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Strain Name:
C57BL/6J-MtgxR1984Btlr/Mmmh
Stock Number:
039996-MU
Citation ID:
RRID:MMRRC_039996-MU
Other Names:
R1984 (G1), C57BL/6J-MtgxR1984Btlr
Major Collection:

Strain Information

Kcna6
Name: potassium voltage-gated channel, shaker-related, subfamily, member 6
Synonyms: Kv1.6, MK1.6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16494
HGNC: HGNC:6225
Homologene: 1684
Agap1
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Synonyms: Ggap1, Centg2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 347722
Homologene: 56689
Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: Hbp, 1200004O12Rik, 5730456G07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56324
Homologene: 68490
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF kappaB1, p50 subunit of NF kappaB, p50/p105, p50, nuclear factor kappaB p50, NF-kappaB, NF-kappaB p50
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: D1Ertd101e, 1110005P14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 5033407O22Rik, 4833414K03Rik, Ltpr7, CHAK1, CHAK, TRP-PLIK, 2310022G15Rik, LTRPC7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 58,153,061 bp
  • T to C, chromosome 1 at 89,766,323 bp
  • A to G, chromosome 1 at 93,431,118 bp
  • G to A, chromosome 1 at 130,882,531 bp
  • A to G, chromosome 1 at 135,962,044 bp
  • G to A, chromosome 1 at 136,147,546 bp
  • A to G, chromosome 1 at 171,461,870 bp
  • A to T, chromosome 2 at 24,648,986 bp
  • T to A, chromosome 2 at 32,749,244 bp
  • T to C, chromosome 2 at 52,709,626 bp
  • G to A, chromosome 2 at 101,886,331 bp
  • T to A, chromosome 2 at 126,323,008 bp
  • A to G, chromosome 2 at 126,799,245 bp
  • C to A, chromosome 2 at 128,669,688 bp
  • A to T, chromosome 2 at 140,148,886 bp
  • T to C, chromosome 3 at 40,760,401 bp
  • T to A, chromosome 3 at 73,701,826 bp
  • G to T, chromosome 3 at 73,701,827 bp
  • T to C, chromosome 3 at 97,213,734 bp
  • G to A, chromosome 3 at 135,615,349 bp
  • T to C, chromosome 4 at 14,708,669 bp
  • C to A, chromosome 4 at 41,497,501 bp
  • T to C, chromosome 4 at 134,057,455 bp
  • G to T, chromosome 4 at 154,267,667 bp
  • T to C, chromosome 4 at 156,199,793 bp
  • C to T, chromosome 5 at 90,474,708 bp
  • A to G, chromosome 5 at 106,880,555 bp
  • A to T, chromosome 5 at 106,898,576 bp
  • T to C, chromosome 5 at 114,124,054 bp
  • A to G, chromosome 5 at 135,011,388 bp
  • A to G, chromosome 5 at 136,990,853 bp
  • T to A, chromosome 6 at 67,490,668 bp
  • A to T, chromosome 6 at 120,198,639 bp
  • A to T, chromosome 6 at 124,347,819 bp
  • T to C, chromosome 6 at 126,738,510 bp
  • A to T, chromosome 6 at 128,326,806 bp
  • A to T, chromosome 7 at 15,555,210 bp
  • A to G, chromosome 7 at 16,811,877 bp
  • C to T, chromosome 7 at 27,523,995 bp
  • T to C, chromosome 7 at 44,639,022 bp
  • C to A, chromosome 7 at 105,751,698 bp
  • A to C, chromosome 7 at 122,127,080 bp
  • T to A, chromosome 8 at 53,513,534 bp
  • C to T, chromosome 8 at 70,724,542 bp
  • A to G, chromosome 9 at 59,737,438 bp
  • T to C, chromosome 9 at 71,253,052 bp
  • T to C, chromosome 9 at 108,534,047 bp
  • A to G, chromosome 9 at 120,572,187 bp
  • A to G, chromosome 10 at 3,958,181 bp
  • A to T, chromosome 10 at 51,481,735 bp
  • T to A, chromosome 10 at 58,235,963 bp
  • A to T, chromosome 10 at 79,867,460 bp
  • T to C, chromosome 10 at 92,714,160 bp
  • T to C, chromosome 10 at 99,014,492 bp
  • G to A, chromosome 10 at 109,770,184 bp
  • A to G, chromosome 11 at 109,977,841 bp
  • T to C, chromosome 12 at 64,474,683 bp
  • G to A, chromosome 13 at 21,180,929 bp
  • T to A, chromosome 13 at 81,523,749 bp
  • A to T, chromosome 14 at 26,429,781 bp
  • A to G, chromosome 14 at 31,150,648 bp
  • A to T, chromosome 14 at 50,425,391 bp
  • A to T, chromosome 15 at 31,469,646 bp
  • A to G, chromosome 15 at 66,682,842 bp
  • A to G, chromosome 17 at 6,045,689 bp
  • T to A, chromosome 17 at 24,216,317 bp
  • C to A, chromosome 17 at 24,216,318 bp
  • C to T, chromosome 17 at 87,719,296 bp
  • C to T, chromosome 18 at 84,559,773 bp
  • T to C, chromosome 18 at 89,560,110 bp
  • A to G, chromosome 19 at 25,121,181 bp
  • G to T, chromosome X at 73,127,655 bp
  • A to T, chromosome X at 118,427,993 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1984 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039996-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.