RRID:MMRRC_039738-MU
Other Names:
R1705 (G1), C57BL/6J-MtgxR1705Btlr
Major Collection:

Gene Information

Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms: Semae, 1110036B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20348
Homologene: 36201
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, HGF/SF, NK2, C230052L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Smarcad1
Name: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Synonyms: D6Pas1, Etl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13990
Homologene: 5301
Sec23a
Name: SEC23 homolog A, COPII coat complex component
Synonyms: Sec23r, Msec23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20334
Homologene: 4642
Faf1
Name: Fas-associated factor 1
Synonyms: Fam, Dffrx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14084
HGNC: HGNC:3578
Homologene: 5120
R3hdm1
Name: R3H domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226412
HGNC: HGNC:9757
Homologene: 9108
Nap1l4
Name: nucleosome assembly protein 1-like 4
Synonyms: Nap2, D7Wsu30e, 2810410H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17955
HGNC: HGNC:7640
Homologene: 133933
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: Apaf1l, 6230400I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Akap8l
Name: A kinase (PRKA) anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54194
VEGA: 17
Homologene: 8658
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20563
Homologene: 3516
C1ql2
Name: complement component 1, q subcomponent-like 2
Synonyms: CTRP10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226359
Homologene: 18792
Ywhaz
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Synonyms: 1110013I11Rik, 14-3-3 zeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22631
Homologene: 56528
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235627
Homologene: 86422
Hmces
Name: 5-hydroxymethylcytosine (hmC) binding, ES cell specific
Synonyms: 8430410A17Rik, Srap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232210
Homologene: 6636
Mis18bp1
Name: MIS18 binding protein 1
Synonyms: C79407
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217653
Homologene: 10147
Nav1
Name: neuron navigator 1
Synonyms: POMFIL3, 9930003A20Rik, C230080M11Rik, unc53H1, steerin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Phaf1
Name: phagosome assembly factor 1
Synonyms: Lin10, D230025D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234678
Homologene: 11864
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Podn
Name: podocan
Synonyms: SLRR5A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242608
Homologene: 17803
Trhde
Name: TRH-degrading enzyme
Synonyms: 9330155P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237553
Homologene: 75007
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: CD135, Flk-2, Flt-3, Flk2, wmfl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Qrfprl
Name: pyroglutamylated RFamide peptide receptor like
Synonyms: C130060K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243407
Homologene: 135976
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Pld1
Name: phospholipase D1
Synonyms: Pld1b, Pld1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Sec14l2
Name: SEC14-like lipid binding 2
Synonyms: 1300013M05Rik, tap, Spf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67815
Homologene: 8245
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242505
Homologene: 28424
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: A830008O07Rik, 1700010C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, 9430031G15Rik, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Stk31
Name: serine threonine kinase 31
Synonyms: C330007K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 77485
Homologene: 12677
Kcnh4
Name: potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: BEC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380728
HGNC: HGNC:6253
Homologene: 8180
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Coil
Name: coilin
Synonyms: p80-coilin, Cln80
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12812
HGNC: HGNC:2184
Homologene: 3413
Olfr744
Name: olfactory receptor 744
Synonyms: GA_x6K02T2PMLR-6326342-6327313, MOR106-13P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 257884
Homologene: 128063
Card14
Name: caspase recruitment domain family, member 14
Synonyms: CARMA2, Bimp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170720
Homologene: 11469
Syt10
Name: synaptotagmin X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54526
Homologene: 10303
Svop
Name: SV2 related protein
Synonyms: 1110030H18Rik, msvop
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68666
Homologene: 41283
Zc3h10
Name: zinc finger CCCH type containing 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103284
Homologene: 13114
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Olfr1263
Name: olfactory receptor 1263
Synonyms: GA_x6K02T2Q125-51447049-51447969, MOR234-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258790
Homologene: 45043
Catsperd
Name: cation channel sperm associated auxiliary subunit delta
Synonyms: 4933402B14Rik, Gm6095, 4921529N20Rik, Tmem146
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106757
VEGA: 17
Homologene: 51896
Vdr
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor
Synonyms: Nr1i1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22337
Homologene: 37297
Olfr11
Name: olfactory receptor 11
Synonyms: MOR256-11, GA_x6K02T2QHY8-11597382-11598323
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218066
HGNC: HGNC:8241
Homologene: 40838
Meox2
Name: mesenchyme homeobox 2
Synonyms: Gax, Mox-2, Mox2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17286
HGNC: HGNC:7014
Homologene: 4330
Defa24
Name: defensin, alpha, 24
Synonyms: Defcr24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 503491
Homologene: 113382
Cox14
Name: cytochrome c oxidase assembly protein 14
Synonyms: 2310016M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66379
VEGA: 15
Homologene: 50025
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 120,342,542 bp
  • T to A, chromosome 1 at 128,235,084 bp
  • G to T, chromosome 1 at 135,584,599 bp
  • T to C, chromosome 1 at 164,217,490 bp
  • T to A, chromosome 1 at 188,874,869 bp
  • T to A, chromosome 1 at 188,911,541 bp
  • A to T, chromosome 2 at 90,015,511 bp
  • A to G, chromosome 2 at 155,963,786 bp
  • G to A, chromosome 3 at 28,071,277 bp
  • A to T, chromosome 4 at 73,744,064 bp
  • T to C, chromosome 4 at 108,017,858 bp
  • C to T, chromosome 4 at 109,677,002 bp
  • A to T, chromosome 5 at 16,615,802 bp
  • A to C, chromosome 5 at 17,694,632 bp
  • T to A, chromosome 5 at 48,189,472 bp
  • A to G, chromosome 5 at 114,042,295 bp
  • A to G, chromosome 5 at 121,298,104 bp
  • A to G, chromosome 5 at 147,370,593 bp
  • A to T, chromosome 6 at 49,423,384 bp
  • G to A, chromosome 6 at 65,056,416 bp
  • A to T, chromosome 6 at 65,456,306 bp
  • T to C, chromosome 6 at 87,933,301 bp
  • A to T, chromosome 7 at 29,078,564 bp
  • A to T, chromosome 7 at 143,541,760 bp
  • T to C, chromosome 8 at 21,734,601 bp
  • T to C, chromosome 8 at 105,238,472 bp
  • A to T, chromosome 8 at 125,861,269 bp
  • A to G, chromosome 9 at 110,625,196 bp
  • A to G, chromosome 10 at 91,067,271 bp
  • A to G, chromosome 10 at 114,486,863 bp
  • A to T, chromosome 10 at 128,544,803 bp
  • A to G, chromosome 11 at 4,103,980 bp
  • A to G, chromosome 11 at 88,974,136 bp
  • A to G, chromosome 11 at 100,741,772 bp
  • A to G, chromosome 11 at 119,338,406 bp
  • G to A, chromosome 12 at 37,167,494 bp
  • T to C, chromosome 12 at 59,001,866 bp
  • A to C, chromosome 12 at 65,149,339 bp
  • C to A, chromosome 13 at 21,639,161 bp
  • A to T, chromosome 14 at 50,619,122 bp
  • G to T, chromosome 15 at 36,790,715 bp
  • T to C, chromosome 15 at 71,456,909 bp
  • C to T, chromosome 15 at 89,790,776 bp
  • A to T, chromosome 15 at 97,867,171 bp
  • A to G, chromosome 15 at 99,727,678 bp
  • C to T, chromosome 17 at 32,332,483 bp
  • T to C, chromosome 17 at 56,633,521 bp
  • T to C, chromosome 17 at 75,385,201 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1705 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039738-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.