Strain Name:
C57BL/6J-MtgxR2182Btlr/Mmmh
Stock Number:
040184-MU
Citation ID:
RRID:MMRRC_040184-MU
Other Names:
R2182 (G1), C57BL/6J-MtgxR2182Btlr
Major Collection:

Gene Information

Slc6a2
Name: solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Synonyms: Slc6a5, NE transporter, NET, norepinephrine transporter
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20538
Homologene: 816
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330286
Homologene: 19782
Scd1
Name: stearoyl-Coenzyme A desaturase 1
Synonyms: stearoyl-CoA desaturase, Scd-1, SCD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20249
VEGA: 19
Homologene: 74538
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20269
Homologene: 56005
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 207521
VEGA: 19
Homologene: 27781
Eprs
Name: glutamyl-prolyl-tRNA synthetase
Synonyms: 2410081F06Rik, 3010002K18Rik, Qprs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Zc3h4
Name: zinc finger CCCH-type containing 4
Synonyms: LOC330474, Bwq1, Kiaa1064-hp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330474
Homologene: 87150
Nav2
Name: neuron navigator 2
Synonyms: POMFIL2, Unc53H2, HELAD1, RAINB2, 5330421F07Rik, Rainb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78286
Homologene: 52330
Zfp292
Name: zinc finger protein 292
Synonyms: Zn-16, Zn-15, Krox-10, Zfp-15, 9430062L07Rik, 5730450D02Rik, Zfp15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30046
Homologene: 8493
Mrps5
Name: mitochondrial ribosomal protein S5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77721
Homologene: 32726
Fntb
Name: farnesyltransferase, CAAX box, beta
Synonyms: 2010013E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110606
Homologene: 1535
Scaf4
Name: SR-related CTD-associated factor 4
Synonyms: Sra4, Sfrs15, Srsf15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224432
VEGA: 16
Homologene: 16227
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Nob1
Name: NIN1/RPN12 binding protein 1 homolog
Synonyms: ART-4, Nob1p, 1700021I09Rik, Psmd8bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67619
Homologene: 31924
Obi1
Name: ORC ubiquitin ligase 1
Synonyms: 2810449K13Rik, 2610206B13Rik, Rnf219
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 72486
VEGA: 14
Homologene: 11578
Dcaf6
Name: DDB1 and CUL4 associated factor 6
Synonyms: PC326, 1200006M05Rik, Iqwd1, NRIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74106
Homologene: 10199
Golm2
Name: golgi membrane protein 2
Synonyms: D130060C09Rik, Casc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319996
Homologene: 16310
Sost
Name: sclerostin
Synonyms: 5430411E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74499
Homologene: 11542
Zbtb44
Name: zinc finger and BTB domain containing 44
Synonyms: 6030404E16Rik, Btbd15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235132
VEGA: 9
Homologene: 18221
Zfp839
Name: zinc finger protein 839
Synonyms: 2810455K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 72805
VEGA: 12
Homologene: 49541
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329278
Homologene: 18634
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: WND, Wilson protein, Atp7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Abca15
Name: ATP-binding cassette, sub-family A (ABC1), member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320631
Homologene: 87255
Dxo
Name: decapping exoribonuclease
Synonyms: Dom3z
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 112403
HGNC: HGNC:2992
Homologene: 38061
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: D13Lsd1, Naip, Birc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Or13p3
Name: olfactory receptor family 13 subfamily P member 3
Synonyms: GA_x6K02T2QD9B-18838170-18837232, MOR258-1, Olfr1341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258852
Homologene: 27281
Cox7a2l
Name: cytochrome c oxidase subunit 7A2 like
Synonyms: SIG-81, COX7RP, COX7AR, EB1, SIG81
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20463
VEGA: 17
HGNC: HGNC:2289
Homologene: 3463
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Zscan12
Name: zinc finger and SCAN domain containing 12
Synonyms: Zfp96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 22758
Homologene: 86980
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: EG381742, Zfp469
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231861
Homologene: 45603
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665210
Homologene: 115024
Mpl
Name: myeloproliferative leukemia virus oncogene
Synonyms: c-mpl, thrombopoietin receptor, TPO-R, CD110, c-mpl-II, c-mpl-I, hlb219
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17480
HGNC: HGNC:7217
Homologene: 7845
Gm5773
Name: predicted pseudogene 5773
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 436563
Hyal5
Name: hyaluronoglucosaminidase 5
Synonyms: 4933439A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74468
Homologene: 50610
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Arhgap26
Name: Rho GTPase activating protein 26
Synonyms: 1810044B20Rik, 2610010G17Rik, 4933432P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71302
Homologene: 36349
Or7g33
Name: olfactory receptor family 7 subfamily G member 33
Synonyms: GA_x6K02T2PVTD-13277703-13276786, MOR154-1, Olfr853
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258908
HGNC: HGNC:8466
Homologene: 133623
Lamc2
Name: laminin, gamma 2
Synonyms: nicein, 100kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16782
HGNC: HGNC:6493
Homologene: 4062
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: A930009L15Rik, 4930544G21Rik, SKIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77629
Homologene: 18172
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, EG637898, Gprc2a-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637898
Homologene: 129683
4930550C14Rik
Name: RIKEN cDNA 4930550C14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75311
VEGA: 9
Homologene: 12595
Or8g36
Name: olfactory receptor family 8 subfamily G member 36
Synonyms: GA_x6K02T2PVTD-33208209-33207274, MOR171-12, Olfr957
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258740
VEGA: 9
Clgn
Name: calmegin
Synonyms: Cln, 4930459O04Rik, calnexin-t, A2/6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12745
HGNC: HGNC:2060
Homologene: 68392
Scarf2
Name: scavenger receptor class F, member 2
Synonyms: Srec2, SREC-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224024
VEGA: 16
Homologene: 17817
Cyp2a12
Name: cytochrome P450, family 2, subfamily a, polypeptide 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13085
Homologene: 69128
Clec4a4
Name: C-type lectin domain family 4, member a4
Synonyms: Dcir2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 474145
Homologene: 133910
Lpxn
Name: leupaxin
Synonyms: 4933402K05Rik, A530083L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107321
VEGA: 19
Homologene: 3536
Aloxe3
Name: arachidonate lipoxygenase 3
Synonyms: e-LOX-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23801
Homologene: 8013
Mpnd
Name: MPN domain containing
Synonyms: E130307M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68047
Homologene: 12231
Pbx2
Name: pre B cell leukemia homeobox 2
Synonyms: G17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18515
HGNC: HGNC:8633
Homologene: 48115
Or8b43
Name: olfactory receptor family 8 subfamily B member 43
Synonyms: GA_x6K02T2PVTD-32141623-32142552, MOR169-1, Olfr902
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258798
VEGA: 9
Zg16
Name: zymogen granule protein 16
Synonyms: 1810010M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69036
Homologene: 12296
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 83,276,684 bp
  • A to G, chromosome 1 at 153,126,866 bp
  • T to C, chromosome 1 at 160,140,600 bp
  • A to T, chromosome 1 at 165,424,295 bp
  • G to A, chromosome 1 at 172,290,728 bp
  • G to A, chromosome 1 at 185,379,742 bp
  • A to T, chromosome 2 at 65,507,291 bp
  • A to G, chromosome 2 at 121,867,428 bp
  • T to C, chromosome 2 at 127,602,487 bp
  • T to A, chromosome 3 at 93,773,513 bp
  • A to G, chromosome 4 at 34,807,417 bp
  • A to T, chromosome 4 at 81,348,722 bp
  • T to A, chromosome 4 at 118,457,413 bp
  • T to C, chromosome 4 at 118,710,345 bp
  • A to G, chromosome 4 at 123,492,671 bp
  • T to A, chromosome 4 at 143,897,190 bp
  • T to C, chromosome 5 at 142,760,061 bp
  • T to C, chromosome 6 at 24,877,880 bp
  • C to T, chromosome 6 at 38,174,147 bp
  • A to G, chromosome 6 at 123,013,757 bp
  • G to A, chromosome 7 at 16,422,516 bp
  • A to T, chromosome 7 at 27,031,146 bp
  • A to G, chromosome 7 at 42,195,507 bp
  • G to A, chromosome 7 at 49,597,254 bp
  • G to T, chromosome 7 at 109,933,994 bp
  • G to A, chromosome 7 at 120,340,227 bp
  • A to G, chromosome 7 at 127,050,372 bp
  • T to C, chromosome 8 at 22,014,547 bp
  • C to T, chromosome 8 at 83,410,410 bp
  • A to G, chromosome 8 at 92,961,248 bp
  • C to T, chromosome 8 at 107,421,469 bp
  • T to C, chromosome 9 at 19,537,342 bp
  • T to C, chromosome 9 at 31,066,676 bp
  • A to G, chromosome 9 at 38,449,124 bp
  • A to T, chromosome 9 at 39,511,426 bp
  • T to A, chromosome 9 at 45,928,619 bp
  • A to G, chromosome 9 at 53,422,943 bp
  • G to A, chromosome 11 at 69,129,600 bp
  • T to C, chromosome 11 at 101,963,850 bp
  • A to G, chromosome 12 at 76,862,535 bp
  • C to T, chromosome 12 at 110,868,338 bp
  • A to G, chromosome 13 at 21,368,791 bp
  • T to A, chromosome 13 at 100,413,680 bp
  • A to G, chromosome 14 at 104,506,176 bp
  • T to C, chromosome 15 at 6,772,204 bp
  • T to C, chromosome 16 at 17,803,022 bp
  • T to C, chromosome 16 at 90,230,140 bp
  • C to A, chromosome 17 at 18,105,429 bp
  • C to A, chromosome 17 at 34,595,666 bp
  • T to C, chromosome 17 at 34,838,892 bp
  • A to G, chromosome 17 at 56,015,964 bp
  • C to T, chromosome 17 at 83,503,920 bp
  • G to T, chromosome 18 at 39,357,809 bp
  • C to A, chromosome 19 at 12,483,107 bp
  • T to C, chromosome 19 at 12,832,758 bp
  • T to G, chromosome 19 at 44,403,293 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2182 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040184-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.