Strain Name:
C57BL/6J-MtgxR2077Btlr/Mmmh
Stock Number:
040082-MU
Citation ID:
RRID:MMRRC_040082-MU
Other Names:
R2077 (G1), C57BL/6J-MtgxR2077Btlr
Major Collection:

Gene Information

Itm2b
Name: integral membrane protein 2B
Synonyms: D14Sel6, Bri2, Bricd2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16432
VEGA: 14
HGNC: HGNC:6174
Homologene: 7388
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20564
Homologene: 2303
Cops3
Name: COP9 signalosome subunit 3
Synonyms: Sgn3, COP9 complex S3, Csn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26572
HGNC: HGNC:2239
Homologene: 2710
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Tnpo3
Name: transportin 3
Synonyms: 5730544L10Rik, C430013M08Rik, D6Ertd313e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320938
Homologene: 40848
Slc44a2
Name: solute carrier family 44, member 2
Synonyms: 1110028E10Rik, CTL2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68682
VEGA: 9
Homologene: 10711
Herc4
Name: hect domain and RLD 4
Synonyms: 4921531D01Rik, 1700056O17Rik, 9530080M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67345
VEGA: 10
Homologene: 56715
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: E130319N12Rik, 2810017C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215351
Homologene: 9196
Sik3
Name: SIK family kinase 3
Synonyms: 5730525O22Rik, 9030204A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70661
Homologene: 57023
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Tex2
Name: testis expressed gene 2
Synonyms: Taz4, Def-5, 4930568E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21763
Homologene: 32414
Fas
Name: Fas (TNF receptor superfamily member 6)
Synonyms: CD95, APO-1, TNFR6, Tnfrsf6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14102
VEGA: 19
Homologene: 27
Grb2
Name: growth factor receptor bound protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14784
HGNC: HGNC:4566
Homologene: 1576
Nbn
Name: nibrin
Synonyms: Nbs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27354
HGNC: HGNC:7652
Homologene: 1858
Rab3ip
Name: RAB3A interacting protein
Synonyms: Gtpat12, SSX2 interacting protein, Rabin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216363
VEGA: 10
Homologene: 32340
Crygd
Name: crystallin, gamma D
Synonyms: DGcry-1, Cryg-1, Aey4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12967
HGNC: HGNC:2411
Homologene: 36213
Scaf4
Name: SR-related CTD-associated factor 4
Synonyms: Sra4, Sfrs15, Srsf15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224432
VEGA: 16
Homologene: 16227
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Cdc25c
Name: cell division cycle 25C
Synonyms: Cdc25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12532
VEGA: 18
HGNC: HGNC:1727
Homologene: 1356
Ptprs
Name: protein tyrosine phosphatase, receptor type, S
Synonyms: PTP-NU3, PTPsigma, RPTPsigma, Ptpt9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Ext2
Name: exostosin glycosyltransferase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14043
HGNC: HGNC:3513
Homologene: 345
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Zbtb41
Name: zinc finger and BTB domain containing 41
Synonyms: 8430415N23Rik, 9830132G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226470
Homologene: 27795
Ccdc175
Name: coiled-coil domain containing 175
Synonyms: 4930403N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73936
VEGA: 12
Homologene: 79144
Galnt18
Name: polypeptide N-acetylgalactosaminyltransferase 18
Synonyms: 2900011G21Rik, Galntl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233733
Homologene: 18347
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Cdkl3
Name: cyclin-dependent kinase-like 3
Synonyms: B230379H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 213084
Homologene: 49467
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: t2md1, LLGL4, A830015P08Rik, insulin level locus 1, tomosyn-2, T2dm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207227
Homologene: 18173
Nlrc3
Name: NLR family, CARD domain containing 3
Synonyms: D230007K08Rik, Caterpiller 16.2, CLR16.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268857
Homologene: 18720
Megf8
Name: multiple EGF-like-domains 8
Synonyms: Egfl4, b2b288Clo, b2b1702Clo, m687Ddg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Wipi1
Name: WD repeat domain, phosphoinositide interacting 1
Synonyms: 4930533H01Rik, D11Ertd498e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52639
Homologene: 117983
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mdga2, 9330209L04Rik, 6720489L24Rik, Mamdc1, Adp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320772
Homologene: 45659
Tmem184c
Name: transmembrane protein 184C
Synonyms: 8430433H16Rik, Tmem34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234463
Homologene: 32403
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: B0AT1, 4632401C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74338
Homologene: 52819
Plcl2
Name: phospholipase C-like 2
Synonyms: Plce2, PRIP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224860
VEGA: 17
HGNC: HGNC:9064
Homologene: 9052
Shpk
Name: sedoheptulokinase
Synonyms: 4930431K22Rik, Carkl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74637
HGNC: HGNC:1492
Homologene: 8319
Acp7
Name: acid phosphatase 7, tartrate resistant
Synonyms: C330005M16Rik, Papl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101744
Homologene: 23924
Olfr1131
Name: olfactory receptor 1131
Synonyms: GA_x6K02T2Q125-49133664-49134593, MOR177-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258652
Homologene: 133019
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Intin3, Itih-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243628
Homologene: 135915
Arhgap25
Name: Rho GTPase activating protein 25
Synonyms: A130039I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232201
Homologene: 45507
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, potassium channel Kv4.3L, Kv4.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
G6pd2
Name: glucose-6-phosphate dehydrogenase 2
Synonyms: Gpd2, Gpd-2, G6pdx-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14380
Aadacl3
Name: arylacetamide deacetylase like 3
Synonyms: LOC230883
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230883
Homologene: 28426
Caps2
Name: calcyphosphine 2
Synonyms: D630005B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 353025
Homologene: 72278
Clec2d
Name: C-type lectin domain family 2, member d
Synonyms: Clr-b, Clrb, Ocil
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93694
Homologene: 136309
Vmn1r158
Name: vomeronasal 1 receptor 158
Synonyms: Gm16455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043067
Homologene: 104166
Abhd16b
Name: abhydrolase domain containing 16B
Synonyms: BC050777
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241850
Homologene: 15422
Ighv7-2
Name: immunoglobulin heavy variable 7-2
Synonyms: Gm16699
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 780800
Ltb4r2
Name: leukotriene B4 receptor 2
Synonyms: BLT2, 5830462O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 57260
VEGA: 14
Homologene: 10519
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 34,211,170 bp
  • T to C, chromosome 1 at 65,063,246 bp
  • T to C, chromosome 1 at 139,424,093 bp
  • C to T, chromosome 2 at 69,507,843 bp
  • A to G, chromosome 2 at 87,628,829 bp
  • T to C, chromosome 2 at 93,798,162 bp
  • A to C, chromosome 2 at 181,493,416 bp
  • T to C, chromosome 3 at 105,666,999 bp
  • A to T, chromosome 4 at 15,979,389 bp
  • T to A, chromosome 4 at 144,457,034 bp
  • T to A, chromosome 5 at 61,810,251 bp
  • A to G, chromosome 6 at 29,586,144 bp
  • T to A, chromosome 6 at 85,622,309 bp
  • T to A, chromosome 6 at 87,460,008 bp
  • T to A, chromosome 6 at 123,815,399 bp
  • G to T, chromosome 6 at 129,183,190 bp
  • T to A, chromosome 7 at 22,790,390 bp
  • T to A, chromosome 7 at 25,353,738 bp
  • T to C, chromosome 7 at 28,629,482 bp
  • G to A, chromosome 7 at 111,554,602 bp
  • T to C, chromosome 8 at 77,610,333 bp
  • A to G, chromosome 9 at 21,353,724 bp
  • T to A, chromosome 9 at 46,219,503 bp
  • T to C, chromosome 9 at 80,126,155 bp
  • A to G, chromosome 10 at 63,264,053 bp
  • C to T, chromosome 10 at 112,199,727 bp
  • A to T, chromosome 10 at 116,918,960 bp
  • A to T, chromosome 11 at 35,544,748 bp
  • A to T, chromosome 11 at 52,026,839 bp
  • A to T, chromosome 11 at 59,824,310 bp
  • T to C, chromosome 11 at 69,496,606 bp
  • T to C, chromosome 11 at 73,203,959 bp
  • T to C, chromosome 11 at 106,506,864 bp
  • T to C, chromosome 11 at 109,577,664 bp
  • C to A, chromosome 11 at 115,645,825 bp
  • A to G, chromosome 12 at 66,655,362 bp
  • A to G, chromosome 12 at 72,140,020 bp
  • A to G, chromosome 12 at 111,299,196 bp
  • T to C, chromosome 12 at 113,912,107 bp
  • A to G, chromosome 13 at 73,700,566 bp
  • A to G, chromosome 14 at 30,909,835 bp
  • A to G, chromosome 14 at 55,761,987 bp
  • T to C, chromosome 14 at 73,363,120 bp
  • G to A, chromosome 15 at 4,944,966 bp
  • A to G, chromosome 15 at 8,143,026 bp
  • A to G, chromosome 16 at 3,963,992 bp
  • A to G, chromosome 16 at 37,236,275 bp
  • A to T, chromosome 16 at 90,252,435 bp
  • A to G, chromosome 17 at 50,606,829 bp
  • C to T, chromosome 17 at 56,434,990 bp
  • G to C, chromosome 18 at 34,738,239 bp
  • C to T, chromosome 19 at 34,320,553 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2077 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040082-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.