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Strain Name:
C57BL/6J-MtgxR2092Btlr/Mmmh
Stock Number:
040097-MU
Citation ID:
RRID:MMRRC_040097-MU
Other Names:
R2092 (G1), C57BL/6J-MtgxR2092Btlr
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: D0Jmb2, E030044M24Rik, NMHC II-A, Myhn-1, Myhn1, myosin IIA, Fltn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Ptk2
Name: PTK2 protein tyrosine kinase 2
Synonyms: Fadk, FAK, FRNK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14083
VEGA: 15
HGNC: HGNC:9611
Homologene: 7314
Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Syngr1
Name: synaptogyrin 1
Synonyms: Syngr1b, p29
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20972
Homologene: 3456
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 45,909,454 bp
  • G to A, chromosome 1 at 82,498,946 bp
  • A to T, chromosome 1 at 128,374,018 bp
  • A to G, chromosome 1 at 130,577,135 bp
  • T to C, chromosome 2 at 23,226,871 bp
  • G to A, chromosome 2 at 30,108,274 bp
  • T to C, chromosome 2 at 66,533,376 bp
  • C to T, chromosome 2 at 69,536,021 bp
  • A to G, chromosome 2 at 88,897,267 bp
  • C to T, chromosome 2 at 153,054,063 bp
  • T to C, chromosome 2 at 155,709,049 bp
  • T to C, chromosome 3 at 33,841,060 bp
  • A to G, chromosome 3 at 96,652,623 bp
  • T to C, chromosome 4 at 99,009,308 bp
  • T to C, chromosome 4 at 104,328,514 bp
  • T to G, chromosome 4 at 104,678,777 bp
  • T to A, chromosome 4 at 123,383,178 bp
  • T to C, chromosome 4 at 137,404,426 bp
  • T to C, chromosome 5 at 35,700,658 bp
  • A to T, chromosome 5 at 38,299,766 bp
  • A to G, chromosome 5 at 41,831,517 bp
  • G to GA, chromosome 5 at 90,463,983 bp
  • C to T, chromosome 5 at 110,341,141 bp
  • T to A, chromosome 5 at 142,718,855 bp
  • A to G, chromosome 6 at 69,701,074 bp
  • T to A, chromosome 6 at 121,674,937 bp
  • C to T, chromosome 7 at 23,835,153 bp
  • G to A, chromosome 7 at 24,916,946 bp
  • A to G, chromosome 7 at 29,560,564 bp
  • G to A, chromosome 7 at 29,953,924 bp
  • T to C, chromosome 7 at 41,374,617 bp
  • T to C, chromosome 7 at 42,933,571 bp
  • C to T, chromosome 7 at 47,464,160 bp
  • A to T, chromosome 7 at 75,610,570 bp
  • T to C, chromosome 7 at 98,716,449 bp
  • T to A, chromosome 7 at 100,020,977 bp
  • G to A, chromosome 7 at 103,329,109 bp
  • A to T, chromosome 7 at 103,788,072 bp
  • CAAATA to CA, chromosome 7 at 108,667,662 bp
  • C to T, chromosome 7 at 127,033,630 bp
  • G to T, chromosome 7 at 131,050,018 bp
  • A to G, chromosome 7 at 140,969,514 bp
  • T to C, chromosome 8 at 22,380,934 bp
  • C to A, chromosome 8 at 91,409,687 bp
  • T to A, chromosome 8 at 105,887,528 bp
  • A to T, chromosome 9 at 38,995,189 bp
  • G to T, chromosome 9 at 80,245,682 bp
  • A to G, chromosome 9 at 96,335,364 bp
  • T to C, chromosome 9 at 106,060,331 bp
  • T to C, chromosome 9 at 119,121,844 bp
  • A to G, chromosome 10 at 10,689,225 bp
  • A to T, chromosome 10 at 12,678,698 bp
  • T to G, chromosome 10 at 88,440,305 bp
  • C to T, chromosome 10 at 117,288,599 bp
  • T to G, chromosome 11 at 46,060,904 bp
  • G to A, chromosome 11 at 101,076,720 bp
  • A to G, chromosome 11 at 109,966,708 bp
  • T to C, chromosome 12 at 113,157,720 bp
  • A to T, chromosome 12 at 118,012,716 bp
  • A to G, chromosome 13 at 22,354,715 bp
  • T to C, chromosome 13 at 58,127,800 bp
  • C to A, chromosome 13 at 73,265,486 bp
  • A to G, chromosome 15 at 48,161,011 bp
  • A to G, chromosome 15 at 66,849,607 bp
  • A to T, chromosome 15 at 73,236,191 bp
  • G to A, chromosome 15 at 77,764,350 bp
  • A to T, chromosome 15 at 80,115,940 bp
  • A to G, chromosome 15 at 85,018,085 bp
  • A to C, chromosome 15 at 96,415,827 bp
  • T to C, chromosome 15 at 97,760,723 bp
  • G to T, chromosome 15 at 98,293,712 bp
  • T to C, chromosome 15 at 99,402,068 bp
  • A to T, chromosome 16 at 36,510,043 bp
  • A to G, chromosome 16 at 38,252,820 bp
  • C to T, chromosome 16 at 94,442,832 bp
  • CAGGAA to CA, chromosome 17 at 18,022,334 bp
  • T to C, chromosome 17 at 45,558,539 bp
  • T to C, chromosome 17 at 55,510,266 bp
  • T to A, chromosome 18 at 37,414,187 bp
  • T to A, chromosome 19 at 13,063,802 bp
  • T to C, chromosome 19 at 23,238,899 bp
  • A to G, chromosome 19 at 58,741,184 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2092 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040097-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.