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Strain Name:
C57BL/6J-MtgxR1868Btlr/Mmmh
Stock Number:
039890-MU
Citation ID:
RRID:MMRRC_039890-MU
Other Names:
R1868 (G1), C57BL/6J-MtgxR1868Btlr
Major Collection:

Strain Information

Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: 2610028O16Rik, D11Ertd530e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52615
Homologene: 32256
Acadm
Name: acyl-Coenzyme A dehydrogenase, medium chain
Synonyms: MCAD
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11364
HGNC: HGNC:89
Homologene: 3
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22427
Homologene: 6659
Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Cbx1
Name: chromobox 1
Synonyms: MOD1, M31, Cbx-rs2, HP1B, E430007M08Rik, Hp1beta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12412
HGNC: HGNC:1551
Homologene: 89116
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 39,300,678 bp
  • A to G, chromosome 1 at 92,644,463 bp
  • G to T, chromosome 1 at 105,844,705 bp
  • A to G, chromosome 1 at 151,641,551 bp
  • A to T, chromosome 1 at 185,318,568 bp
  • T to A, chromosome 2 at 35,129,815 bp
  • A to G, chromosome 2 at 48,910,293 bp
  • T to C, chromosome 2 at 52,326,744 bp
  • T to A, chromosome 2 at 71,137,634 bp
  • T to A, chromosome 2 at 71,421,283 bp
  • T to A, chromosome 2 at 85,608,065 bp
  • G to A, chromosome 2 at 86,677,285 bp
  • T to C, chromosome 2 at 88,973,784 bp
  • T to C, chromosome 2 at 127,459,343 bp
  • A to G, chromosome 2 at 140,181,589 bp
  • T to C, chromosome 2 at 150,408,180 bp
  • A to G, chromosome 3 at 5,412,714 bp
  • G to T, chromosome 3 at 40,664,335 bp
  • G to A, chromosome 3 at 64,259,116 bp
  • T to A, chromosome 3 at 81,960,546 bp
  • A to G, chromosome 3 at 92,656,011 bp
  • A to G, chromosome 3 at 95,170,813 bp
  • A to T, chromosome 3 at 133,348,097 bp
  • C to A, chromosome 3 at 142,306,299 bp
  • T to C, chromosome 3 at 153,930,252 bp
  • C to A, chromosome 4 at 11,241,684 bp
  • C to T, chromosome 4 at 21,874,086 bp
  • T to C, chromosome 4 at 32,730,997 bp
  • T to C, chromosome 4 at 43,447,201 bp
  • T to A, chromosome 4 at 49,529,283 bp
  • T to C, chromosome 4 at 88,879,671 bp
  • A to T, chromosome 4 at 147,921,388 bp
  • T to A, chromosome 5 at 9,479,251 bp
  • G to A, chromosome 5 at 36,616,427 bp
  • T to C, chromosome 5 at 64,954,829 bp
  • A to T, chromosome 5 at 66,000,217 bp
  • C to T, chromosome 5 at 75,170,873 bp
  • T to C, chromosome 5 at 91,951,903 bp
  • T to A, chromosome 5 at 95,482,899 bp
  • A to C, chromosome 5 at 117,505,529 bp
  • T to A, chromosome 6 at 24,118,000 bp
  • T to A, chromosome 6 at 37,951,512 bp
  • C to A, chromosome 6 at 42,216,002 bp
  • G to T, chromosome 6 at 83,671,701 bp
  • C to T, chromosome 6 at 85,155,903 bp
  • T to A, chromosome 6 at 113,176,433 bp
  • G to T, chromosome 6 at 113,392,764 bp
  • A to G, chromosome 6 at 127,470,777 bp
  • T to C, chromosome 6 at 128,432,490 bp
  • C to T, chromosome 6 at 132,626,494 bp
  • T to A, chromosome 6 at 140,729,291 bp
  • T to A, chromosome 7 at 39,473,304 bp
  • T to A, chromosome 7 at 44,829,048 bp
  • C to T, chromosome 7 at 45,287,828 bp
  • T to C, chromosome 7 at 62,463,668 bp
  • A to T, chromosome 7 at 78,192,604 bp
  • A to T, chromosome 7 at 92,386,952 bp
  • T to A, chromosome 7 at 98,454,061 bp
  • C to T, chromosome 7 at 99,686,036 bp
  • A to G, chromosome 7 at 100,878,977 bp
  • G to A, chromosome 7 at 101,250,438 bp
  • T to C, chromosome 7 at 115,659,538 bp
  • A to G, chromosome 7 at 139,007,587 bp
  • C to A, chromosome 7 at 143,715,773 bp
  • C to A, chromosome 8 at 24,553,760 bp
  • A to G, chromosome 8 at 33,257,221 bp
  • T to C, chromosome 8 at 112,014,456 bp
  • C to A, chromosome 8 at 126,970,881 bp
  • A to G, chromosome 9 at 38,253,690 bp
  • T to C, chromosome 9 at 49,016,707 bp
  • A to G, chromosome 9 at 121,965,427 bp
  • A to T, chromosome 10 at 18,661,387 bp
  • A to G, chromosome 10 at 34,153,288 bp
  • A to G, chromosome 10 at 79,548,830 bp
  • T to C, chromosome 10 at 80,542,920 bp
  • T to C, chromosome 10 at 98,996,888 bp
  • A to T, chromosome 11 at 5,902,165 bp
  • C to A, chromosome 11 at 30,114,781 bp
  • A to T, chromosome 11 at 46,625,566 bp
  • TG to TGG, chromosome 11 at 54,546,397 bp
  • A to G, chromosome 11 at 67,085,026 bp
  • A to T, chromosome 11 at 69,562,164 bp
  • A to G, chromosome 11 at 80,013,599 bp
  • T to G, chromosome 11 at 94,364,063 bp
  • T to C, chromosome 11 at 96,802,728 bp
  • T to C, chromosome 11 at 98,052,945 bp
  • G to T, chromosome 11 at 100,874,129 bp
  • T to A, chromosome 11 at 101,498,013 bp
  • T to A, chromosome 12 at 51,353,629 bp
  • T to C, chromosome 12 at 79,261,799 bp
  • C to T, chromosome 12 at 80,679,523 bp
  • T to A, chromosome 12 at 109,590,536 bp
  • G to T, chromosome 13 at 8,836,851 bp
  • C to T, chromosome 13 at 11,731,700 bp
  • C to T, chromosome 13 at 20,589,653 bp
  • T to C, chromosome 13 at 22,851,609 bp
  • T to C, chromosome 13 at 27,804,940 bp
  • T to C, chromosome 13 at 49,641,283 bp
  • A to T, chromosome 13 at 60,902,528 bp
  • A to T, chromosome 13 at 60,902,530 bp
  • A to G, chromosome 13 at 89,690,871 bp
  • G to T, chromosome 14 at 31,667,309 bp
  • A to G, chromosome 14 at 34,692,458 bp
  • G to A, chromosome 14 at 66,077,658 bp
  • T to A, chromosome 15 at 9,461,830 bp
  • C to A, chromosome 15 at 10,633,228 bp
  • A to T, chromosome 15 at 38,041,846 bp
  • T to A, chromosome 15 at 55,447,462 bp
  • T to C, chromosome 15 at 82,124,953 bp
  • C to T, chromosome 16 at 32,756,341 bp
  • T to C, chromosome 16 at 95,715,074 bp
  • A to G, chromosome 17 at 26,093,973 bp
  • G to A, chromosome 17 at 26,280,056 bp
  • A to C, chromosome 18 at 37,402,084 bp
  • T to A, chromosome 18 at 42,214,837 bp
  • A to G, chromosome 18 at 59,176,488 bp
  • T to C, chromosome 18 at 63,019,344 bp
  • G to A, chromosome 19 at 3,921,271 bp
  • A to T, chromosome 19 at 29,743,598 bp
  • T to C, chromosome 19 at 57,386,305 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1868 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039890-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.