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Strain Name:
C57BL/6J-MtgxR2168Btlr/Mmmh
Stock Number:
040171-MU
Citation ID:
RRID:MMRRC_040171-MU
Other Names:
R2168 (G1), C57BL/6J-MtgxR2168Btlr
Major Collection:

Strain Information

Sod1
Name: superoxide dismutase 1, soluble
Synonyms: CuZnSOD, SODC, Cu/Zn-SOD, Cu(2+)-Zn2+ superoxide dismutase, Sod-1, Ipo1, Ipo-1, B430204E11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20655
VEGA: 16
Homologene: 392
Neurog2
Name: neurogenin 2
Synonyms: Math4A, ngn2, Atoh4, bHLHa8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11924
Homologene: 7633
Ptch1
Name: patched 1
Synonyms: Ptc, Patched 1, Ptc1, A230106A15Rik, wig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11287
Homologene: 104112
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 319765
Homologene: 4774
Rfesd
Name: Rieske (Fe-S) domain containing
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218341
VEGA: 13
Homologene: 18282
Ipo11
Name: importin 11
Synonyms: E330021B14Rik, 1700081H05Rik, 2510001A17Rik, Ranbp11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76582
Homologene: 7089
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, 1810043M20Rik, Bat2d, Bat2l2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226562
Homologene: 41015
Nol10
Name: nucleolar protein 10
Synonyms: LOC217431
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217431
VEGA: 12
Homologene: 5998
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Gas2l3
Name: growth arrest-specific 2 like 3
Synonyms: LOC237436, 8430435B07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237436
VEGA: 10
Homologene: 18386
Ap3s2
Name: adaptor-related protein complex 3, sigma 2 subunit
Synonyms: sigma 3B, [s]3B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11778
HGNC: HGNC:571
Homologene: 100592
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76501
Homologene: 8584
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Zfp369
Name: zinc finger protein 369
Synonyms: NRIF2, D230020H11Rik, B930030B22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 170936
Homologene: 129707
Serpina3c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3C
Synonyms: Kalbp, 1A1, Klkbp, alpha-1 antiproteinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16625
HGNC: HGNC:16
Homologene: 111129
Megf9
Name: multiple EGF-like-domains 9
Synonyms: 4933405H16Rik, Egfl5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230316
HGNC: HGNC:3234
Homologene: 18209
Nectin2
Name: nectin cell adhesion molecule 2
Synonyms: nectin-2, MPH, Cd112, Pvs, Pvrl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19294
HGNC: HGNC:9707
Homologene: 86092
Gdap2
Name: ganglioside-induced differentiation-associated-protein 2
Synonyms: D3Ertd801e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14547
Homologene: 7728
Itsn2
Name: intersectin 2
Synonyms: Sh3p18, Ese2, Eh domain, SH3 domain regulator of endocytosis 2, Sh3d1B
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Rai1
Name: retinoic acid induced 1
Synonyms: Gt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19377
HGNC: HGNC:9834
Homologene: 7508
F2
Name: coagulation factor II
Synonyms: prothrombin, Cf-2, Cf2, FII, thrombin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14061
HGNC: HGNC:3535
Homologene: 426
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 3110001A05Rik, 1810064L21Rik, 3110027P15Rik, A230065J02Rik, Ugcgl2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66435
Homologene: 56875
Msh4
Name: mutS homolog 4
Synonyms: mMsh4, 4930485C04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55993
HGNC: HGNC:7327
Homologene: 1830
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Zfp608
Name: zinc finger protein 608
Synonyms: 4932417D18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269023
VEGA: 18
Homologene: 18485
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Mrc1
Name: mannose receptor, C type 1
Synonyms: CD206, MR
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Serpinb6d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms: SPI3D, Gm11390
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238568
HGNC: HGNC:8950
Jakmip2
Name: janus kinase and microtubule interacting protein 2
Synonyms: 6430702L21Rik, D930046L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76217
VEGA: 18
Homologene: 8866
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: PAG1, IGFBP-4ase, PAPP-A, 8430414N03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Gm16432
Name: predicted gene 16432
Type: Gene
Species: Mouse
Chromosome: 1
Rd3
Name: retinal degeneration 3
Synonyms: rd-3, 3322402L07Rik, rd3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74023
Homologene: 11373
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Plekhn1
Name: pleckstrin homology domain containing, family N member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231002
VEGA: 4
Homologene: 12949
Als2cl
Name: ALS2 C-terminal like
Synonyms: mRn.49018, D930044G19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235633
Homologene: 17152
Ctsll3
Name: cathepsin L-like 3
Synonyms: 2310051M13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70202
VEGA: 13
Homologene: 134916
Vmn1r217
Name: vomeronasal 1 receptor 217
Synonyms: V1rh14
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171273
Homologene: 110880
Or4c29
Name: olfactory receptor family 4 subfamily C member 29
Synonyms: GA_x6K02T2Q125-50386882-50385950, MOR230-7, Olfr1209
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258453
Homologene: 128155
Card14
Name: caspase recruitment domain family, member 14
Synonyms: CARMA2, Bimp2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170720
Homologene: 11469
Pcdhb7
Name: protocadherin beta 7
Synonyms: Pcdhb4B, PcdhbG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93878
HGNC: HGNC:8689
Homologene: 87123
Or5h23
Name: olfactory receptor family 5 subfamily H member 23
Synonyms: GA_x54KRFPKG5P-55314632-55313703, MOR183-5P, Olfr191
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258035
Homologene: 128162
Lrrc17
Name: leucine rich repeat containing 17
Synonyms: 6130400C22Rik, 4833425M04Rik, 37kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74511
Homologene: 55929
Fpr1
Name: formyl peptide receptor 1
Synonyms: FPR, fMLF-R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14293
HGNC: HGNC:3826
Homologene: 20466
Radil
Name: Ras association and DIL domains
Synonyms: D930005D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231858
Homologene: 77648
Zer1
Name: zyg-11 related, cell cycle regulator
Synonyms: C230075L19Rik, Zyg11bl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227693
Homologene: 4621
Acoxl
Name: acyl-Coenzyme A oxidase-like
Synonyms: 1200014P05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74121
Homologene: 75083
Or51h7
Name: olfactory receptor family 51 subfamily H member 7
Synonyms: GA_x6K02T2PBJ9-5653743-5652872, MOR10-3P, MOR10-4, Olfr573
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258230
Skint4
Name: selection and upkeep of intraepithelial T cells 4
Synonyms: 9530098N22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320640
Akr1c14
Name: aldo-keto reductase family 1, member C14
Synonyms: 9030611N15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105387
Homologene: 138093
FP885536.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Or1f12
Name: olfactory receptor family 1 subfamily F member 12
Synonyms: GA_x6K02T2QHY8-11707053-11707994, MOR130-2, Olfr1366
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258280
Homologene: 105872
Stfa3
Name: stefin A3
Synonyms: Stf3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20863
VEGA: 16
HGNC: HGNC:2481
Homologene: 115602
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: PC3, prohormone convertase 1/3, Nec-1, Nec1, PC1, SPC3, Phpp-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Fam78b
Name: family with sequence similarity 78, member B
Synonyms: C030020L09Rik, C030014K22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226610
Homologene: 18451
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 162,710,334 bp
  • G to A, chromosome 1 at 167,078,650 bp
  • C to T, chromosome 1 at 178,015,911 bp
  • A to G, chromosome 1 at 191,983,527 bp
  • T to C, chromosome 2 at 14,244,204 bp
  • A to G, chromosome 2 at 30,104,875 bp
  • A to T, chromosome 2 at 41,375,846 bp
  • A to G, chromosome 2 at 88,910,178 bp
  • C to T, chromosome 2 at 91,628,348 bp
  • G to A, chromosome 2 at 101,886,331 bp
  • T to A, chromosome 2 at 127,878,781 bp
  • C to T, chromosome 3 at 93,201,937 bp
  • A to C, chromosome 3 at 100,187,883 bp
  • A to T, chromosome 3 at 127,634,105 bp
  • A to T, chromosome 3 at 153,867,835 bp
  • A to C, chromosome 4 at 65,156,445 bp
  • T to C, chromosome 4 at 70,433,442 bp
  • A to T, chromosome 4 at 112,086,986 bp
  • A to G, chromosome 4 at 139,410,649 bp
  • G to T, chromosome 4 at 145,087,323 bp
  • T to A, chromosome 4 at 156,221,882 bp
  • A to T, chromosome 4 at 156,338,378 bp
  • A to T, chromosome 5 at 21,575,048 bp
  • A to C, chromosome 5 at 142,506,963 bp
  • A to G, chromosome 6 at 113,591,159 bp
  • A to G, chromosome 6 at 121,870,499 bp
  • G to A, chromosome 6 at 128,488,047 bp
  • G to T, chromosome 6 at 146,111,678 bp
  • G to T, chromosome 7 at 19,730,614 bp
  • C to A, chromosome 7 at 79,915,267 bp
  • A to T, chromosome 7 at 102,942,471 bp
  • T to A, chromosome 9 at 55,743,639 bp
  • C to A, chromosome 9 at 110,888,742 bp
  • A to G, chromosome 10 at 89,414,098 bp
  • T to C, chromosome 11 at 60,187,596 bp
  • TCCCCCCCCCCC to TCCCCCCCCCCCCCCC, chromosome 11 at 119,321,798 bp
  • CCCC to CCCCCCCC, chromosome 11 at 119,321,806 bp
  • A to C, chromosome 11 at 119,415,070 bp
  • G to T, chromosome 12 at 4,633,044 bp
  • A to T, chromosome 12 at 17,373,584 bp
  • T to C, chromosome 12 at 104,149,369 bp
  • T to C, chromosome 13 at 4,081,106 bp
  • T to G, chromosome 13 at 21,537,252 bp
  • G to A, chromosome 13 at 23,114,544 bp
  • A to T, chromosome 13 at 33,666,374 bp
  • C to T, chromosome 13 at 60,800,935 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • T to C, chromosome 13 at 65,296,948 bp
  • T to A, chromosome 13 at 75,112,534 bp
  • T to C, chromosome 13 at 76,008,125 bp
  • T to C, chromosome 13 at 106,879,610 bp
  • T to A, chromosome 14 at 119,019,505 bp
  • C to A, chromosome 15 at 35,792,188 bp
  • C to A, chromosome 15 at 35,792,189 bp
  • A to T, chromosome 15 at 76,603,737 bp
  • T to A, chromosome 16 at 22,079,608 bp
  • C to A, chromosome 16 at 36,450,680 bp
  • T to A, chromosome 16 at 59,085,586 bp
  • T to C, chromosome 16 at 90,220,913 bp
  • T to C, chromosome 17 at 17,877,209 bp
  • T to A, chromosome 18 at 37,343,282 bp
  • A to G, chromosome 18 at 43,565,930 bp
  • A to T, chromosome 18 at 54,898,053 bp
  • G to A, chromosome 18 at 60,916,651 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2168 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040171-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.