Strain Name:
C57BL/6J-MtgxR1710Btlr/Mmmh
Stock Number:
039743-MU
Citation ID:
RRID:MMRRC_039743-MU
Other Names:
R1710 (G1), C57BL/6J-MtgxR1710Btlr
Major Collection:

Gene Information

Gene Symbol: Sulf2 [MGI:1919293] (Mus musculus (mouse))
Name: sulfatase 2
Synonyms: 2010004N24Rik
Chromosome: 2
Alteration at locus: Chemically Induced
Gene Symbol: Ncor1 [MGI:1349717] (Mus musculus (mouse))
Name: nuclear receptor co-repressor 1
Synonyms: Rxrip13, A230020K14Rik, N-CoR, 5730405M06Rik
Chromosome: 11
Alteration at locus: Chemically Induced
Gene Symbol: Arhgap10 [MGI:1925764] (Mus musculus (mouse))
Name: Rho GTPase activating protein 10
Synonyms: PSGAP-m, PSGAP-s, A930033B01Rik
Chromosome: 8
Alteration at locus: Chemically Induced
Gene Symbol: Ank2 [MGI:88025] (Mus musculus (mouse))
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-B, Ankyrin-2, Gm4392
Chromosome: 3
Alteration at locus: Chemically Induced
Gene Symbol: Nos1 [MGI:97360] (Mus musculus (mouse))
Name: nitric oxide synthase 1, neuronal
Synonyms: nNOS, bNOS, Nos-1, 2310005C01Rik, NO
Chromosome: 5
Alteration at locus: Chemically Induced
Gene Symbol: Mbd5 [MGI:2138934] (Mus musculus (mouse))
Name: methyl-CpG binding domain protein 5
Synonyms: 9430004D19Rik, OTTMUSG00000012483, C030040A15Rik
Chromosome: 2
Alteration at locus: Chemically Induced
Gene Symbol: Ndrg4 [MGI:2384590] (Mus musculus (mouse))
Name: N-myc downstream regulated gene 4
Synonyms: Ndr4, SMAP-8, D8Bwg1337e, Ndr1-rs
Chromosome: 8
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 37,396,061 bp
  • T to C, chromosome 1 at 39,406,837 bp
  • T to C, chromosome 1 at 65,336,838 bp
  • T to G, chromosome 1 at 74,362,770 bp
  • T to A, chromosome 1 at 74,572,230 bp
  • C to A, chromosome 1 at 93,385,624 bp
  • A to T, chromosome 1 at 150,675,984 bp
  • T to C, chromosome 1 at 155,225,864 bp
  • A to G, chromosome 1 at 162,967,787 bp
  • T to C, chromosome 1 at 171,503,600 bp
  • A to G, chromosome 1 at 181,051,319 bp
  • G to A, chromosome 2 at 5,053,130 bp
  • A to G, chromosome 2 at 31,178,399 bp
  • T to C, chromosome 2 at 32,212,222 bp
  • A to G, chromosome 2 at 49,257,032 bp
  • C to T, chromosome 2 at 85,769,855 bp
  • T to C, chromosome 2 at 140,193,602 bp
  • T to C, chromosome 2 at 166,079,072 bp
  • T to A, chromosome 3 at 30,599,752 bp
  • C to A, chromosome 3 at 38,951,155 bp
  • A to T, chromosome 3 at 57,292,883 bp
  • T to C, chromosome 3 at 64,117,399 bp
  • G to A, chromosome 3 at 90,591,392 bp
  • T to A, chromosome 3 at 116,923,657 bp
  • A to G, chromosome 3 at 118,610,443 bp
  • T to A, chromosome 3 at 122,008,080 bp
  • C to A, chromosome 3 at 126,933,060 bp
  • T to A, chromosome 4 at 49,380,587 bp
  • T to A, chromosome 4 at 105,003,916 bp
  • T to C, chromosome 4 at 127,351,870 bp
  • T to C, chromosome 4 at 141,251,116 bp
  • C to T, chromosome 4 at 155,262,512 bp
  • A to T, chromosome 5 at 23,775,870 bp
  • T to A, chromosome 5 at 38,382,044 bp
  • T to C, chromosome 5 at 77,309,725 bp
  • A to G, chromosome 5 at 106,880,514 bp
  • T to C, chromosome 5 at 106,896,003 bp
  • A to T, chromosome 5 at 107,343,584 bp
  • C to T, chromosome 5 at 117,351,654 bp
  • A to T, chromosome 5 at 117,895,919 bp
  • A to G, chromosome 5 at 120,519,652 bp
  • T to G, chromosome 5 at 134,211,240 bp
  • C to T, chromosome 5 at 135,371,316 bp
  • T to A, chromosome 5 at 140,902,905 bp
  • G to T, chromosome 6 at 49,105,631 bp
  • C to A, chromosome 6 at 54,944,059 bp
  • T to C, chromosome 6 at 83,758,390 bp
  • A to G, chromosome 6 at 106,790,945 bp
  • G to T, chromosome 6 at 113,697,927 bp
  • A to G, chromosome 6 at 114,957,934 bp
  • C to T, chromosome 7 at 3,611,856 bp
  • A to G, chromosome 7 at 18,480,041 bp
  • A to G, chromosome 7 at 41,546,477 bp
  • G to A, chromosome 7 at 86,695,110 bp
  • A to T, chromosome 7 at 97,662,349 bp
  • A to G, chromosome 7 at 120,047,512 bp
  • A to T, chromosome 7 at 120,804,031 bp
  • A to G, chromosome 7 at 122,168,898 bp
  • C to T, chromosome 7 at 133,677,285 bp
  • T to C, chromosome 8 at 45,010,482 bp
  • A to T, chromosome 8 at 46,116,207 bp
  • C to A, chromosome 8 at 77,358,587 bp
  • A to G, chromosome 8 at 95,710,686 bp
  • A to T, chromosome 8 at 121,799,487 bp
  • T to G, chromosome 8 at 122,479,576 bp
  • C to T, chromosome 9 at 36,694,255 bp
  • A to G, chromosome 9 at 38,975,906 bp
  • T to C, chromosome 9 at 39,258,571 bp
  • T to C, chromosome 9 at 65,659,212 bp
  • T to A, chromosome 9 at 67,911,529 bp
  • T to A, chromosome 9 at 92,205,528 bp
  • T to C, chromosome 9 at 99,336,191 bp
  • C to T, chromosome 9 at 109,181,518 bp
  • C to T, chromosome 9 at 121,819,581 bp
  • A to T, chromosome 10 at 14,129,505 bp
  • A to G, chromosome 10 at 17,843,455 bp
  • A to T, chromosome 10 at 18,118,950 bp
  • T to C, chromosome 10 at 24,664,641 bp
  • C to T, chromosome 10 at 80,018,098 bp
  • G to T, chromosome 10 at 127,286,968 bp
  • G to A, chromosome 10 at 130,391,099 bp
  • T to A, chromosome 11 at 34,404,263 bp
  • T to C, chromosome 11 at 49,217,683 bp
  • T to A, chromosome 11 at 52,242,615 bp
  • A to T, chromosome 11 at 54,027,975 bp
  • G to A, chromosome 11 at 60,239,075 bp
  • T to C, chromosome 11 at 62,423,005 bp
  • T to A, chromosome 11 at 70,010,355 bp
  • T to A, chromosome 11 at 82,443,517 bp
  • A to T, chromosome 11 at 84,818,692 bp
  • A to T, chromosome 11 at 87,086,287 bp
  • T to A, chromosome 11 at 100,703,574 bp
  • C to T, chromosome 12 at 21,224,392 bp
  • T to C, chromosome 12 at 38,852,262 bp
  • A to T, chromosome 12 at 100,403,408 bp
  • C to A, chromosome 13 at 56,176,620 bp
  • T to C, chromosome 13 at 73,267,638 bp
  • T to G, chromosome 13 at 96,489,204 bp
  • G to T, chromosome 14 at 41,966,883 bp
  • C to G, chromosome 14 at 50,084,370 bp
  • C to A, chromosome 14 at 55,065,998 bp
  • T to C, chromosome 14 at 70,443,010 bp
  • C to A, chromosome 14 at 122,436,154 bp
  • C to T, chromosome 15 at 31,602,161 bp
  • T to C, chromosome 15 at 36,244,207 bp
  • A to T, chromosome 15 at 37,929,096 bp
  • G to T, chromosome 15 at 97,010,380 bp
  • A to C, chromosome 16 at 3,999,158 bp
  • T to A, chromosome 16 at 55,915,022 bp
  • A to G, chromosome 16 at 58,761,141 bp
  • T to C, chromosome 16 at 97,408,504 bp
  • A to T, chromosome 17 at 18,061,925 bp
  • T to C, chromosome 17 at 30,854,940 bp
  • A to G, chromosome 17 at 34,743,664 bp
  • A to T, chromosome 17 at 35,926,536 bp
  • A to G, chromosome 17 at 67,753,791 bp
  • T to C, chromosome 18 at 4,674,511 bp
  • G to T, chromosome 18 at 12,142,961 bp
  • A to G, chromosome 18 at 36,532,022 bp
  • A to T, chromosome 18 at 70,468,063 bp
  • G to T, chromosome 19 at 10,442,813 bp
  • G to A, chromosome 19 at 18,960,501 bp
  • A to T, chromosome 19 at 23,979,695 bp
  • A to T, chromosome 19 at 40,726,236 bp
  • A to T, chromosome 19 at 47,670,931 bp
  • A to G, chromosome 19 at 60,817,583 bp
  • A to C, chromosome X at 136,927,467 bp
  • A to C, chromosome X at 139,854,530 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1710 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039743-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.