Strain Name:
C57BL/6J-MtgxR2189Btlr/Mmmh
Stock Number:
040191-MU
Citation ID:
RRID:MMRRC_040191-MU
Other Names:
R2189 (G1), C57BL/6J-MtgxR2189Btlr
Major Collection:

Gene Information

Itga6
Name: integrin alpha 6
Synonyms: Cd49f, 5033401O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16403
HGNC: HGNC:6142
Homologene: 20091
Pml
Name: promyelocytic leukemia
Synonyms: Trim19, 1200009E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18854
HGNC: HGNC:9113
Homologene: 13245
Clptm1
Name: cleft lip and palate associated transmembrane protein 1
Synonyms: N14, HS9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56457
HGNC: HGNC:2087
Homologene: 37464
Traf3ip1
Name: TRAF3 interacting protein 1
Synonyms: 3930402D05Rik, MIP-T3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74019
Homologene: 22913
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208727
Homologene: 55946
Yars
Name: tyrosyl-tRNA synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 107271
Homologene: 2730
Dffa
Name: DNA fragmentation factor, alpha subunit
Synonyms: ICAD-S, ICAD-L, Dff45, DFF35, A330085O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13347
HGNC: HGNC:2772
Homologene: 3240
Pan3
Name: PAN3 poly(A) specific ribonuclease subunit
Synonyms: 2700050F09Rik, A430027N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72587
Homologene: 6372
Mmadhc
Name: methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
Synonyms: 2010311D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109129
Homologene: 9248
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Esrp1
Name: epithelial splicing regulatory protein 1
Synonyms: 2210008M09Rik, Rbm35a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 207920
Homologene: 9785
Dlk1
Name: delta like non-canonical Notch ligand 1
Synonyms: pref-1, ZOG, SCP1, FA1, pG2, Peg9, DlkI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13386
HGNC: HGNC:2907
Homologene: 2846
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: FOG-2, FOG2, B330005D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22762
VEGA: 15
Homologene: 8008
Bsph1
Name: binder of sperm protein homolog 1
Synonyms: LOC330470
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330470
Homologene: 86818
Tnfrsf1a
Name: tumor necrosis factor receptor superfamily, member 1a
Synonyms: TNF receptor alpha chain, CD120a, TNF-R1, p55, TNF-R55, TNFRp55, Tnfr1, TNF-R-I, TNFR60, TNFAR, p55-R, TNFRI, TNF-alphaR1, TNF-alpha-R1, TNFalpha-R1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21937
Homologene: 828
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, crash, Adgrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Eral1
Name: Era (G-protein)-like 1 (E. coli)
Synonyms: MERA-S, MERA-W, 9130407C09Rik, 2610524P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57837
HGNC: HGNC:3424
Homologene: 4167
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 637515
Homologene: 19080
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Sugct
Name: succinyl-CoA glutarate-CoA transferase
Synonyms: 5033411D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 192136
VEGA: 13
Homologene: 11681
Scap
Name: SREBF chaperone
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235623
Homologene: 8160
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: MyHC-IId/x, Myhs-f2, Myhs-f, Myhsf2, A530084A17Rik, MYHC-IIX, myosin heavy chain 2X, IId, IId/x
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Vmn2r5
Name: vomeronasal 2, receptor 5
Synonyms: EG667060
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 667060
Lipa
Name: lysosomal acid lipase A
Synonyms: Lal, Lip-1, Lip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16889
VEGA: 19
HGNC: HGNC:6617
Homologene: 37277
Olfr1030
Name: olfactory receptor 1030
Synonyms: GA_x6K02T2Q125-47462755-47463693, MOR196-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258581
Homologene: 64892
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mdga2, 9330209L04Rik, 6720489L24Rik, Mamdc1, Adp, Tg(Prnp-PFN1*G118V)838Kiaei
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320772
Homologene: 45659
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: ojoplano, Opo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Olfr691
Name: olfactory receptor 691
Synonyms: GA_x6K02T2PBJ9-7966695-7965727, MOR31-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259063
Homologene: 17483
Sgsm2
Name: small G protein signaling modulator 2
Synonyms: D630003G22Rik, Rutbc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 97761
Homologene: 14780
Fam83e
Name: family with sequence similarity 83, member E
Synonyms: 4930403C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73813
Homologene: 9791
Acan
Name: aggrecan
Synonyms: Cspg1, Agc1, b2b183Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11595
HGNC: HGNC:319
Homologene: 137204
Icosl
Name: icos ligand
Synonyms: B7h, GL50, ICOS-L, B7RP-1, GL50-B, LICOS, B7-H2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 50723
VEGA: 10
Homologene: 49412
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Tnk2
Name: tyrosine kinase, non-receptor, 2
Synonyms: P21cdc42Hs kinase, Ack, activated p21cdc42Hs kinase, ACK1, Pyk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 51789
Homologene: 4224
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR3, VEGFR-3, Flt-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
CT573017.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Olfr469
Name: olfactory receptor 469
Synonyms: GA_x6K02T2PBJ9-10152980-10152036, MOR204-21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258418
Homologene: 44979
V1ra8
Name: vomeronasal 1 receptor, A8
Synonyms: Vmn1r-ps33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113850
Olfr481
Name: olfactory receptor 481
Synonyms: GA_x6K02T2PBJ9-10409785-10410723, MOR204-2, MOR204-39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258927
Homologene: 105166
Adamtsl2
Name: ADAMTS-like 2
Synonyms: A930008K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77794
Homologene: 8798
AC158220.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Cry2
Name: cryptochrome 2 (photolyase-like)
Synonyms: D130054K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12953
HGNC: HGNC:2385
Homologene: 56466
H2bc15
Name: H2B clustered histone 15
Synonyms: Hist1h2bn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319187
HGNC: HGNC:4750
Homologene: 136772
Lhx1
Name: LIM homeobox protein 1
Synonyms: Lim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16869
HGNC: HGNC:6593
Homologene: 4068
Tmco5b
Name: transmembrane and coiled-coil domains 5B
Synonyms: 4930563P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75275
Homologene: 52839
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 91,499,494 bp
  • T to C, chromosome 1 at 91,975,522 bp
  • T to C, chromosome 2 at 27,081,738 bp
  • A to C, chromosome 2 at 50,288,946 bp
  • A to G, chromosome 2 at 71,825,617 bp
  • A to G, chromosome 2 at 85,984,068 bp
  • T to C, chromosome 2 at 92,411,692 bp
  • T to G, chromosome 2 at 113,290,839 bp
  • A to C, chromosome 3 at 64,509,593 bp
  • A to T, chromosome 4 at 11,357,603 bp
  • A to G, chromosome 4 at 129,206,189 bp
  • C to A, chromosome 4 at 149,107,926 bp
  • T to A, chromosome 5 at 147,453,242 bp
  • A to C, chromosome 6 at 90,202,962 bp
  • T to A, chromosome 6 at 125,357,805 bp
  • G to A, chromosome 7 at 13,470,329 bp
  • A to T, chromosome 7 at 19,637,145 bp
  • C to A, chromosome 7 at 27,989,055 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • G to T, chromosome 7 at 45,722,183 bp
  • G to C, chromosome 7 at 79,098,091 bp
  • A to G, chromosome 7 at 105,337,602 bp
  • T to C, chromosome 7 at 107,822,615 bp
  • A to T, chromosome 7 at 108,081,036 bp
  • T to C, chromosome 7 at 128,193,340 bp
  • T to C, chromosome 9 at 58,234,874 bp
  • T to A, chromosome 9 at 110,377,693 bp
  • A to G, chromosome 10 at 78,073,925 bp
  • G to A, chromosome 11 at 49,635,698 bp
  • A to G, chromosome 11 at 67,221,604 bp
  • T to A, chromosome 11 at 71,169,795 bp
  • A to G, chromosome 11 at 74,853,082 bp
  • A to G, chromosome 11 at 78,075,831 bp
  • A to G, chromosome 11 at 84,524,000 bp
  • A to G, chromosome 11 at 119,430,361 bp
  • A to G, chromosome 12 at 66,473,196 bp
  • G to A, chromosome 12 at 109,455,049 bp
  • T to C, chromosome 13 at 17,662,266 bp
  • A to G, chromosome 13 at 21,754,277 bp
  • T to A, chromosome 13 at 40,180,448 bp
  • A to T, chromosome 13 at 81,509,551 bp
  • T to A, chromosome 15 at 41,101,183 bp
  • G to T, chromosome 15 at 85,979,230 bp
  • C to T, chromosome 16 at 32,671,421 bp
  • C to T, chromosome 17 at 46,943,364 bp
  • A to G, chromosome 17 at 68,840,686 bp
  • T to C, chromosome 18 at 44,534,230 bp
  • A to T, chromosome 19 at 34,524,799 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2189 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040191-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.