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Strain Name:
C57BL/6J-MtgxR2190Btlr/Mmmh
Stock Number:
040192-MU
Citation ID:
RRID:MMRRC_040192-MU
Other Names:
R2190 (G1), C57BL/6J-MtgxR2190Btlr
Major Collection:

Strain Information

Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Bicral
Name: BRD4 interacting chromatin remodeling complex associated protein like
Synonyms: BC032203, Gltscr1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210982
VEGA: 17
Homologene: 19366
Hsd17b12
Name: hydroxysteroid (17-beta) dehydrogenase 12
Synonyms: KIK-I, 2610510O05Rik, keratoadhesin, keratonectin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56348
Homologene: 95094
Dlg4
Name: discs large MAGUK scaffold protein 4
Synonyms: SAP90, PSD-95, SAP90A, PSD95, Dlgh4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13385
HGNC: HGNC:2903
Homologene: 1047
Usp14
Name: ubiquitin specific peptidase 14
Synonyms: dUB-type TGT, 2610005K12Rik, ataxia, ax, NMF375, 2610037B11Rik, nmf375
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 59025
Homologene: 3780
Chd4
Name: chromodomain helicase DNA binding protein 4
Synonyms: D6Ertd380e, 9530019N15Rik, Mi-2beta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107932
HGNC: HGNC:1919
Homologene: 68175
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Ccdc60
Name: coiled-coil domain containing 60
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269693
Homologene: 18624
Acbd6
Name: acyl-Coenzyme A binding domain containing 6
Synonyms: 0610010G04Rik, 2610100E10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72482
Homologene: 12465
Usf2
Name: upstream transcription factor 2
Synonyms: Usf-2, bHLHb12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22282
Homologene: 2527
Pan3
Name: PAN3 poly(A) specific ribonuclease subunit
Synonyms: 2700050F09Rik, A430027N15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72587
Homologene: 6372
Casr
Name: calcium-sensing receptor
Synonyms: CaR, Gprc2a, cation sensing receptor
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12374
HGNC: HGNC:1514
Homologene: 332
Pygo1
Name: pygopus 1
Synonyms: 2600014C22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72135
Homologene: 41050
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: NMHC II-C, 2400004E04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Dcc
Name: DCC netrin 1 receptor
Synonyms: C030036D22Rik, Igdcc1, deleted in colorectal carcinoma
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Aars1
Name: alanyl-tRNA synthetase 1
Synonyms: Aars
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234734
HGNC: HGNC:20
Homologene: 1213
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Adgrg5
Name: adhesion G protein-coupled receptor G5
Synonyms: LOC382045, PGR27, Gpr114
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382045
Homologene: 17828
Il36rn
Name: interleukin 36 receptor antagonist
Synonyms: IL-1H3, IL1HY1, FIL1delta, IL1F5, Il1f5, If36rn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54450
Homologene: 10453
Inpp5b
Name: inositol polyphosphate-5-phosphatase B
Synonyms: 75kDa
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16330
HGNC: HGNC:6077
Homologene: 69021
Trmt1
Name: tRNA methyltransferase 1
Synonyms: 6720406L13Rik, D8Ertd812e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212528
Homologene: 5632
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, 2610100B16Rik, Odz3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Rfx7
Name: regulatory factor X, 7
Synonyms: 2510005N23Rik, 9930116O05Rik, D130086K05Rik, Rfxdc2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319758
Homologene: 11275
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: D330050P16Rik, 2010013B10Rik, A230048G03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Akap11
Name: A kinase anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Spint1
Name: serine protease inhibitor, Kunitz type 1
Synonyms: HAI-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20732
Homologene: 9653
Wdr19
Name: WD repeat domain 19
Synonyms: D330023L08Rik, C330027H04Rik, Ift144, DYF2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 213081
Homologene: 11842
Itga2
Name: integrin alpha 2
Synonyms: VLA-2 receptor, alpha 2 subunit, CD49B, DX5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Irak2
Name: interleukin-1 receptor-associated kinase 2
Synonyms: 6330415L08Rik, IRAK-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108960
HGNC: HGNC:6113
Homologene: 1207
Pitx3
Name: paired-like homeodomain transcription factor 3
Synonyms: Ptx3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18742
HGNC: HGNC:9006
Homologene: 3689
Mocos
Name: molybdenum cofactor sulfurase
Synonyms: 1110018O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68591
VEGA: 18
Homologene: 9931
Slc9a5
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 5
Synonyms: LOC277973
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 277973
Homologene: 31247
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Epha3
Name: Eph receptor A3
Synonyms: Tyro4, Mek4, Hek4, Hek, Cek4, End3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Ankrd52
Name: ankyrin repeat domain 52
Synonyms: G431002C21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237615
Homologene: 18227
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: N-3 kinesin, Kif16a, 4831403C07Rik, E230025N21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: PYPAF2, E330007A02Rik, Nalp2, Pan1, Nbs1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232827
Homologene: 56789
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320083
Homologene: 110776
Or5b105
Name: olfactory receptor family 5 subfamily B member 105
Synonyms: GA_x6K02T2RE5P-3430689-3429787, MOR202-24, EG667271, Olfr1458
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667271
HGNC: HGNC:8324
Arid3a
Name: AT-rich interaction domain 3A
Synonyms: Bright, Dri1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13496
HGNC: HGNC:3031
Homologene: 124247
Acnat2
Name: acyl-coenzyme A amino acid N-acyltransferase 2
Synonyms: C730036D15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 209186
Homologene: 28287
Guf1
Name: GUF1 homolog, GTPase
Synonyms: mtEF4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231279
Homologene: 6505
Stil
Name: Scl/Tal1 interrupting locus
Synonyms: Sil
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20460
Homologene: 2283
Ntsr2
Name: neurotensin receptor 2
Synonyms: NTRL, NT2R
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18217
VEGA: 12
HGNC: HGNC:8040
Homologene: 7452
Cds1
Name: CDP-diacylglycerol synthase 1
Synonyms: phosphatidate cytidylyltransferase, 4833409J18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74596
HGNC: HGNC:1800
Homologene: 68173
Slco1c1
Name: solute carrier organic anion transporter family, member 1c1
Synonyms: OATP-F, Slc21a14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58807
Homologene: 23008
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: EG381742, Zfp469
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231861
Homologene: 45603
Slc5a1
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms: Sglt1, sodium glucose cotransporter 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20537
Homologene: 55456
Lipo2
Name: lipase, member O2
Synonyms: Gm8981
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 101055671
Homologene: 103863
Has2
Name: hyaluronan synthase 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15117
HGNC: HGNC:4819
Homologene: 3892
Itprid1
Name: ITPR interacting domain containing 1
Synonyms: D530004J12Rik, Ccdc129
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232016
Homologene: 52344
Vmn1r52
Name: vomeronasal 1 receptor 52
Synonyms: VN3, V1ra7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113849
Rab13
Name: RAB13, member RAS oncogene family
Synonyms: B230212B15Rik, 0610007N03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68328
HGNC: HGNC:9762
Homologene: 113882
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: pheromone recepter, EC1-VR2, V2rf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216144
Homologene: 83483
Fgf14
Name: fibroblast growth factor 14
Synonyms: Fhf4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14169
HGNC: HGNC:3671
Homologene: 3037
Rpl23a-ps1
Name: ribosomal protein 23A, pseudogene 1
Synonyms: Gm4851
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227054
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57257
Homologene: 38143
Col25a1
Name: collagen, type XXV, alpha 1
Synonyms: 2700062B08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77018
Homologene: 57111
Aspg
Name: asparaginase
Synonyms: A530050D06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104816
VEGA: 12
Homologene: 113390
Or14c43
Name: olfactory receptor family 14 subfamily C member 43
Synonyms: GA_x6K02T2NHDJ-9643949-9642957, MOR221-2, Olfr299
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257929
Homologene: 115489
Klrb1b
Name: killer cell lectin-like receptor subfamily B member 1B
Synonyms: Nkrp1-b, NKR-P1D, Ly55d, Ly55b, Nkrp1d, NKR-P1B, Klrb1d
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 80782
HGNC: HGNC:6373
Homologene: 84369
Thap4
Name: THAP domain containing 4
Synonyms: 2010320B01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67026
Homologene: 12075
AC238840.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Gm7932
Name: predicted gene 7932
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 666105
Tmed9
Name: transmembrane p24 trafficking protein 9
Synonyms: 2400003B06Rik, p24alpha2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67511
VEGA: 13
Homologene: 68707
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 45,981,996 bp
  • G to T, chromosome 1 at 93,750,659 bp
  • T to C, chromosome 1 at 135,879,971 bp
  • A to T, chromosome 1 at 155,624,906 bp
  • A to T, chromosome 2 at 24,280,819 bp
  • T to C, chromosome 2 at 94,034,063 bp
  • A to G, chromosome 2 at 119,238,180 bp
  • T to A, chromosome 2 at 120,714,120 bp
  • T to C, chromosome 2 at 127,810,725 bp
  • A to G, chromosome 3 at 90,223,544 bp
  • C to A, chromosome 3 at 109,562,814 bp
  • C to T, chromosome 3 at 130,584,715 bp
  • A to T, chromosome 4 at 11,197,241 bp
  • T to A, chromosome 4 at 49,383,551 bp
  • C to T, chromosome 4 at 91,264,094 bp
  • T to C, chromosome 4 at 115,032,629 bp
  • A to G, chromosome 4 at 123,459,212 bp
  • T to A, chromosome 4 at 124,785,195 bp
  • T to C, chromosome 5 at 33,104,593 bp
  • G to A, chromosome 5 at 65,244,166 bp
  • G to A, chromosome 5 at 69,559,542 bp
  • G to T, chromosome 5 at 101,821,421 bp
  • A to G, chromosome 5 at 116,157,580 bp
  • C to T, chromosome 5 at 142,775,889 bp
  • A to G, chromosome 5 at 147,545,748 bp
  • A to T, chromosome 6 at 48,862,875 bp
  • A to G, chromosome 6 at 55,897,700 bp
  • C to A, chromosome 6 at 85,667,963 bp
  • A to G, chromosome 6 at 90,179,169 bp
  • T to A, chromosome 6 at 113,686,943 bp
  • A to G, chromosome 6 at 125,114,297 bp
  • A to G, chromosome 6 at 128,826,200 bp
  • A to G, chromosome 6 at 141,563,167 bp
  • A to T, chromosome 7 at 5,319,238 bp
  • A to G, chromosome 7 at 30,955,181 bp
  • A to G, chromosome 7 at 38,768,172 bp
  • G to A, chromosome 7 at 44,661,063 bp
  • A to G, chromosome 7 at 86,466,365 bp
  • T to G, chromosome 8 at 48,395,544 bp
  • A to T, chromosome 8 at 84,689,841 bp
  • A to T, chromosome 8 at 94,933,951 bp
  • T to C, chromosome 8 at 105,359,084 bp
  • A to T, chromosome 8 at 111,040,153 bp
  • T to C, chromosome 8 at 123,129,538 bp
  • A to G, chromosome 9 at 72,617,919 bp
  • C to T, chromosome 9 at 72,945,247 bp
  • G to A, chromosome 9 at 109,436,671 bp
  • A to G, chromosome 10 at 79,268,251 bp
  • A to G, chromosome 10 at 79,946,531 bp
  • A to G, chromosome 10 at 128,383,618 bp
  • A to G, chromosome 11 at 70,042,604 bp
  • T to C, chromosome 11 at 103,500,043 bp
  • T to A, chromosome 12 at 16,654,017 bp
  • G to T, chromosome 12 at 112,124,888 bp
  • A to G, chromosome 13 at 55,593,343 bp
  • C to A, chromosome 13 at 114,870,605 bp
  • A to G, chromosome 14 at 78,502,249 bp
  • T to C, chromosome 14 at 123,983,918 bp
  • C to A, chromosome 15 at 56,667,787 bp
  • G to A, chromosome 16 at 36,495,416 bp
  • A to G, chromosome 16 at 63,546,189 bp
  • A to G, chromosome 17 at 46,825,123 bp
  • T to C, chromosome 17 at 47,000,580 bp
  • G to A, chromosome 17 at 78,801,756 bp
  • A to T, chromosome 18 at 10,007,835 bp
  • C to A, chromosome 18 at 24,664,057 bp
  • A to G, chromosome 18 at 71,547,420 bp
  • T to G, chromosome 19 at 13,102,493 bp
  • A to T, chromosome 19 at 33,748,569 bp
  • T to C, chromosome 19 at 46,137,047 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2190 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040192-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.