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Strain Name:
C57BL/6J-MtgxR1820Btlr/Mmmh
Stock Number:
039848-MU
Citation ID:
RRID:MMRRC_039848-MU
Other Names:
R1820 (G1), C57BL/6J-MtgxR1820Btlr
Major Collection:

Strain Information

Itprip
Name: inositol 1,4,5-triphosphate receptor interacting protein
Synonyms: DANGER
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 414801
VEGA: 19
Homologene: 62157
Gabrg1
Name: gamma-aminobutyric acid type A receptor subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Kdm5b
Name: lysine demethylase 5B
Synonyms: PLU-1, 2010009J12Rik, Plu1, Rb-Bp2, 2210016I17Rik, D1Ertd202e, Jarid1b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 1810033J14Rik, D230038D11Rik, 9530077A04Rik, Mll5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: Nezha, 2310057J16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69697
Homologene: 18966
Ambra1
Name: autophagy/beclin 1 regulator 1
Synonyms: 2310079H06Rik, D030051N19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228361
Homologene: 18204
Luc7l2
Name: LUC7-like 2 (S. cerevisiae)
Synonyms: CGI-74, CGI-59, 4930471C18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192196
Homologene: 56737
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 9,576,182 bp
  • A to G, chromosome 1 at 16,460,431 bp
  • G to T, chromosome 1 at 134,597,670 bp
  • A to T, chromosome 1 at 156,301,504 bp
  • A to G, chromosome 1 at 180,745,138 bp
  • C to T, chromosome 2 at 30,797,992 bp
  • T to C, chromosome 2 at 34,870,746 bp
  • A to T, chromosome 2 at 39,106,978 bp
  • T to A, chromosome 2 at 91,917,317 bp
  • G to A, chromosome 2 at 122,368,682 bp
  • A to T, chromosome 3 at 35,919,004 bp
  • T to C, chromosome 3 at 72,921,142 bp
  • A to G, chromosome 3 at 83,773,154 bp
  • T to A, chromosome 3 at 85,665,829 bp
  • A to T, chromosome 3 at 89,095,043 bp
  • C to T, chromosome 4 at 128,743,543 bp
  • A to G, chromosome 5 at 23,473,547 bp
  • T to C, chromosome 5 at 25,849,158 bp
  • T to A, chromosome 5 at 69,340,341 bp
  • T to A, chromosome 5 at 70,774,413 bp
  • G to A, chromosome 5 at 135,636,049 bp
  • G to A, chromosome 6 at 38,598,819 bp
  • A to G, chromosome 6 at 121,024,843 bp
  • C to A, chromosome 7 at 6,239,163 bp
  • G to A, chromosome 7 at 16,561,949 bp
  • G to T, chromosome 7 at 25,058,273 bp
  • G to T, chromosome 7 at 67,641,111 bp
  • A to G, chromosome 7 at 80,358,933 bp
  • T to C, chromosome 8 at 3,603,485 bp
  • T to A, chromosome 8 at 23,085,689 bp
  • A to G, chromosome 8 at 36,103,804 bp
  • T to C, chromosome 8 at 71,333,358 bp
  • A to T, chromosome 8 at 84,066,194 bp
  • A to G, chromosome 9 at 39,258,399 bp
  • T to C, chromosome 9 at 61,926,438 bp
  • A to G, chromosome 9 at 74,139,741 bp
  • T to G, chromosome 10 at 51,723,125 bp
  • A to T, chromosome 10 at 77,294,972 bp
  • C to A, chromosome 10 at 83,533,957 bp
  • T to A, chromosome 11 at 30,977,496 bp
  • A to T, chromosome 11 at 70,791,597 bp
  • G to T, chromosome 11 at 116,354,651 bp
  • A to G, chromosome 11 at 119,347,678 bp
  • T to C, chromosome 11 at 120,466,761 bp
  • T to C, chromosome 12 at 71,150,244 bp
  • A to G, chromosome 13 at 11,587,316 bp
  • T to C, chromosome 13 at 24,927,572 bp
  • A to T, chromosome 13 at 59,701,255 bp
  • T to C, chromosome 14 at 12,091,487 bp
  • G to A, chromosome 14 at 27,497,463 bp
  • C to A, chromosome 14 at 50,964,457 bp
  • A to T, chromosome 14 at 55,870,378 bp
  • A to T, chromosome 14 at 60,244,670 bp
  • A to G, chromosome 15 at 8,269,645 bp
  • T to C, chromosome 15 at 25,139,090 bp
  • T to A, chromosome 15 at 102,409,076 bp
  • T to A, chromosome 16 at 37,029,418 bp
  • C to A, chromosome 17 at 25,725,939 bp
  • A to G, chromosome 18 at 43,989,419 bp
  • T to C, chromosome 18 at 64,269,632 bp
  • A to G, chromosome 19 at 4,726,596 bp
  • A to T, chromosome 19 at 12,241,248 bp
  • A to T, chromosome 19 at 33,464,595 bp
  • A to G, chromosome 19 at 34,877,684 bp
  • T to A, chromosome 19 at 44,127,387 bp
  • A to T, chromosome 19 at 44,241,806 bp
  • T to A, chromosome 19 at 47,897,216 bp
  • A to G, chromosome 19 at 56,478,522 bp
  • T to A, chromosome X at 95,081,536 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1820 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039848-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.