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Strain Name:
C57BL/6J-MtgxR1924Btlr/Mmmh
Stock Number:
039942-MU
Citation ID:
RRID:MMRRC_039942-MU
Other Names:
R1924 (G1), C57BL/6J-MtgxR1924Btlr
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: dyn, SpbIV, neuroaxonal dystrophy, 5830426A08Rik, ROSA62, nmf261, 1700022P15Rik, Spnb4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Myo5a
Name: myosin VA
Synonyms: MVa, MyoVA, Myo5, flail, 9630007J19Rik, Dbv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Polr3e
Name: polymerase (RNA) III (DNA directed) polypeptide E
Synonyms: RPC5, Sin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26939
Homologene: 14052
Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Cdk17
Name: cyclin dependent kinase 17
Synonyms: 6430598J10Rik, Pctk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237459
VEGA: 10
HGNC: HGNC:8750
Homologene: 55666
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NMDAR-L, NR3A, A830097C19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 92,620,803 bp
  • C to A, chromosome 1 at 136,089,017 bp
  • T to A, chromosome 1 at 169,982,072 bp
  • A to G, chromosome 2 at 5,911,933 bp
  • A to T, chromosome 2 at 26,984,141 bp
  • T to A, chromosome 2 at 30,255,250 bp
  • T to A, chromosome 2 at 37,495,759 bp
  • A to G, chromosome 2 at 45,002,612 bp
  • T to A, chromosome 2 at 65,461,534 bp
  • T to C, chromosome 2 at 98,663,852 bp
  • A to G, chromosome 2 at 104,992,292 bp
  • T to G, chromosome 3 at 63,998,628 bp
  • A to T, chromosome 4 at 19,379,321 bp
  • A to G, chromosome 4 at 22,427,137 bp
  • A to G, chromosome 4 at 49,844,988 bp
  • A to G, chromosome 4 at 141,464,603 bp
  • A to G, chromosome 5 at 31,088,404 bp
  • A to T, chromosome 5 at 76,858,623 bp
  • G to A, chromosome 5 at 106,878,577 bp
  • A to G, chromosome 5 at 110,791,070 bp
  • G to A, chromosome 5 at 114,230,720 bp
  • A to G, chromosome 5 at 123,302,739 bp
  • T to C, chromosome 6 at 23,688,858 bp
  • A to T, chromosome 6 at 68,161,608 bp
  • T to C, chromosome 6 at 76,954,847 bp
  • C to T, chromosome 7 at 27,407,138 bp
  • T to A, chromosome 7 at 41,393,218 bp
  • A to G, chromosome 7 at 44,209,681 bp
  • T to C, chromosome 7 at 105,772,280 bp
  • A to G, chromosome 7 at 108,630,355 bp
  • T to A, chromosome 7 at 120,940,597 bp
  • G to A, chromosome 7 at 141,638,400 bp
  • A to G, chromosome 7 at 141,868,223 bp
  • T to A, chromosome 8 at 22,157,031 bp
  • C to G, chromosome 8 at 67,491,424 bp
  • G to A, chromosome 8 at 95,035,934 bp
  • A to G, chromosome 8 at 124,576,226 bp
  • T to A, chromosome 9 at 38,877,851 bp
  • A to T, chromosome 9 at 39,393,867 bp
  • T to A, chromosome 9 at 66,165,360 bp
  • G to T, chromosome 9 at 75,116,207 bp
  • T to A, chromosome 9 at 85,325,240 bp
  • T to C, chromosome 10 at 59,104,167 bp
  • T to A, chromosome 10 at 82,151,267 bp
  • T to C, chromosome 10 at 93,226,117 bp
  • A to G, chromosome 10 at 129,187,175 bp
  • A to G, chromosome 11 at 34,464,934 bp
  • G to T, chromosome 11 at 59,613,123 bp
  • A to G, chromosome 11 at 94,444,054 bp
  • A to C, chromosome 11 at 94,565,558 bp
  • CTAGTA to CTA, chromosome 11 at 99,333,526 bp
  • T to A, chromosome 11 at 108,942,968 bp
  • C to T, chromosome 11 at 113,656,212 bp
  • T to G, chromosome 12 at 9,579,268 bp
  • A to G, chromosome 13 at 33,253,445 bp
  • A to C, chromosome 13 at 97,936,816 bp
  • A to T, chromosome 14 at 43,922,900 bp
  • C to A, chromosome 14 at 64,031,543 bp
  • C to T, chromosome 14 at 70,164,779 bp
  • T to C, chromosome 15 at 12,160,629 bp
  • G to T, chromosome 15 at 80,884,206 bp
  • C to T, chromosome 15 at 98,209,990 bp
  • C to T, chromosome 15 at 102,108,934 bp
  • A to T, chromosome 17 at 3,519,671 bp
  • A to G, chromosome 17 at 34,729,657 bp
  • T to C, chromosome 19 at 5,990,056 bp
  • T to A, chromosome 19 at 41,302,614 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1924 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039942-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.