Strain Name:
C57BL/6J-MtgxR1757Btlr/Mmmh
Stock Number:
039789-MU
Citation ID:
RRID:MMRRC_039789-MU
Other Names:
R1757 (G1), C57BL/6J-MtgxR1757Btlr
Major Collection:

Gene Information

Gene Symbol: Hgs [MGI:104681] (Mus musculus (mouse))
Name: HGF-regulated tyrosine kinase substrate
Synonyms: Hrs, tn
Chromosome: 11
Alteration at locus: Chemically Induced
Gene Symbol: Cntnap2 [MGI:1914047] (Mus musculus (mouse))
Name: contactin associated protein-like 2
Synonyms: Caspr2, 5430425M22Rik
Chromosome: 6
Alteration at locus: Chemically Induced
Gene Symbol: Foxp4 [MGI:1921373] (Mus musculus (mouse))
Name: forkhead box P4
Synonyms: 2310007G05Rik, 1200010K03Rik
Chromosome: 17
Alteration at locus: Chemically Induced
Gene Symbol: Ptprz1 [MGI:97816] (Mus musculus (mouse))
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: Ptprz, phosphacan, DSD-1-PG, PTPzeta, PTPbeta, Rptpbeta, RPTPz, Ptpz
Chromosome: 6
Alteration at locus: Chemically Induced
Gene Symbol: Lmf1 [MGI:1923733] (Mus musculus (mouse))
Name: lipase maturation factor 1
Synonyms: 2400010G15Rik, Tmem112
Chromosome: 17
Alteration at locus: Chemically Induced
Gene Symbol: Herc3 [MGI:1921248] (Mus musculus (mouse))
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Chromosome: 6
Alteration at locus: Chemically Induced
Gene Symbol: Ulk2 [MGI:1352758] (Mus musculus (mouse))
Name: unc-51 like kinase 2
Synonyms: A830085I22Rik, Unc51.2
Chromosome: 11
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 65,252,548 bp
  • C to T, chromosome 1 at 75,493,883 bp
  • T to C, chromosome 1 at 80,533,869 bp
  • A to T, chromosome 1 at 91,522,857 bp
  • G to T, chromosome 1 at 128,301,257 bp
  • A to G, chromosome 1 at 132,434,094 bp
  • A to C, chromosome 1 at 143,677,628 bp
  • A to T, chromosome 1 at 174,069,658 bp
  • A to G, chromosome 2 at 28,686,113 bp
  • G to A, chromosome 2 at 28,830,636 bp
  • G to A, chromosome 2 at 76,655,888 bp
  • T to G, chromosome 2 at 87,990,582 bp
  • G to T, chromosome 2 at 88,746,017 bp
  • T to C, chromosome 2 at 127,232,443 bp
  • T to C, chromosome 2 at 132,810,237 bp
  • C to A, chromosome 2 at 169,883,923 bp
  • T to C, chromosome 2 at 181,236,263 bp
  • A to G, chromosome 3 at 55,630,189 bp
  • T to C, chromosome 3 at 95,677,942 bp
  • C to T, chromosome 3 at 154,695,765 bp
  • A to C, chromosome 4 at 11,254,109 bp
  • T to C, chromosome 4 at 45,307,946 bp
  • C to T, chromosome 4 at 53,747,003 bp
  • A to G, chromosome 4 at 101,597,831 bp
  • A to G, chromosome 4 at 109,064,583 bp
  • A to G, chromosome 4 at 112,413,962 bp
  • A to T, chromosome 4 at 134,217,901 bp
  • A to T, chromosome 4 at 136,931,478 bp
  • C to T, chromosome 4 at 151,042,792 bp
  • T to C, chromosome 4 at 156,199,990 bp
  • A to G, chromosome 5 at 4,001,667 bp
  • A to T, chromosome 5 at 8,987,828 bp
  • A to T, chromosome 5 at 21,281,037 bp
  • A to G, chromosome 5 at 21,653,457 bp
  • A to G, chromosome 5 at 105,094,453 bp
  • A to T, chromosome 5 at 106,880,360 bp
  • T to A, chromosome 6 at 23,044,320 bp
  • T to A, chromosome 6 at 46,759,829 bp
  • G to A, chromosome 6 at 52,234,489 bp
  • T to C, chromosome 6 at 58,916,470 bp
  • T to C, chromosome 6 at 73,160,982 bp
  • T to C, chromosome 6 at 87,749,283 bp
  • A to G, chromosome 6 at 89,384,644 bp
  • G to A, chromosome 7 at 12,991,066 bp
  • T to C, chromosome 7 at 24,608,474 bp
  • T to C, chromosome 7 at 27,342,351 bp
  • T to A, chromosome 7 at 29,935,061 bp
  • A to T, chromosome 7 at 63,891,765 bp
  • T to G, chromosome 7 at 79,675,323 bp
  • C to A, chromosome 7 at 79,679,046 bp
  • T to G, chromosome 7 at 89,633,022 bp
  • C to A, chromosome 8 at 4,249,548 bp
  • T to A, chromosome 8 at 61,089,813 bp
  • T to A, chromosome 8 at 105,381,661 bp
  • CAT to C, chromosome 8 at 105,941,814 bp
  • G to A, chromosome 9 at 35,210,834 bp
  • T to A, chromosome 9 at 106,483,004 bp
  • A to T, chromosome 9 at 109,557,279 bp
  • T to C, chromosome 10 at 18,545,101 bp
  • A to T, chromosome 10 at 23,900,828 bp
  • G to T, chromosome 10 at 23,900,829 bp
  • G to A, chromosome 10 at 29,347,479 bp
  • G to T, chromosome 10 at 34,297,580 bp
  • A to C, chromosome 10 at 58,704,047 bp
  • T to C, chromosome 10 at 78,196,275 bp
  • T to C, chromosome 10 at 78,747,224 bp
  • G to A, chromosome 10 at 93,494,628 bp
  • T to C, chromosome 10 at 93,970,563 bp
  • T to C, chromosome 10 at 122,089,015 bp
  • G to T, chromosome 10 at 127,876,896 bp
  • T to A, chromosome 11 at 3,504,738 bp
  • A to T, chromosome 11 at 61,841,339 bp
  • T to A, chromosome 11 at 62,119,284 bp
  • T to A, chromosome 11 at 69,135,949 bp
  • A to G, chromosome 11 at 72,043,159 bp
  • G to T, chromosome 11 at 77,508,382 bp
  • G to A, chromosome 11 at 77,508,383 bp
  • T to C, chromosome 11 at 83,185,385 bp
  • C to T, chromosome 11 at 88,845,752 bp
  • T to A, chromosome 11 at 113,652,304 bp
  • C to T, chromosome 11 at 120,480,063 bp
  • T to G, chromosome 12 at 51,602,848 bp
  • T to C, chromosome 12 at 109,459,687 bp
  • T to C, chromosome 13 at 4,595,649 bp
  • T to C, chromosome 13 at 33,399,353 bp
  • T to C, chromosome 13 at 67,207,537 bp
  • C to T, chromosome 13 at 108,323,948 bp
  • A to T, chromosome 14 at 8,049,867 bp
  • T to A, chromosome 14 at 122,478,619 bp
  • A to T, chromosome 15 at 6,330,452 bp
  • G to A, chromosome 15 at 6,773,862 bp
  • A to T, chromosome 15 at 9,717,482 bp
  • T to C, chromosome 15 at 74,813,613 bp
  • T to C, chromosome 15 at 78,889,030 bp
  • G to A, chromosome 15 at 95,962,267 bp
  • A to C, chromosome 15 at 99,736,331 bp
  • A to G, chromosome 15 at 101,198,822 bp
  • A to T, chromosome 15 at 102,331,829 bp
  • T to C, chromosome 16 at 18,218,688 bp
  • T to C, chromosome 17 at 5,279,192 bp
  • A to T, chromosome 17 at 25,655,210 bp
  • A to G, chromosome 17 at 29,571,673 bp
  • A to T, chromosome 17 at 31,008,700 bp
  • A to T, chromosome 17 at 32,929,958 bp
  • G to A, chromosome 17 at 34,514,088 bp
  • A to C, chromosome 17 at 36,813,151 bp
  • G to T, chromosome 17 at 46,723,498 bp
  • T to C, chromosome 17 at 47,871,364 bp
  • G to A, chromosome 17 at 67,697,383 bp
  • A to T, chromosome 17 at 67,763,836 bp
  • A to G, chromosome 18 at 12,465,499 bp
  • G to A, chromosome 18 at 25,066,278 bp
  • C to T, chromosome 19 at 5,046,407 bp
  • A to T, chromosome 19 at 6,536,731 bp
  • A to C, chromosome 19 at 13,479,607 bp
  • T to C, chromosome 19 at 40,739,006 bp
  • A to G, chromosome 19 at 41,941,955 bp
Genotype Determination
ES Cell Line
N/A
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
MeSH Terms
    Strain Development
    C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
    Suggested Control Mice
    Wild-type littermates or C57BL/6J mice
    Donor
    Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
    Primary Reference
    MUTAGENETIX record for R1757 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

    Colony and Husbandry Information

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
    Coat Color
    Black
    MMRRC Breeding System
    Random intra-strain mating
    Breeding Scheme(s)
    When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
    Overall Breeding Performance
    Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
    Average litter size
    Undetermined
    Recommended wean age
    3 weeks

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    039789-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.