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Strain Name:
C57BL/6J-MtgxR2039Btlr/Mmmh
Stock Number:
040046-MU
Citation ID:
RRID:MMRRC_040046-MU
Other Names:
R2039 (G1), C57BL/6J-MtgxR2039Btlr
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Gap43
Name: growth associated protein 43
Synonyms: B-50, neuromodulin, GAP-43, Basp2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14432
HGNC: HGNC:4140
Homologene: 1545
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Myo1e
Name: myosin IE
Synonyms: 2310020N23Rik, 9130023P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: hsp4, Hsp90, Hsp86-1, Hsp89, Hspca
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15519
Homologene: 68464
Hira
Name: histone cell cycle regulator
Synonyms: Tuple1, D16Ertd95e, Gm15797
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15260
HGNC: HGNC:4916
Homologene: 48172
Uhmk1
Name: U2AF homology motif (UHM) kinase 1
Synonyms: KIS, Kist, OTTMUSG00000021542, C820018A03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16589
Homologene: 7801
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,428,454 bp
  • T to G, chromosome 1 at 88,055,981 bp
  • T to C, chromosome 1 at 170,212,267 bp
  • T to C, chromosome 2 at 20,785,228 bp
  • T to G, chromosome 2 at 76,868,466 bp
  • G to A, chromosome 2 at 122,792,404 bp
  • G to A, chromosome 2 at 127,234,984 bp
  • T to A, chromosome 3 at 37,003,878 bp
  • A to G, chromosome 3 at 66,994,618 bp
  • T to A, chromosome 4 at 53,679,972 bp
  • T to C, chromosome 4 at 101,988,986 bp
  • A to G, chromosome 5 at 25,329,040 bp
  • C to A, chromosome 5 at 143,173,175 bp
  • G to A, chromosome 6 at 12,408,923 bp
  • T to C, chromosome 6 at 17,886,112 bp
  • T to A, chromosome 6 at 42,434,623 bp
  • C to A, chromosome 6 at 96,654,764 bp
  • T to A, chromosome 6 at 116,224,439 bp
  • C to A, chromosome 6 at 121,659,949 bp
  • T to C, chromosome 6 at 148,165,577 bp
  • T to A, chromosome 7 at 39,409,188 bp
  • C to T, chromosome 7 at 45,618,991 bp
  • T to C, chromosome 7 at 105,056,390 bp
  • T to G, chromosome 7 at 113,285,112 bp
  • T to C, chromosome 7 at 120,312,264 bp
  • T to C, chromosome 7 at 131,309,616 bp
  • A to T, chromosome 7 at 131,314,914 bp
  • T to A, chromosome 7 at 133,653,949 bp
  • A to T, chromosome 8 at 39,589,377 bp
  • T to C, chromosome 9 at 70,320,133 bp
  • T to A, chromosome 9 at 119,909,387 bp
  • A to G, chromosome 10 at 39,824,444 bp
  • A to G, chromosome 10 at 82,284,676 bp
  • A to G, chromosome 10 at 115,406,483 bp
  • C to T, chromosome 10 at 128,511,951 bp
  • A to G, chromosome 11 at 110,299,929 bp
  • G to A, chromosome 11 at 117,351,617 bp
  • T to C, chromosome 12 at 61,840,323 bp
  • T to C, chromosome 12 at 110,693,782 bp
  • A to G, chromosome 13 at 74,192,977 bp
  • G to A, chromosome 15 at 65,936,377 bp
  • T to C, chromosome 15 at 75,895,769 bp
  • A to G, chromosome 16 at 18,951,701 bp
  • G to A, chromosome 16 at 29,277,743 bp
  • A to T, chromosome 16 at 42,292,352 bp
  • T to C, chromosome 17 at 25,391,845 bp
  • T to G, chromosome 17 at 62,881,066 bp
  • A to G, chromosome 18 at 44,276,003 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2039 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040046-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.