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Strain Name:
C57BL/6J-MtgxR1987Btlr/Mmmh
Stock Number:
039999-MU
Citation ID:
RRID:MMRRC_039999-MU
Other Names:
R1987 (G1), C57BL/6J-MtgxR1987Btlr
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: MAPKKKK5, GCKR, KHS, 4432415E19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199
Pcdh9
Name: protocadherin 9
Synonyms: C630029H24Rik, 1500001L12Rik, LOC382930, A730003J17Rik, C530050I23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Dgat2
Name: diacylglycerol O-acyltransferase 2
Synonyms: 0610010B06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67800
Homologene: 23580
Fzr1
Name: fizzy and cell division cycle 20 related 1
Synonyms: Fyr, Cdh1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56371
Homologene: 9444
Rorb
Name: RAR-related orphan receptor beta
Synonyms: RZR-beta, Nr1f2, Rorbeta, hstp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225998
Homologene: 38250
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,558,014 bp
  • T to C, chromosome 1 at 71,651,625 bp
  • G to T, chromosome 1 at 74,685,368 bp
  • A to C, chromosome 1 at 91,934,645 bp
  • T to C, chromosome 1 at 132,610,886 bp
  • T to A, chromosome 1 at 164,142,758 bp
  • T to C, chromosome 1 at 194,643,989 bp
  • A to T, chromosome 2 at 24,094,732 bp
  • C to A, chromosome 2 at 62,268,204 bp
  • T to A, chromosome 2 at 94,364,345 bp
  • T to A, chromosome 2 at 104,931,045 bp
  • A to G, chromosome 2 at 104,999,159 bp
  • T to C, chromosome 2 at 132,870,443 bp
  • G to T, chromosome 2 at 161,558,898 bp
  • A to G, chromosome 2 at 161,766,321 bp
  • C to T, chromosome 3 at 8,664,897 bp
  • T to A, chromosome 3 at 36,953,985 bp
  • A to T, chromosome 3 at 40,805,817 bp
  • G to A, chromosome 3 at 87,742,643 bp
  • A to G, chromosome 3 at 93,332,604 bp
  • A to G, chromosome 3 at 142,314,460 bp
  • T to A, chromosome 4 at 116,819,368 bp
  • A to T, chromosome 4 at 139,966,024 bp
  • A to G, chromosome 4 at 140,818,387 bp
  • A to G, chromosome 4 at 143,132,509 bp
  • G to A, chromosome 4 at 148,258,753 bp
  • T to C, chromosome 5 at 30,958,813 bp
  • T to C, chromosome 5 at 31,245,391 bp
  • A to G, chromosome 5 at 76,597,428 bp
  • T to A, chromosome 5 at 88,521,467 bp
  • A to T, chromosome 5 at 123,147,706 bp
  • T to C, chromosome 5 at 135,757,122 bp
  • T to A, chromosome 6 at 53,954,611 bp
  • T to C, chromosome 6 at 73,095,044 bp
  • T to C, chromosome 6 at 83,273,232 bp
  • T to A, chromosome 6 at 110,914,511 bp
  • C to T, chromosome 6 at 130,377,779 bp
  • A to G, chromosome 6 at 136,820,585 bp
  • T to C, chromosome 6 at 146,422,703 bp
  • A to G, chromosome 7 at 26,378,056 bp
  • A to C, chromosome 7 at 28,757,283 bp
  • A to C, chromosome 7 at 43,298,649 bp
  • A to T, chromosome 7 at 65,927,287 bp
  • A to G, chromosome 7 at 81,559,659 bp
  • A to C, chromosome 7 at 99,156,971 bp
  • A to G, chromosome 7 at 104,148,485 bp
  • G to C, chromosome 7 at 126,649,477 bp
  • A to G, chromosome 7 at 127,018,730 bp
  • T to C, chromosome 7 at 143,638,389 bp
  • A to T, chromosome 8 at 3,542,370 bp
  • A to G, chromosome 9 at 49,057,786 bp
  • A to G, chromosome 9 at 107,108,421 bp
  • A to G, chromosome 9 at 108,576,534 bp
  • A to G, chromosome 10 at 81,370,319 bp
  • C to T, chromosome 10 at 84,896,088 bp
  • G to T, chromosome 11 at 68,814,496 bp
  • A to T, chromosome 11 at 78,268,167 bp
  • A to T, chromosome 11 at 86,217,800 bp
  • C to T, chromosome 11 at 100,049,580 bp
  • G to A, chromosome 11 at 119,441,107 bp
  • A to T, chromosome 11 at 121,069,680 bp
  • T to A, chromosome 12 at 36,521,996 bp
  • T to C, chromosome 12 at 53,140,795 bp
  • T to G, chromosome 12 at 69,842,912 bp
  • T to C, chromosome 12 at 84,441,759 bp
  • T to A, chromosome 12 at 91,230,829 bp
  • T to A, chromosome 12 at 99,915,572 bp
  • A to G, chromosome 13 at 11,712,266 bp
  • C to A, chromosome 13 at 19,260,994 bp
  • T to C, chromosome 13 at 33,029,559 bp
  • T to A, chromosome 13 at 55,412,155 bp
  • T to C, chromosome 13 at 68,585,241 bp
  • T to C, chromosome 13 at 97,967,096 bp
  • T to C, chromosome 13 at 102,754,041 bp
  • T to C, chromosome 13 at 103,886,203 bp
  • A to G, chromosome 14 at 16,398,916 bp
  • T to C, chromosome 14 at 45,380,998 bp
  • G to A, chromosome 14 at 93,888,305 bp
  • A to C, chromosome 14 at 121,591,830 bp
  • T to C, chromosome 15 at 28,343,591 bp
  • A to C, chromosome 15 at 44,514,848 bp
  • T to C, chromosome 15 at 76,329,022 bp
  • C to A, chromosome 16 at 36,321,832 bp
  • G to A, chromosome 16 at 75,884,030 bp
  • T to A, chromosome 17 at 6,996,477 bp
  • T to A, chromosome 17 at 20,889,950 bp
  • A to G, chromosome 17 at 24,206,872 bp
  • G to T, chromosome 17 at 24,576,592 bp
  • T to C, chromosome 17 at 34,876,268 bp
  • A to G, chromosome 17 at 54,293,835 bp
  • T to C, chromosome 18 at 47,300,142 bp
  • G to A, chromosome 19 at 6,338,837 bp
  • A to T, chromosome 19 at 9,015,251 bp
  • A to T, chromosome 19 at 11,013,655 bp
  • A to C, chromosome 19 at 18,952,152 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1987 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039999-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.