Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR1978Btlr/Mmmh
Stock Number:
039991-MU
Citation ID:
RRID:MMRRC_039991-MU
Other Names:
R1978 (G1), C57BL/6J-MtgxR1978Btlr
Major Collection:

Strain Information

Smyd1
Name: SET and MYND domain containing 1
Synonyms: Bop, 4632404M21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12180
Homologene: 7645
Ncoa7
Name: nuclear receptor coactivator 7
Synonyms: 9030406N13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 211329
VEGA: 10
Homologene: 65245
Nln
Name: neurolysin (metallopeptidase M3 family)
Synonyms: 4930472G13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75805
VEGA: 13
Homologene: 69315
Trappc9
Name: trafficking protein particle complex 9
Synonyms: 4632408O18Rik, 2900005P22Rik, Nibp, TRS130, 1810044A24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Hnrnpll
Name: heterogeneous nuclear ribonucleoprotein L-like
Synonyms: 2510028H02Rik, 2810036L13Rik, Hnrpll
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72692
Homologene: 26701
Zc3h14
Name: zinc finger CCCH type containing 14
Synonyms: 1700016A15Rik, 1010001P15Rik, 2700069A02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75553
VEGA: 12
Homologene: 32605
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 18,128,665 bp
  • A to G, chromosome 1 at 91,320,169 bp
  • C to A, chromosome 1 at 92,511,777 bp
  • C to A, chromosome 1 at 134,196,996 bp
  • T to G, chromosome 1 at 150,419,907 bp
  • A to G, chromosome 1 at 153,133,597 bp
  • T to A, chromosome 1 at 174,431,091 bp
  • A to G, chromosome 1 at 192,717,107 bp
  • GCCACCA to GCCA, chromosome 2 at 52,110,324 bp
  • T to C, chromosome 2 at 52,287,345 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • C to T, chromosome 2 at 87,048,835 bp
  • G to T, chromosome 2 at 153,129,856 bp
  • A to G, chromosome 2 at 160,752,578 bp
  • T to A, chromosome 3 at 64,287,290 bp
  • T to C, chromosome 3 at 79,825,400 bp
  • T to C, chromosome 3 at 93,446,799 bp
  • CCAGGGCAG to CCAG, chromosome 3 at 152,335,304 bp
  • C to A, chromosome 4 at 58,097,292 bp
  • T to C, chromosome 4 at 81,378,481 bp
  • T to A, chromosome 4 at 103,270,764 bp
  • T to C, chromosome 4 at 107,904,567 bp
  • A to T, chromosome 4 at 115,438,145 bp
  • A to G, chromosome 4 at 118,593,132 bp
  • A to T, chromosome 4 at 118,934,184 bp
  • A to T, chromosome 4 at 119,247,976 bp
  • T to C, chromosome 5 at 14,713,795 bp
  • C to T, chromosome 5 at 62,882,250 bp
  • T to A, chromosome 5 at 63,898,537 bp
  • T to C, chromosome 5 at 72,165,499 bp
  • C to A, chromosome 5 at 143,563,127 bp
  • C to T, chromosome 6 at 31,490,530 bp
  • T to A, chromosome 6 at 57,159,509 bp
  • T to C, chromosome 6 at 58,009,126 bp
  • A to T, chromosome 6 at 71,312,719 bp
  • T to G, chromosome 6 at 73,121,970 bp
  • C to A, chromosome 6 at 83,763,203 bp
  • A to T, chromosome 6 at 121,332,373 bp
  • T to A, chromosome 6 at 149,326,432 bp
  • T to A, chromosome 7 at 3,305,346 bp
  • T to C, chromosome 7 at 30,754,988 bp
  • A to G, chromosome 7 at 42,613,841 bp
  • T to A, chromosome 7 at 104,164,741 bp
  • A to G, chromosome 7 at 120,758,954 bp
  • G to T, chromosome 7 at 122,999,488 bp
  • G to A, chromosome 8 at 46,562,653 bp
  • A to G, chromosome 8 at 71,644,980 bp
  • T to A, chromosome 9 at 61,394,633 bp
  • A to T, chromosome 9 at 80,228,925 bp
  • T to G, chromosome 9 at 100,888,086 bp
  • A to G, chromosome 9 at 108,114,549 bp
  • G to A, chromosome 9 at 119,780,795 bp
  • C to T, chromosome 9 at 120,018,591 bp
  • A to G, chromosome 10 at 4,313,855 bp
  • A to G, chromosome 10 at 30,691,299 bp
  • A to C, chromosome 10 at 70,559,761 bp
  • A to G, chromosome 10 at 78,879,280 bp
  • G to A, chromosome 11 at 3,502,150 bp
  • T to C, chromosome 11 at 6,520,829 bp
  • T to C, chromosome 11 at 17,204,519 bp
  • T to C, chromosome 11 at 82,956,616 bp
  • C to T, chromosome 12 at 4,194,314 bp
  • A to T, chromosome 12 at 51,939,658 bp
  • T to G, chromosome 12 at 98,763,922 bp
  • T to C, chromosome 13 at 23,791,098 bp
  • A to G, chromosome 13 at 46,848,391 bp
  • T to C, chromosome 13 at 76,134,815 bp
  • A to T, chromosome 13 at 104,036,995 bp
  • A to T, chromosome 15 at 73,000,025 bp
  • A to C, chromosome 15 at 77,423,339 bp
  • C to T, chromosome 15 at 95,632,353 bp
  • T to C, chromosome 15 at 103,010,007 bp
  • T to A, chromosome 16 at 11,367,724 bp
  • T to C, chromosome 16 at 57,189,351 bp
  • A to G, chromosome 17 at 12,906,505 bp
  • A to G, chromosome 17 at 27,029,543 bp
  • G to A, chromosome 17 at 33,939,077 bp
  • T to A, chromosome 17 at 35,622,965 bp
  • A to G, chromosome 17 at 80,044,518 bp
  • T to C, chromosome 18 at 67,803,158 bp
  • T to A, chromosome 18 at 77,321,642 bp
  • C to T, chromosome 19 at 4,107,973 bp
  • T to C, chromosome 19 at 12,036,341 bp
  • A to G, chromosome X at 8,204,301 bp
  • A to C, chromosome X at 36,432,128 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1978 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039991-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.