Strain Name:
C57BL/6J-MtgxR2161Btlr/Mmmh
Stock Number:
040164-MU
Citation ID:
RRID:MMRRC_040164-MU
Other Names:
R2161 (G1), C57BL/6J-MtgxR2161Btlr
Major Collection:

Strain Information

Trmt9b
Name: tRNA methyltransferase 9B
Synonyms: 6430573F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319582
Homologene: 35306
Blm
Name: Bloom syndrome, RecQ like helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12144
HGNC: HGNC:1058
Homologene: 47902
Tsnax
Name: translin-associated factor X
Synonyms: Trax
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 53424
Homologene: 4374
Arhgef18
Name: rho/rac guanine nucleotide exchange factor (GEF) 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102098
Homologene: 32254
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: DIF-3, Zfp403, D330017P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217039
Homologene: 11750
Mark2
Name: MAP/microtubule affinity regulating kinase 2
Synonyms: Par-1, Emk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13728
HGNC: HGNC:3332
Homologene: 69013
Reps1
Name: RalBP1 associated Eps domain containing protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19707
Homologene: 7515
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Cxxc2, Jhdm1b, Fbxl10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 30841
Homologene: 13069
Golph3l
Name: golgi phosphoprotein 3-like
Synonyms: GPP34R, 2010204I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229593
Homologene: 23082
Fbxo21
Name: F-box protein 21
Synonyms: 2810425J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231670
Homologene: 14145
Stag1
Name: stromal antigen 1
Synonyms: SA-1, Scc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20842
Homologene: 21191
Ap1g1
Name: adaptor protein complex AP-1, gamma 1 subunit
Synonyms: gamma-adaptin, Adtg, D8Ertd374e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11765
HGNC: HGNC:555
Homologene: 47995
Niban2
Name: niban apoptosis regulator 2
Synonyms: 9130404D14Rik, Fam129b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227737
Homologene: 11269
Arel1
Name: apoptosis resistant E3 ubiquitin protein ligase 1
Synonyms: 1110018G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68497
Homologene: 8885
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71722
Homologene: 87637
Dsp
Name: desmoplakin
Synonyms: DP, 2300002E22Rik, 5730453H04Rik, rul
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Trim71
Name: tripartite motif-containing 71
Synonyms: LOC382112, lin-41, mlin-41, Lin41, 2610206G21Rik, 636931, mLin41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 636931
Homologene: 9076
Tmed8
Name: transmembrane p24 trafficking protein 8
Synonyms: LOC382620, 6430595O10Rik, Mem1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 382620
VEGA: 12
Homologene: 19600
Arhgap33
Name: Rho GTPase activating protein 33
Synonyms: Tcgap, Snx26, NOMA-GAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233071
Homologene: 76448
Adamts12
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Crispld2
Name: cysteine-rich secretory protein LCCL domain containing 2
Synonyms: 1810049K24Rik, coffeecrisp, Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78892
Homologene: 41792
Notch1
Name: notch 1
Synonyms: lin-12, Tan1, Mis6, 9930111A19Rik, Motch A, N1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Naa20
Name: N(alpha)-acetyltransferase 20, NatB catalytic subunit
Synonyms: 2900026I01Rik, 1500004D14Rik, D2Ertd186e, Nat5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67877
Homologene: 7165
Tubgcp3
Name: tubulin, gamma complex associated protein 3
Synonyms: Spc98p, GCP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 259279
Homologene: 4609
Siglece
Name: sialic acid binding Ig-like lectin E
Synonyms: mSiglec-E, Siglecl1, Siglec5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83382
Homologene: 130669
Cmtr1
Name: cap methyltransferase 1
Synonyms: 1300018I05Rik, Ftsjd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74157
Homologene: 9003
Cep295
Name: centrosomal protein 295
Synonyms: LOC382128, 5830418K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319675
Homologene: 27936
Krt14
Name: keratin 14
Synonyms: epidermolysis bullosa simplex, Dowling-Meara, Koebner, Krt-1.14, K14, Cytokeratin 14, Krt1-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16664
HGNC: HGNC:6416
Homologene: 110439
Sohlh1
Name: spermatogenesis and oogenesis specific basic helix-loop-helix 1
Synonyms: LOC227631, NOHLH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227631
Homologene: 45955
Ldb3
Name: LIM domain binding 3
Synonyms: ZASP, cypher
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 24131
VEGA: 14
Homologene: 134626
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Col11a2
Name: collagen, type XI, alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12815
HGNC: HGNC:2187
Homologene: 22547
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: PYPAF2, E330007A02Rik, Nalp2, Pan1, Nbs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232827
Homologene: 56789
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
L3hypdh
Name: L-3-hydroxyproline dehydratase (trans-)
Synonyms: 2810055F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67217
Homologene: 12100
Tectb
Name: tectorin beta
Synonyms: [b]-tectorin, Tctnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21684
Homologene: 7568
Blk
Name: B lymphoid kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12143
VEGA: 14
HGNC: HGNC:1057
Homologene: 1297
Rgs6
Name: regulator of G-protein signaling 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 50779
Homologene: 68385
Ndufa8
Name: NADH:ubiquinone oxidoreductase subunit A8
Synonyms: 0610033L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68375
HGNC: HGNC:7692
Homologene: 40932
Hlx
Name: H2.0-like homeobox
Synonyms: Hlx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15284
HGNC: HGNC:4978
Homologene: 7363
Ptgir
Name: prostaglandin I receptor (IP)
Synonyms: prostacyclin receptor, IP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19222
HGNC: HGNC:9602
Homologene: 7496
Esp4
Name: exocrine gland secreted peptide 4
Synonyms: Gm20580
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100126777
VEGA: 17
Homologene: 136356
Or5b108
Name: olfactory receptor family 5 subfamily B member 108
Synonyms: GA_x6K02T2RE5P-3517488-3518411, MOR202-13, Olfr1462
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258688
HGNC: HGNC:8324
Homologene: 133607
Slc5a10
Name: solute carrier family 5 (sodium/glucose cotransporter), member 10
Synonyms: SGLT5, C330021F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 109342
Homologene: 65037
Cep295nl
Name: CEP295 N-terminal like
Synonyms: Ddc8, BC100451
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 58251
Homologene: 75164
Or52e19b
Name: olfactory receptor family 52 subfamily E member 19B
Synonyms: GA_x6K02T2PBJ9-6096387-6095449, GA_x6K02T2PBJ9-6092550-6092362, MOR32-2, MOR32-14_i, Olfr604, Olfr603
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259073
Homologene: 121535
Chchd2
Name: coiled-coil-helix-coiled-coil-helix domain containing 2
Synonyms: Etohi6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14004
Homologene: 49449
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 184,727,641 bp
  • A to G, chromosome 2 at 25,844,636 bp
  • T to C, chromosome 2 at 26,480,971 bp
  • G to A, chromosome 2 at 32,919,481 bp
  • A to T, chromosome 2 at 36,036,515 bp
  • T to A, chromosome 2 at 145,911,795 bp
  • G to A, chromosome 3 at 95,617,125 bp
  • T to C, chromosome 5 at 117,995,386 bp
  • T to A, chromosome 5 at 122,880,699 bp
  • G to T, chromosome 5 at 129,884,148 bp
  • A to G, chromosome 6 at 137,449,887 bp
  • A to T, chromosome 7 at 5,325,042 bp
  • A to G, chromosome 7 at 16,906,869 bp
  • A to G, chromosome 7 at 25,288,134 bp
  • T to C, chromosome 7 at 30,528,650 bp
  • T to C, chromosome 7 at 43,659,369 bp
  • T to C, chromosome 7 at 80,481,370 bp
  • T to A, chromosome 7 at 103,383,200 bp
  • T to G, chromosome 8 at 3,439,575 bp
  • T to C, chromosome 8 at 12,632,292 bp
  • T to C, chromosome 8 at 36,505,650 bp
  • A to T, chromosome 8 at 109,844,354 bp
  • A to G, chromosome 8 at 120,015,339 bp
  • A to T, chromosome 8 at 125,015,689 bp
  • T to G, chromosome 9 at 15,353,058 bp
  • T to A, chromosome 9 at 100,889,595 bp
  • A to G, chromosome 9 at 114,512,772 bp
  • A to G, chromosome 10 at 18,096,283 bp
  • T to A, chromosome 10 at 127,555,738 bp
  • C to T, chromosome 11 at 61,719,934 bp
  • A to G, chromosome 11 at 84,834,433 bp
  • C to T, chromosome 11 at 100,207,113 bp
  • T to C, chromosome 11 at 118,332,509 bp
  • T to C, chromosome 12 at 72,079,474 bp
  • A to G, chromosome 12 at 83,091,804 bp
  • A to G, chromosome 12 at 84,921,256 bp
  • A to G, chromosome 12 at 87,174,257 bp
  • G to A, chromosome 13 at 38,196,451 bp
  • A to G, chromosome 14 at 34,567,396 bp
  • A to G, chromosome 14 at 63,379,613 bp
  • A to G, chromosome 15 at 11,215,735 bp
  • CCTTTGCGCTT to CCTT, chromosome 15 at 47,741,236 bp
  • C to T, chromosome 17 at 29,702,173 bp
  • C to A, chromosome 17 at 34,064,797 bp
  • C to A, chromosome 17 at 40,602,393 bp
  • G to C, chromosome 19 at 7,282,747 bp
  • T to A, chromosome 19 at 13,191,309 bp
  • C to G, chromosome 19 at 55,180,999 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2161 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040164-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.