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Strain Name:
C57BL/6J-MtgxR2083Btlr/Mmmh
Stock Number:
040088-MU
Citation ID:
RRID:MMRRC_040088-MU
Other Names:
R2083 (G1), C57BL/6J-MtgxR2083Btlr
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: dyn, SpbIV, neuroaxonal dystrophy, 5830426A08Rik, ROSA62, nmf261, 1700022P15Rik, Spnb4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Gpr37
Name: G protein-coupled receptor 37
Synonyms: Pael-R, parkin-associated endothelin B-like receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Cenpv
Name: centromere protein V
Synonyms: 3110013H01Rik, Prr6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73139
Homologene: 42965
En2
Name: engrailed 2
Synonyms: En-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13799
HGNC: HGNC:3343
Homologene: 55579
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Ambra1
Name: autophagy/beclin 1 regulator 1
Synonyms: 2310079H06Rik, D030051N19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228361
Homologene: 18204
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Atxn2
Name: ataxin 2
Synonyms: ATX2, 9630045M23Rik, Sca2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20239
Homologene: 2234
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: D15Ertd586e, trichorhinophalangeal syndrome I (human)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83925
Homologene: 8556
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, Lek1, mitosin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Slc8a2
Name: solute carrier family 8 (sodium/calcium exchanger), member 2
Synonyms: Ncx2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110891
Homologene: 27358
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Nol6
Name: nucleolar protein family 6 (RNA-associated)
Synonyms: Nrap
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230082
Homologene: 41505
Slc25a40
Name: solute carrier family 25, member 40
Synonyms: B230315F11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319653
Homologene: 6040
Ttf2
Name: transcription termination factor, RNA polymerase II
Synonyms: 4632434F22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74044
Homologene: 37826
Acsl3
Name: acyl-CoA synthetase long-chain family member 3
Synonyms: 2610510B12Rik, C85929, Facl3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74205
HGNC: HGNC:3570
Homologene: 3278
Peak1
Name: pseudopodium-enriched atypical kinase 1
Synonyms: 1110049L02Rik, NKF3 kinase family member, C230081A13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244895
Homologene: 18259
Ptpn4
Name: protein tyrosine phosphatase, non-receptor type 4
Synonyms: hPTP-MEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), TEP/mPTPMEG, testis-enriched phosphatase, TEP, PTPMEG
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19258
HGNC: HGNC:9656
Homologene: 2120
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Ttll7
Name: tubulin tyrosine ligase-like family, member 7
Synonyms: 1110049N09Rik, 4921517B04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70892
Homologene: 41578
Tubgcp6
Name: tubulin, gamma complex component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328580
Homologene: 32477
Slc38a4
Name: solute carrier family 38, member 4
Synonyms: Ata3, 1700012A18Rik, 1110012E16Rik, SNAT4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69354
VEGA: 15
Homologene: 75077
Pter
Name: phosphotriesterase related
Synonyms: Mpr56-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19212
HGNC: HGNC:9590
Homologene: 7495
Adcy3
Name: adenylate cyclase 3
Synonyms: AC3, ACIII
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104111
HGNC: HGNC:234
Homologene: 2978
Cyp4a10
Name: cytochrome P450, family 4, subfamily a, polypeptide 10
Synonyms: RP1, D4Rp1, Cyp4a, Msp-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13117
HGNC: HGNC:2642
Homologene: 128044
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195046
Homologene: 133820
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5c, Nav1.5, mH1, SkM2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Sfmbt1
Name: Scm-like with four mbt domains 1
Synonyms: Smr, 4930442N21Rik, 9330180L21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54650
Homologene: 9472
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235505
Homologene: 25183
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 5930426O13Rik, 9030605H24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319767
Homologene: 70969
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Rpp40
Name: ribonuclease P 40 subunit
Synonyms: D8Bwg1265e, Rnasep1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208366
Homologene: 4836
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Mapkbp1
Name: mitogen-activated protein kinase binding protein 1
Synonyms: Jnkbp1, 2810483F24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26390
Homologene: 69109
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
Zfp27
Name: zinc finger protein 27
Synonyms: mkr-4, Zfp-27
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22689
Homologene: 81823
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Gm6041, Fam196b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218441
Homologene: 8826
AA986860
Name: expressed sequence AA986860
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212439
Homologene: 49741
Clip2
Name: CAP-GLY domain containing linker protein 2
Synonyms: CLIP-115, WSCR4, Cyln2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269713
HGNC: HGNC:2586
Homologene: 20718
Tspyl5
Name: testis-specific protein, Y-encoded-like 5
Synonyms: E130308C19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239364
VEGA: 15
Homologene: 14134
Sec61a2
Name: SEC61 translocon subunit alpha 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57743
Homologene: 38481
Etfb
Name: electron transferring flavoprotein, beta polypeptide
Synonyms: 2810441H06Rik, 0610009I16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110826
HGNC: HGNC:3482
Homologene: 1503
Klhl22
Name: kelch-like 22
Synonyms: 2610318I18Rik, Kelchl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224023
Homologene: 23784
Or8d1
Name: olfactory receptor family 8 subfamily D member 1
Synonyms: MTPCR09, MOR171-9, GA_x6K02T2PVTD-32550930-32551856, Olfr26
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18324
VEGA: 9
HGNC: HGNC:8481
Homologene: 79676
Adgra1
Name: adhesion G protein-coupled receptor A1
Synonyms: 2900059M17Rik, D7Ertd680e, Gpr123
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52389
Homologene: 18582
Vmn1r8
Name: vomeronasal 1 receptor 8
Synonyms: V1rc32
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171205
Homologene: 83427
1700001J03Rik
Name: RIKEN cDNA 1700001J03 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69282
Homologene: 86127
Mkx
Name: mohawk homeobox
Synonyms: 9430023B20Rik, Irxl1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 210719
Homologene: 72239
Ly6e
Name: lymphocyte antigen 6 family member E
Synonyms: Sca-2, Ly67, Tsa1, 9804, RIG-E, TSA-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17069
HGNC: HGNC:6727
Homologene: 56411
Or4f59
Name: olfactory receptor family 4 subfamily F member 59
Synonyms: GA_x6K02T2Q125-73090482-73089529, MOR245-20, Olfr1312
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258359
Homologene: 128122
Dmrtb1
Name: DMRT-like family B with proline-rich C-terminal, 1
Synonyms: Dmrt6, Prp13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56296
Homologene: 13207
Tas1r1
Name: taste receptor, type 1, member 1
Synonyms: TR1, T1r1, Gpr70, T1R1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110326
Homologene: 12888
Gm17728
Name: predicted gene, 17728
Type: Gene
Species: Mouse
Chromosome: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 46,241,067 bp
  • A to T, chromosome 1 at 78,699,811 bp
  • T to C, chromosome 1 at 90,782,011 bp
  • A to G, chromosome 1 at 119,687,759 bp
  • A to T, chromosome 1 at 130,741,069 bp
  • T to C, chromosome 1 at 189,672,646 bp
  • T to G, chromosome 2 at 5,873,734 bp
  • T to A, chromosome 2 at 12,978,436 bp
  • T to A, chromosome 2 at 20,743,549 bp
  • T to A, chromosome 2 at 91,766,600 bp
  • C to T, chromosome 2 at 112,042,553 bp
  • T to C, chromosome 2 at 120,015,482 bp
  • A to G, chromosome 3 at 5,403,163 bp
  • A to T, chromosome 3 at 100,969,501 bp
  • A to G, chromosome 3 at 146,930,104 bp
  • A to G, chromosome 4 at 41,115,513 bp
  • C to T, chromosome 4 at 107,683,612 bp
  • T to C, chromosome 4 at 115,525,308 bp
  • T to A, chromosome 4 at 152,028,391 bp
  • A to T, chromosome 5 at 8,440,803 bp
  • T to C, chromosome 5 at 28,167,073 bp
  • G to T, chromosome 5 at 121,784,006 bp
  • A to T, chromosome 5 at 134,494,205 bp
  • T to A, chromosome 5 at 146,184,871 bp
  • T to C, chromosome 6 at 25,688,417 bp
  • T to A, chromosome 6 at 57,036,340 bp
  • T to G, chromosome 7 at 16,134,515 bp
  • T to C, chromosome 7 at 27,428,256 bp
  • T to C, chromosome 7 at 29,894,783 bp
  • A to G, chromosome 7 at 43,456,500 bp
  • T to C, chromosome 7 at 139,875,631 bp
  • T to G, chromosome 9 at 38,855,341 bp
  • G to A, chromosome 9 at 56,258,949 bp
  • T to C, chromosome 9 at 78,667,293 bp
  • A to G, chromosome 9 at 118,532,590 bp
  • T to C, chromosome 9 at 119,492,123 bp
  • A to G, chromosome 11 at 34,402,141 bp
  • A to G, chromosome 11 at 43,212,423 bp
  • A to C, chromosome 11 at 59,073,631 bp
  • G to A, chromosome 11 at 62,527,482 bp
  • A to T, chromosome 11 at 71,124,220 bp
  • T to C, chromosome 12 at 4,173,512 bp
  • A to G, chromosome 12 at 85,269,041 bp
  • A to T, chromosome 13 at 35,898,992 bp
  • T to C, chromosome 13 at 92,524,262 bp
  • T to C, chromosome 14 at 30,816,734 bp
  • A to G, chromosome 14 at 61,206,506 bp
  • T to C, chromosome 15 at 33,686,746 bp
  • G to T, chromosome 15 at 50,822,305 bp
  • T to A, chromosome 15 at 74,958,319 bp
  • A to T, chromosome 15 at 89,122,376 bp
  • T to C, chromosome 15 at 97,008,993 bp
  • A to G, chromosome 16 at 17,776,525 bp
  • C to A, chromosome 17 at 9,422,289 bp
  • A to T, chromosome 18 at 6,992,855 bp
  • A to T, chromosome 18 at 14,974,055 bp
  • C to T, chromosome 19 at 9,011,557 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2083 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040088-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.