Strain Name:
C57BL/6J-MtgxR2181Btlr/Mmmh
Stock Number:
040183-MU
Citation ID:
RRID:MMRRC_040183-MU
Other Names:
R2181 (G1), C57BL/6J-MtgxR2181Btlr
Major Collection:

Gene Information

Penk
Name: preproenkephalin
Synonyms: Penk, Penk1, PPA, ENK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18619
HGNC: HGNC:8831
Homologene: 4528
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, b2b1562Clo, 6030440P17Rik, ne, my
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242022
Homologene: 18454
Htr6
Name: 5-hydroxytryptamine (serotonin) receptor 6
Synonyms: 5-HT6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15565
HGNC: HGNC:5301
Homologene: 673
Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: 5730456G07Rik, 1200004O12Rik, Hbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56324
Homologene: 68490
Slc4a2
Name: solute carrier family 4 (anion exchanger), member 2
Synonyms: Ae2, B3RP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20535
Homologene: 128699
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Ppp2r5e
Name: protein phosphatase 2, regulatory subunit B', epsilon
Synonyms: B56beta, protein phosphatase 2A subunit beta, 4633401M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 26932
VEGA: 12
HGNC: HGNC:9313
Homologene: 55962
Trappc8
Name: trafficking protein particle complex 8
Synonyms: Trs85, 5033403J15Rik, D030074E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75964
VEGA: 18
Homologene: 40993
Ift74
Name: intraflagellar transport 74
Synonyms: Ccdc2, 1700029H06Rik, b2b796Clo, Cmg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67694
Homologene: 11831
Gabrr3
Name: gamma-aminobutyric acid (GABA) receptor, rho 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 328699
VEGA: 16
Homologene: 26716
Tmtc3
Name: transmembrane and tetratricopeptide repeat containing 3
Synonyms: B130008E12Rik, mSmile, 9130014E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237500
Homologene: 27616
Ptprm
Name: protein tyrosine phosphatase, receptor type, M
Synonyms: RPTPmu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Numbl
Name: numb-like
Synonyms: nbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18223
HGNC: HGNC:8061
Homologene: 68413
Nelfa
Name: negative elongation factor complex member A, Whsc2
Synonyms: Whsc2h, Whsc2, Nelf-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 24116
Homologene: 68478
Trim11
Name: tripartite motif-containing 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94091
Homologene: 14225
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Nbeal1
Name: neurobeachin like 1
Synonyms: 2310076G13Rik, ALS2CR17, A530083I02Rik, A530050O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269198
Homologene: 16453
Kdm6b
Name: KDM1 lysine (K)-specific demethylase 6B
Synonyms: Jmjd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216850
Homologene: 18945
Pglyrp2
Name: peptidoglycan recognition protein 2
Synonyms: C730002N09Rik, PGRP-L, tagL, tagl-beta, Pglyrpl, tagL-alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57757
VEGA: 17
Homologene: 49671
Colec12
Name: collectin sub-family member 12
Synonyms: Scara4, SRCL, CL-P1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 140792
VEGA: 18
Homologene: 34248
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: C130041O22Rik, Zfh-4, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Pigg
Name: phosphatidylinositol glycan anchor biosynthesis, class G
Synonyms: Gpi7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 433931
Homologene: 39421
Gorasp1
Name: golgi reassembly stacking protein 1
Synonyms: 5430411C10Rik, P65, GOLPH5, GRASP65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74498
VEGA: 9
Homologene: 49916
Sh3rf1
Name: SH3 domain containing ring finger 1
Synonyms: Sh3md2, Posh, 2200003J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 59009
Homologene: 10988
C7
Name: complement component 7
Synonyms: LOC383055
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109828
VEGA: 15
HGNC: HGNC:1346
Homologene: 489
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207618
Homologene: 52304
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: OTTMUSG00000020804, ENSMUSG00000044873, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Ecm2
Name: extracellular matrix protein 2, female organ and adipocyte specific
Synonyms: 9030618O22Rik, tenonectin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 407800
VEGA: 13
HGNC: HGNC:3154
Homologene: 1064
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: Heatr7a, D330001F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223658
Homologene: 44882
Abcb5
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Olfr346
Name: olfactory receptor 346
Synonyms: MOR136-11, GA_x6K02T2NLDC-33382467-33383396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258940
Homologene: 133616
Gbp7
Name: guanylate binding protein 7
Synonyms: 9830147J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229900
Homologene: 138296
Zfp811
Name: zinc finger protein 811
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240063
Pld2
Name: phospholipase D2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18806
HGNC: HGNC:9068
Homologene: 55672
Faxc
Name: failed axon connections homolog
Synonyms: 6230409E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76132
Homologene: 32781
Tmc3
Name: transmembrane channel-like gene family 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233424
Homologene: 45588
Olfr272
Name: olfactory receptor 272
Synonyms: GA_x6K02T2N78B-7084885-7085844, MOR262-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258836
Homologene: 17409
Olfr1370
Name: olfactory receptor 1370
Synonyms: MOR256-14, GA_x6K02T2QHY8-12181473-12182423
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 258528
Homologene: 105231
Vmn1r72
Name: vomeronasal 1 receptor 72
Synonyms: V1rg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 252905
Homologene: 74318
Mmp28
Name: matrix metallopeptidase 28 (epilysin)
Synonyms: epilysin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 118453
Homologene: 41559
Olfr1467
Name: olfactory receptor 1467
Synonyms: MOR202-15, GA_x6K02T2RE5P-3695694-3696620
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258686
Homologene: 133888
Vmn2r76
Name: vomeronasal 2, receptor 76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 675969
Homologene: 104330
1700037C18Rik
Name: RIKEN cDNA 1700037C18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 73261
Homologene: 47480
Zfp764
Name: zinc finger protein 764
Synonyms: 8030466O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233893
Homologene: 62158
Cyp2c67
Name: cytochrome P450, family 2, subfamily c, polypeptide 67
Synonyms: C730004C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 545288
Homologene: 74936
Adgra2
Name: adhesion G protein-coupled receptor A2
Synonyms: 9530074E10Rik, Gpr124, Tem5, 8430414O08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78560
Homologene: 13112
Olfr678
Name: olfactory receptor 678
Synonyms: MOR32-5, GA_x6K02T2PBJ9-7698491-7699432
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258753
Homologene: 27254
Trdv2-1
Name: T cell receptor delta variable 2-1
Synonyms: ENSMUSG00000068352
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100101942
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 60,278,780 bp
  • CTCTCTCTCTCTCTCTCTCTC to CTCTCTCTCTCTCTCTCTCTCTCTCTCTC, chromosome 1 at 88,247,720 bp
  • A to G, chromosome 1 at 133,735,219 bp
  • G to A, chromosome 2 at 36,688,334 bp
  • A to T, chromosome 2 at 52,703,144 bp
  • A to C, chromosome 3 at 5,403,332 bp
  • A to G, chromosome 3 at 53,574,587 bp
  • A to T, chromosome 3 at 56,029,939 bp
  • A to G, chromosome 3 at 142,544,030 bp
  • T to C, chromosome 4 at 4,134,041 bp
  • T to A, chromosome 4 at 21,931,591 bp
  • T to A, chromosome 4 at 52,911,524 bp
  • A to G, chromosome 4 at 94,632,714 bp
  • A to G, chromosome 4 at 139,074,425 bp
  • G to A, chromosome 5 at 6,771,674 bp
  • A to G, chromosome 5 at 24,435,653 bp
  • T to C, chromosome 5 at 33,900,509 bp
  • T to C, chromosome 5 at 108,336,500 bp
  • A to T, chromosome 7 at 11,669,668 bp
  • T to A, chromosome 7 at 27,268,921 bp
  • A to G, chromosome 7 at 83,610,708 bp
  • T to C, chromosome 7 at 86,225,535 bp
  • T to C, chromosome 7 at 105,070,211 bp
  • A to G, chromosome 7 at 127,406,499 bp
  • G to A, chromosome 8 at 27,121,673 bp
  • G to T, chromosome 8 at 61,363,238 bp
  • A to G, chromosome 9 at 119,928,356 bp
  • T to C, chromosome 10 at 100,448,973 bp
  • T to A, chromosome 11 at 58,990,182 bp
  • A to T, chromosome 11 at 69,401,126 bp
  • A to G, chromosome 11 at 70,542,989 bp
  • A to C, chromosome 11 at 83,442,717 bp
  • T to C, chromosome 12 at 75,462,324 bp
  • T to G, chromosome 12 at 118,867,946 bp
  • G to T, chromosome 13 at 21,073,224 bp
  • T to A, chromosome 13 at 49,530,289 bp
  • A to T, chromosome 14 at 53,946,320 bp
  • T to A, chromosome 15 at 4,990,501 bp
  • T to A, chromosome 15 at 76,428,394 bp
  • C to T, chromosome 16 at 3,907,086 bp
  • T to A, chromosome 16 at 59,448,009 bp
  • A to G, chromosome 17 at 32,418,962 bp
  • T to G, chromosome 17 at 32,797,721 bp
  • A to G, chromosome 17 at 66,683,544 bp
  • T to C, chromosome 17 at 67,896,117 bp
  • T to A, chromosome 18 at 9,846,828 bp
  • A to G, chromosome 18 at 20,819,222 bp
  • G to T, chromosome 19 at 13,365,074 bp
  • A to G, chromosome 19 at 39,609,097 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2181 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040183-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.