Strain Name:
C57BL/6J-MtgxR1734Btlr/Mmmh
Stock Number:
039766-MU
Citation ID:
RRID:MMRRC_039766-MU
Other Names:
R1734 (G1), C57BL/6J-MtgxR1734Btlr
Major Collection:

Strain Information

Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Pepd
Name: peptidase D
Synonyms: Pep-4, peptidase D, Pep4, dal
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18624
HGNC: HGNC:8840
Homologene: 239
Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: G430090F17Rik, LOC328902
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 64291
Homologene: 84746
Syce2
Name: synaptonemal complex central element protein 2
Synonyms: 1700013H19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71846
Homologene: 12414
Anln
Name: anillin, actin binding protein
Synonyms: 1110037A17Rik, Scraps, 2900037I21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68743
VEGA: 9
Homologene: 41281
Atp2c1
Name: ATPase, Ca++-sequestering
Synonyms: 1700121J11Rik, PMR1, D930003G21Rik, ATP2C1A, SPCA
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235574
Homologene: 56672
Nav2
Name: neuron navigator 2
Synonyms: Rainb1, POMFIL2, Unc53H2, 5330421F07Rik, HELAD1, RAINB2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Prrc2a
Name: proline-rich coiled-coil 2A
Synonyms: 3110039B05Rik, Bat-2, Bat2, G2, D17H6S51E, Wbp12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53761
Homologene: 10567
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: Ssfa2, SPAG13, KRAP, CS1, CS-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70599
Homologene: 4912
Aimp1
Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Synonyms: 9830137A06Rik, AIMP1/p43, Emap2, Scye1, EMAPII
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13722
Homologene: 31260
Tspan5
Name: tetraspanin 5
Synonyms: NET-4, 4930505M03Rik, Tm4sf9, 2810455A09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56224
Homologene: 4182
Actr10
Name: ARP10 actin-related protein 10
Synonyms: Arp11
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56444
VEGA: 12
Homologene: 10220
Vps18
Name: VPS18 CORVET/HOPS core subunit
Synonyms: 9930024E13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228545
Homologene: 13302
Jcad
Name: junctional cadherin 5 associated
Synonyms: 9430020K01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240185
VEGA: 18
Homologene: 19370
Trappc3
Name: trafficking protein particle complex 3
Synonyms: 1110058K12Rik, Bet3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27096
Homologene: 6399
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Nol11
Name: nucleolar protein 11
Synonyms: 1500002M01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68979
Homologene: 32264
Cblb
Name: Casitas B-lineage lymphoma b
Synonyms: Cbl-b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208650
VEGA: 16
HGNC: HGNC:1542
Homologene: 15856
Dact2
Name: dishevelled-binding antagonist of beta-catenin 2
Synonyms: Dpr2, Frd2, 2900084M21Rik, dapper2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240025
VEGA: 17
Homologene: 18237
Cep295
Name: centrosomal protein 295
Synonyms: LOC382128, 5830418K08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319675
Homologene: 27936
Hspa12b
Name: heat shock protein 12B
Synonyms: 2700081N06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72630
Homologene: 41749
Ethe1
Name: ethylmalonic encephalopathy 1
Synonyms: 0610025L15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66071
Homologene: 8622
Ckap4
Name: cytoskeleton-associated protein 4
Synonyms: 5630400A09Rik, CLIMP-63, P63
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216197
VEGA: 10
Homologene: 4970
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, mKIAA0811, LOC245827, Fath2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Grm3
Name: glutamate receptor, metabotropic 3
Synonyms: 0710001G23Rik, mGlu3, mGluR3, Gprc1c
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108069
HGNC: HGNC:4595
Homologene: 651
Map3k10
Name: mitogen-activated protein kinase kinase kinase 10
Synonyms: Mlk2, serine/threonine kinase, MKN28 kinase, mixed lineage kinase 2, MKN28 derived nonreceptor_type
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269881
HGNC: HGNC:6849
Homologene: 1834
Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif 16
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271127
Homologene: 15146
Clstn3
Name: calsyntenin 3
Synonyms: Cst-3, alcadein-beta, CSTN3, Clstn3b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232370
Homologene: 22836
Vmn1r20
Name: vomeronasal 1 receptor 20
Synonyms: Gm5569
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434017
Homologene: 79462
Il10ra
Name: interleukin 10 receptor, alpha
Synonyms: CDw210, Il10r, mIL-10R
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16154
HGNC: HGNC:5964
Homologene: 1196
Zbtb4
Name: zinc finger and BTB domain containing 4
Synonyms: 2310026P19Rik, 9230111I22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75580
Homologene: 10846
Tmem260
Name: transmembrane protein 260
Synonyms: 6720456H20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218989
Homologene: 49506
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244810
HGNC: HGNC:6658
Retreg2
Name: reticulophagy regulator family member 2
Synonyms: MGC47289, Fam134a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227298
Homologene: 11507
Chac1
Name: ChaC, cation transport regulator 1
Synonyms: 1810008K03Rik, Botch
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69065
Homologene: 11470
Pde6a
Name: phosphodiesterase 6A, cGMP-specific, rod, alpha
Synonyms: Pdea
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225600
HGNC: HGNC:8785
Homologene: 380
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: Snep, 6720455I24Rik, D430044C15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208777
Homologene: 14708
Piwil2
Name: piwi-like RNA-mediated gene silencing 2
Synonyms: Miwi like, mili
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57746
VEGA: 14
Homologene: 23071
Ces4a
Name: carboxylesterase 4A
Synonyms: Ces8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234677
Homologene: 71949
Ttbk2
Name: tau tubulin kinase 2
Synonyms: 2610507N02Rik, B930008N24Rik, TTK
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140810
Homologene: 62795
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: 4930544G21Rik, SKIP, A930009L15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77629
Homologene: 18172
Gad1-ps
Name: glutamate decarboxylase 1, pseudogene
Synonyms: Gad-1ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382407
VEGA: 10
BC049715
Name: cDNA sequence BC049715
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320135
Homologene: 52193
Aadacl4fm4
Name: AADACL4 family member 4
Synonyms: LOC230890, Gm436
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230890
Homologene: 135765
Mettl9
Name: methyltransferase like 9
Synonyms: 0610012D09Rik, Drev
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 59052
Homologene: 41092
Cherp
Name: calcium homeostasis endoplasmic reticulum protein
Synonyms: DAN16, SCAF6, 5730408I11Rik, D8Wsu96e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 27967
Homologene: 4656
Ahsa2
Name: AHA1, activator of heat shock protein ATPase 2
Synonyms: 1110064P04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268390
Homologene: 72214
Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Synonyms: System xc, 9930009M05Rik, sut, xc, xCT
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26570
Homologene: 22684
Fbxl7
Name: F-box and leucine-rich repeat protein 7
Synonyms: Fbl6, D230018M15Rik, FBL7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 448987
VEGA: 15
Homologene: 69121
Trim30d
Name: tripartite motif-containing 30D
Synonyms: TRIM30-3, Trim79
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209387
Homologene: 114426
Trim35
Name: tripartite motif-containing 35
Synonyms: Hls5, A430106H13Rik, 0710005M05Rik, Mair
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66854
Homologene: 134331
Or14a256
Name: olfactory receptor family 14 subfamily A member 256
Synonyms: GA_x6K02T2NHDJ-9504525-9505532, MOR219-5, Olfr294
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257904
Crb2
Name: crumbs family member 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241324
Homologene: 45474
Fahd2a
Name: fumarylacetoacetate hydrolase domain containing 2A
Synonyms: B430104H02Rik, 1500003K14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68126
Homologene: 131290
Spmip9
Name: sperm microtubule inner protein 9
Synonyms: 1700011F03Rik, Tex37
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74221
Homologene: 17643
Esp31
Name: exocrine gland secreted peptide 31
Synonyms: Gm20516
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126768
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 75,142,986 bp
  • G to A, chromosome 1 at 83,277,515 bp
  • G to A, chromosome 1 at 93,259,768 bp
  • T to A, chromosome 2 at 37,793,656 bp
  • T to C, chromosome 2 at 76,745,813 bp
  • G to A, chromosome 2 at 79,657,822 bp
  • A to T, chromosome 2 at 119,293,942 bp
  • A to T, chromosome 2 at 119,353,458 bp
  • T to C, chromosome 2 at 120,755,838 bp
  • T to C, chromosome 2 at 127,440,372 bp
  • A to G, chromosome 2 at 131,138,536 bp
  • G to A, chromosome 3 at 50,372,346 bp
  • A to T, chromosome 3 at 132,674,796 bp
  • T to C, chromosome 3 at 138,898,140 bp
  • T to A, chromosome 4 at 126,274,085 bp
  • A to T, chromosome 4 at 144,670,026 bp
  • C to T, chromosome 5 at 9,589,742 bp
  • A to G, chromosome 6 at 57,432,300 bp
  • T to A, chromosome 6 at 70,913,661 bp
  • G to A, chromosome 6 at 73,044,761 bp
  • T to A, chromosome 6 at 85,641,550 bp
  • G to A, chromosome 6 at 124,436,814 bp
  • C to T, chromosome 6 at 136,840,308 bp
  • A to G, chromosome 7 at 24,608,384 bp
  • T to C, chromosome 7 at 27,658,115 bp
  • A to T, chromosome 7 at 35,031,426 bp
  • G to A, chromosome 7 at 49,575,720 bp
  • C to T, chromosome 7 at 86,616,217 bp
  • T to C, chromosome 7 at 104,472,920 bp
  • T to A, chromosome 7 at 121,047,841 bp
  • A to T, chromosome 8 at 72,470,088 bp
  • G to A, chromosome 8 at 84,887,147 bp
  • G to A, chromosome 8 at 105,138,097 bp
  • C to T, chromosome 9 at 15,340,883 bp
  • A to T, chromosome 9 at 22,350,955 bp
  • C to A, chromosome 9 at 39,597,045 bp
  • T to C, chromosome 9 at 45,255,943 bp
  • T to C, chromosome 9 at 105,414,655 bp
  • A to G, chromosome 10 at 84,527,874 bp
  • A to T, chromosome 10 at 88,767,461 bp
  • A to T, chromosome 10 at 99,445,775 bp
  • T to C, chromosome 11 at 9,585,460 bp
  • T to C, chromosome 11 at 23,497,495 bp
  • A to G, chromosome 11 at 55,281,371 bp
  • A to G, chromosome 11 at 69,776,463 bp
  • G to A, chromosome 11 at 107,175,623 bp
  • T to A, chromosome 12 at 70,961,996 bp
  • G to A, chromosome 13 at 70,779,518 bp
  • G to T, chromosome 14 at 48,509,093 bp
  • A to G, chromosome 14 at 66,309,329 bp
  • A to T, chromosome 14 at 70,426,505 bp
  • T to C, chromosome 15 at 26,543,649 bp
  • C to T, chromosome 15 at 76,186,218 bp
  • T to C, chromosome 16 at 52,186,240 bp
  • T to C, chromosome 17 at 14,196,639 bp
  • A to G, chromosome 17 at 35,150,707 bp
  • G to A, chromosome 17 at 38,644,526 bp
  • T to C, chromosome 18 at 4,674,526 bp
  • T to C, chromosome 18 at 12,788,316 bp
  • A to G, chromosome 18 at 61,285,965 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1734 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039766-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.