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Strain Name:
C57BL/6J-MtgxR1934Btlr/Mmmh
Stock Number:
039952-MU
Citation ID:
RRID:MMRRC_039952-MU
Other Names:
R1934 (G1), C57BL/6J-MtgxR1934Btlr
Major Collection:

Strain Information

Pax3
Name: paired box 3
Synonyms: Pax-3, Splchl2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18505
HGNC: HGNC:8617
Homologene: 22494
Arhgef7
Name: Rho guanine nucleotide exchange factor
Synonyms: Cool, PIX, Pak interacting exchange factor, p85SPR, betaPix-c, betaPix-b, cool-1, betaPix
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54126
Homologene: 2895
Atg7
Name: autophagy related 7
Synonyms: 1810013K23Rik, Apg7l
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74244
Homologene: 4662
Gli1
Name: GLI-Kruppel family member GLI1
Synonyms: Zfp-5, Zfp5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14632
VEGA: 10
HGNC: HGNC:4317
Homologene: 3859
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 58,245,936 bp
  • G to A, chromosome 1 at 78,103,480 bp
  • A to G, chromosome 1 at 123,445,330 bp
  • G to A, chromosome 1 at 135,449,064 bp
  • A to T, chromosome 1 at 151,804,283 bp
  • A to G, chromosome 1 at 161,063,241 bp
  • T to G, chromosome 1 at 181,099,128 bp
  • A to T, chromosome 2 at 27,089,593 bp
  • A to T, chromosome 2 at 32,687,981 bp
  • T to C, chromosome 2 at 60,669,149 bp
  • A to T, chromosome 2 at 71,522,583 bp
  • A to T, chromosome 2 at 76,747,040 bp
  • A to G, chromosome 2 at 82,980,558 bp
  • A to G, chromosome 2 at 91,480,432 bp
  • A to T, chromosome 2 at 91,937,104 bp
  • A to T, chromosome 2 at 105,001,279 bp
  • A to T, chromosome 2 at 120,318,077 bp
  • A to G, chromosome 2 at 131,179,264 bp
  • A to G, chromosome 2 at 167,065,849 bp
  • G to A, chromosome 2 at 180,607,134 bp
  • G to A, chromosome 3 at 88,629,791 bp
  • A to G, chromosome 3 at 97,692,691 bp
  • T to A, chromosome 3 at 103,056,481 bp
  • T to A, chromosome 4 at 62,415,266 bp
  • C to T, chromosome 4 at 65,435,189 bp
  • A to T, chromosome 5 at 18,019,510 bp
  • T to A, chromosome 5 at 100,661,865 bp
  • G to A, chromosome 5 at 114,198,282 bp
  • G to T, chromosome 5 at 134,390,945 bp
  • A to T, chromosome 6 at 77,244,966 bp
  • G to T, chromosome 6 at 82,930,927 bp
  • T to A, chromosome 6 at 88,093,859 bp
  • A to G, chromosome 6 at 92,943,121 bp
  • T to A, chromosome 6 at 114,701,235 bp
  • T to C, chromosome 6 at 121,649,833 bp
  • T to C, chromosome 6 at 146,561,726 bp
  • A to G, chromosome 7 at 24,405,961 bp
  • G to A, chromosome 7 at 28,107,093 bp
  • C to T, chromosome 7 at 45,856,827 bp
  • T to C, chromosome 7 at 66,172,243 bp
  • T to C, chromosome 7 at 79,711,538 bp
  • T to A, chromosome 7 at 80,320,524 bp
  • T to G, chromosome 7 at 105,708,582 bp
  • A to G, chromosome 7 at 110,122,491 bp
  • T to C, chromosome 7 at 118,876,379 bp
  • A to G, chromosome 7 at 127,712,764 bp
  • T to C, chromosome 7 at 127,886,748 bp
  • C to A, chromosome 7 at 140,668,038 bp
  • A to T, chromosome 7 at 141,199,852 bp
  • A to T, chromosome 7 at 144,505,110 bp
  • T to C, chromosome 8 at 11,505,424 bp
  • C to A, chromosome 8 at 11,808,712 bp
  • C to A, chromosome 8 at 11,808,713 bp
  • A to G, chromosome 8 at 35,591,097 bp
  • A to T, chromosome 8 at 40,754,885 bp
  • A to G, chromosome 8 at 45,943,250 bp
  • G to T, chromosome 8 at 55,940,907 bp
  • G to A, chromosome 8 at 66,512,347 bp
  • A to G, chromosome 8 at 70,056,575 bp
  • A to G, chromosome 8 at 72,255,793 bp
  • A to G, chromosome 8 at 77,689,118 bp
  • A to T, chromosome 8 at 85,670,404 bp
  • T to C, chromosome 8 at 88,663,719 bp
  • T to A, chromosome 8 at 94,345,762 bp
  • A to G, chromosome 8 at 104,617,963 bp
  • G to A, chromosome 8 at 104,619,063 bp
  • A to G, chromosome 8 at 110,637,040 bp
  • T to C, chromosome 9 at 7,854,499 bp
  • T to C, chromosome 9 at 15,720,789 bp
  • A to G, chromosome 9 at 21,034,786 bp
  • A to T, chromosome 9 at 41,581,262 bp
  • T to C, chromosome 9 at 59,394,932 bp
  • T to A, chromosome 9 at 62,744,514 bp
  • T to C, chromosome 9 at 67,963,039 bp
  • C to T, chromosome 9 at 75,267,022 bp
  • A to G, chromosome 9 at 78,095,137 bp
  • G to A, chromosome 9 at 79,604,522 bp
  • C to T, chromosome 9 at 82,903,182 bp
  • G to T, chromosome 9 at 89,953,913 bp
  • A to T, chromosome 10 at 76,081,473 bp
  • A to C, chromosome 10 at 77,112,744 bp
  • A to G, chromosome 10 at 79,247,794 bp
  • T to C, chromosome 10 at 117,078,901 bp
  • A to T, chromosome 10 at 127,331,239 bp
  • T to A, chromosome 11 at 5,061,408 bp
  • A to T, chromosome 11 at 16,409,734 bp
  • T to A, chromosome 11 at 41,920,470 bp
  • A to G, chromosome 11 at 70,724,137 bp
  • A to G, chromosome 11 at 110,210,083 bp
  • T to C, chromosome 11 at 115,863,484 bp
  • T to G, chromosome 12 at 69,648,541 bp
  • T to C, chromosome 12 at 84,106,593 bp
  • T to C, chromosome 12 at 91,537,181 bp
  • A to G, chromosome 12 at 118,907,500 bp
  • T to A, chromosome 13 at 34,910,881 bp
  • A to T, chromosome 13 at 49,615,722 bp
  • T to A, chromosome 13 at 49,901,435 bp
  • T to C, chromosome 13 at 65,297,151 bp
  • T to A, chromosome 13 at 89,702,926 bp
  • A to T, chromosome 13 at 91,983,706 bp
  • T to C, chromosome 13 at 104,631,676 bp
  • T to C, chromosome 14 at 40,934,252 bp
  • A to G, chromosome 14 at 50,956,218 bp
  • T to A, chromosome 14 at 51,711,939 bp
  • A to T, chromosome 14 at 52,114,644 bp
  • A to T, chromosome 14 at 59,589,860 bp
  • T to C, chromosome 15 at 6,765,130 bp
  • C to T, chromosome 17 at 12,876,951 bp
  • A to G, chromosome 17 at 16,973,431 bp
  • A to G, chromosome 17 at 20,182,890 bp
  • A to G, chromosome 17 at 22,373,652 bp
  • A to T, chromosome 17 at 25,824,266 bp
  • T to C, chromosome 17 at 32,906,315 bp
  • A to T, chromosome 17 at 37,086,014 bp
  • T to C, chromosome 17 at 78,795,918 bp
  • A to G, chromosome 17 at 86,102,893 bp
  • A to G, chromosome 18 at 20,395,906 bp
  • A to T, chromosome 18 at 25,090,278 bp
  • A to G, chromosome 18 at 34,813,544 bp
  • T to G, chromosome 18 at 61,523,943 bp
  • A to T, chromosome 18 at 65,685,611 bp
  • A to G, chromosome 19 at 5,953,741 bp
  • A to G, chromosome 19 at 6,964,609 bp
  • A to T, chromosome 19 at 40,382,511 bp
  • C to A, chromosome X at 163,549,141 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1934 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039952-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.