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Strain Name:
C57BL/6J-MtgxR1758Btlr/Mmmh
Stock Number:
039790-MU
Citation ID:
RRID:MMRRC_039790-MU
Other Names:
R1758 (G1), C57BL/6J-MtgxR1758Btlr
Major Collection:

Strain Information

Fgf4
Name: fibroblast growth factor 4
Synonyms: Hst1, kFGF, Fgf-4, Hstf-1, Fgfk
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14175
HGNC: HGNC:3682
Homologene: 1522
Cdk17
Name: cyclin dependent kinase 17
Synonyms: 6430598J10Rik, Pctk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237459
VEGA: 10
HGNC: HGNC:8750
Homologene: 55666
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Gtf2i
Name: general transcription factor II I
Synonyms: TFII-I, BAP-135, 6030441I21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Clasp1
Name: CLIP associating protein 1
Synonyms: 5730583A19Rik, 1700030C23Rik, mCLASP1, CLASP1alpha, CLASP1, B130045P17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76707
Homologene: 41024
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 38,813,276 bp
  • G to T, chromosome 1 at 59,634,010 bp
  • C to T, chromosome 1 at 118,548,025 bp
  • G to A, chromosome 1 at 135,808,682 bp
  • C to T, chromosome 1 at 160,147,584 bp
  • A to G, chromosome 1 at 164,132,285 bp
  • C to T, chromosome 1 at 172,104,144 bp
  • C to A, chromosome 1 at 185,283,884 bp
  • C to A, chromosome 2 at 5,004,050 bp
  • T to A, chromosome 2 at 12,265,333 bp
  • C to T, chromosome 2 at 25,288,423 bp
  • G to A, chromosome 2 at 49,723,133 bp
  • T to G, chromosome 2 at 66,680,183 bp
  • A to T, chromosome 2 at 66,700,887 bp
  • A to T, chromosome 2 at 87,213,414 bp
  • T to C, chromosome 2 at 90,021,329 bp
  • G to A, chromosome 2 at 121,343,234 bp
  • C to A, chromosome 2 at 126,775,862 bp
  • T to A, chromosome 2 at 155,025,458 bp
  • T to A, chromosome 2 at 160,751,422 bp
  • C to A, chromosome 2 at 181,378,840 bp
  • A to G, chromosome 3 at 53,653,357 bp
  • G to A, chromosome 3 at 59,329,196 bp
  • G to A, chromosome 3 at 101,860,453 bp
  • A to C, chromosome 4 at 14,548,491 bp
  • T to C, chromosome 4 at 33,945,000 bp
  • T to C, chromosome 4 at 83,237,349 bp
  • C to A, chromosome 4 at 130,011,875 bp
  • G to A, chromosome 4 at 141,476,375 bp
  • A to C, chromosome 5 at 90,801,464 bp
  • A to C, chromosome 5 at 134,239,585 bp
  • A to T, chromosome 5 at 136,392,322 bp
  • A to T, chromosome 5 at 139,393,382 bp
  • A to T, chromosome 5 at 146,526,226 bp
  • T to C, chromosome 6 at 29,941,941 bp
  • A to T, chromosome 6 at 57,691,832 bp
  • T to A, chromosome 6 at 85,447,221 bp
  • T to A, chromosome 6 at 85,628,505 bp
  • T to G, chromosome 6 at 87,388,835 bp
  • T to C, chromosome 6 at 91,915,222 bp
  • T to A, chromosome 6 at 142,472,706 bp
  • C to T, chromosome 7 at 4,340,808 bp
  • G to A, chromosome 7 at 16,276,236 bp
  • T to C, chromosome 7 at 23,632,356 bp
  • T to A, chromosome 7 at 30,267,903 bp
  • T to C, chromosome 7 at 45,425,162 bp
  • T to C, chromosome 7 at 92,859,363 bp
  • T to C, chromosome 7 at 106,423,234 bp
  • T to A, chromosome 7 at 141,801,531 bp
  • A to G, chromosome 7 at 144,862,312 bp
  • T to C, chromosome 8 at 13,562,237 bp
  • T to C, chromosome 8 at 15,065,795 bp
  • T to C, chromosome 8 at 22,160,262 bp
  • T to A, chromosome 8 at 106,099,136 bp
  • C to T, chromosome 9 at 21,955,984 bp
  • A to T, chromosome 9 at 27,334,252 bp
  • A to T, chromosome 9 at 38,815,575 bp
  • A to G, chromosome 9 at 56,926,698 bp
  • A to G, chromosome 9 at 63,500,859 bp
  • G to A, chromosome 9 at 65,874,977 bp
  • A to G, chromosome 9 at 119,223,800 bp
  • A to G, chromosome 10 at 10,426,605 bp
  • C to T, chromosome 10 at 93,208,250 bp
  • T to G, chromosome 10 at 117,761,343 bp
  • A to T, chromosome 10 at 127,588,584 bp
  • C to T, chromosome 11 at 5,571,281 bp
  • T to C, chromosome 11 at 48,908,032 bp
  • G to T, chromosome 11 at 70,661,425 bp
  • C to T, chromosome 11 at 99,538,775 bp
  • T to C, chromosome 11 at 100,025,535 bp
  • T to A, chromosome 11 at 101,184,623 bp
  • T to C, chromosome 11 at 101,766,738 bp
  • T to A, chromosome 11 at 117,760,730 bp
  • A to T, chromosome 11 at 120,377,233 bp
  • T to A, chromosome 12 at 4,658,160 bp
  • T to A, chromosome 12 at 29,827,242 bp
  • T to C, chromosome 12 at 32,967,521 bp
  • A to T, chromosome 12 at 40,214,140 bp
  • G to A, chromosome 12 at 55,407,532 bp
  • A to G, chromosome 12 at 79,238,944 bp
  • T to C, chromosome 12 at 81,983,484 bp
  • T to C, chromosome 12 at 91,347,578 bp
  • C to T, chromosome 13 at 24,925,966 bp
  • T to A, chromosome 13 at 47,060,768 bp
  • T to G, chromosome 13 at 60,935,442 bp
  • A to G, chromosome 13 at 113,368,732 bp
  • C to A, chromosome 14 at 26,766,114 bp
  • T to C, chromosome 14 at 51,105,265 bp
  • C to A, chromosome 14 at 63,919,575 bp
  • G to A, chromosome 14 at 123,303,003 bp
  • T to C, chromosome 15 at 5,121,027 bp
  • C to T, chromosome 15 at 80,257,213 bp
  • T to C, chromosome 16 at 17,626,008 bp
  • T to A, chromosome 16 at 17,640,880 bp
  • T to C, chromosome 17 at 25,163,182 bp
  • A to T, chromosome 17 at 37,211,313 bp
  • T to C, chromosome 17 at 43,424,593 bp
  • A to G, chromosome 17 at 58,042,550 bp
  • A to T, chromosome 17 at 73,910,209 bp
  • A to C, chromosome 18 at 25,120,310 bp
  • A to G, chromosome 18 at 30,277,010 bp
  • C to T, chromosome 18 at 37,989,912 bp
  • G to T, chromosome 18 at 61,298,786 bp
  • A to G, chromosome 19 at 8,217,762 bp
  • G to A, chromosome 19 at 11,757,815 bp
  • G to T, chromosome 19 at 15,914,879 bp
  • A to G, chromosome 19 at 15,959,536 bp
  • A to G, chromosome X at 23,906,751 bp
  • T to C, chromosome X at 93,461,366 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1758 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039790-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.