Strain Name:
C57BL/6J-MtgxR2158Btlr/Mmmh
Stock Number:
040161-MU
Citation ID:
RRID:MMRRC_040161-MU
Other Names:
R2158 (G1), C57BL/6J-MtgxR2158Btlr
Major Collection:

Strain Information

Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Ewsr1
Name: Ewing sarcoma breakpoint region 1
Synonyms: Ews
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14030
HGNC: HGNC:3508
Homologene: 134632
Zic1
Name: zinc finger protein of the cerebellum 1
Synonyms: odd-paired homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22771
Homologene: 2562
Kif11
Name: kinesin family member 11
Synonyms: Eg5, Knsl1, Kifl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: ENSMUSG00000075261, CAMDI, 2610301F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545428
Homologene: 52149
Amotl1
Name: angiomotin-like 1
Synonyms: 4932416D09Rik, JEAP, 2310067L22Rik, 2310010G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75723
Homologene: 43977
Golga3
Name: golgi autoantigen, golgin subfamily a, 3
Synonyms: Mea-2, Mea2, 5430416E01Rik, G1-499-14, repro27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Nid2
Name: nidogen 2
Synonyms: entactin-2, entactin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18074
VEGA: 14
Homologene: 40575
Akap7
Name: A kinase (PRKA) anchor protein 7
Synonyms: Akap18, AKAP15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432442
HGNC: HGNC:377
Homologene: 49463
Atad2
Name: ATPase family, AAA domain containing 2
Synonyms: 2610509G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70472
VEGA: 15
Homologene: 6044
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Pglyrp2
Name: peptidoglycan recognition protein 2
Synonyms: tagl-beta, tagL-alpha, tagL, PGRP-L, C730002N09Rik, Pglyrpl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57757
VEGA: 17
Homologene: 49671
Ret
Name: ret proto-oncogene
Synonyms: RET51, RET9, c-Ret
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19713
HGNC: HGNC:9967
Homologene: 7517
Mapk11
Name: mitogen-activated protein kinase 11
Synonyms: Prkm11, p38beta, Sapk2, P38b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19094
VEGA: 15
HGNC: HGNC:6873
Homologene: 55684
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 674895
Homologene: 130947
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, erythroid, ihj, Spna1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20739
Homologene: 74460
Vnn1
Name: vanin 1
Synonyms: pantetheinase, V-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22361
Homologene: 32130
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: Myak, 1110062K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15257
Homologene: 56483
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70882
Homologene: 31589
Astn2
Name: astrotactin 2
Synonyms: 1d8, Astnl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56079
Homologene: 77850
Rnasel
Name: ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
Synonyms: 2-5A-dependent RNAase, E230029I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 24014
Homologene: 8040
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Strc
Name: stereocilin
Synonyms: DFNB16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140476
Homologene: 15401
Apcs
Name: amyloid P component, serum
Synonyms: Sap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20219
HGNC: HGNC:584
Homologene: 123932
Snx25
Name: sorting nexin 25
Synonyms: LOC382008, SBBI31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102141
Homologene: 23744
Caskin1
Name: CASK interacting protein 1
Synonyms: C630036E02Rik, 3300002N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D3Bwg1078e, 4732458A06Rik, D130016K21Rik, 9430063L05Rik, Usmg4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 83679
Homologene: 66961
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: SMC1beta, Smc1l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
4930402F06Rik
Name: RIKEN cDNA 4930402F06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74854
Homologene: 78017
Or8d23
Name: olfactory receptor family 8 subfamily D member 23
Synonyms: GA_x6K02T2PVTD-32626123-32627049, MOR171-46, Olfr930
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258269
VEGA: 9
HGNC: HGNC:8481
Homologene: 138304
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mdga2, 9330209L04Rik, 6720489L24Rik, Mamdc1, Adp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320772
Homologene: 45659
Myom1
Name: myomesin 1
Synonyms: skelemin, D430047A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
Hormad2
Name: HORMA domain containing 2
Synonyms: 4930529M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75828
Homologene: 45130
Taar5
Name: trace amine-associated receptor 5
Synonyms: LOC215854
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215854
Homologene: 20850
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 209683
Homologene: 41023
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241175
Homologene: 104295
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 3110007G05Rik, 1700084G18Rik, 2310039H16Rik, B130050I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 213027
Homologene: 134635
Or52a5b
Name: olfactory receptor family 52 subfamily A member 5B
Synonyms: 3'[b]3, MOR22-2, GA_x6K02T2PBJ9-6494485-6493535, Olfr69
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18370
Homologene: 128070
Nid1
Name: nidogen 1
Synonyms: entactin, entactin 1, nidogen-1, entactin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18073
VEGA: 13
HGNC: HGNC:7821
Homologene: 1878
Plch1
Name: phospholipase C, eta 1
Synonyms: PLCeta1, Plcl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269437
Homologene: 88833
Irs3
Name: insulin receptor substrate 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16369
HGNC: HGNC:6127
Homologene: 84788
Ido2
Name: indoleamine 2,3-dioxygenase 2
Synonyms: C230043N17Rik, Ido2, Indol1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 209176
Homologene: 48830
Itgb1bp1
Name: integrin beta 1 binding protein 1
Synonyms: bodenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16413
Homologene: 3496
Or51v14
Name: olfactory receptor family 51 subfamily V member 14
Synonyms: GA_x6K02T2PBJ9-6335095-6334154, MOR4-1, Olfr620
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258808
Homologene: 103777
Or2t47
Name: olfactory receptor family 2 subfamily T member 47
Synonyms: GA_x6K02T2NKPP-873285-874217, MOR275-2, Olfr328
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258495
Homologene: 133015
Adam4
Name: a disintegrin and metallopeptidase domain 4
Synonyms: tMDCV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11498
Homologene: 86950
Agmo
Name: alkylglycerol monooxygenase
Synonyms: A530016O06Rik, Tmem195
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319660
Homologene: 45620
Galnt17
Name: polypeptide N-acetylgalactosaminyltransferase 17
Synonyms: E330012B09Rik, Gcap8, Galnt19, Wbscr17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212996
Homologene: 49707
1810055G02Rik
Name: RIKEN cDNA 1810055G02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72056
VEGA: 19
HGNC: HGNC:1174
Homologene: 11174
Cnbd2
Name: cyclic nucleotide binding domain containing 2
Synonyms: 5430421B09Rik, 4921517L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70873
Homologene: 15440
Or51a24
Name: olfactory receptor family 51 subfamily A member 24
Synonyms: GA_x6K02T2PBJ9-6819097-6818150, MOR13-5, Olfr645
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258247
Homologene: 66155
Bmp10
Name: bone morphogenetic protein 10
Synonyms: b2b2711Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12154
Homologene: 7644
Lysmd3
Name: LysM, putative peptidoglycan-binding, domain containing 3
Synonyms: 1110030H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 80289
VEGA: 13
Homologene: 12722
Or4k1
Name: olfactory receptor family 4 subfamily K member 1
Synonyms: GA_x6K02T2PMLR-5831021-5830086, MOR246-1P, Olfr728
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258039
Homologene: 74224
Popdc2
Name: popeye domain containing 2
Synonyms: Pop2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 64082
Homologene: 11147
Riox1
Name: ribosomal oxygenase 1
Synonyms: NO66, 2410016O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71952
VEGA: 12
Homologene: 11366
Fn3k
Name: fructosamine 3 kinase
Synonyms: 2310074G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 63828
Homologene: 23336
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 100,390,572 bp
  • G to A, chromosome 1 at 153,754,901 bp
  • A to G, chromosome 1 at 172,894,533 bp
  • A to T, chromosome 1 at 174,229,258 bp
  • C to A, chromosome 2 at 19,248,633 bp
  • A to T, chromosome 2 at 35,385,668 bp
  • T to G, chromosome 2 at 40,879,555 bp
  • T to A, chromosome 2 at 77,030,671 bp
  • T to C, chromosome 2 at 121,365,862 bp
  • C to T, chromosome 2 at 156,338,565 bp
  • A to G, chromosome 3 at 63,721,234 bp
  • A to T, chromosome 3 at 97,757,621 bp
  • A to G, chromosome 3 at 103,760,538 bp
  • A to T, chromosome 4 at 66,404,254 bp
  • A to T, chromosome 4 at 137,517,604 bp
  • T to C, chromosome 4 at 143,994,315 bp
  • A to T, chromosome 5 at 110,187,361 bp
  • C to T, chromosome 5 at 111,177,617 bp
  • C to T, chromosome 5 at 130,906,702 bp
  • A to G, chromosome 5 at 137,644,699 bp
  • A to T, chromosome 6 at 87,434,080 bp
  • A to G, chromosome 6 at 118,165,993 bp
  • G to C, chromosome 7 at 103,612,236 bp
  • G to T, chromosome 7 at 103,767,961 bp
  • T to G, chromosome 7 at 104,084,826 bp
  • T to C, chromosome 8 at 4,193,195 bp
  • T to A, chromosome 8 at 24,540,636 bp
  • A to G, chromosome 8 at 46,041,407 bp
  • G to T, chromosome 9 at 14,575,169 bp
  • T to C, chromosome 9 at 38,930,579 bp
  • T to C, chromosome 9 at 91,364,893 bp
  • C to T, chromosome 10 at 23,900,755 bp
  • T to A, chromosome 10 at 23,971,088 bp
  • A to G, chromosome 10 at 25,171,164 bp
  • T to A, chromosome 11 at 4,424,808 bp
  • A to G, chromosome 11 at 5,091,450 bp
  • T to A, chromosome 11 at 58,551,942 bp
  • A to T, chromosome 11 at 121,448,886 bp
  • T to C, chromosome 12 at 21,276,859 bp
  • T to A, chromosome 12 at 37,357,710 bp
  • C to T, chromosome 12 at 66,689,381 bp
  • A to G, chromosome 12 at 81,421,763 bp
  • A to G, chromosome 12 at 83,950,935 bp
  • T to C, chromosome 12 at 98,843,946 bp
  • A to G, chromosome 13 at 13,502,538 bp
  • A to G, chromosome 13 at 81,669,618 bp
  • A to T, chromosome 13 at 89,703,529 bp
  • T to G, chromosome 14 at 14,885,047 bp
  • G to A, chromosome 14 at 19,778,043 bp
  • T to A, chromosome 14 at 50,140,123 bp
  • A to T, chromosome 15 at 58,098,566 bp
  • A to G, chromosome 15 at 85,121,851 bp
  • G to A, chromosome 15 at 89,146,372 bp
  • C to T, chromosome 16 at 32,754,563 bp
  • T to A, chromosome 16 at 38,362,826 bp
  • T to C, chromosome 17 at 24,505,154 bp
  • T to A, chromosome 17 at 32,418,248 bp
  • T to C, chromosome 17 at 71,064,597 bp
  • T to C, chromosome 19 at 3,716,608 bp
  • A to G, chromosome 19 at 37,410,614 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2158 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040161-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.