Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR1885Btlr/Mmmh
Stock Number:
039906-MU
Citation ID:
RRID:MMRRC_039906-MU
Other Names:
R1885 (G1), C57BL/6J-MtgxR1885Btlr
Major Collection:

Strain Information

Apobec3
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
Synonyms: Rfv-3, CEM15, Rfv3, Gm20117
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 80287
Homologene: 105420
Dap3
Name: death associated protein 3
Synonyms: 4921514D13Rik, DAP-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 65111
HGNC: HGNC:2673
Homologene: 3404
Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Trdmt1
Name: tRNA aspartic acid methyltransferase 1
Synonyms: Rnmt2, Dnmt2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13434
HGNC: HGNC:2977
Homologene: 3249
Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, sAC, 4930431D04Rik, Sacy
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271639
Homologene: 10188
Ncoa7
Name: nuclear receptor coactivator 7
Synonyms: 9030406N13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 211329
VEGA: 10
Homologene: 65245
Ap2b1
Name: adaptor-related protein complex 2, beta 1 subunit
Synonyms: 1300012O03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71770
HGNC: HGNC:563
Homologene: 137384
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 20,935,480 bp
  • A to G, chromosome 1 at 165,570,808 bp
  • T to G, chromosome 2 at 13,523,414 bp
  • T to A, chromosome 2 at 20,743,984 bp
  • T to C, chromosome 2 at 87,532,824 bp
  • T to C, chromosome 2 at 104,230,455 bp
  • G to T, chromosome 2 at 111,664,754 bp
  • T to G, chromosome 2 at 147,049,361 bp
  • A to T, chromosome 3 at 8,541,904 bp
  • C to T, chromosome 3 at 27,279,296 bp
  • A to G, chromosome 3 at 88,930,974 bp
  • A to C, chromosome 3 at 105,904,836 bp
  • T to C, chromosome 3 at 130,629,462 bp
  • A to T, chromosome 3 at 157,543,156 bp
  • A to T, chromosome 4 at 63,170,417 bp
  • C to T, chromosome 4 at 104,731,751 bp
  • A to C, chromosome 4 at 136,940,355 bp
  • G to A, chromosome 4 at 154,890,876 bp
  • T to C, chromosome 5 at 6,770,376 bp
  • A to T, chromosome 5 at 24,388,254 bp
  • A to G, chromosome 5 at 67,747,318 bp
  • A to G, chromosome 5 at 76,856,742 bp
  • C to T, chromosome 5 at 109,092,076 bp
  • A to G, chromosome 5 at 150,953,494 bp
  • T to C, chromosome 6 at 120,223,640 bp
  • G to A, chromosome 6 at 121,428,367 bp
  • G to T, chromosome 6 at 126,877,181 bp
  • A to T, chromosome 6 at 141,683,225 bp
  • T to C, chromosome 6 at 145,232,117 bp
  • A to T, chromosome 6 at 148,877,885 bp
  • T to C, chromosome 7 at 19,377,571 bp
  • T to C, chromosome 7 at 45,286,632 bp
  • G to A, chromosome 7 at 62,418,738 bp
  • T to C, chromosome 7 at 89,866,611 bp
  • G to A, chromosome 7 at 99,459,997 bp
  • A to T, chromosome 7 at 104,150,065 bp
  • A to G, chromosome 7 at 105,756,561 bp
  • A to G, chromosome 7 at 107,436,529 bp
  • T to C, chromosome 7 at 108,066,778 bp
  • A to T, chromosome 7 at 118,561,087 bp
  • A to G, chromosome 7 at 127,405,039 bp
  • T to G, chromosome 7 at 139,096,807 bp
  • T to A, chromosome 8 at 10,322,656 bp
  • A to T, chromosome 8 at 67,491,001 bp
  • T to C, chromosome 8 at 72,704,994 bp
  • A to G, chromosome 8 at 105,293,186 bp
  • A to G, chromosome 8 at 106,131,821 bp
  • T to C, chromosome 9 at 56,925,837 bp
  • A to G, chromosome 9 at 75,249,761 bp
  • T to A, chromosome 9 at 108,393,610 bp
  • C to A, chromosome 9 at 111,258,556 bp
  • T to C, chromosome 10 at 24,891,111 bp
  • T to C, chromosome 10 at 30,648,452 bp
  • A to G, chromosome 10 at 42,912,227 bp
  • C to T, chromosome 10 at 75,581,289 bp
  • G to A, chromosome 10 at 80,691,234 bp
  • T to C, chromosome 10 at 81,341,347 bp
  • A to G, chromosome 11 at 3,969,482 bp
  • T to C, chromosome 11 at 49,340,835 bp
  • A to G, chromosome 11 at 67,086,627 bp
  • C to T, chromosome 11 at 69,945,007 bp
  • C to A, chromosome 11 at 79,020,378 bp
  • T to C, chromosome 11 at 79,036,521 bp
  • T to A, chromosome 11 at 83,390,735 bp
  • C to A, chromosome 11 at 86,138,815 bp
  • T to A, chromosome 11 at 100,875,672 bp
  • T to C, chromosome 11 at 101,411,401 bp
  • T to C, chromosome 11 at 105,131,620 bp
  • T to A, chromosome 12 at 4,134,951 bp
  • C to A, chromosome 12 at 84,372,464 bp
  • G to T, chromosome 13 at 45,567,804 bp
  • T to G, chromosome 13 at 59,702,007 bp
  • A to T, chromosome 13 at 76,113,047 bp
  • A to G, chromosome 13 at 76,130,235 bp
  • C to T, chromosome 14 at 8,248,102 bp
  • A to C, chromosome 14 at 13,828,607 bp
  • T to A, chromosome 14 at 16,383,226 bp
  • T to C, chromosome 14 at 64,028,390 bp
  • G to T, chromosome 14 at 120,919,908 bp
  • A to G, chromosome 15 at 31,502,806 bp
  • G to T, chromosome 15 at 75,926,989 bp
  • A to T, chromosome 15 at 79,897,705 bp
  • A to G, chromosome 15 at 80,211,619 bp
  • A to G, chromosome 15 at 80,358,944 bp
  • A to G, chromosome 16 at 25,412,891 bp
  • A to C, chromosome 16 at 45,096,720 bp
  • T to C, chromosome 16 at 73,916,145 bp
  • ATCTTCT to ATCT, chromosome 17 at 23,359,988 bp
  • T to C, chromosome 17 at 46,262,421 bp
  • T to A, chromosome 17 at 64,138,914 bp
  • A to T, chromosome 17 at 78,932,116 bp
  • A to G, chromosome 17 at 86,805,295 bp
  • G to A, chromosome 18 at 24,601,482 bp
  • G to A, chromosome 19 at 11,752,324 bp
  • T to C, chromosome 19 at 56,860,252 bp
  • GTCATCATCATCATC to GTCATCATCATCATCATC, chromosome X at 6,082,591 bp
  • G to A, chromosome X at 73,795,446 bp
  • G to T, chromosome Y at 940,781 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1885 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039906-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.