Strain Name:
C57BL/6J-MtgxR2080Btlr/Mmmh
Stock Number:
040085-MU
Citation ID:
RRID:MMRRC_040085-MU
Other Names:
R2080 (G1), C57BL/6J-MtgxR2080Btlr
Major Collection:

Strain Information

Ednrb
Name: endothelin receptor type B
Synonyms: ETR-b, Sox10m1, ETb
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13618
VEGA: 14
HGNC: HGNC:3180
Homologene: 89
Utrn
Name: utrophin
Synonyms: DRP, G-utrophin, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: Mll3, HALR, E330008K23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Gart
Name: phosphoribosylglycinamide formyltransferase
Synonyms: Gaps, Prgs
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14450
HGNC: HGNC:4163
Homologene: 637
Ireb2
Name: iron responsive element binding protein 2
Synonyms: Irp2, D9Ertd85e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64602
VEGA: 9
HGNC: HGNC:6115
Homologene: 11280
Ambra1
Name: autophagy/beclin 1 regulator 1
Synonyms: D030051N19Rik, 2310079H06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228361
Homologene: 18204
Prmt7
Name: protein arginine N-methyltransferase 7
Synonyms: 4933402B05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 214572
Homologene: 10382
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107182
Homologene: 31978
Epb41l3
Name: erythrocyte membrane protein band 4.1 like 3
Synonyms: 4.1B, DAL1P, NBL3, Epb4.1l3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13823
HGNC: HGNC:3380
Homologene: 49308
Ogdh
Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: 2210403E04Rik, d1401, 2210412K19Rik, alpha-ketoglutarate dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18293
HGNC: HGNC:8124
Homologene: 55662
Tipin
Name: timeless interacting protein
Synonyms: 1110018P21Rik, 1110005A05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66131
VEGA: 9
Homologene: 32373
Tlk1
Name: tousled-like kinase 1
Synonyms: 4930545J15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228012
Homologene: 130657
Xdh
Name: xanthine dehydrogenase
Synonyms: Xor, Xox1, xanthine oxidase, XO, Xox-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Nemf
Name: nuclear export mediator factor
Synonyms: Sdccag1, 1500011I12Rik, 4933405E14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66244
VEGA: 12
Homologene: 3458
Scube2
Name: signal peptide, CUB domain, EGF-like 2
Synonyms: ICRFP703N2430Q5.1, 4932442O19Rik, Cegf1, ICRFP703B1614Q5.1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56788
Homologene: 36383
Epg5
Name: ectopic P-granules 5 autophagy tethering factor
Synonyms: 5430411K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
D5Ertd579e
Name: DNA segment, Chr 5, ERATO Doi 579, expressed
Synonyms: A930018H20Rik, 9030221A05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320661
Homologene: 19716
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: C030034P18Rik, TRPP2, PC2, polycystin-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Egln1
Name: egl-9 family hypoxia-inducible factor 1
Synonyms: ORF13, Hif-p4h-2, SM-20, Phd2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 112405
HGNC: HGNC:1232
Homologene: 56936
Atp10a
Name: ATPase, class V, type 10A
Synonyms: Atp10c, pfatp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11982
Homologene: 56461
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Lgn1, Birc1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Or8b42
Name: olfactory receptor family 8 subfamily B member 42
Synonyms: GA_x6K02T2PVTD-32123032-32123967, Olfr901, MOR162-8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258028
VEGA: 9
Homologene: 79399
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241589
Homologene: 115928
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: MyHC-IIa, Myhsf1, Myhs-f, MHC2A, Myhs-f1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, 2300002I04Rik, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Or13c3
Name: olfactory receptor family 13 subfamily C member 3
Synonyms: MOR262-8, GA_x6K02T2N78B-7137430-7138383, Olfr273
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258821
Homologene: 73999
Cgnl1
Name: cingulin-like 1
Synonyms: Jacop, 4933421H10Rik, 9930020M10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68178
Homologene: 41901
Plce1
Name: phospholipase C, epsilon 1
Synonyms: 4933403A21Rik, PLCepsilon
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74055
Homologene: 9478
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: Armc4, b2b643Clo, 4930463I21Rik, b2b227.1Clo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Aox3
Name: aldehyde oxidase 3
Synonyms: 1200011D03Rik, AOH1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71724
Homologene: 90899
Smgc
Name: submandibular gland protein C
Synonyms: Sfc21, DXImx49e, 2310010P21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223809
Necab1
Name: N-terminal EF-hand calcium binding protein 1
Synonyms: STIP-1, 1700003H21Rik, NECAB1, Efcbp1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69352
Homologene: 11172
Masp1
Name: MBL associated serine protease 1
Synonyms: Crarf
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17174
VEGA: 16
HGNC: HGNC:6901
Homologene: 88793
L3hypdh
Name: L-3-hydroxyproline dehydratase (trans-)
Synonyms: 2810055F11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67217
Homologene: 12100
Nfil3
Name: nuclear factor, interleukin 3, regulated
Synonyms: E4BP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18030
HGNC: HGNC:7787
Homologene: 3928
Dsel
Name: dermatan sulfate epimerase-like
Synonyms: 9330132E09Rik, DS-epi2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319901
Homologene: 12964
Car6
Name: carbonic anhydrase 6
Synonyms: DOC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12353
HGNC: HGNC:1380
Homologene: 20324
Or51f5
Name: olfactory receptor family 51 subfamily F member 5
Synonyms: MOR14-2, GA_x6K02T2PBJ9-5491151-5492095, Olfr561
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259096
Homologene: 133029
Zfp598
Name: zinc finger protein 598
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213753
VEGA: 17
Homologene: 5672
Or4k47
Name: olfactory receptor family 4 subfamily K member 47
Synonyms: GA_x6K02T2Q125-72673494-72672556, MOR248-4, Olfr1297
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258890
Homologene: 115545
Gm1527
Name: predicted gene 1527
Synonyms: LOC385263
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 385263
Homologene: 133976
Ppm1f
Name: protein phosphatase 1F (PP2C domain containing)
Synonyms: 4933427B07Rik, 1110021B16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68606
Homologene: 22828
Rbm44
Name: RNA binding motif protein 44
Synonyms: LOC329207
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329207
Homologene: 66636
Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Synonyms: D7Ucla4, Cyp15a1, testosterone 15alpha-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13086
Homologene: 85917
H1f1
Name: H1.1 linker histone, cluster member
Synonyms: Hist1h1a, H1var3, H1.1, H1a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 80838
HGNC: HGNC:4715
Homologene: 135937
Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Synonyms: cyclooxygenase 1, COX1, Pghs1, Cox-1, Cox-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19224
HGNC: HGNC:9604
Homologene: 743
Or2b6
Name: olfactory receptor family 2 subfamily B member 6
Synonyms: GA_x6K02T2QHY8-11597382-11598323, MOR256-11, Olfr11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218066
HGNC: HGNC:8241
Homologene: 40838
Oacyl
Name: O-acyltransferase like
Synonyms: 5330437I02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319888
Homologene: 129774
Amdhd2
Name: amidohydrolase domain containing 2
Synonyms: 5730457F11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 245847
Homologene: 9311
Tmem59
Name: transmembrane protein 59
Synonyms: MTDCF1, 3110046P06Rik, thymic dendritic cell-derived factor 1, D4Ertd20e, 1110001M20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56374
HGNC: HGNC:1239
Homologene: 3583
Mfsd13b
Name: major facilitator superfamily domain containing 13B
Synonyms: 4933427G17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74466
Homologene: 62261
2310003L06Rik
Name: RIKEN cDNA 2310003L06 gene
Type: Gene
Species: Mouse
Chromosome: 5
Yjefn3
Name: YjeF N-terminal domain containing 3
Synonyms: LOC234365
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234365
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 58,186,280 bp
  • T to C, chromosome 1 at 91,153,885 bp
  • T to C, chromosome 1 at 111,859,962 bp
  • C to T, chromosome 2 at 36,242,847 bp
  • T to A, chromosome 2 at 70,738,445 bp
  • T to A, chromosome 2 at 91,885,719 bp
  • C to T, chromosome 2 at 104,156,816 bp
  • C to T, chromosome 2 at 111,621,739 bp
  • T to A, chromosome 3 at 28,926,661 bp
  • T to C, chromosome 3 at 87,814,291 bp
  • A to G, chromosome 3 at 113,558,094 bp
  • T to C, chromosome 4 at 15,140,219 bp
  • T to C, chromosome 4 at 52,855,568 bp
  • C to A, chromosome 4 at 107,178,774 bp
  • T to C, chromosome 4 at 138,873,419 bp
  • T to C, chromosome 4 at 150,198,141 bp
  • T to C, chromosome 5 at 25,354,717 bp
  • T to A, chromosome 5 at 36,616,206 bp
  • A to T, chromosome 5 at 87,971,933 bp
  • A to G, chromosome 5 at 104,477,123 bp
  • G to A, chromosome 7 at 26,308,537 bp
  • C to A, chromosome 7 at 58,824,327 bp
  • T to C, chromosome 7 at 102,180,424 bp
  • T to C, chromosome 7 at 102,775,243 bp
  • T to C, chromosome 7 at 109,808,505 bp
  • A to G, chromosome 7 at 120,991,824 bp
  • T to C, chromosome 7 at 141,869,754 bp
  • T to C, chromosome 8 at 69,889,487 bp
  • T to A, chromosome 8 at 106,243,792 bp
  • A to G, chromosome 8 at 124,948,306 bp
  • T to A, chromosome 9 at 38,431,082 bp
  • T to C, chromosome 9 at 54,896,552 bp
  • T to A, chromosome 9 at 64,290,376 bp
  • C to T, chromosome 9 at 71,656,096 bp
  • T to C, chromosome 10 at 12,737,082 bp
  • T to A, chromosome 11 at 6,349,393 bp
  • A to T, chromosome 11 at 67,174,941 bp
  • A to G, chromosome 12 at 69,353,786 bp
  • A to T, chromosome 12 at 72,079,527 bp
  • A to T, chromosome 13 at 21,639,436 bp
  • A to G, chromosome 13 at 23,763,949 bp
  • A to T, chromosome 13 at 52,968,033 bp
  • A to G, chromosome 13 at 100,221,533 bp
  • A to G, chromosome 14 at 47,725,960 bp
  • A to T, chromosome 14 at 103,843,100 bp
  • G to A, chromosome 15 at 91,847,153 bp
  • T to A, chromosome 16 at 16,923,880 bp
  • T to G, chromosome 16 at 23,491,959 bp
  • T to A, chromosome 16 at 91,642,997 bp
  • T to C, chromosome 17 at 24,156,604 bp
  • A to C, chromosome 17 at 24,679,667 bp
  • A to T, chromosome 17 at 69,253,468 bp
  • A to T, chromosome 17 at 73,909,325 bp
  • T to A, chromosome 18 at 7,127,198 bp
  • A to G, chromosome 18 at 65,725,318 bp
  • T to C, chromosome 18 at 77,948,745 bp
  • C to T, chromosome 19 at 36,951,148 bp
  • C to T, chromosome 19 at 38,727,013 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2080 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040085-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.