Strain Name:
C57BL/6J-MtgxR2039Btlr/Mmmh
Stock Number:
040046-MU
Citation ID:
RRID:MMRRC_040046-MU
Other Names:
R2039 (G1), C57BL/6J-MtgxR2039Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Gap43
Name: growth associated protein 43
Synonyms: B-50, neuromodulin, GAP-43, Basp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14432
HGNC: HGNC:4140
Homologene: 1545
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: Cav3.2, alpha13.2, T-type Cav3.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Myo1e
Name: myosin IE
Synonyms: 2310020N23Rik, 9130023P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: hsp4, Hsp90, Hsp86-1, Hsp89, Hspca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Hira
Name: histone cell cycle regulator
Synonyms: Tuple1, D16Ertd95e, Gm15797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15260
HGNC: HGNC:4916
Homologene: 48172
Uhmk1
Name: U2AF homology motif (UHM) kinase 1
Synonyms: KIS, Kist, OTTMUSG00000021542, C820018A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16589
Homologene: 7801
Washc2
Name: WASH complex subunit 2`
Synonyms: C530005J20Rik, D6Wsu116e, Fam21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 28006
Homologene: 41686
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: U5-200KD, HELIC2, A330064G03Rik, Ascc3l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320632
Homologene: 5859
Wdr48
Name: WD repeat domain 48
Synonyms: 8430408H12Rik, Uaf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67561
VEGA: 9
Homologene: 10830
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: Tweek, FSA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Msr1
Name: macrophage scavenger receptor 1
Synonyms: SR-AII, SR-AI, MSR-A, Scara1, Scvr, MRS-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20288
HGNC: HGNC:7376
Homologene: 12822
Arntl
Name: aryl hydrocarbon receptor nuclear translocator-like
Synonyms: Arnt3, MOP3, Bmal1, bHLHe5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11865
HGNC: HGNC:701
Homologene: 910
St7
Name: suppression of tumorigenicity 7
Synonyms: RAY1, HELG, SEN4, TSG7, Fam4a2, 9430001H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 64213
Homologene: 10185
Eef1d
Name: eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Synonyms: 5730529A16Rik, 1700026P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66656
HGNC: HGNC:3211
Homologene: 23404
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268878
Homologene: 77451
Cuzd1
Name: CUB and zona pellucida-like domains 1
Synonyms: UTCZP, Itmap1, UO-44, ERG-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16433
Homologene: 7389
Septin9
Name: septin 9
Synonyms: SL3-3 integration site 1, Sint1, Msf, MSF1, PNUTL4, Sept9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53860
HGNC: HGNC:7323
Homologene: 90949
Rsrc1
Name: arginine/serine-rich coiled-coil 1
Synonyms: SRrp53, 1200013F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66880
Homologene: 41147
Edrf1
Name: erythroid differentiation regulatory factor 1
Synonyms: 2700050L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 214764
Homologene: 27985
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216345
Homologene: 17017
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fsd1l
Name: fibronectin type III and SPRY domain containing 1-like
Synonyms: A230072O16Rik, Csdufd1, Ccdc10, Fsd1nl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 319636
Homologene: 45825
Gm5114
Name: predicted gene 5114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330513
Homologene: 45597
Exoc3
Name: exocyst complex component 3
Synonyms: E430013E20Rik, Sec6l1, 2810050O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 211446
VEGA: 13
Homologene: 38296
Esyt1
Name: extended synaptotagmin-like protein 1
Synonyms: vp115, Mbc2, Fam62a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 23943
VEGA: 10
Homologene: 40794
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Efna5
Name: ephrin A5
Synonyms: AL-1, RAGS, Ephrin-A5, Epl7, EFL-5, LERK-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13640
HGNC: HGNC:3225
Homologene: 1482
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Olfr677
Name: olfactory receptor 677
Synonyms: GA_x6K02T2PBJ9-7685262-7686200, MOR32-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258355
Homologene: 81596
Tas2r126
Name: taste receptor, type 2, member 126
Synonyms: Tas2r26, mGR26, T2R12, mt2r35, T2R26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387353
Homologene: 16412
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
4932415D10Rik
Name: RIKEN cDNA 4932415D10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Abca5
Name: ATP-binding cassette, sub-family A (ABC1), member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Fut1
Name: fucosyltransferase 1
Synonyms: H transferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14343
HGNC: HGNC:4012
Homologene: 120
Abca14
Name: ATP-binding cassette, sub-family A (ABC1), member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67928
Homologene: 86128
Rbak
Name: RB-associated KRAB zinc finger
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57782
Homologene: 23287
Sqor
Name: sulfide quinone oxidoreductase
Synonyms: flavo-binding protein, 4930557M22Rik, 0610039J17Rik, Sqrdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 59010
Homologene: 10921
Lman2l
Name: lectin, mannose-binding 2-like
Synonyms: VIP36-like, A630028F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214895
Homologene: 57125
Gm12789
Name: predicted gene 12789
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381536
Hhla1
Name: HERV-H LTR-associating 1
Synonyms: F930104E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 654498
HGNC: HGNC:4904
Homologene: 129987
Far2
Name: fatty acyl CoA reductase 2
Synonyms: Mlstd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330450
Homologene: 69247
Lrfn5
Name: leucine rich repeat and fibronectin type III domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238205
Homologene: 17582
Ugt1a10
Name: UDP glycosyltransferase 1 family, polypeptide A10
Synonyms: A13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 394430
Homologene: 133281
Npy6r
Name: neuropeptide Y receptor Y6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18169
VEGA: 18
HGNC: HGNC:7959
Homologene: 134692
Tafa1
Name: TAFA chemokine like family member 1
Synonyms: Tafa-1, C630007B19Rik, Fam19a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320265
Homologene: 45655
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,428,454 bp
  • T to G, chromosome 1 at 88,055,981 bp
  • T to C, chromosome 1 at 170,212,267 bp
  • T to C, chromosome 2 at 20,785,228 bp
  • T to G, chromosome 2 at 76,868,466 bp
  • G to A, chromosome 2 at 122,792,404 bp
  • G to A, chromosome 2 at 127,234,984 bp
  • T to A, chromosome 3 at 37,003,878 bp
  • A to G, chromosome 3 at 66,994,618 bp
  • T to A, chromosome 4 at 53,679,972 bp
  • T to C, chromosome 4 at 101,988,986 bp
  • A to G, chromosome 5 at 25,329,040 bp
  • C to A, chromosome 5 at 143,173,175 bp
  • G to A, chromosome 6 at 12,408,923 bp
  • T to C, chromosome 6 at 17,886,112 bp
  • T to A, chromosome 6 at 42,434,623 bp
  • C to A, chromosome 6 at 96,654,764 bp
  • T to A, chromosome 6 at 116,224,439 bp
  • C to A, chromosome 6 at 121,659,949 bp
  • T to C, chromosome 6 at 148,165,577 bp
  • T to A, chromosome 7 at 39,409,188 bp
  • C to T, chromosome 7 at 45,618,991 bp
  • T to C, chromosome 7 at 105,056,390 bp
  • T to G, chromosome 7 at 113,285,112 bp
  • T to C, chromosome 7 at 120,312,264 bp
  • T to C, chromosome 7 at 131,309,616 bp
  • A to T, chromosome 7 at 131,314,914 bp
  • T to A, chromosome 7 at 133,653,949 bp
  • A to T, chromosome 8 at 39,589,377 bp
  • T to C, chromosome 9 at 70,320,133 bp
  • T to A, chromosome 9 at 119,909,387 bp
  • A to G, chromosome 10 at 39,824,444 bp
  • A to G, chromosome 10 at 82,284,676 bp
  • A to G, chromosome 10 at 115,406,483 bp
  • C to T, chromosome 10 at 128,511,951 bp
  • A to G, chromosome 11 at 110,299,929 bp
  • G to A, chromosome 11 at 117,351,617 bp
  • T to C, chromosome 12 at 61,840,323 bp
  • T to C, chromosome 12 at 110,693,782 bp
  • A to G, chromosome 13 at 74,192,977 bp
  • G to A, chromosome 15 at 65,936,377 bp
  • T to C, chromosome 15 at 75,895,769 bp
  • A to G, chromosome 16 at 18,951,701 bp
  • G to A, chromosome 16 at 29,277,743 bp
  • A to T, chromosome 16 at 42,292,352 bp
  • T to C, chromosome 17 at 25,391,845 bp
  • T to G, chromosome 17 at 62,881,066 bp
  • A to G, chromosome 18 at 44,276,003 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2039 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040046-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.