Strain Name:
C57BL/6J-MtgxR2097Btlr/Mmmh
Stock Number:
040101-MU
Citation ID:
RRID:MMRRC_040101-MU
Other Names:
R2097 (G1), C57BL/6J-MtgxR2097Btlr
Major Collection:

Gene Information

Notch3
Name: notch 3
Synonyms: N3, hpbk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Ptch1
Name: patched 1
Synonyms: Patched 1, wig, Ptc, Ptc1, A230106A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Map7
Name: microtubule-associated protein 7
Synonyms: mshi, E-MAP-115, Mtap7, mste, ste
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17761
VEGA: 10
HGNC: HGNC:6869
Homologene: 20851
Dnmt1
Name: DNA methyltransferase (cytosine-5) 1
Synonyms: MommeD2, Cxxc9, Dnmt1o, MTase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, Ndrp, 4632404O06Rik, 2810004D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83946
Homologene: 41209
Fndc3a
Name: fibronectin type III domain containing 3A
Synonyms: 1700094E19Rik, sys, F730017H24Rik, Fndc3, D14Ertd453e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 319448
Homologene: 8952
Actr8
Name: ARP8 actin-related protein 8
Synonyms: ARP8, 5730542K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56249
VEGA: 14
Homologene: 11286
Ccdc138
Name: coiled-coil domain containing 138
Synonyms: 6230424H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76138
VEGA: 10
Homologene: 44912
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Pggt1b
Name: protein geranylgeranyltransferase type I, beta subunit
Synonyms: BGG1, 2010207C17Rik, GGT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225467
VEGA: 18
HGNC: HGNC:8895
Homologene: 3685
Zbtb20
Name: zinc finger and BTB domain containing 20
Synonyms: 1300017A20Rik, A930017C21Rik, HOF, 7330412A13Rik, D16Wsu73e, Zfp288
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 56490
Homologene: 9226
Dsg4
Name: desmoglein 4
Synonyms: CDHF13, lah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16769
Homologene: 65341
Msh6
Name: mutS homolog 6
Synonyms: GTBP, Msh6, Gtmbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17688
VEGA: 17
HGNC: HGNC:7329
Homologene: 149
Aqp3
Name: aquaporin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11828
HGNC: HGNC:636
Homologene: 21025
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: Pwp2h, Pwp2, 6530411D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Pitx3
Name: paired-like homeodomain transcription factor 3
Synonyms: Ptx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18742
HGNC: HGNC:9006
Homologene: 3689
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Trim9
Name: tripartite motif-containing 9
Synonyms: C030048G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94090
VEGA: 12
Homologene: 9045
Il20ra
Name: interleukin 20 receptor, alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237313
VEGA: 10
HGNC: HGNC:6003
Homologene: 8685
Ptprq
Name: protein tyrosine phosphatase, receptor type, Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Zfp990
Name: zinc finger protein 990
Synonyms: Gm13225
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 101056073
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71395
Homologene: 138430
Ptpdc1
Name: protein tyrosine phosphatase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218232
VEGA: 13
Homologene: 17576
Casq1
Name: calsequestrin 1
Synonyms: CSQ1, CSQ, CSQ-1, sCSQ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12372
HGNC: HGNC:1512
Homologene: 20329
Ttc25
Name: tetratricopeptide repeat domain 25
Synonyms: 4933404O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74407
Homologene: 12860
Pglyrp3
Name: peptidoglycan recognition protein 3
Synonyms: LOC242100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242100
Homologene: 71559
Hacd2
Name: 3-hydroxyacyl-CoA dehydratase 2
Synonyms: 6330408J20Rik, Ptplb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70757
VEGA: 16
HGNC: HGNC:9640
Homologene: 23409
Slc7a4
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224022
Homologene: 20883
Bace1
Name: beta-site APP cleaving enzyme 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23821
HGNC: HGNC:933
Homologene: 8014
Cts6
Name: cathepsin 6
Synonyms: 1600022N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 58518
Homologene: 75165
Bbof1
Name: basal body orientation factor 1
Synonyms: Ccdc176, 2900006K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 72873
Homologene: 75215
Galc
Name: galactosylceramidase
Synonyms: 2310068B06Rik, A930008M05Rik, galactocerebrosidase, Gacy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14420
VEGA: 12
HGNC: HGNC:4115
Homologene: 124
Cnga1
Name: cyclic nucleotide gated channel alpha 1
Synonyms: Cncg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12788
HGNC: HGNC:2148
Homologene: 55432
Zfp777
Name: zinc finger protein 777
Synonyms: 2500002G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72306
Homologene: 56721
Apol6
Name: apolipoprotein L 6
Synonyms: 2310076O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71939
Homologene: 49940
Gfm1
Name: G elongation factor, mitochondrial 1
Synonyms: D3Wsu133e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 28030
Homologene: 6449
Tmem132b
Name: transmembrane protein 132B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208151
Homologene: 28135
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: 9130203F04Rik, D130016B08Rik, Zfhx1b, Zfx1b, SIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 24136
Homologene: 8868
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101613
Homologene: 15881
Olfr1051
Name: olfactory receptor 1051
Synonyms: GA_x6K02T2Q125-47756192-47755266, MOR187-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404324
Homologene: 77387
Olfr603
Name: olfactory receptor 603
Synonyms: MOR32-14_i, Olfr604, GA_x6K02T2PBJ9-6096387-6095449, GA_x6K02T2PBJ9-6092550-6092362, MOR32-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259073
Homologene: 121535
Tspan13
Name: tetraspanin 13
Synonyms: 1100001I23Rik, Tm4sf13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66109
Homologene: 8671
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 172,210,421 bp
  • T to A, chromosome 2 at 31,380,419 bp
  • A to T, chromosome 2 at 44,997,156 bp
  • A to T, chromosome 2 at 86,276,039 bp
  • T to C, chromosome 3 at 55,723,217 bp
  • T to C, chromosome 3 at 67,449,746 bp
  • T to A, chromosome 3 at 92,028,171 bp
  • C to T, chromosome 4 at 41,098,004 bp
  • A to G, chromosome 4 at 145,537,322 bp
  • C to T, chromosome 5 at 72,619,061 bp
  • T to A, chromosome 5 at 125,638,208 bp
  • C to T, chromosome 6 at 48,044,242 bp
  • A to G, chromosome 6 at 104,861,949 bp
  • T to A, chromosome 7 at 103,383,633 bp
  • A to T, chromosome 7 at 131,181,964 bp
  • A to T, chromosome 7 at 140,923,204 bp
  • A to G, chromosome 9 at 20,909,788 bp
  • G to T, chromosome 9 at 45,860,222 bp
  • T to C, chromosome 9 at 82,915,339 bp
  • T to A, chromosome 9 at 107,526,333 bp
  • T to C, chromosome 10 at 19,759,463 bp
  • G to T, chromosome 10 at 20,246,616 bp
  • T to A, chromosome 10 at 58,561,937 bp
  • T to C, chromosome 10 at 76,512,489 bp
  • C to A, chromosome 10 at 78,177,742 bp
  • T to C, chromosome 10 at 107,653,493 bp
  • T to A, chromosome 11 at 100,563,582 bp
  • T to C, chromosome 12 at 36,021,830 bp
  • T to C, chromosome 12 at 70,347,159 bp
  • C to A, chromosome 12 at 84,413,307 bp
  • T to C, chromosome 12 at 98,252,032 bp
  • T to A, chromosome 13 at 48,592,659 bp
  • T to A, chromosome 13 at 61,195,445 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • T to C, chromosome 14 at 29,987,228 bp
  • C to A, chromosome 14 at 72,574,351 bp
  • T to A, chromosome 15 at 77,047,133 bp
  • G to T, chromosome 16 at 17,573,455 bp
  • A to G, chromosome 16 at 35,048,720 bp
  • A to G, chromosome 16 at 43,609,519 bp
  • A to T, chromosome 17 at 32,122,754 bp
  • A to G, chromosome 17 at 87,985,416 bp
  • C to A, chromosome 18 at 20,471,044 bp
  • T to C, chromosome 18 at 46,246,628 bp
  • T to C, chromosome 19 at 46,136,613 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2097 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040101-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.