Strain Name:
C57BL/6J-MtgxR1902Btlr/Mmmh
Stock Number:
039922-MU
Citation ID:
RRID:MMRRC_039922-MU
Other Names:
R1902 (G1), C57BL/6J-MtgxR1902Btlr
Major Collection:

Gene Information

Gene Symbol: Dct [MGI:102563] (Mus musculus (mouse))
Name: dopachrome tautomerase
Synonyms: tyrosinase-related protein-2, TRP-2, Tyrp2, Tyrp-2, TRP2
Chromosome: 14
Alteration at locus: Chemically Induced
Gene Symbol: Ncor1 [MGI:1349717] (Mus musculus (mouse))
Name: nuclear receptor co-repressor 1
Synonyms: Rxrip13, A230020K14Rik, N-CoR, 5730405M06Rik
Chromosome: 11
Alteration at locus: Chemically Induced
Gene Symbol: Arhgef7 [MGI:1860493] (Mus musculus (mouse))
Name: Rho guanine nucleotide exchange factor (GEF7)
Synonyms: cool-1, betaPix-b, Pak interacting exchange factor, betaPix, Cool, betaPix-c, PIX, p85SPR
Chromosome: 8
Alteration at locus: Chemically Induced
Gene Symbol: Gria2 [MGI:95809] (Mus musculus (mouse))
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: Glur-2, GluR2, GluR-B, GluA2, Glur2
Chromosome: 3
Alteration at locus: Chemically Induced
Gene Symbol: Ip6k1 [MGI:1351633] (Mus musculus (mouse))
Name: inositol hexaphosphate kinase 1
Synonyms: 1200016D08Rik, Ihpk1, InsP6k1, InsP6
Chromosome: 9
Alteration at locus: Chemically Induced
Gene Symbol: Macf1 [MGI:108559] (Mus musculus (mouse))
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Chromosome: 4
Alteration at locus: Chemically Induced
Gene Symbol: Mad1l1 [MGI:1341857] (Mus musculus (mouse))
Name: MAD1 mitotic arrest deficient 1-like 1
Synonyms: Mad1
Chromosome: 5
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 53,535,478 bp
  • T to G, chromosome 1 at 94,008,889 bp
  • T to G, chromosome 1 at 120,241,734 bp
  • T to G, chromosome 1 at 135,472,410 bp
  • T to A, chromosome 1 at 150,388,609 bp
  • T to C, chromosome 1 at 174,070,126 bp
  • T to C, chromosome 2 at 36,927,185 bp
  • T to C, chromosome 2 at 40,860,661 bp
  • T to A, chromosome 2 at 52,116,673 bp
  • T to G, chromosome 2 at 58,771,452 bp
  • T to C, chromosome 2 at 62,385,247 bp
  • T to C, chromosome 2 at 85,647,857 bp
  • A to T, chromosome 2 at 89,575,603 bp
  • T to C, chromosome 2 at 119,801,695 bp
  • T to C, chromosome 2 at 120,446,482 bp
  • G to A, chromosome 2 at 134,813,613 bp
  • A to T, chromosome 2 at 154,261,991 bp
  • A to G, chromosome 3 at 80,722,108 bp
  • A to T, chromosome 3 at 127,540,578 bp
  • T to C, chromosome 3 at 129,791,246 bp
  • A to G, chromosome 4 at 19,281,046 bp
  • A to T, chromosome 4 at 41,625,319 bp
  • T to C, chromosome 4 at 104,856,601 bp
  • A to G, chromosome 4 at 118,160,399 bp
  • T to C, chromosome 4 at 118,622,066 bp
  • T to A, chromosome 4 at 123,471,165 bp
  • T to C, chromosome 4 at 126,042,918 bp
  • T to C, chromosome 4 at 129,197,108 bp
  • A to T, chromosome 4 at 135,750,908 bp
  • T to C, chromosome 4 at 139,607,701 bp
  • G to A, chromosome 4 at 144,273,863 bp
  • T to C, chromosome 4 at 148,936,195 bp
  • T to A, chromosome 5 at 53,829,353 bp
  • C to T, chromosome 5 at 73,607,622 bp
  • T to C, chromosome 5 at 90,759,785 bp
  • A to C, chromosome 5 at 107,369,295 bp
  • A to T, chromosome 5 at 114,165,734 bp
  • A to G, chromosome 5 at 136,091,238 bp
  • A to G, chromosome 5 at 137,600,415 bp
  • A to G, chromosome 5 at 140,303,688 bp
  • T to G, chromosome 5 at 144,816,053 bp
  • T to A, chromosome 6 at 22,120,981 bp
  • T to C, chromosome 6 at 27,429,482 bp
  • T to A, chromosome 6 at 29,379,804 bp
  • T to A, chromosome 6 at 40,409,046 bp
  • T to C, chromosome 6 at 42,593,552 bp
  • T to A, chromosome 6 at 43,167,723 bp
  • A to C, chromosome 6 at 67,423,734 bp
  • T to C, chromosome 6 at 83,306,731 bp
  • A to G, chromosome 6 at 121,881,821 bp
  • A to T, chromosome 6 at 125,872,684 bp
  • T to C, chromosome 6 at 132,910,176 bp
  • C to A, chromosome 6 at 141,498,770 bp
  • T to A, chromosome 6 at 146,229,703 bp
  • T to C, chromosome 7 at 6,065,819 bp
  • A to T, chromosome 7 at 17,975,327 bp
  • T to A, chromosome 7 at 18,724,438 bp
  • C to T, chromosome 7 at 43,798,614 bp
  • A to C, chromosome 7 at 43,826,057 bp
  • T to C, chromosome 7 at 44,390,516 bp
  • T to C, chromosome 7 at 48,871,172 bp
  • T to C, chromosome 7 at 68,201,249 bp
  • C to T, chromosome 7 at 79,838,256 bp
  • T to C, chromosome 7 at 81,372,119 bp
  • C to T, chromosome 7 at 107,746,378 bp
  • G to T, chromosome 7 at 141,864,105 bp
  • T to C, chromosome 7 at 143,703,181 bp
  • C to A, chromosome 8 at 11,808,712 bp
  • C to A, chromosome 8 at 11,808,713 bp
  • T to A, chromosome 8 at 45,306,952 bp
  • T to C, chromosome 8 at 69,707,438 bp
  • A to G, chromosome 8 at 78,251,732 bp
  • T to C, chromosome 8 at 95,743,121 bp
  • T to C, chromosome 9 at 39,750,806 bp
  • G to A, chromosome 9 at 108,040,996 bp
  • T to A, chromosome 10 at 7,623,780 bp
  • C to A, chromosome 10 at 9,812,298 bp
  • T to C, chromosome 10 at 19,008,189 bp
  • C to A, chromosome 10 at 80,025,466 bp
  • G to T, chromosome 10 at 88,753,026 bp
  • A to G, chromosome 10 at 89,429,024 bp
  • A to G, chromosome 10 at 93,707,372 bp
  • A to G, chromosome 10 at 105,826,087 bp
  • T to A, chromosome 10 at 108,198,891 bp
  • A to G, chromosome 10 at 112,928,673 bp
  • G to T, chromosome 10 at 129,842,506 bp
  • G to T, chromosome 11 at 29,461,788 bp
  • T to C, chromosome 11 at 32,423,559 bp
  • A to T, chromosome 11 at 46,407,011 bp
  • G to A, chromosome 11 at 53,436,953 bp
  • G to A, chromosome 11 at 54,125,048 bp
  • A to C, chromosome 11 at 62,338,158 bp
  • T to C, chromosome 11 at 115,980,738 bp
  • A to T, chromosome 12 at 4,339,049 bp
  • C to T, chromosome 12 at 18,534,003 bp
  • T to C, chromosome 12 at 81,104,671 bp
  • T to G, chromosome 12 at 111,326,016 bp
  • G to T, chromosome 12 at 116,241,790 bp
  • A to C, chromosome 13 at 23,012,306 bp
  • A to T, chromosome 13 at 46,788,162 bp
  • A to T, chromosome 13 at 61,201,515 bp
  • C to G, chromosome 14 at 20,310,641 bp
  • T to A, chromosome 14 at 20,982,699 bp
  • T to C, chromosome 14 at 31,319,759 bp
  • T to C, chromosome 14 at 47,074,128 bp
  • T to A, chromosome 14 at 51,116,864 bp
  • T to G, chromosome 14 at 52,372,717 bp
  • T to A, chromosome 14 at 57,826,729 bp
  • C to T, chromosome 14 at 66,355,609 bp
  • T to C, chromosome 14 at 66,638,235 bp
  • T to C, chromosome 14 at 68,124,114 bp
  • T to C, chromosome 14 at 118,034,278 bp
  • G to T, chromosome 15 at 9,607,377 bp
  • T to C, chromosome 15 at 55,606,715 bp
  • T to A, chromosome 15 at 76,175,551 bp
  • C to A, chromosome 15 at 89,116,241 bp
  • A to T, chromosome 15 at 101,946,963 bp
  • C to A, chromosome 15 at 102,460,698 bp
  • T to C, chromosome 16 at 16,246,857 bp
  • T to A, chromosome 16 at 17,771,787 bp
  • G to T, chromosome 16 at 20,604,832 bp
  • C to T, chromosome 16 at 35,853,518 bp
  • A to C, chromosome 16 at 44,422,374 bp
  • A to T, chromosome 16 at 59,362,163 bp
  • A to G, chromosome 16 at 72,960,204 bp
  • A to G, chromosome 16 at 93,870,497 bp
  • C to T, chromosome 17 at 3,670,017 bp
  • T to A, chromosome 17 at 25,471,858 bp
  • A to T, chromosome 17 at 30,530,228 bp
  • A to T, chromosome 17 at 36,083,953 bp
  • T to A, chromosome 17 at 37,701,421 bp
  • A to T, chromosome 17 at 42,503,616 bp
  • T to C, chromosome 17 at 46,655,740 bp
  • A to G, chromosome 17 at 56,129,400 bp
  • G to A, chromosome 17 at 73,326,361 bp
  • A to T, chromosome 18 at 20,095,988 bp
  • A to T, chromosome 18 at 46,877,050 bp
  • A to G, chromosome 18 at 61,130,141 bp
  • G to A, chromosome 18 at 80,089,418 bp
  • G to T, chromosome 19 at 4,166,338 bp
  • A to G, chromosome 19 at 5,884,522 bp
  • G to T, chromosome 19 at 24,124,726 bp
  • T to A, chromosome 19 at 55,210,237 bp
  • T to C, chromosome X at 36,000,212 bp
  • G to A, chromosome X at 47,849,963 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1902 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039922-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.