Strain Name:
C57BL/6J-MtgxR2047Btlr/Mmmh
Stock Number:
040054-MU
Citation ID:
RRID:MMRRC_040054-MU
Other Names:
R2047 (G1), C57BL/6J-MtgxR2047Btlr
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20742
Homologene: 2354
Eno2
Name: enolase 2, gamma neuronal
Synonyms: Eno-2, D6Ertd375e, NSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13807
HGNC: HGNC:3353
Homologene: 74414
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 22359
Homologene: 443
Epb41l4a
Name: erythrocyte membrane protein band 4.1 like 4a
Synonyms: NBL4, Epb4.1l4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13824
VEGA: 18
Homologene: 8398
Drd5
Name: dopamine receptor D5
Synonyms: DRD1b, Drd-5, Gpcr1, Drd1b, D5R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13492
HGNC: HGNC:3026
Homologene: 20216
Zfp619
Name: zinc finger protein 619
Synonyms: 3000002G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70227
Homologene: 133818
Ptpn6
Name: protein tyrosine phosphatase, non-receptor type 6
Synonyms: SHP-1, Ptp1C, hcp, Hcph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15170
HGNC: HGNC:9658
Homologene: 56589
Arl5a
Name: ADP-ribosylation factor-like 5A
Synonyms: 2410015N24Rik, 2810410P22Rik, Arl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75423
HGNC: HGNC:696
Homologene: 100572
Ei24
Name: etoposide induced 2.4 mRNA
Synonyms: PIG8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13663
Homologene: 3588
Cramp1
Name: cramped chromatin regulator 1
Synonyms: 5830477H08Rik, Tce4, Cramp1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Sqle
Name: squalene epoxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20775
Homologene: 2355
Ube2d3
Name: ubiquitin-conjugating enzyme E2D 3
Synonyms: 9430029A22Rik, 1100001F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66105
Homologene: 123914
Ccdc47
Name: coiled-coil domain containing 47
Synonyms: asp4, 2610204L23Rik, calumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67163
Homologene: 41351
Rnf6
Name: ring finger protein (C3H2C3 type) 6
Synonyms: 5730419H05Rik, 1200013I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74132
Homologene: 14036
Ckap2
Name: cytoskeleton associated protein 2
Synonyms: LB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 80986
HGNC: HGNC:1990
Homologene: 10070
Sppl2a
Name: signal peptide peptidase like 2A
Synonyms: C130089K23Rik, 2010106G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66552
Homologene: 36411
Tub
Name: tubby bipartite transcription factor
Synonyms: rd5, tub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22141
Homologene: 31147
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Slc35f4
Name: solute carrier family 35, member F4
Synonyms: 4930550L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75288
Homologene: 45939
C7
Name: complement component 7
Synonyms: LOC383055
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109828
VEGA: 15
HGNC: HGNC:1346
Homologene: 489
Asns
Name: asparagine synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27053
HGNC: HGNC:753
Homologene: 69113
Npas3
Name: neuronal PAS domain protein 3
Synonyms: 4930423H22Rik, bHLHe12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27386
VEGA: 12
Homologene: 8461
Nrp1
Name: neuropilin 1
Synonyms: Neuropilin-1, NP-1, NPN-1, Npn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Adcy5
Name: adenylate cyclase 5
Synonyms: AC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224129
VEGA: 16
HGNC: HGNC:236
Homologene: 11213
Kcnj16
Name: potassium inwardly-rectifying channel, subfamily J, member 16
Synonyms: Kir5.1, 6430410F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16517
HGNC: HGNC:6262
Homologene: 23112
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Slc25a39
Name: solute carrier family 25, member 39
Synonyms: 3010027G13Rik, D11Ertd333e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68066
Homologene: 69200
Acot12
Name: acyl-CoA thioesterase 12
Synonyms: 1300004O04Rik, 4930449F15Rik, Cach
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74156
Homologene: 12540
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: PAG1, IGFBP-4ase, PAPP-A, 8430414N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Vmn2r56
Name: vomeronasal 2, receptor 56
Synonyms: EG629079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 629079
Homologene: 104040
Mthfs
Name: 5, 10-methenyltetrahydrofolate synthetase
Synonyms: 1110034I12Rik, 2310020H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 107885
Homologene: 4702
Ivns1abp
Name: influenza virus NS1A binding protein
Synonyms: Nd1-S, Nd1-L, NS-1, ND1, HSPC068, NS1-BP, 1190004M08Rik, 1700126I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 117198
Homologene: 31384
Gp6
Name: glycoprotein 6 (platelet)
Synonyms: Gpvi, 9830166G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243816
Homologene: 9488
Lpcat4
Name: lysophosphatidylcholine acyltransferase 4
Synonyms: Aytl3, Agpat7, LPEAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99010
Homologene: 27544
F13b
Name: coagulation factor XIII, beta subunit
Synonyms: Cf-13b, Cf13b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14060
HGNC: HGNC:3534
Homologene: 1512
Or5d37
Name: olfactory receptor family 5 subfamily D member 37
Synonyms: GA_x6K02T2Q125-49585842-49584862, MOR174-11, Olfr1164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258634
Homologene: 74077
Zfp777
Name: zinc finger protein 777
Synonyms: 2500002G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72306
Homologene: 56721
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216188
Homologene: 51942
Ttbk2
Name: tau tubulin kinase 2
Synonyms: TTK, B930008N24Rik, 2610507N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140810
Homologene: 62795
Pycr1
Name: pyrroline-5-carboxylate reductase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 209027
HGNC: HGNC:9721
Homologene: 56002
4933402N03Rik
Name: RIKEN cDNA 4933402N03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233918
Homologene: 52852
Or13g1
Name: olfactory receptor family 13 subfamily G member 1
Synonyms: GA_x6K02T2NHDJ-9801340-9802266, MOR251-4P, Olfr309
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258196
Homologene: 47595
Dgki
Name: diacylglycerol kinase, iota
Synonyms: C130010K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320127
HGNC: HGNC:2855
Homologene: 37956
Mrgpra2b
Name: MAS-related GPR, member A2B
Synonyms: MrgA2, Mrgpra2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 235712
Homologene: 79615
Lrrc14b
Name: leucine rich repeat containing 14B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 432779
Homologene: 47758
Ocln
Name: occludin
Synonyms: Ocl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18260
HGNC: HGNC:8104
Homologene: 1905
Vmn1r54
Name: vomeronasal 1 receptor 54
Synonyms: VN7, V1ra9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113851
Mrpl46
Name: mitochondrial ribosomal protein L46
Synonyms: P2ECSL, LIECG2, 3110052F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67308
HGNC: HGNC:1192
Homologene: 6747
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433586
Homologene: 41284
H2-Q7
Name: histocompatibility 2, Q region locus 7
Synonyms: H-2Q7, Qa-7, Qa7, Ped
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15018
Homologene: 128352
Ccdc121rt2
Name: coiled-coil domain containing 121, retrogene 2
Synonyms: Gm6588
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 625464
Homologene: 116059
Terb1
Name: telomere repeat binding bouquet formation protein 1
Synonyms: 4930532D21Rik, Ccdc79
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320022
Homologene: 18330
Apol7e
Name: apolipoprotein L 7e
Synonyms: ENSMUSG00000071716
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666348
VEGA: 15
Homologene: 40940
Zfp358
Name: zinc finger protein 358
Synonyms: Zfend
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 140482
Homologene: 9996
Ccr4
Name: chemokine (C-C motif) receptor 4
Synonyms: CC CKR-4, Cmkbr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12773
VEGA: 9
HGNC: HGNC:1605
Homologene: 21135
Cacng2
Name: calcium channel, voltage-dependent, gamma subunit 2
Synonyms: stargazin, B230105C07Rik, B930041E13Rik, TARP gamma 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12300
HGNC: HGNC:1406
Homologene: 4432
Or10ad1c
Name: olfactory receptor family 10 subfamily AD member 1C
Synonyms: GA_x6K02T2NBG7-5568919-5569857, MOR286-3P, Olfr288
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 545140
Homologene: 128379
Nectin4
Name: nectin cell adhesion molecule 4
Synonyms: nectin 4, Prr4, 1200017F15Rik, Pvrl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71740
Homologene: 32744
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 139,508,223 bp
  • T to A, chromosome 1 at 151,351,631 bp
  • T to C, chromosome 1 at 171,385,152 bp
  • A to G, chromosome 2 at 52,412,060 bp
  • T to C, chromosome 2 at 76,907,535 bp
  • A to T, chromosome 2 at 88,093,893 bp
  • T to C, chromosome 2 at 112,244,797 bp
  • T to C, chromosome 2 at 120,748,916 bp
  • C to T, chromosome 2 at 126,926,852 bp
  • C to A, chromosome 3 at 51,690,445 bp
  • T to A, chromosome 3 at 135,465,206 bp
  • T to C, chromosome 4 at 65,231,141 bp
  • C to T, chromosome 5 at 38,320,336 bp
  • A to G, chromosome 5 at 112,450,709 bp
  • T to C, chromosome 5 at 146,211,864 bp
  • G to T, chromosome 6 at 7,680,093 bp
  • A to G, chromosome 6 at 36,913,646 bp
  • A to G, chromosome 6 at 48,044,346 bp
  • A to T, chromosome 6 at 90,269,988 bp
  • T to C, chromosome 6 at 124,721,789 bp
  • A to T, chromosome 6 at 124,767,696 bp
  • A to T, chromosome 7 at 4,373,271 bp
  • A to G, chromosome 7 at 12,732,991 bp
  • T to C, chromosome 7 at 39,537,638 bp
  • C to T, chromosome 7 at 47,464,160 bp
  • T to A, chromosome 7 at 78,781,564 bp
  • G to A, chromosome 7 at 86,306,804 bp
  • A to G, chromosome 7 at 109,026,732 bp
  • A to G, chromosome 7 at 131,146,107 bp
  • A to G, chromosome 8 at 3,495,934 bp
  • A to G, chromosome 8 at 22,168,747 bp
  • A to T, chromosome 8 at 104,485,462 bp
  • G to A, chromosome 8 at 128,498,096 bp
  • T to C, chromosome 9 at 36,780,163 bp
  • T to A, chromosome 9 at 89,215,303 bp
  • A to G, chromosome 9 at 114,492,565 bp
  • G to A, chromosome 10 at 83,506,743 bp
  • A to C, chromosome 11 at 30,138,360 bp
  • G to A, chromosome 11 at 102,405,831 bp
  • A to T, chromosome 11 at 106,203,525 bp
  • A to G, chromosome 11 at 111,025,120 bp
  • A to T, chromosome 11 at 120,641,686 bp
  • T to C, chromosome 12 at 54,068,829 bp
  • T to C, chromosome 13 at 74,363,442 bp
  • T to C, chromosome 13 at 91,783,003 bp
  • C to A, chromosome 13 at 100,535,124 bp
  • G to T, chromosome 14 at 49,303,572 bp
  • A to G, chromosome 15 at 5,045,661 bp
  • T to C, chromosome 15 at 59,326,058 bp
  • A to G, chromosome 15 at 77,717,610 bp
  • C to T, chromosome 15 at 78,118,837 bp
  • T to A, chromosome 15 at 98,187,039 bp
  • G to A, chromosome 16 at 35,290,108 bp
  • A to T, chromosome 17 at 25,003,215 bp
  • A to T, chromosome 17 at 35,440,147 bp
  • T to C, chromosome 18 at 33,828,206 bp
  • A to G, chromosome 19 at 9,014,300 bp
  • G to T, chromosome 19 at 27,234,838 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2047 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040054-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.