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Strain Name:
C57BL/6J-MtgxR1738Btlr/Mmmh
Stock Number:
039770-MU
Citation ID:
RRID:MMRRC_039770-MU
Other Names:
R1738 (G1), C57BL/6J-MtgxR1738Btlr
Major Collection:

Strain Information

Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Nes
Name: nestin
Synonyms: RC2, Marc2, ESTM46, Ifaprc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Cpe
Name: carboxypeptidase E
Synonyms: carboxypeptidase H, CPH, Cph1, Cph-1, NF-alpha1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12876
HGNC: HGNC:2303
Homologene: 48052
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Hsp90ab1
Name: heat shock protein 90 alpha (cytosolic), class B member 1
Synonyms: Hsp84, Hsp90, Hsp84-1, C81438, Hspcb
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15516
Homologene: 74306
Wdr47
Name: WD repeat domain 47
Synonyms: 1810073M12Rik, nemitin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99512
Homologene: 8984
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 45,426,978 bp
  • T to C, chromosome 1 at 63,093,465 bp
  • T to C, chromosome 1 at 90,816,361 bp
  • T to A, chromosome 1 at 93,874,596 bp
  • T to A, chromosome 1 at 130,887,362 bp
  • A to T, chromosome 2 at 25,493,251 bp
  • T to C, chromosome 2 at 36,688,785 bp
  • T to C, chromosome 2 at 76,946,813 bp
  • A to T, chromosome 2 at 86,217,716 bp
  • G to A, chromosome 2 at 88,391,327 bp
  • T to C, chromosome 2 at 89,418,018 bp
  • T to A, chromosome 2 at 122,293,414 bp
  • G to A, chromosome 2 at 180,911,492 bp
  • A to T, chromosome 3 at 63,719,238 bp
  • A to T, chromosome 3 at 86,120,606 bp
  • C to A, chromosome 3 at 87,976,421 bp
  • A to G, chromosome 3 at 103,029,177 bp
  • A to C, chromosome 3 at 108,633,057 bp
  • T to A, chromosome 3 at 133,481,387 bp
  • A to T, chromosome 4 at 66,841,076 bp
  • A to G, chromosome 4 at 99,033,262 bp
  • A to G, chromosome 4 at 108,576,921 bp
  • G to A, chromosome 4 at 116,530,421 bp
  • A to G, chromosome 4 at 123,510,805 bp
  • C to T, chromosome 4 at 140,720,542 bp
  • T to C, chromosome 4 at 154,925,331 bp
  • T to A, chromosome 5 at 28,358,493 bp
  • T to C, chromosome 5 at 77,316,011 bp
  • T to G, chromosome 5 at 81,387,979 bp
  • T to C, chromosome 5 at 105,326,644 bp
  • C to T, chromosome 5 at 108,430,559 bp
  • T to C, chromosome 5 at 108,616,976 bp
  • T to A, chromosome 5 at 109,428,511 bp
  • A to T, chromosome 6 at 13,190,724 bp
  • G to A, chromosome 6 at 34,884,308 bp
  • A to G, chromosome 6 at 37,057,432 bp
  • A to G, chromosome 6 at 43,275,436 bp
  • A to G, chromosome 6 at 122,318,566 bp
  • C to T, chromosome 6 at 136,840,308 bp
  • T to C, chromosome 6 at 145,815,308 bp
  • A to G, chromosome 7 at 12,635,888 bp
  • C to A, chromosome 7 at 42,662,949 bp
  • G to A, chromosome 7 at 75,677,194 bp
  • A to G, chromosome 7 at 120,035,359 bp
  • T to A, chromosome 8 at 11,446,238 bp
  • A to G, chromosome 8 at 46,607,838 bp
  • A to T, chromosome 8 at 64,611,441 bp
  • T to C, chromosome 8 at 70,784,556 bp
  • T to A, chromosome 8 at 105,019,065 bp
  • G to A, chromosome 8 at 105,138,097 bp
  • T to C, chromosome 8 at 120,566,919 bp
  • T to A, chromosome 9 at 42,089,965 bp
  • T to C, chromosome 9 at 108,106,934 bp
  • C to A, chromosome 9 at 110,894,402 bp
  • A to G, chromosome 10 at 10,936,419 bp
  • A to T, chromosome 10 at 41,335,921 bp
  • G to A, chromosome 10 at 84,880,975 bp
  • A to G, chromosome 11 at 23,649,458 bp
  • A to G, chromosome 11 at 77,469,425 bp
  • A to G, chromosome 11 at 78,499,596 bp
  • T to C, chromosome 13 at 46,560,593 bp
  • G to A, chromosome 13 at 70,779,518 bp
  • T to G, chromosome 13 at 113,367,500 bp
  • A to T, chromosome 14 at 20,309,694 bp
  • A to G, chromosome 14 at 66,056,461 bp
  • C to T, chromosome 14 at 75,593,057 bp
  • C to T, chromosome 15 at 76,186,218 bp
  • A to G, chromosome 15 at 77,099,341 bp
  • T to C, chromosome 15 at 103,753,619 bp
  • A to G, chromosome 16 at 4,864,611 bp
  • A to T, chromosome 16 at 23,927,673 bp
  • A to T, chromosome 17 at 33,817,194 bp
  • G to A, chromosome 17 at 34,998,599 bp
  • T to C, chromosome 17 at 45,571,806 bp
  • A to G, chromosome 17 at 84,566,697 bp
  • T to C, chromosome 19 at 5,753,919 bp
  • A to G, chromosome 19 at 17,125,010 bp
  • T to C, chromosome 19 at 30,786,922 bp
  • A to G, chromosome 19 at 41,784,381 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1738 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039770-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.